Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Adal KA et al. | Photo quiz. Bacillary angiomatosis. | 1995 | Clin. Infect. Dis. | pmid:7727641 |
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Domingo S et al. | Comparative activity of azithromycin and doxycycline against Brucella spp. infection in mice. | 1995 | J. Antimicrob. Chemother. | pmid:8591939 |
Nash KA and Inderlied CB | Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease. | 1995 | Antimicrob. Agents Chemother. | pmid:8592991 |
Bohte R et al. | Levels of azithromycin and alpha-1 acid glycoprotein in serum in patients with community-acquired pneumonia. | 1995 | Antimicrob. Agents Chemother. | pmid:8593024 |
Tribble D et al. | Efficacy of azithromycin for typhoid fever. | 1995 | Clin. Infect. Dis. | pmid:8645805 |
Strickman D et al. | In vitro effectiveness of azithromycin against doxycycline-resistant and -susceptible strains of Rickettsia tsutsugamushi, etiologic agent of scrub typhus. | 1995 | Antimicrob. Agents Chemother. | pmid:8585717 |
Kuzman I et al. | Azithromycin for treatment of community acquired pneumonia caused by Legionella pneumophila: a retrospective study. | 1995 | Scand. J. Infect. Dis. | pmid:8588143 |
Principi N | Multicentre comparative study of the efficacy and safety of azithromycin compared with amoxicillin/clavulanic acid in the treatment of paediatric patients with otitis media. | 1995 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8565983 |
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Silvestri M et al. | Azithromycin induces in vitro a time-dependent increase in the intracellular killing of Staphylococcus aureus by human polymorphonuclear leucocytes without damaging phagocytes. | 1995 | J. Antimicrob. Chemother. | pmid:8821593 |
Patton DL et al. | The activity of azithromycin on the infectivity of Chlamydia trachomatis in human amniotic cells. | 1995 | J. Antimicrob. Chemother. | pmid:8821594 |
Spangler SK et al. | Susceptibilities of 201 anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin by oxyrase agar dilution and E test methodologies. | 1995 | J. Clin. Microbiol. | pmid:7615756 |
Ramadan MA et al. | Post-antibiotic effect of azithromycin and erythromycin on streptococcal susceptibility to phagocytosis. | 1995 | J. Med. Microbiol. | pmid:7752216 |
Lo KK et al. | An open non-comparative pilot study with azithromycin in the treatment of non-gonococcal urethritis in the sexually transmitted disease clinics in Hong Kong. | 1995 | Ann. Acad. Med. Singap. | pmid:8849186 |
Martin DH et al. | Comparison of azithromycin and ceftriaxone for the treatment of chancroid. | 1995 | Clin. Infect. Dis. | pmid:8562752 |
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van Rijsoort-Vos JH et al. | In-vitro activity of a new quinolone (CP-99,219) compared with ciprofloxacin, pefloxacin, azithromycin and penicillin against Neisseria gonorrhoeae. | 1995 | J. Antimicrob. Chemother. | pmid:8537268 |
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Tissi L et al. | In vivo efficacy of azithromycin in treatment of systemic infection and septic arthritis induced by type IV group B Streptococcus strains in mice: comparative study with erythromycin and penicillin G. | 1995 | Antimicrob. Agents Chemother. | pmid:8540695 |
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Felstead S | Azithromycin drug interactions. | 1995 | Pathol. Biol. | pmid:8539073 |
Modaï J | [Azithromycin: clinical assessment]. | 1995 | Pathol. Biol. | pmid:8539076 |
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Micoud M and Pépin LF | [Azithromycin and genital infections]. | 1995 | Pathol. Biol. | pmid:8539079 |
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Edelstein PH | Review of azithromycin activity against Legionella spp. | 1995 | Pathol. Biol. | pmid:8539085 |
Oh YK et al. | Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection. | 1995 | Antimicrob. Agents Chemother. | pmid:8540724 |
Clancy J et al. | Assays to detect and characterize synthetic agents that inhibit the ErmC methyltransferase. | 1995 | J. Antibiot. | pmid:8557568 |
Amsden GW | Macrolides versus azalides: a drug interaction update. | 1995 | Ann Pharmacother | pmid:8547740 |
Kuschner RA et al. | Use of azithromycin for the treatment of Campylobacter enteritis in travelers to Thailand, an area where ciprofloxacin resistance is prevalent. | 1995 | Clin. Infect. Dis. | pmid:8527539 |
Wahlstrom E et al. | Improvement in cyclosporine-associated gingival hyperplasia with azithromycin therapy. | 1995 | N. Engl. J. Med. | pmid:7854392 |
Beckers CJ et al. | Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics. | 1995 | J. Clin. Invest. | pmid:7814637 |
Friis HM | [Azithromycin--an exciting new antibiotic]. | 1995 | Ugeskr. Laeg. | pmid:7831724 |
Tajima T et al. | [Pharmacokinetic and clinical studies with azithromycin (fine granule) in the pediatric field. Pediatric Study Group of Azithromycin]. | 1995 | Jpn J Antibiot | pmid:7474329 |
Dessau RB | [Azithromycin]. | 1995 | Ugeskr. Laeg. | pmid:7831733 |
Fujii R et al. | [Pharmacokinetic and clinical studies with azithromycin (capsule) in the pediatric field. Pediatric Study Group of Azithromycin]. | 1995 | Jpn J Antibiot | pmid:7474330 |
Sasaki J et al. | [Comparative clinical study of azithromycin with tosufloxacin tosilate in the treatment of acute odontogenic infection]. | 1995 | Jpn J Antibiot | pmid:7474331 |
Uchino U et al. | [Effects of azithromycin on fecal flora of healthy adult volunteers]. | 1995 | Jpn J Antibiot | pmid:7474332 |
Toscano MA et al. | [Efficacy and tolerance of azithromycin in respiratory tract infections in children]. | 1995 | Minerva Pediatr. | pmid:7476752 |
Scheen AJ | [Pharma-clinics. Drug of the month. Azithromycin (Zitromax)]. | 1995 | Rev Med Liege | pmid:7481274 |
Nahata MC et al. | Pharmacokinetics of azithromycin in pediatric patients with acute otitis media. | 1995 | Antimicrob. Agents Chemother. | pmid:7486938 |
Tomazic J et al. | Ex vivo effect of azithromycin in human leukocyte bactericidal functions. | 1995 | Antimicrob. Agents Chemother. | pmid:7486947 |
al-Assi MT et al. | Azithromycin triple therapy for Helicobacter pylori infection: azithromycin, tetracycline, and bismuth. | 1995 | Am. J. Gastroenterol. | pmid:7872278 |
Andersen SL et al. | Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. | 1995 | Am. J. Trop. Med. Hyg. | pmid:7872444 |
Zuckerman JM and Kaye KM | The newer macrolides. Azithromycin and clarithromycin. | 1995 | Infect. Dis. Clin. North Am. | pmid:7490441 |
Schlossberg D | Azithromycin and clarithromycin. | 1995 | Med. Clin. North Am. | pmid:7791424 |
Weber JT and Johnson RE | New treatments for Chlamydia trachomatis genital infection. | 1995 | Clin. Infect. Dis. | pmid:7795110 |
Kobayashi H et al. | [Study on azithromycin in treatment of diffuse panbronchiolitis]. | 1995 | Kansenshogaku Zasshi | pmid:7616016 |
Ljutić D and Rumboldt Z | Possible interaction between azithromycin and cyclosporin: a case report. | 1995 | Nephron | pmid:7617103 |
Nilsen OG | Pharmacokinetics of macrolides. Comparison of plasma, tissue and free concentrations with special reference to roxithromycin. | 1995 | Infection | pmid:7782117 |
Anderson SL et al. | Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers. | 1995 | Ann. Intern. Med. | pmid:7574195 |
Backman JT et al. | Azithromycin does not increase plasma concentrations of oral midazolam. | 1995 | Int J Clin Pharmacol Ther | pmid:7582388 |
Harris S et al. | Azithromycin and terfenadine: lack of drug interaction. | 1995 | Clin. Pharmacol. Ther. | pmid:7554704 |
Bokemeyer B | [Combined therapy with azithromycin and omeprazole for the eradication of Helicobacter pylori]. | 1995 | Dtsch. Med. Wochenschr. | pmid:7555645 |
Péc J et al. | [Treatment of chlamydia infections and a brief review of the problems]. | 1995 | Bratisl Lek Listy | pmid:7633932 |
Bowden FJ et al. | Azithromycin and syphilis. | 1995 | Genitourin Med | pmid:7635501 |
Yeo AE and Rieckmann KH | Increased antimalarial activity of azithromycin during prolonged exposure of Plasmodium falciparum in vitro. | 1995 | Int. J. Parasitol. | pmid:7635629 |
Bamberger DM et al. | Azithromycin in an experimental Staphylococcus aureus abscess model. | 1995 | J. Antimicrob. Chemother. | pmid:7592175 |
Adegbola RA et al. | Effect of azithromycin on pharyngeal microflora. | 1995 | Pediatr. Infect. Dis. J. | pmid:7603826 |
Vartiovaara I | Living with Lyme. | 1995 | Lancet | pmid:7605437 |
Fouda HG and Schneider RP | Quantitative determination of the antibiotic azithromycin in human serum by high-performance liquid chromatography (HPLC)-atmospheric pressure chemical ionization mass spectrometry: correlation with a standard HPLC-electrochemical method. | 1995 | Ther Drug Monit | pmid:7624907 |
Goldstein EJ et al. | Comparative in vitro activities of azithromycin, Bay y 3118, levofloxacin, sparfloxacin, and 11 other oral antimicrobial agents against 194 aerobic and anaerobic bite wound isolates. | 1995 | Antimicrob. Agents Chemother. | pmid:7625795 |
Rizzato G et al. | Efficacy of a three day course of azithromycin in moderately severe community-acquired pneumonia. | 1995 | Eur. Respir. J. | pmid:7789484 |
Barry AL et al. | Relative potencies of azithromycin, clarithromycin and five other orally administered antibiotics. | 1995 | J. Antimicrob. Chemother. | pmid:7628991 |
Stamm WE et al. | Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study. | 1995 | JAMA | pmid:7629982 |
Schmid GP and Fontanarosa PB | Evolving strategies for management of the nongonococcal urethritis syndrome. | 1995 | JAMA | pmid:7629989 |
Sadiq ST et al. | Effects of azithromycin on malariometric indices in The Gambia. | 1995 | Lancet | pmid:7564674 |
Wawer MJ et al. | AIDS intervention in Uganda. | 1995 | Science | pmid:7570005 |
Pascual A et al. | Factors affecting the intracellular accumulation and activity of azithromycin. | 1995 | J. Antimicrob. Chemother. | pmid:7768786 |
Beghi G et al. | Efficacy and tolerability of azithromycin versus amoxicillin/clavulanic acid in acute purulent exacerbation of chronic bronchitis. | 1995 | J Chemother | pmid:7666122 |
Amland PF et al. | A prospective, double-blind, placebo-controlled trial of a single dose of azithromycin on postoperative wound infections in plastic surgery. | 1995 | Plast. Reconstr. Surg. | pmid:7480237 |
Worm AM and Osterlind A | Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis. | 1995 | Genitourin Med | pmid:7590717 |
[New ways of antibiotic therapy]. | 1995 | Internist (Berl) | pmid:9431354 | |
Gastearena I et al. | Determination of the alpha1-acid glycoprotein binding of azithromycin in vitro by equilibrium dialysis. | 1995 | J Chemother | pmid:8904095 |
Domingo S et al. | Significance of environmental conditions (pH and serum) on the in vitro potency of azithromycin against Brucella melitensis. | 1995 | J Chemother | pmid:8904096 |
Van Asselt GJ et al. | Susceptibility of Streptococcus pyogenes to azithromycin, clarithromycin, erythromycin and roxithromycin in vitro. | 1995 | J. Med. Microbiol. | pmid:7563004 |
Bessette RE and Amsden GW | Treatment of non-HIV cryptosporidial diarrhea with azithromycin. | 1995 | Ann Pharmacother | pmid:8845560 |
Sher AA et al. | [Interactions in the system of copper ion-azalide (azithromycin)]. | 1994 Sep-Oct | Antibiot. Khimioter. | pmid:7695446 |
Handsfield HH et al. | Multicenter trial of single-dose azithromycin vs. ceftriaxone in the treatment of uncomplicated gonorrhea. Azithromycin Gonorrhea Study Group. | 1994 Mar-Apr | Sex Transm Dis | pmid:9071422 |
Tyndall MW et al. | Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin. | 1994 Jul-Aug | Sex Transm Dis | pmid:7974076 |
Lang R et al. | Therapeutic effects of roxithromycin and azithromycin in experimental murine brucellosis. | 1994 Jul-Aug | Chemotherapy | pmid:8082413 |
SteingrÃmsson O et al. | Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men. | 1994 Jan-Feb | Sex Transm Dis | pmid:8140488 |
Tuffrey M et al. | The effect of a single oral dose of azithromycin on chlamydial infertility and oviduct ultrastructure in mice. | 1994 | J. Antimicrob. Chemother. | pmid:7730241 |
Carlier MB et al. | Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture. | 1994 | Int J Tissue React | pmid:7558665 |
Uzun O et al. | Efficacy of a three-day course of azithromycin in the treatment of community-acquired pneumococcal pneumonia. Preliminary report. | 1994 | J Chemother | pmid:8071680 |