Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jernberg EJ and Moi H | [Mycoplasma genitalium--aetiological agent of sexually transmitted infection]. | 2007 | Tidsskr. Nor. Laegeforen. | pmid:17828317 |
Moi H et al. | [Reduce the use of one-dose azithromycin]. | 2011 | Tidsskr. Nor. Laegeforen. | pmid:21494300 |
van den Wollenberg L et al. | Lawsonia intracellularis-associated proliferative enteritis in weanling foals in the Netherlands. | 2011 | Tijdschr Diergeneeskd | pmid:22111417 |
Kaneko A and Sasaki J | Comparison of in vitro activity of azithromycin and ampicillin against 31 isolates of Streptococcus milleri. | 1997 | Tokai J. Exp. Clin. Med. | pmid:9618830 |
Montenez JP et al. | Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10198278 |
Mahgoub A et al. | Azithromycin and erythromycin ameliorate the extent of colonic damage induced by acetic acid in rats. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15885263 |
Baronas ET et al. | Biomarkers to monitor drug-induced phospholipidosis. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17156806 |
Ferslew BC and Brouwer KL | Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates. | 2014 | Toxicol. Sci. | pmid:24563379 |
Liu Y et al. | One man's poison is another man's meat: using azithromycin-induced phospholipidosis to promote ocular surface health. | 2014 | Toxicology | pmid:24613571 |
Alexander ND et al. | An index of community ocular Chlamydia trachomatis load for control of trachoma. | 2005 | Trans. R. Soc. Trop. Med. Hyg. | pmid:15653119 |