erythromycin

erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with erythromycin?

erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with erythromycin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Tuberculosis D014376 20 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Adenocarcinoma D000230 166 associated lipids
Bacterial Infections D001424 21 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Stomach Diseases D013272 7 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Alveolitis, Extrinsic Allergic D000542 6 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Skin Neoplasms D012878 12 associated lipids
Pleurisy D010998 20 associated lipids
Inflammation D007249 119 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Genital Diseases, Male D005832 3 associated lipids
Sexually Transmitted Diseases D012749 4 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Bone Resorption D001862 7 associated lipids
Arthritis D001168 41 associated lipids
Surgical Wound Infection D013530 7 associated lipids
Abscess D000038 13 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Heart Failure D006333 36 associated lipids
Osteitis D010000 10 associated lipids
Osteomyelitis D010019 10 associated lipids
Liver Diseases D008107 31 associated lipids
Corneal Diseases D003316 13 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Hypersensitivity D006967 22 associated lipids
Acne Vulgaris D000152 35 associated lipids
Osteolysis D010014 8 associated lipids
Rhinitis D012220 10 associated lipids
Skin Ulcer D012883 6 associated lipids
Heart Diseases D006331 8 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Multiple Myeloma D009101 13 associated lipids
Quadriplegia D011782 4 associated lipids
Pain, Postoperative D010149 13 associated lipids
Porphyrias D011164 2 associated lipids
Femoral Fractures D005264 7 associated lipids
Hematuria D006417 13 associated lipids
Labyrinth Diseases D007759 3 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Endocarditis, Bacterial D004697 5 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Obesity D009765 29 associated lipids
Bradycardia D001919 13 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Intraoperative Complications D007431 5 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Eye Diseases D005128 12 associated lipids
Salpingitis D012488 2 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Fractures, Open D005597 3 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Crohn Disease D003424 12 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Prosthesis-Related Infections D016459 7 associated lipids
Cholestasis D002779 23 associated lipids
Sinusitis D012852 9 associated lipids
Glomerulonephritis D005921 35 associated lipids
Sepsis D018805 11 associated lipids
Nervous System Diseases D009422 37 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Ataxia D001259 20 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Cross Infection D003428 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Wound Infection D014946 12 associated lipids
Bacteriuria D001437 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with erythromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with erythromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with erythromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with erythromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with erythromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with erythromycin?

Mouse Model

Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).

Knock-out

Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with erythromycin

Download all related citations
Per page 10 20 50 100 | Total 13660
Authors Title Published Journal PubMed Link
Rashed SM et al. Genetic characteristics of drug-resistant Vibrio cholerae O1 causing endemic cholera in Dhaka, 2006-2011. 2012 J. Med. Microbiol. pmid:22977073
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Wills RH et al. Structural characterization of polyketides using high mass accuracy tandem mass spectrometry. 2012 Anal. Chem. pmid:22985101
Oo C and Shah B Does erythromycin have anti-inflammatory effects independent of its antimicrobial action? 2012 J Clin Pharmacol pmid:21868717
Sommerfeld Ross S and Fiegel J Nutrient dispersion enhances conventional antibiotic activity against Pseudomonas aeruginosa biofilms. 2012 Int. J. Antimicrob. Agents pmid:22727773
Zaknoon F et al. Antibacterial properties of an oligo-acyl-lysyl hexamer targeting Gram-negative species. 2012 Antimicrob. Agents Chemother. pmid:22751534
García-Pérez ME et al. Picea mariana bark: a new source of trans-resveratrol and other bioactive polyphenols. 2012 Food Chem pmid:22953840
Martins ER et al. Dominance of serotype Ia among group B Streptococci causing invasive infections in nonpregnant adults in Portugal. 2012 J. Clin. Microbiol. pmid:22219307
Shore EM and Yudin MH Choice of antibiotic for group B streptococcus in women in labour based on antibiotic sensitivity testing. 2012 J Obstet Gynaecol Can pmid:22385665
Ullrich K et al. Neuroretinitis following bull ant sting. 2012 BMJ Case Rep pmid:22865803
Pinto A et al. 6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. 2012 Org. Lett. pmid:22519860
Yuzawa S et al. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. 2012 Biochemistry pmid:22509729
Wang Y et al. The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes. 2012 Beilstein J Org Chem pmid:23019458
Shimizu S et al. Reactivity of lignin with different composition of aromatic syringyl/guaiacyl structures and erythro/threo side chain structures in β-O-4 type during alkaline delignification: as a basis for the different degradability of hardwood and softwood lignin. 2012 J. Agric. Food Chem. pmid:22694300
Noormohamed A and Fakhr MK Incidence and antimicrobial resistance profiling of Campylobacter in retail chicken livers and gizzards. 2012 Foodborne Pathog. Dis. pmid:22545960
Pinto TF et al. Tolerance to enteral nutrition therapy in traumatic brain injury patients. 2012 Brain Inj pmid:22571511
Deane AM et al. Randomized double-blind crossover study to determine the effects of erythromycin on small intestinal nutrient absorption and transit in the critically ill. 2012 Am. J. Clin. Nutr. pmid:22572649
Rocco L et al. Micronucleus test and comet assay for the evaluation of zebrafish genomic damage induced by erythromycin and lincomycin. 2012 Environ. Toxicol. pmid:21384490
Izumikawa M et al. JBIR-78 and JBIR-95: phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56. 2012 J. Nat. Prod. pmid:22264203
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Henningsen E and Bygum A Budesonide-induced periorificial dermatitis presenting as chalazion and blepharitis. 2011 Sep-Oct Pediatr Dermatol pmid:21895758
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Zhang W et al. Construction and expression of food-grade β-galactosidase gene in Lactococcus Lactis. 2011 Curr. Microbiol. pmid:20924584
Hewer RC et al. PKA and Epac synergistically inhibit smooth muscle cell proliferation. 2011 J. Mol. Cell. Cardiol. pmid:20971121
Fessler AT et al. Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. 2011 Antimicrob. Agents Chemother. pmid:20876371
Cai XJ et al. [Protective effects of erythromycin on human bronchial epithelial cells impaired by interleukin-4]. 2011 Zhonghua Yi Xue Za Zhi pmid:22094097
Otsu K et al. Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line. 2011 Pharmacology pmid:22116077
Nakashima R et al. Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. 2011 Nature pmid:22121023
Abarzúa F et al. [Streptococcus agalactiae increase in resistance to erythromycin and clindamycin in vaginal-anal colonization in third quarter of pregnancy in one decade of universal screening]. 2011 Rev Chilena Infectol pmid:22052397
Song W et al. Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application. 2011 Int J Nanomedicine pmid:22228990
Hiller NL et al. Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone. 2011 PLoS ONE pmid:22205975
Tachecí I et al. Electrogastrography in experimental pigs: the influence of gastrointestinal injury induced by dextran sodium sulphate on porcine gastric erythromycin-stimulated myoelectric activity. 2011 Neuro Endocrinol. Lett. pmid:22167215
Nielsen EI et al. Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model. 2011 Antimicrob. Agents Chemother. pmid:21282424
Belousoff MJ et al. Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21282615
Spigaglia P et al. Surface layer protein A variant of Clostridium difficile PCR-ribotype 027. 2011 Emerging Infect. Dis. pmid:21291621
Huppertz A et al. Evaluation of possible drug-drug interaction between gadoxetic acid and erythromycin as an inhibitor of organic anion transporting peptides (OATP). 2011 J Magn Reson Imaging pmid:21274983
Saderi H et al. Phenotypic and genotypic study of macrolide, lincosamide and streptogramin B (MLSB) resistance in clinical isolates of Staphylococcus aureus in Tehran, Iran. 2011 Med. Sci. Monit. pmid:21278685
Zhang Q et al. Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C and D at different conversion ratios. 2011 Lett. Appl. Microbiol. pmid:21175699
Lam HS and Ng PC Use of prokinetics in the preterm infant. 2011 Curr. Opin. Pediatr. pmid:21178622
Ma S et al. Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. 2011 Eur J Med Chem pmid:21159410
Mak PJ et al. Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450. 2011 J. Am. Chem. Soc. pmid:21207936
Chen Y et al. Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions. 2011 Drug Metab. Dispos. pmid:21835977
Ahmetagic A et al. Plasmid encoded antibiotics inhibit protozoan predation of Escherichia coli K12. 2011 Plasmid pmid:21839110
Zhou L et al. Serotype distribution and antibiotic resistance of 140 pneumococcal isolates from pediatric patients with upper respiratory infections in Beijing, 2010. 2011 Vaccine pmid:21839135
Wu J et al. Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. 2011 Appl. Environ. Microbiol. pmid:21841022
Raynes Greenow CH et al. Antibiotics for ureaplasma in the vagina in pregnancy. 2011 Cochrane Database Syst Rev pmid:21901685
Wunder DB et al. Sorption of antibiotics to biofilm. 2011 Water Res. pmid:21334040
Senthilkumaran S and Subramanian PT Prolonged sedation related to erythromycin and midazolam interaction: a word of caution. 2011 Indian Pediatr pmid:22711153
Sonnevend Á et al. Lack of correlation between the 257C-to-T mutation in the gyrA gene and clinical severity of Campylobacter jejuni infection in a region of high incidence of ciprofloxacin resistance. 2011 Scand. J. Infect. Dis. pmid:21905953
Sigaroudinia MO and Quayle AR Oral erythromycin relieves dysphagia in a patient with known oesophageal hypomotility disorder who has had a Nissen's fundoplication. 2011 Surgeon pmid:21550524
Szary NM et al. Erythromycin prior to endoscopy in acute upper gastrointestinal bleeding: a meta-analysis. 2011 Scand. J. Gastroenterol. pmid:21561232
Wei Z and Wang J Detection of antibiotic residues in bovine milk by a voltammetric electronic tongue system. 2011 Anal. Chim. Acta pmid:21565301
Ren W and Markel DC Emerging ideas: can erythromycin reduce the risk of aseptic loosening? 2011 Clin. Orthop. Relat. Res. pmid:21584820
Torra S et al. Meal size can be decreased in obese subjects through pharmacological acceleration of gastric emptying (The OBERYTH trial). 2011 Int J Obes (Lond) pmid:20938444
Andini N and Nash KA Expression of tmRNA in mycobacteria is increased by antimicrobial agents that target the ribosome. 2011 FEMS Microbiol. Lett. pmid:21718348
Li AP and Doshi U Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4. 2011 Drug Metab Lett pmid:21722087
Imperi M et al. Invasive neonatal GBS infections from an area-based surveillance study in Italy. 2011 Clin. Microbiol. Infect. pmid:21722258
Wan G et al. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms. 2011 Cell. Signal. pmid:21723942
Kalmokoff M et al. Continuous feeding of antimicrobial growth promoters to commercial swine during the growing/finishing phase does not modify faecal community erythromycin resistance or community structure. 2011 J. Appl. Microbiol. pmid:21395944
Juntunen P et al. Longitudinal on-farm study of the development of antimicrobial resistance in Campylobacter coli from pigs before and after danofloxacin and tylosin treatments. 2011 Vet. Microbiol. pmid:21397412
Boghigian BA et al. Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. 2011 J. Ind. Microbiol. Biotechnol. pmid:21487833
Miyashita N et al. Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age. 2011 J. Infect. Chemother. pmid:20676912
Chen I et al. Emergence of erythromycin- and clindamycin-resistant Streptococcus pyogenes emm 90 strains in Hawaii. 2011 J. Clin. Microbiol. pmid:21068284
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Mikura S et al. Erythromycin prevents the pulmonary inflammation induced by exposure to cigarette smoke. 2011 Transl Res pmid:21708354
Richter SS et al. Activity of ceftaroline and epidemiologic trends in Staphylococcus aureus isolates collected from 43 medical centers in the United States in 2009. 2011 Antimicrob. Agents Chemother. pmid:21709080
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Ng PC Erythromycin as a prokinetic agent in newborns--useful or doubtful. Commentary on Y. Mansi et al.: Randomized controlled trial of a high dose of oral erythromycin for the treatment of feeding intolerance in preterm infants (Neonatology 2011;100:290-294). 2011 Neonatology pmid:21701224
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Wang SM et al. Clinical significance of erythromycin-resistant Campylobacter jejuni in children. 2011 J Microbiol Immunol Infect pmid:21531355
Dinh QT et al. Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC-MS/MS. 2011 Talanta pmid:21807177
Boghigian BA et al. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. 2011 Biotechnol. Bioeng. pmid:21337322
Kataoka M et al. Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation. 2011 Eur J Pharm Sci pmid:21963456
Hernández y Ballinas A et al. [Comparison of maternal and perinatal outcomes in the conservative treatment preterm premature membrane rupture between the use of erythromycin and clindamycin]. 2011 Ginecol Obstet Mex pmid:21966834
Gupta R et al. A 14-year-old with rectal bleeding and abdominal pain. 2011 J. Pediatr. Gastroenterol. Nutr. pmid:21970991
Pignatello R et al. Amphiphilic erythromycin-lipoamino acid ion pairs: characterization and in vitro microbiological evaluation. 2011 AAPS PharmSciTech pmid:21479751
Keelan JA et al. Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep. 2011 Am. J. Obstet. Gynecol. pmid:21481833
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Fan C and He J Proliferation of antibiotic resistance genes in microbial consortia of sequencing batch reactors (SBRs) upon exposure to trace erythromycin or erythromycin-H2O. 2011 Water Res. pmid:21482429
Franke RM et al. Effect of ABCC2 (MRP2) transport function on erythromycin metabolism. 2011 Clin. Pharmacol. Ther. pmid:21451505
Gozalbes R et al. QSAR-based permeability model for drug-like compounds. 2011 Bioorg. Med. Chem. pmid:21458999
Boleda MA et al. Behavior of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatments. 2011 Environ. Pollut. pmid:21459501
Zhang Z et al. Novel molecularly imprinted polymers based on multi-walled carbon nanotubes with binary functional monomer for the solid-phase extraction of erythromycin from chicken muscle. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21498135
Del Grosso M et al. Genetic resistance elements carrying mef subclasses other than mef(A) in Streptococcus pyogenes. 2011 Antimicrob. Agents Chemother. pmid:21502613
Loreto ES et al. In vitro susceptibility of Pythium insidiosum to macrolides and tetracycline antibiotics. 2011 Antimicrob. Agents Chemother. pmid:21537028
Nakamura PA et al. Antimicrobial resistance profiles and genetic characterisation of macrolide resistant isolates of Streptococcus agalactiae. 2011 Mem. Inst. Oswaldo Cruz pmid:21537668
Chen HX et al. [Compound erythromycin sustained release preparation and its in vitro release]. 2011 Yao Xue Xue Bao pmid:22260035
Wei Z et al. [Treatment of low-dose erythromycin and sinus displacement on sinusitis in patients with nasopharyngeal carcinoma after radiotherapy]. 2011 Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi pmid:22260078
Li Y et al. Molecular characterization of erm(B)- and mef(E)-mediated erythromycin-resistant Streptococcus pneumoniae in China and complete DNA sequence of Tn2010. 2011 J. Appl. Microbiol. pmid:20961364
Vuppalanchi R et al. Drug-induced QT prolongation in cirrhotic patients with transjugular intrahepatic portosystemic shunt. 2011 J. Clin. Gastroenterol. pmid:20962670