Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bala M et al. | Trends of resistance to antimicrobials recommended currently and in the past for management of gonorrhea in the Apex STD center in India and comparison of antimicrobial resistance profile between 2002-2006 and 2007-2012. | 2015 | Sex Transm Dis | pmid:25763675 |
Schillinger JA et al. | Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women: a randomized, controlled trial. | 2003 | Sex Transm Dis | pmid:12514443 |
Martin DH | The US Chlamydia trachomatis control program: successes, shortcomings and ideas for the future. | 2012 | Sex Transm Dis | pmid:23169170 |
Chen XS | Azithromycin versus penicillin G benzathine for early syphilis. | 2012 | Sex Transm Dis | pmid:23060081 |
Soge OO et al. | Emergence of increased azithromycin resistance during unsuccessful treatment of Neisseria gonorrhoeae infection with azithromycin (Portland, OR, 2011). | 2012 | Sex Transm Dis | pmid:23064537 |
Leeyaphan C et al. | Treatment Outcomes for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men Using Doxycycline, Azithromycin, or Both: A Review of Clinical Cases. | 2017 | Sex Transm Dis | pmid:28282652 |
Ito S et al. | Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. | 2017 | Sex Transm Dis | pmid:28282645 |
Ehret JM et al. | A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin. | 1996 Jul-Aug | Sex Transm Dis | pmid:8836018 |
Batteiger BE | Azithromycin Efficacy in Asymptomatic Rectal Chlamydial Infection in Men Who Have Sex With Men: A More Definitive Answer Soon? | 2017 | Sex Transm Dis | pmid:28604482 |
Zhu BY et al. | Surveillance of antimicrobial susceptibilities of Neisseria gonorrhoeae in Nanning, China, 2000 to 2012. | 2014 | Sex Transm Dis | pmid:25013979 |
Zhou P et al. | Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai. | 2010 | Sex Transm Dis | pmid:20644500 |
Smith KS et al. | Biological and Behavioral Factors Associated With Positive Chlamydia Retests. | 2017 | Sex Transm Dis | pmid:28608791 |
Labbé AC et al. | Periodical antibiotic treatment for the control of gonococcal and chlamydial infections among sex workers in Benin and Ghana: a cluster-randomized placebo-controlled trial. | 2012 | Sex Transm Dis | pmid:22421690 |
Kissinger PJ et al. | Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. | 2016 | Sex Transm Dis | pmid:27631353 |
Vandepitte J et al. | High prevalence of ciprofloxacin-resistant gonorrhea among female sex workers in Kampala, Uganda (2008-2009). | 2014 | Sex Transm Dis | pmid:24622633 |
Campos-Outcalt D et al. | Use of directly observed azithromycin treatment for syphilis in a homeless woman. | 2002 | Sex Transm Dis | pmid:12035029 |
Singh AE et al. | Neisseria gonorrhoeae multiantigen sequence typing is beneficial in further characterizing gonococcal populations in Alberta, Canada. | 2013 | Sex Transm Dis | pmid:23945428 |
Chaudhary C et al. | A pilot study on antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Nepal. | 2005 | Sex Transm Dis | pmid:16205307 |
O'Farrell N et al. | Periodic presumptive treatment for cervical infections in service women in 3 border provinces of Laos. | 2006 | Sex Transm Dis | pmid:16645552 |
SteingrÃmsson O et al. | Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men. | 1994 Jan-Feb | Sex Transm Dis | pmid:8140488 |
Dan M et al. | Pharyngeal Gonorrhea in female sex workers: Response to a single 2-g dose of azithromycin. | 2006 | Sex Transm Dis | pmid:16572040 |
Hottes TS et al. | Cephalosporin and azithromycin susceptibility in Neisseria gonorrhoeae isolates by site of infection, British Columbia, 2006 to 2011. | 2013 | Sex Transm Dis | pmid:23250301 |
Handsfield HH | Questioning azithromycin for chlamydial infection. | 2011 | Sex Transm Dis | pmid:21992978 |
Herchline TE and Inkrott BP | Resistance trends in Neisseria gonorrhoeae in southwestern Ohio. | 2010 | Sex Transm Dis | pmid:19901861 |
Van Damme K et al. | Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar. | 2009 | Sex Transm Dis | pmid:19901863 |
Horner P et al. | Which azithromycin regimen should be used for treating ? A meta-analysis. | 2018 | Sex Transm Infect | pmid:28717050 |
Nieuwenhuis RF et al. | Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin. | 2003 | Sex Transm Infect | pmid:14663119 |
Bowden FJ and Savage J | Azithromycin for the treatment of donovanosis. | 1998 | Sex Transm Infect | pmid:9634320 |
Magbanua JP et al. | Chlamydia trachomatis variant not detected by plasmid based nucleic acid amplification tests: molecular characterisation and failure of single dose azithromycin. | 2007 | Sex Transm Infect | pmid:17567684 |
Bignell C and Garley J | Azithromycin in the treatment of infection with Neisseria gonorrhoeae. | 2010 | Sex Transm Infect | pmid:20940153 |
Downing J et al. | Management of cases testing positive for gonococcal infection in a community-based chlamydia screening programme. | 2010 | Sex Transm Infect | pmid:20940161 |
Falk L et al. | Tetracycline treatment does not eradicate Mycoplasma genitalium. | 2003 | Sex Transm Infect | pmid:12902584 |
Gundevia Z et al. | Positivity at test of cure following first-line treatment for genital Mycoplasma genitalium: follow-up of a clinical cohort. | 2015 | Sex Transm Infect | pmid:25096921 |
Romoren M et al. | Costs and health consequences of chlamydia management strategies among pregnant women in sub-Saharan Africa. | 2007 | Sex Transm Infect | pmid:17932126 |
Domeika M et al. | Chlamydia trachomatis infections in eastern Europe: legal aspects, epidemiology, diagnosis, and treatment. | 2002 | Sex Transm Infect | pmid:12081171 |
Patrick DM et al. | Heterosexual outbreak of infectious syphilis: epidemiological and ethnographic analysis and implications for control. | 2002 | Sex Transm Infect | pmid:12083438 |
Björnelius E et al. | macrolide resistance in Stockholm, Sweden. | 2017 | Sex Transm Infect | pmid:27502694 |
Horner PJ | Azithromycin antimicrobial resistance and genital Chlamydia trachomatis infection: duration of therapy may be the key to improving efficacy. | 2012 | Sex Transm Infect | pmid:22416272 |
Thompson C | Azithromycin v oxytetracycline for the treatment of non-specific urethritis. | 2000 | Sex Transm Infect | pmid:10961211 |
Bartelsman M et al. | Comparison of two Gram stain point-of-care systems for urogenital gonorrhoea among high-risk patients: diagnostic accuracy and cost-effectiveness before and after changing the screening algorithm at an STI clinic in Amsterdam. | 2014 | Sex Transm Infect | pmid:24860102 |
Marks M et al. | Mass drug administration of azithromycin for trachoma reduces the prevalence of genital Chlamydia trachomatis infection in the Solomon Islands. | 2016 | Sex Transm Infect | pmid:26888658 |
Murray S and Marshall L | Empiric NSU treatment needs updating. | 2014 | Sex Transm Infect | pmid:25028712 |
Jang D et al. | Correlation between culture testing of swabs and ligase chain reaction of first void urine from patients recently treated for Chlamydia trachomatis. | 2003 | Sex Transm Infect | pmid:12794211 |
Gayet-Ageron A et al. | Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples. | 2009 | Sex Transm Infect | pmid:19155240 |
Chisholm SA et al. | An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England. | 2016 | Sex Transm Infect | pmid:26601852 |
Ito S et al. | Selection of Mycoplasma genitalium strains harbouring macrolide resistance-associated 23S rRNA mutations by treatment with a single 1 g dose of azithromycin. | 2011 | Sex Transm Infect | pmid:21653933 |
Fifer H et al. | Gonorrhoea treatment position statement. | 2015 | Sex Transm Infect | pmid:26195472 |
Björnelius E et al. | Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial. | 2008 | Sex Transm Infect | pmid:17932127 |
Horner P | The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection. | 2006 | Sex Transm Infect | pmid:16877590 |
Rice LB | Will use of combination cephalosporin/azithromycin therapy forestall resistance to cephalosporins in Neisseria gonorrhoeae? | 2015 | Sex Transm Infect | pmid:25926405 |