Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sahm DF et al. | Need for annual surveillance of antimicrobial resistance in Streptococcus pneumoniae in the United States: 2-year longitudinal analysis. | 2001 | Antimicrob. Agents Chemother. | pmid:11257013 |
De Diego JI et al. | Comparison of amoxicillin and azithromycin in the prevention of recurrent acute otitis media. | 2001 | Int. J. Pediatr. Otorhinolaryngol. | pmid:11249979 |
Amábile-Cuevas CF et al. | Comparative in vitro activity of moxifloxacin by E-test against Streptococcus pyogenes. | 2001 | Clin. Infect. Dis. | pmid:11249826 |
Duran JM and Amsden GW | Azithromycin: indications for the future? | 2000 | Expert Opin Pharmacother | pmid:11249533 |
Cascaval RI and Lancaster DJ | Hypersensitivity syndrome associated with azithromycin. | 2001 | Am. J. Med. | pmid:11247598 |
Hyde TB et al. | Azithromycin prophylaxis during a hospital outbreak of Mycoplasma pneumoniae pneumonia. | 2001 | J. Infect. Dis. | pmid:11237807 |
Dagan R et al. | Antibiotic treatment in acute Otitis Media promotes superinfection with resistant Streptococcus pneumoniae carried before initiation of treatment. | 2001 | J. Infect. Dis. | pmid:11237804 |
Ranque S | The treatment of babesiosis. | 2001 | N. Engl. J. Med. | pmid:11236790 |
Weiss LM et al. | The treatment of babesiosis. | 2001 | N. Engl. J. Med. | pmid:11236789 |
Mizen L | The activity of antibiotics against Legionella pneumophila: in vitro and in vivo studies. | 2001 | J. Antimicrob. Chemother. | pmid:11222573 |
Bregani ER et al. | Azithromycin in the treatment of Plasmodium falciparum gametocytes. Preliminary observation. | 2000 | Panminerva Med | pmid:11218625 |
Solomon AW et al. | Pilot study of the use of community volunteers to distribute azithromycin for trachoma control in Ghana. | 2001 | Bull. World Health Organ. | pmid:11217675 |
Budanov SV | [Azithromycin (sumamed)--basic properties and therapy of community-acquired pneumonia]. | 2000 | Antibiot. Khimioter. | pmid:11212397 |
Bogdanov MB and Chernen'kaia TV | [Microbiological evaluation of antibiotics for empirical therapy of community-acquired infections of the lower respiratory tract]. | 2000 | Antibiot. Khimioter. | pmid:11212394 |
Amsden G et al. | Lack of an effect of azithromycin on the disposition of zidovudine and dideoxyinosine in HIV-infected patients. | 2001 | J Clin Pharmacol | pmid:11210404 |
Khera M | Azithromycin. | 2000 | Conn Med | pmid:11210327 |
Mamikoglu B and Mamikoglu O | Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A case report. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201801 |
Amsden GW et al. | A study of the pharmacokinetics of azithromycin and nelfinavir when coadministered in healthy volunteers. | 2000 | J Clin Pharmacol | pmid:11185676 |
McNabb J et al. | Comparison of azithromycin leukocyte disposition in healthy volunteers and volunteers with AIDS. | 2000 | Int. J. Antimicrob. Agents | pmid:11185411 |
West S | The red eye. | 2000 | N. Engl. J. Med. | pmid:11184764 |
From the Centers for Disease Control and Prevention. Fluoroquinolone resistance in Neisseria gonorrhoeae, Hawaii, 1999, and decreased susceptibility to azithromycin in N. gonorrhoeae, Missouri, 1999. | 2000 | JAMA | pmid:11183745 | |
Conrad DA | Treatment of cat-scratch disease. | 2001 | Curr. Opin. Pediatr. | pmid:11176245 |
Gerber MA and Tanz RR | New approaches to the treatment of group A streptococcal pharyngitis. | 2001 | Curr. Opin. Pediatr. | pmid:11176244 |
Solera J et al. | Azithromycin and gentamicin therapy for the treatment of humans with brucellosis. | 2001 | Clin. Infect. Dis. | pmid:11170962 |
Simsir A et al. | Rhodococcus equi and cytomegalovirus pneumonia in a renal transplant patient: diagnosis by fine-needle aspiration biopsy. | 2001 | Diagn. Cytopathol. | pmid:11169894 |
Putnam SD et al. | Pharyngeal colonization prevalence rates for Streptococcus pyogenes and Streptococcus pneumoniae in a respiratory chemoprophylaxis intervention study using azithromycin. | 2000 | Clin. Microbiol. Infect. | pmid:11168029 |
Gieffers J et al. | Chlamydia pneumoniae infection in circulating human monocytes is refractory to antibiotic treatment. | 2001 | Circulation | pmid:11157684 |
Skerk V et al. | Duration of clinical symptoms in female patients with acute urethral syndrome caused by Ureaplasma urealyticum treated with azithromycin or doxycycline. | 2000 | J Chemother | pmid:11154040 |
Giacometti A et al. | Activity of buforin II alone and in combination with azithromycin and minocycline against Cryptosporidium parvum in cell culture. | 2001 | J. Antimicrob. Chemother. | pmid:11152438 |
Amsden GW and Gray CL | Serum and WBC pharmacokinetics of 1500 mg of azithromycin when given either as a single dose or over a 3 day period in healthy volunteers. | 2001 | J. Antimicrob. Chemother. | pmid:11152432 |
Vallejo C et al. | Resolution of cyclosporine-induced gingival hyperplasia resistant to azithromycin by switching to tacrolimus. | 2001 | Haematologica | pmid:11146586 |
Powers JL et al. | Comparison of the palatability of the oral suspension of cefdinir vs. amoxicillin/clavulanate potassium, cefprozil and azithromycin in pediatric patients. | 2000 | Pediatr. Infect. Dis. J. | pmid:11144401 |
Schilling F and Wagner AD | [Azithromycin: an anti-inflammatory effect in chronic recurrent multifocal osteomyelitis? A preliminary report]. | 2000 | Z Rheumatol | pmid:11142932 |
Fonck K et al. | A randomized, placebo-controlled trial of monthly azithromycin prophylaxis to prevent sexually transmitted infections and HIV-1 in Kenyan sex workers: study design and baseline findings. | 2000 | Int J STD AIDS | pmid:11138916 |
Fuchs PC et al. | Influence of variations in test methods on susceptibility of Haemophilus influenzae to ampicillin, azithromycin, clarithromycin, and telithromycin. | 2001 | J. Clin. Microbiol. | pmid:11136745 |
DeAbate CA et al. | The safety and efficacy of short course (5-day) moxifloxacin vs. azithromycin in the treatment of patients with acute exacerbation of chronic bronchitis. | 2000 | Respir Med | pmid:11127487 |
Calabrese C et al. | Pantoprazole, azithromycin and tinidazole: short duration triple therapy for eradication of Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:11121909 |
Bermudez LE et al. | Activity of moxifloxacin by itself and in combination with ethambutol, rifabutin, and azithromycin in vitro and in vivo against Mycobacterium avium. | 2001 | Antimicrob. Agents Chemother. | pmid:11120969 |
Rothstein NM et al. | Effect of azithromycin on murine arteriosclerosis exacerbated by Chlamydia pneumoniae. | 2001 | J. Infect. Dis. | pmid:11120929 |
Esposito S and Ascione T | Short-course treatment for acute tonsillopharyngitis. | 2000 | Int. J. Antimicrob. Agents | pmid:11118866 |
Waterer GW et al. | Fatal pneumococcal pneumonia attributed to macrolide resistance and azithromycin monotherapy. | 2000 | Chest | pmid:11115489 |
Nagai K et al. | In vitro development of resistance to ceftriaxone, cefprozil and azithromycin in Streptococcus pneumoniae. | 2000 | J. Antimicrob. Chemother. | pmid:11102409 |
Bowman RJ et al. | Operational comparison of single-dose azithromycin and topical tetracycline for trachoma. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:11095598 |
Gandhi R et al. | Validated LC method for in-vitro analysis of azithromycin using electrochemical detection. | 2000 | J Pharm Biomed Anal | pmid:11095310 |
Alvarez MP et al. | [Pharmacovigilance study of azithromycin tablets (500 mg) in the treatment of adult patients with respiratory tract infections]. | 2000 | Rev Esp Quimioter | pmid:11086281 |
Macaigne G et al. | [Acute pseudoangiocholitic hepatitis probably induced by azithromycin]. | 2000 | Gastroenterol. Clin. Biol. | pmid:11084438 |
Krause PJ et al. | Atovaquone and azithromycin for the treatment of babesiosis. | 2000 | N. Engl. J. Med. | pmid:11078770 |
Dunne M et al. | A randomized, double-blind trial comparing azithromycin and clarithromycin in the treatment of disseminated Mycobacterium avium infection in patients with human immunodeficiency virus. | 2000 | Clin. Infect. Dis. | pmid:11073759 |
Frenck RW et al. | Azithromycin versus ceftriaxone for the treatment of uncomplicated typhoid fever in children. | 2000 | Clin. Infect. Dis. | pmid:11073741 |
Sader H and Del'Alamo L | Etest compared to broth microdilution: discrepant results when testing macrolides against Streptococcus pneumoniae indicate a need for better clinical and serum level/MIC correlation. | 2000 | Braz J Infect Dis | pmid:11063559 |