erythromycin
erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with erythromycin?
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (35)
- J. Antimicrob. Chemother. (18)
- J. Pharmacol. Exp. Ther. (2)
- Others (29)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with erythromycin
PubChem Associated disorders and diseases
What pathways are associated with erythromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with erythromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with erythromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with erythromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with erythromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (19)
- J. Antimicrob. Chemother. (10)
- Drug Metab. Dispos. (5)
- Others (29)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with erythromycin?
Mouse Model
Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with erythromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cimolai N | Ocular methicillin-resistant Staphylococcus aureus infections in a newborn intensive care cohort. | 2006 | Am. J. Ophthalmol. | pmid:16815280 |
| Maskin SL | Infectious scleritis after a diabetic foot ulcer. | 1993 | Am. J. Ophthalmol. | pmid:8430739 |
| Cunningham ET and Koehler JE | Ocular bartonellosis. | 2000 | Am. J. Ophthalmol. | pmid:11020414 |
| HALLETT JW and LEOPOLD IH | Clinical trial of erythromycin ophthalmic ointment. | 1957 | Am. J. Ophthalmol. | pmid:13469938 |
| Bartley GB and Messenger MM | Outcome of tarsoconjunctival flap dehiscence after eyelid reconstruction. | 2002 | Am. J. Ophthalmol. | pmid:12383835 |
| GOULD EL et al. | VACCINIA LID INFECTION. | 1963 | Am. J. Ophthalmol. | pmid:14077194 |
| Steele RJ and Meyer DR | Nasolacrimal duct obstruction and acute dacryocystitis associated with infectious mononucleosis (Epstein-Barr virus) | 1993 | Am. J. Ophthalmol. | pmid:8381586 |
| Bellows AR and Grant WM | Cyclocryotherapy in advanced inadequately controlled glaucoma. | 1973 | Am. J. Ophthalmol. | pmid:4696671 |
| Strugnell RA et al. | Characterization of the proteoglycans synthesized by rabbit testis in response to infection by Treponema pallidum. | 1986 | Am. J. Pathol. | pmid:3740214 |
| Reutenauer-Patte J et al. | Urocortins improve dystrophic skeletal muscle structure and function through both PKA- and Epac-dependent pathways. | 2012 | Am. J. Pathol. | pmid:22192627 |
| Chen J et al. | Effect of erythromycin on gastric myoelectrical activity in normal human subjects. | 1992 | Am. J. Physiol. | pmid:1636712 |
| Yamada K et al. | Electrophysiological characterization of a motilin agonist, GM611, on rabbit duodenal smooth muscle. | 1996 | Am. J. Physiol. | pmid:8997244 |
| Holle GE et al. | Effects of erythromycin in the dog upper gastrointestinal tract. | 1992 | Am. J. Physiol. | pmid:1353302 |
| Prather CM et al. | Gastric axial forces in experimentally delayed and accelerated gastric emptying. | 1993 | Am. J. Physiol. | pmid:8498519 |
| Parkman HP et al. | Gastrokinetic effects of erythromycin: myogenic and neurogenic mechanisms of action in rabbit stomach. | 1995 | Am. J. Physiol. | pmid:7573453 |
| Mathis C and Malbert CH | Erythromycin gastrokinetic activity is partially vagally mediated. | 1998 | Am. J. Physiol. | pmid:9458776 |
| Hasler WL et al. | Erythromycin contracts rabbit colon myocytes via occupation of motilin receptors. | 1992 | Am. J. Physiol. | pmid:1733270 |
| Otterson MF and Sarna SK | Gastrointestinal motor effects of erythromycin. | 1990 | Am. J. Physiol. | pmid:2399980 |
| Irokawa T et al. | Cholinomimetic action of macrolide antibiotics on airway gland electrolyte secretion. | 1999 | Am. J. Physiol. | pmid:10362719 |
| Itoh Z et al. | Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. | 1984 | Am. J. Physiol. | pmid:6507625 |
| Sun WM et al. | Relationship between surface electrogastrography and antropyloric pressures. | 1995 | Am. J. Physiol. | pmid:7900804 |
| Liu YF et al. | Sphincter of Oddi regulates flow by acting as a variable resistor to flow. | 1992 | Am. J. Physiol. | pmid:1443142 |
| Peeters T et al. | Erythromycin is a motilin receptor agonist. | 1989 | Am. J. Physiol. | pmid:2782416 |
| Tanaka T et al. | A new method to measure gastric emptying in conscious dogs: a validity study and effects of EM523 and L-NNA. | 1997 | Am. J. Physiol. | pmid:9142925 |
| Itoh Z et al. | Structure-activity relation among macrolide antibiotics in initiation of interdigestive migrating contractions in the canine gastrointestinal tract. | 1985 | Am. J. Physiol. | pmid:3976891 |
| Faas H et al. | Pressure-geometry relationship in the antroduodenal region in humans. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11668030 |
| Lemahieu WP et al. | Measurement of hepatic and intestinal CYP3A4 and PGP activity by combined po + iv [14C]erythromycin breath and urine test. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12909563 |
| Bryant LK et al. | Stimulation of small intestinal burst activity in the postprandial state differentially affects lipid and glucose absorption in healthy adult humans. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15191881 |
| Sarna SK et al. | Enteric locus of action of prokinetics: ABT-229, motilin, and erythromycin. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10801267 |
| Sun XJ et al. | Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR expression. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25957293 |
| Zhao DM et al. | Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10749750 |
| Ishizawa K et al. | Erythromycin increases bactericidal activity of surface liquid in human airway epithelial cells. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16148051 |
| Hodge S et al. | Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. | 2017 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:28258107 |
| Wyatt TA et al. | cAMP-dependent protein kinase activation decreases cytokine release in bronchial epithelial cells. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25150062 |
| Tarran R et al. | Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23542952 |
| Takagi Y et al. | Erythromycin-induced CXCR4 expression on microvascular endothelial cells. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19502290 |
| Sakahara S et al. | Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus). | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20686171 |
| Kondo M et al. | Erythromycin inhibits ATP-induced intracellular calcium responses in bovine tracheal epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9806744 |
| Dakhama A et al. | Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-beta 1 in airway epithelial cells by Mycoplasma pneumoniae. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12714377 |
| Gorrini M et al. | Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibiotics. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11694455 |
| Kudoh S et al. | Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620913 |
| Hayakawa H et al. | Bronchiolar disease in rheumatoid arthritis. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8912776 |
| Carvalho P et al. | Effects of erythromycin on the rabbit pleura: its potential role as a pleural sclerosant. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7697257 |
| Suzuki T et al. | Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11956054 |
| Tamaoki J et al. | Effect of erythromycin on endotoxin-induced microvascular leakage in the rat trachea and lungs. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7735618 |
| Azuma M et al. | Role of alpha1-acid glycoprotein in therapeutic antifibrotic effects of imatinib with macrolides in mice. | 2007 | Am. J. Respir. Crit. Care Med. | pmid:17717205 |
| Sato K et al. | Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9517602 |
| Takizawa H et al. | Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230759 |
| Seemungal TA et al. | Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. | 2008 | Am. J. Respir. Crit. Care Med. | pmid:18723437 |
| Kunisaki KM and Niewoehner DE | Antibiotic prophylaxis for chronic obstructive pulmonary disease: resurrecting an old idea. | 2008 | Am. J. Respir. Crit. Care Med. | pmid:19023036 |