Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Stomach Diseases D013272 7 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Lung Diseases D008171 37 associated lipids
Sarcoidosis D012507 13 associated lipids
Hyperglycemia D006943 21 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Genital Diseases, Male D005832 3 associated lipids
Sexually Transmitted Diseases D012749 4 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Abscess D000038 13 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Osteitis D010000 10 associated lipids
Dog Diseases D004283 5 associated lipids
Osteomyelitis D010019 10 associated lipids
Coronary Disease D003327 70 associated lipids
Pancreatitis D010195 10 associated lipids
Acne Vulgaris D000152 35 associated lipids
Skin Ulcer D012883 6 associated lipids
Eyelid Diseases D005141 4 associated lipids
Multiple Myeloma D009101 13 associated lipids
Pain, Postoperative D010149 13 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Corneal Opacity D003318 3 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Eye Diseases D005128 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Crohn Disease D003424 12 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Sinusitis D012852 9 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Penile Diseases D010409 2 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Cross Infection D003428 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Wound Infection D014946 12 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Nephritis, Interstitial D009395 10 associated lipids
Peptic Ulcer D010437 19 associated lipids
Cat-Scratch Disease D002372 4 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Periodontitis D010518 22 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Vomiting D014839 21 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Toxoplasmosis D014123 9 associated lipids
Toxoplasmosis, Congenital D014125 2 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Shock, Septic D012772 11 associated lipids
Syphilis D013587 6 associated lipids
Hearing Disorders D006311 10 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Precursor Cell Lymphoblastic Leukemia-Lymphoma D054198 10 associated lipids
Uterine Cervicitis D002575 3 associated lipids
Neutropenia D009503 15 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Urticaria D014581 13 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Respiratory Tract Infections D012141 4 associated lipids
Agammaglobulinemia D000361 4 associated lipids
Corneal Edema D015715 3 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
HIV Seropositivity D006679 15 associated lipids
Endophthalmitis D009877 12 associated lipids
Enteritis D004751 8 associated lipids
Leprosy D007918 8 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

Download all related citations
Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Bellon H et al. Interleukin-1α induced release of interleukin-8 by human bronchial epithelial cells in vitro: assessing mechanisms and possible treatment options. 2017 Transpl. Int. pmid:28078769
Geudens N et al. Azithromycin reduces airway inflammation in a murine model of lung ischaemia reperfusion injury. 2008 Transpl. Int. pmid:18435685
Verleden GM et al. Obliterative bronchiolitis following lung transplantation: from old to new concepts? 2009 Transpl. Int. pmid:19490538
Verleden GM et al. Montelukast for bronchiolitis obliterans syndrome after lung transplantation: a pilot study. 2011 Transpl. Int. pmid:21401732
Verleden GM et al. Current views on chronic rejection after lung transplantation. 2015 Transpl. Int. pmid:25857869
Verleden SE et al. Azithromycin decreases MMP-9 expression in the airways of lung transplant recipients. 2011 Transpl. Immunol. pmid:21740970
Vandermeulen E et al. BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance. 2015 Transpl. Immunol. pmid:26168736
Mascarenhas TR et al. Tick-borne illness after transplantation: Case and review. 2018 Transpl Infect Dis pmid:29277955
Denkinger CM et al. Cryptosporidium parvum-associated sclerosing cholangitis in a liver transplant patient. 2008 Transpl Infect Dis pmid:17605744
Scolfaro C et al. Possible donor-recipient bartonellosis transmission in a pediatric liver transplant. 2008 Transpl Infect Dis pmid:18651873
Franco M et al. Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy. 2015 Transpl Infect Dis pmid:25846671
Ivetic Tkalcevic V et al. Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories. 2012 Transl Res pmid:22677362
Walsh MS et al. Prevalence of Chlamydia trachomatis infection in Samoan women aged 18 to 29 and assessment of possible risk factors: a community-based study. 2015 Trans. R. Soc. Trop. Med. Hyg. pmid:25732755
Emary K et al. Enteric fever in Cambodian children is dominated by multidrug-resistant H58 Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin. 2012 Trans. R. Soc. Trop. Med. Hyg. pmid:23122884
Shaio MF and Yang KD Response of babesiosis to a combined regimen of quinine and azithromycin. 1997 Mar-Apr Trans. R. Soc. Trop. Med. Hyg. pmid:9196774
Shanks GD et al. Azithromycin prophylaxis prevents epidemic dysentery. 1996 May-Jun Trans. R. Soc. Trop. Med. Hyg. pmid:8758091
Mahmud ZH et al. Phenotypic and genotypic characteristics of Vibrio cholerae O1 isolated from the Sierra Leone cholera outbreak in 2012. 2014 Trans. R. Soc. Trop. Med. Hyg. pmid:25233936
Parry CM The treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever in Viet Nam. 2004 Trans. R. Soc. Trop. Med. Hyg. pmid:15138078
Alexander ND et al. An index of community ocular Chlamydia trachomatis load for control of trachoma. 2005 Trans. R. Soc. Trop. Med. Hyg. pmid:15653119
Marks M Yaws: towards the WHO eradication target. 2016 Trans. R. Soc. Trop. Med. Hyg. pmid:27268712
Pukrittayakamee S et al. Therapeutic responses to antibacterial drugs in vivax malaria. 2001 Sep-Oct Trans. R. Soc. Trop. Med. Hyg. pmid:11706666
Basilion EV et al. Height as a proxy for weight in determining azithromycin treatment for paediatric trachoma. 2002 Nov-Dec Trans. R. Soc. Trop. Med. Hyg. pmid:12625152
Desmond N et al. Acceptability of azithromycin for the control of trachoma in Northern Tanzania. 2005 Trans. R. Soc. Trop. Med. Hyg. pmid:15979657
Basilion EV et al. Simplification and improvement of height-based azithromycin treatment for paediatric trachoma. 2005 Trans. R. Soc. Trop. Med. Hyg. pmid:15550255
Medina AM et al. Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru. 2015 Trans. R. Soc. Trop. Med. Hyg. pmid:26175267
Liu Y et al. One man's poison is another man's meat: using azithromycin-induced phospholipidosis to promote ocular surface health. 2014 Toxicology pmid:24613571
Ferslew BC and Brouwer KL Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates. 2014 Toxicol. Sci. pmid:24563379
Montenez JP et al. Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models. 1999 Toxicol. Appl. Pharmacol. pmid:10198278
Mahgoub A et al. Azithromycin and erythromycin ameliorate the extent of colonic damage induced by acetic acid in rats. 2005 Toxicol. Appl. Pharmacol. pmid:15885263
Baronas ET et al. Biomarkers to monitor drug-induced phospholipidosis. 2007 Toxicol. Appl. Pharmacol. pmid:17156806
Kaneko A and Sasaki J Comparison of in vitro activity of azithromycin and ampicillin against 31 isolates of Streptococcus milleri. 1997 Tokai J. Exp. Clin. Med. pmid:9618830
van den Wollenberg L et al. Lawsonia intracellularis-associated proliferative enteritis in weanling foals in the Netherlands. 2011 Tijdschr Diergeneeskd pmid:22111417
Nilsen E [Should azithromycin dosing be changed?]. 2011 Tidsskr. Nor. Laegeforen. pmid:21844939
Rizvi SM et al. [Young boy with fever, sore throat, sore lips and bullous rashes]. 2013 Tidsskr. Nor. Laegeforen. pmid:23552160
Moi H [New treatment guidelines for gonorrhea]. 2013 Tidsskr. Nor. Laegeforen. pmid:23759772
Jernberg EJ and Moi H [Mycoplasma genitalium--aetiological agent of sexually transmitted infection]. 2007 Tidsskr. Nor. Laegeforen. pmid:17828317
Moi H et al. [Reduce the use of one-dose azithromycin]. 2011 Tidsskr. Nor. Laegeforen. pmid:21494300
Víchová B et al. First molecular identification of Babesia gibsoni in dogs from Slovakia, central Europe. 2016 Ticks Tick Borne Dis pmid:26304014
Farber FR et al. Atraumatic splenic rupture from Babesia: A disease of the otherwise healthy patient. 2015 Ticks Tick Borne Dis pmid:26123434
Ollivier V et al. Modulation of tissue factor expression by rapamycin and FK-506 in lipopolysaccharide-stimulated human mononuclear cells and serum-stimulated aortic smooth muscle cells. 2005 Thromb. Haemost. pmid:16113783
Idris SF et al. Azithromycin therapy for neutrophilic airways disease: myth or magic? 2009 Thorax pmid:19252016
Clement A et al. Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial. 2006 Thorax pmid:16809416
Brusselle GG et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. 2013 Thorax pmid:23291349
Murphy DM et al. Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts. 2007 Thorax pmid:17726173
Wolter J et al. Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised trial. 2002 Thorax pmid:11867823
Segal LN et al. Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. 2017 Thorax pmid:27486204
Hahn DL Azithromycin and severe asthma. 2013 Thorax pmid:23392446
Gibson PG Macrolides for yet another chronic airway disease: severe asthma? 2013 Thorax pmid:23349219
Brusselle GG Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? 2015 Thorax pmid:25870311
Corris PA et al. A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation. 2015 Thorax pmid:25714615