Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Wright HR et al. | Elimination of trachoma: are we in danger of being blinded by the randomised controlled trial? | 2006 | Br J Ophthalmol | pmid:17057171 |
Ngondi J et al. | Estimation of effects of community intervention with antibiotics, facial cleanliness, and environmental improvement (A,F,E) in five districts of Ethiopia hyperendemic for trachoma. | 2010 | Br J Ophthalmol | pmid:19897474 |
De Sole G | Elimination of trachoma. | 1997 | Br J Ophthalmol | pmid:9274426 |
Kuper H and Wormald R | Topical azithromycin: new evidence? | 2007 | Br J Ophthalmol | pmid:17446502 |
Mabey D and Bailey R | Eradication of trachoma worldwide. | 1999 | Br J Ophthalmol | pmid:10535853 |
Chern KC et al. | Alterations in the conjunctival bacterial flora following a single dose of azithromycin in a trachoma endemic area. | 1999 | Br J Ophthalmol | pmid:10574809 |
Kashkouli MB et al. | Oral azithromycin versus doxycycline in meibomian gland dysfunction: a randomised double-masked open-label clinical trial. | 2015 | Br J Ophthalmol | pmid:25138765 |
Zhang H et al. | Impact of oral azithromycin on recurrence of trachomatous trichiasis in Nepal over 1 year. | 2006 | Br J Ophthalmol | pmid:16687452 |
Gaynor BD et al. | Topical ocular antibiotics induce bacterial resistance at extraocular sites. | 2005 | Br J Ophthalmol | pmid:16113356 |
Chidambaram JD and Lietman TM | Trachoma. | 2005 | Br J Ophthalmol | pmid:16170104 |
Burton MJ et al. | A randomised controlled trial of azithromycin following surgery for trachomatous trichiasis in the Gambia. | 2005 | Br J Ophthalmol | pmid:16170117 |
Lietman T and Fry A | Can we eliminate trachoma? | 2001 | Br J Ophthalmol | pmid:11264123 |
Thylefors B | Trachoma--new opportunities to tackle an old problem. | 1996 | Br J Ophthalmol | pmid:9059262 |
Huguet P et al. | Mass treatment of trachoma with azithromycin 1.5% eye drops in the Republic of Cameroon: feasibility, tolerance and effectiveness. | 2010 | Br J Ophthalmol | pmid:19692356 |
Cochereau I et al. | Efficacy and safety of short duration azithromycin eye drops versus azithromycin single oral dose for the treatment of trachoma in children: a randomised, controlled, double-masked clinical trial. | 2007 | Br J Ophthalmol | pmid:17005549 |
Bremond-Gignac D et al. | Efficacy and safety of azithromycin 1.5% eye drops in paediatric population with purulent bacterial conjunctivitis. | 2014 | Br J Ophthalmol | pmid:24526744 |
Steeples LR et al. | Real-time PCR using the 529 bp repeat element for the diagnosis of atypical ocular toxoplasmosis. | 2016 | Br J Ophthalmol | pmid:26174811 |
Javaloy J et al. | Follicular conjunctivitis caused by Chlamydia trachomatis in an infant Saharan population: molecular and clinical diagnosis. | 2003 | Br J Ophthalmol | pmid:12543737 |
Gaynor BD et al. | Community treatment with azithromycin for trachoma is not associated with antibiotic resistance in Streptococcus pneumoniae at 1 year. | 2003 | Br J Ophthalmol | pmid:12543738 |
Taylor KI and Taylor HR | Distribution of azithromycin for the treatment of trachoma. | 1999 | Br J Ophthalmol | pmid:10396186 |
Cochereau I et al. | 3-day treatment with azithromycin 1.5% eye drops versus 7-day treatment with tobramycin 0.3% for purulent bacterial conjunctivitis: multicentre, randomised and controlled trial in adults and children. | 2007 | Br J Ophthalmol | pmid:17050578 |
Jucglà A et al. | The use of azithromycin for cyclosporin-induced gingival overgrowth. | 1998 | Br. J. Dermatol. | pmid:9536254 |
Raja Babu KK et al. | Confluent and reticulate papillomatosis: successful treatment with azithromycin. | 2000 | Br. J. Dermatol. | pmid:10848767 |
Schwartz RA et al. | Bacillary angiomatosis in an HIV seronegative patient on systemic steroid therapy. | 1996 | Br. J. Dermatol. | pmid:8977724 |
Thomsen MB et al. | No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. | 2006 | Br. J. Pharmacol. | pmid:17088870 |
VranÄić M et al. | Azithromycin distinctively modulates classical activation of human monocytes in vitro. | 2012 | Br. J. Pharmacol. | pmid:21726210 |
Broad J and Sanger GJ | The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. | 2013 | Br. J. Pharmacol. | pmid:23190027 |
Balloy V et al. | Azithromycin analogue CSY0073 attenuates lung inflammation induced by LPS challenge. | 2014 | Br. J. Pharmacol. | pmid:24417187 |
Marks M et al. | Yaws. | 2015 | Br. Med. Bull. | pmid:25525120 |
Péc J et al. | [Treatment of chlamydia infections and a brief review of the problems]. | 1995 | Bratisl Lek Listy | pmid:7633932 |
Rubio FG et al. | Intravenous azithromycin plus ceftriaxone followed by oral azithromycin for the treatment of inpatients with community-acquired pneumonia: an open-label, non-comparative multicenter trial. | 2008 | Braz J Infect Dis | pmid:18833404 |
Belda Jr W et al. | A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin. | 2009 | Braz J Infect Dis | pmid:20191200 |
Sader H and Del'Alamo L | Etest compared to broth microdilution: discrepant results when testing macrolides against Streptococcus pneumoniae indicate a need for better clinical and serum level/MIC correlation. | 2000 | Braz J Infect Dis | pmid:11063559 |
Khan FY and A yassin M | Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review. | 2009 | Braz J Infect Dis | pmid:19578637 |
Mendes CM et al. | In vitro susceptibility of gram-positive cocci isolated from skin and respiratory tract to azithromycin and twelve other antimicrobial agents. | 2001 | Braz J Infect Dis | pmid:11779453 |
Ferreira CP et al. | Atypical cutaneous mycobacteriosis caused by Mycobacterium avium complex. | 2010 May-Jun | Braz J Infect Dis | pmid:20835523 |
Oliveira IS et al. | Evaluation of the improvement of quality of life with Azithromycin in the treatment of eosinophilic nasal polyposis. | 2016 Mar-Apr | Braz J Otorhinolaryngol | pmid:26601998 |
Haas AN et al. | Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial. | 2016 | Braz Oral Res | pmid:27223128 |
Narita M et al. | Antimicrobial Susceptibility of Microorganisms Isolated from Periapical Periodontitis Lesions. | 2016 | Bull. Tokyo Dent. Coll. | pmid:27665691 |
Burr SE et al. | Mass administration of azithromycin and Streptococcus pneumoniae carriage: cross-sectional surveys in the Gambia. | 2014 | Bull. World Health Organ. | pmid:25110374 |
Solomon AW et al. | Pilot study of the use of community volunteers to distribute azithromycin for trachoma control in Ghana. | 2001 | Bull. World Health Organ. | pmid:11217675 |
Fraser-Hurt N et al. | Efficacy of oral azithromycin versus topical tetracycline in mass treatment of endemic trachoma. | 2001 | Bull. World Health Organ. | pmid:11477966 |
Frick KD et al. | Household willingness to pay for azithromycin treatment for trachoma control in the United Republic of Tanzania. | 2003 | Bull. World Health Organ. | pmid:12751418 |
Holm SO et al. | Comparison of two azithromycin distribution strategies for controlling trachoma in Nepal. | 2001 | Bull. World Health Organ. | pmid:11285662 |
Frick KD et al. | Cost-effectiveness of trachoma control measures: comparing targeted household treatment and mass treatment of children. | 2001 | Bull. World Health Organ. | pmid:11285663 |
Emerson PM et al. | The SAFE strategy for trachoma control: Using operational research for policy, planning and implementation. | 2006 | Bull. World Health Organ. | pmid:16917648 |
Bailey R and Lietman T | The SAFE strategy for the elimination of trachoma by 2020: will it work? | 2001 | Bull. World Health Organ. | pmid:11285668 |
Lück PC and Steinert M | [Pathogenesis, diagnosis and therapy of Legionella infections]. | 2006 | Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz | pmid:16596363 |
Boyer JM et al. | Nontuberculous mycobacterium infection in a burn ICU patient. | 2010 | Burns | pmid:20594758 |
Yu T and Niu T | Giant inverted T waves and substantial QT interval prolongation induced by azithromycin in an elderly woman with renal insufficiency. | 2014 | Can Fam Physician | pmid:25392441 |
Gesink D et al. | Mycoplasma genitalium in Toronto, Ont: Estimates of prevalence and macrolide resistance. | 2016 | Can Fam Physician | pmid:27331225 |
Pogany L et al. | Management of gonococcal infection among adults and youth: New key recommendations. | 2015 | Can Fam Physician | pmid:26472793 |
Abbass K et al. | Mycobacterium fortuitum breast abscess after nipple piercing. | 2014 | Can Fam Physician | pmid:24452562 |
Emerging risk of untreatable gonorrhea and what to do about it. | 2017 | Can Fam Physician | pmid:28292798 | |
Sirois F | [Delirium associated with azithromycin administration]. | 2002 | Can J Psychiatry | pmid:12211892 |
Rekart M et al. | Mass treatment/prophylaxis during an outbreak of infectious syphilis in Vancouver, British Columbia. | 2000 | Can. Commun. Dis. Rep. | pmid:10932390 |
Yoh M et al. | Effect of subinhibitory concentrations of antimicrobial agents (quinolones and macrolide) on the production of verotoxin by enterohemorrhagic Escherichia coli O157:H7. | 1999 | Can. J. Microbiol. | pmid:10526400 |
Weinstein O et al. | Bilateral acute anterior uveitis as a presenting symptom of Mycoplasma pneumoniae infection. | 2006 | Can. J. Ophthalmol. | pmid:17016530 |
Basque J et al. | Lysosomotropic drugs inhibit maturation of transforming growth factor-beta. | 2008 | Can. J. Physiol. Pharmacol. | pmid:18758509 |
Melnichouk S et al. | Evaluation of lansoprazole (an H+/K+-ATPase inhibitor) and azithromycin (an antibiotic) for control of gastric ulceration in swine during periods of feed deprivation. | 1999 | Can. J. Vet. Res. | pmid:10534003 |
Baumann U et al. | Long term azithromycin therapy in cystic fibrosis patients: a study on drug levels and sputum properties. | 2004 | Can. Respir. J. | pmid:15045047 |
Porhownik NR et al. | Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients. | 2008 May-Jun | Can. Respir. J. | pmid:18551201 |
Weiss K et al. | Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults. | 2004 Nov-Dec | Can. Respir. J. | pmid:15611810 |
Zhang M et al. | Electrophysiologic Studies on the Risks and Potential Mechanism Underlying the Proarrhythmic Nature of Azithromycin. | 2017 | Cardiovasc. Toxicol. | pmid:28213753 |
Ohara H et al. | Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes. | 2015 | Cardiovasc. Toxicol. | pmid:25367413 |
Cocco G and Jerie P | Torsades de pointes induced by the concomitant use of ivabradine and azithromycin: an unexpected dangerous interaction. | 2015 | Cardiovasc. Toxicol. | pmid:25158669 |
Tu D et al. | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. | 2005 | Cell | pmid:15851032 |
Willems-Widyastuti A et al. | Azithromycin attenuates fibroblast growth factors induced vascular endothelial growth factor via p38(MAPK) signaling in human airway smooth muscle cells. | 2013 | Cell Biochem. Biophys. | pmid:22205500 |
Tanyuksel M et al. | Determination of intracellular efficacies of azithromycin against Leishmania major infection in human neutrophils in vitro. | 2003 | Cell Biochem. Funct. | pmid:12579528 |
Nujić K et al. | Impairment of lysosomal functions by azithromycin and chloroquine contributes to anti-inflammatory phenotype. | 2012 | Cell. Immunol. | pmid:23099154 |
Castor D et al. | Antibiotic resistant N. gonorrhoeae in Trinidad and Tobago. | 2001 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:11785665 |
Li Y et al. | Synergistic Activity of Berberine with Azithromycin against Pseudomonas Aeruginosa Isolated from Patients with Cystic Fibrosis of Lung In Vitro and In Vivo. | 2017 | Cell. Physiol. Biochem. | pmid:28738346 |
Jakubů V et al. | Trends in the Minimum Inhibitory Concentrations of Erythromycin, Clarithromycin, Azithromycin, Ciprofloxacin, and Trimethoprim/Sulfamethoxazole for Strains of Bordetella pertussis isolated in the Czech Republic in 1967-2015. | 2017 | Cent. Eur. J. Public Health | pmid:29346850 |
Sobek A et al. | [Prevalence of Chlamydia trachomatis infection in patients treated for infertility]. | 2012 | Ceska Gynekol | pmid:23116355 |
Pavlova A et al. | Toward the rational design of macrolide antibiotics to combat resistance. | 2017 | Chem Biol Drug Des | pmid:28419786 |
Sanchez Garcia D et al. | Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs. | 2018 | Chem. Biol. Interact. | pmid:29248446 |
Tsuji E et al. | Evaluation of bitterness suppression of macrolide dry syrups by jellies. | 2006 | Chem. Pharm. Bull. | pmid:16508183 |
Fa N et al. | Effect of the antibiotic azithromycin on thermotropic behavior of DOPC or DPPC bilayers. | 2006 | Chem. Phys. Lipids | pmid:17007828 |
Fu L et al. | Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action. | 2017 | Chemosphere | pmid:27783962 |
Vermillion Maier ML and Tjeerdema RS | Azithromycin sorption and biodegradation in a simulated California river system. | 2018 | Chemosphere | pmid:29031188 |
Tong L et al. | Photodegradation of azithromycin in various aqueous systems under simulated and natural solar radiation: kinetics and identification of photoproducts. | 2011 | Chemosphere | pmid:21220145 |
Hauke W et al. | Esberitox N as supportive therapy when providing standard antibiotic treatment in subjects with a severe bacterial infection (acute exacerbation of chronic bronchitis). A multicentric, prospective, double-blind, placebo-controlled study. | 2002 | Chemotherapy | pmid:12476043 |
Marrie TJ | Experience with levofloxacin in a critical pathway for the treatment of community-acquired pneumonia. | 2004 | Chemotherapy | pmid:15319549 |
Paulsen P et al. | Influence of azithromycin and other macrolides on the intracellular killing of Staphylococcus aureus by human polymorphonuclear leucocytes of healthy donors and a patient with Chédiak-Higashi syndrome. | 1992 | Chemotherapy | pmid:1324831 |
Minguez F et al. | In vitro killing kinetics and postantibiotic effect of josamycin and other macrolides on several bacteria. | 1993 May-Jun | Chemotherapy | pmid:8389685 |
Chakrabarti MK et al. | Evaluation of different antibiotics in inhibiting colonization of Vibrio cholerae O1 and O139 in the rabbit intestine. | 1998 Mar-Apr | Chemotherapy | pmid:9551241 |
Vranes J | Effect of subinhibitory concentrations of ceftazidime, ciprofloxacin, and azithromycin on the hemagglutination and adherence of uropathogenic Escherichia coli strains. | 1996 May-Jun | Chemotherapy | pmid:8983884 |
Ichimiya T et al. | The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro. | 1996 May-Jun | Chemotherapy | pmid:8983885 |
Galova K et al. | Multicenter randomized study of two once daily regimens in the initial management of community-acquired respiratory tract infections in 163 children: azithromycin versus ceftibuten. | 1996 May-Jun | Chemotherapy | pmid:8983893 |
Wenzler S et al. | Comparative in vitro activities of three new quinolones and azithromycin against aerobic pathogens causing respiratory tract and abdominal wound infections. | 2004 | Chemotherapy | pmid:15084805 |
Pascual A et al. | Effect of azithromycin, roxithromycin and erythromycin on human polymorphonuclear leukocyte function against Staphylococcus aureus. | 1990 | Chemotherapy | pmid:1963394 |
Scaglione F et al. | In vitro comparative dynamics of modified-release clarithromycin and of azithromycin. | 2000 Sep-Oct | Chemotherapy | pmid:10965100 |
Qadri SM et al. | Antibacterial activity of azithromycin against Brucella melitensis. | 1995 Jul-Aug | Chemotherapy | pmid:7555205 |
Kalenić S et al. | Helicobacter pylori: in vitro induction of resistance to azithromycin. | 1998 Jan-Feb | Chemotherapy | pmid:9444404 |
Lang R et al. | Therapeutic effects of roxithromycin and azithromycin in experimental murine brucellosis. | 1994 Jul-Aug | Chemotherapy | pmid:8082413 |
Scaglione F et al. | A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells. | 1993 Nov-Dec | Chemotherapy | pmid:8222870 |
Braga PC and Piatti G | Interference by subinhibitory concentrations of azithromycin with the mechanism of bacterial adhesion to human epithelial cells. | 1993 Nov-Dec | Chemotherapy | pmid:8222872 |
Fernández-Cuenca F et al. | In vitro activity of azithromycin in combination with amikacin, ceftazidime, ciprofloxacin or imipenem against clinical isolates of Acinobacter baumannii. | 2003 | Chemotherapy | pmid:12714805 |
Fontán PA et al. | Haemophilus influenzae type b exoproducts induce chemotaxis and macrolide antibiotic release by human polymorphonuclear leukocytes. | 1996 Jan-Feb | Chemotherapy | pmid:8751269 |
Bhengraj AR et al. | Decreased susceptibility to azithromycin and doxycycline in clinical isolates of Chlamydia trachomatis obtained from recurrently infected female patients in India. | 2010 | Chemotherapy | pmid:20938174 |