Azithramycine
Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
Cross Reference
Introduction
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azithramycine?
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (156)
- Clin. Infect. Dis. (64)
- J. Antimicrob. Chemother. (50)
- Others (435)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azithramycine
PubChem Associated disorders and diseases
What pathways are associated with Azithramycine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azithramycine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (66)
- J. Antimicrob. Chemother. (25)
- Clin. Infect. Dis. (13)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Azithramycine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Azithramycine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Azithramycine?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (44)
- J. Antimicrob. Chemother. (18)
- Clin. Infect. Dis. (10)
- Others (126)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azithramycine?
Mouse Model
Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Azithramycine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Hook EW et al. | A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. | 2002 | Sex Transm Dis | pmid:12172535 |
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| Vandepitte J et al. | High prevalence of ciprofloxacin-resistant gonorrhea among female sex workers in Kampala, Uganda (2008-2009). | 2014 | Sex Transm Dis | pmid:24622633 |
| Singh AE et al. | Neisseria gonorrhoeae multiantigen sequence typing is beneficial in further characterizing gonococcal populations in Alberta, Canada. | 2013 | Sex Transm Dis | pmid:23945428 |
| Chaudhary C et al. | A pilot study on antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Nepal. | 2005 | Sex Transm Dis | pmid:16205307 |
| Carlin EM and Barton SE | Azithromycin as a cost-effective treatment for nongonococcal urethritis in men. | 1997 | Sex Transm Dis | pmid:9018784 |
| Schumacher CM and Ghanem KG | Retreatment rates for uncomplicated gonorrhea infection: comparing ceftriaxone and azithromycin versus ceftriaxone and doxycycline. | 2013 | Sex Transm Dis | pmid:23965767 |
| McLean CA et al. | The emergence of Neisseria gonorrhoeae with decreased susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000. | 2004 | Sex Transm Dis | pmid:14743069 |
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| Galarza PG et al. | Emergence of high level azithromycin-resistant Neisseria gonorrhoeae strain isolated in Argentina. | 2009 | Sex Transm Dis | pmid:19734823 |
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| Haddix AC et al. | The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women. | 1995 Sep-Oct | Sex Transm Dis | pmid:7502180 |
| Meltzer MC et al. | Association of Mobiluncus curtisii with recurrence of bacterial vaginosis. | 2008 | Sex Transm Dis | pmid:18418301 |
| Steen R et al. | Evidence of declining STD prevalence in a South African mining community following a core-group intervention. | 2000 | Sex Transm Dis | pmid:10654860 |
| Dan M et al. | Pharyngeal Gonorrhea in female sex workers: Response to a single 2-g dose of azithromycin. | 2006 | Sex Transm Dis | pmid:16572040 |
| Kiddugavu MG et al. | Effectiveness of syphilis treatment using azithromycin and/or benzathine penicillin in Rakai, Uganda. | 2005 | Sex Transm Dis | pmid:15614114 |
| Hillis SD et al. | Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women. A use-effectiveness study in public health settings. | 1998 | Sex Transm Dis | pmid:9437777 |
| Hottes TS et al. | Cephalosporin and azithromycin susceptibility in Neisseria gonorrhoeae isolates by site of infection, British Columbia, 2006 to 2011. | 2013 | Sex Transm Dis | pmid:23250301 |
| Llata E et al. | Management of Pelvic Inflammatory Disease in Selected U.S. Sexually Transmitted Disease Clinics: Sexually Transmitted Disease Surveillance Network, January 2010-December 2011. | 2015 | Sex Transm Dis | pmid:26165434 |
| Tabidze IL et al. | Adherence to Centers for Disease Control and Prevention Gonococcal Treatment Guidelines Among Chicago Health Care Providers, 2011-2012. | 2015 | Sex Transm Dis | pmid:26165433 |
| Dombrowski JC and Batteiger BE | Reconsidering the Use of Azithromycin for Chlamydial Urethritis. | 2016 | Sex Transm Dis | pmid:27626187 |
| Handsfield HH | Questioning azithromycin for chlamydial infection. | 2011 | Sex Transm Dis | pmid:21992978 |
| Stamm WE et al. | A randomized, double-blind study comparing single-dose rifalazil with single-dose azithromycin for the empirical treatment of nongonococcal urethritis in men. | 2007 | Sex Transm Dis | pmid:17297383 |