Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

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Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Abnormalities, Drug-Induced D000014 10 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Abscess D000038 13 associated lipids
Achondroplasia D000130 1 associated lipids
Acinetobacter Infections D000151 4 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Actinomycetales Infections D000193 4 associated lipids
Agammaglobulinemia D000361 4 associated lipids
Airway Obstruction D000402 13 associated lipids
Amebiasis D000562 2 associated lipids
Anaphylaxis D000707 35 associated lipids
Anaplasmataceae Infections D000711 3 associated lipids
Angina, Unstable D000789 14 associated lipids
Aphasia, Broca D001039 1 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Bacterial Infections D001424 21 associated lipids
Bartonella Infections D001474 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Kobuchi S et al. Transport of Azithromycin into Extravascular Space in Rats. 2016 Antimicrob. Agents Chemother. pmid:27600045
Rajesh AM and Popat KM Taste masking of azithromycin by resin complex and sustained release through interpenetrating polymer network with functionalized biopolymers. 2017 Drug Dev Ind Pharm pmid:27600608
Thompson DF and Ramos CL Antibiotic-Induced Rash in Patients With Infectious Mononucleosis. 2017 Ann Pharmacother pmid:27620494
Peart JM et al. Sporotrichoid fluctuant nodules. 2016 Cutis pmid:27622258
Dombrowski JC and Batteiger BE Reconsidering the Use of Azithromycin for Chlamydial Urethritis. 2016 Sex Transm Dis pmid:27626187
Mitjà O et al. Mass Treatment with Single-Dose Azithromycin for Yaws. 2016 N. Engl. J. Med. pmid:27626525
Eckhoff G et al. Mass Treatment with Single-Dose Azithromycin for Yaws. 2016 N. Engl. J. Med. pmid:27626526
Tepper M et al. Mass Treatment with Single-Dose Azithromycin for Yaws. 2016 N. Engl. J. Med. pmid:27626527
Kissinger PJ et al. Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. 2016 Sex Transm Dis pmid:27631353
Regnath T et al. Antimicrobial resistance of Neisseria gonorrhoeae isolates in south-west Germany, 2004 to 2015: increasing minimal inhibitory concentrations of tetracycline but no resistance to third-generation cephalosporins. 2016 Euro Surveill. pmid:27632642
Mosquera RA et al. Anti-inflammatory effect of prophylactic macrolides on children with chronic lung disease: a protocol for a double-blinded randomised controlled trial. 2016 BMJ Open pmid:27638496
Brunner A et al. Emerging azithromycin-resistance among the Neisseria gonorrhoeae strains isolated in Hungary. 2016 Ann. Clin. Microbiol. Antimicrob. pmid:27646968
Johnston SL et al. Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial. 2016 JAMA Intern Med pmid:27653939
Li S et al. Two case reports: Whole genome sequencing of two clinical macrolide-resistant Mycoplasma pneumoniae isolates with different responses to azithromycin. 2016 Medicine (Baltimore) pmid:27661056
Petrelli F et al. Poly(ADP-ribose) polymerase is not involved in the neuroprotection exerted by azithromycin against ischemic stroke in mice. 2016 Eur. J. Pharmacol. pmid:27663279
Lin SJ et al. Azithromycin modulates immune response of human monocyte-derived dendritic cells and CD4 T cells. 2016 Int. Immunopharmacol. pmid:27664570
Narita M et al. Antimicrobial Susceptibility of Microorganisms Isolated from Periapical Periodontitis Lesions. 2016 Bull. Tokyo Dent. Coll. pmid:27665691
Waites KB et al. In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas. 2016 Antimicrob. Agents Chemother. pmid:27671057
Tita AT et al. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2016 N. Engl. J. Med. pmid:27682034
Jover-García J et al. [In-vitro activity of azithromycin in faecal isolates of Aeromonas hydrophila]. 2017 An Pediatr (Barc) pmid:27686393
Mougari F et al. Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. 2016 Expert Rev Anti Infect Ther pmid:27690688
Bouklouze A et al. Azithromycin assay in drug formulations: Validation of a HPTLC method with a quadratic polynomial calibration model using the accuracy profile approach. 2017 Ann Pharm Fr pmid:27692351
van den Berg GF et al. Chlamydia screening and prophylactic treatment in termination of pregnancy clinics in the Netherlands and Great Britain: a qualitative study. 2016 Eur J Contracept Reprod Health Care pmid:27701927
Wind CM et al. Time to clearance of Chlamydia trachomatis RNA and DNA after treatment in patients coinfected with Neisseria gonorrhoeae - a prospective cohort study. 2016 BMC Infect. Dis. pmid:27724878
Weintraub A et al. In-vitro activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota. 2016 Anaerobe pmid:27725229
Sadatsafavi M et al. The Association Between Rate and Severity of Exacerbations in Chronic Obstructive Pulmonary Disease: An Application of a Joint Frailty-Logistic Model. 2016 Am. J. Epidemiol. pmid:27737842
Johnson P Management of a 16-Year-Old With Axillary Lymphadenopathy: The Cat's in the Bag. J Pediatr Health Care pmid:27742481
Daimee UA et al. A 77-year-old man with fever and night sweats. 2017 Eur. J. Intern. Med. pmid:27765389
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Luo Q et al. Surface plasmon resonance sensor for antibiotics detection based on photo-initiated polymerization molecularly imprinted array. 2016 Talanta pmid:27769483
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Dupin N et al. [Chlamydia trachomatis]. 2016 Ann Dermatol Venereol pmid:27773503
Caumes E et al. [Donovanosis (granuloma inguinale)]. 2016 Ann Dermatol Venereol pmid:27773509
Mwingira UJ et al. Progress of Trachoma Mapping in Mainland Tanzania: Results of Baseline Surveys from 2012 to 2014. 2016 Ophthalmic Epidemiol pmid:27775455
Gerhardt P et al. [Male urethritis]. 2016 Ann Dermatol Venereol pmid:27776813
Fu L et al. Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action. 2017 Chemosphere pmid:27783962
Gomes C et al. Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin. 2017 Crit. Rev. Microbiol. pmid:27786586
Libois A and De Wit S Which empiric syndromic treatment for urethritis? 2016 Int J STD AIDS pmid:27794143
Ervin AM et al. Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics. 2016 Ophthalmic Epidemiol pmid:27820670
Serdar Kutuk M et al. Relationship between maternal c-reactive protein level and neonatal outcome in patients with preterm premature rupture of membranes treated with Ampicillin and Azithromycin. 2016 J Obstet Gynaecol pmid:27825282
Paul SP et al. Spontaneous surgical emphysema: an unusual complication of paediatric asthma. 2016 Br J Hosp Med (Lond) pmid:27828753
Yan M et al. Synthesis and antibacterial activity of novel 3-O-descladinosylazithromycin derivatives. 2017 Eur J Med Chem pmid:27836198
Elshafie BE et al. The Epidemiology of Trachoma in Darfur States and Khartoum State, Sudan: Results of 32 Population-Based Prevalence Surveys. 2016 Ophthalmic Epidemiol pmid:27841721
Zhang C et al. Decreased Susceptibility to Azithromycin Among Clinical Shigella Isolates from China. 2017 Microb. Drug Resist. pmid:27841958
Waites KB et al. In Vitro Activities of Lefamulin and Other Antimicrobial Agents against Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China. 2017 Antimicrob. Agents Chemother. pmid:27855075
Zhang Y et al. Novel Detection Strategy To Rapidly Evaluate the Efficacy of Antichlamydial Agents. 2017 Antimicrob. Agents Chemother. pmid:27855081
Phiri K et al. Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. 2016 PLoS ONE pmid:27861509
Babić I et al. Therapeutic efficacy of azithromycin and acetylcysteine in chronic otitis media with effusion. 2017 Eur Arch Otorhinolaryngol pmid:27873023
Brittain C et al. Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial. 2016 Trials pmid:27881151
Requena-Méndez A et al. Enteric fever in Barcelona: Changing patterns of importation and antibiotic resistance. Travel Med Infect Dis pmid:27890811
Nielsen HL et al. Azithromycin vs. Placebo for the Clinical Outcome in Campylobacter concisus Diarrhoea in Adults: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. 2016 PLoS ONE pmid:27893820
Manesh A et al. A case of clinical and microbiological failure of azithromycin therapy in Salmonella enterica serotype Typhi despite low azithromycin MIC. 2017 Int. J. Infect. Dis. pmid:27894983
Bornstein M et al. Factors Associated With Primary Care Physician Knowledge of the Recommended Regimen for Treating Gonorrhea. 2017 Sex Transm Dis pmid:27898574
Misra R and Prasad KN Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India. 2016 J. Med. Microbiol. pmid:27902389
Zhao X et al. Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids. 2016 PLoS ONE pmid:27907030
Retallack H et al. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:27911847
Valdés SO et al. Cardiac Arrest in Pediatric Patients Receiving Azithromycin. 2017 J. Pediatr. pmid:27912925
Liu Y et al. Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis. 2017 Life Sci. pmid:27916734
Arora N et al. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. 2016 Nat Microbiol pmid:27918528
Collins SA et al. Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms. 2017 Antimicrob. Agents Chemother. pmid:27919896
EmiralioÄŸlu N et al. Long term azithromycin therapy in patients with cystic fibrosis. 2016 Turk. J. Pediatr. pmid:27922234
Amza A et al. A Cluster-Randomized Trial to Assess the Efficacy of Targeting Trachoma Treatment to Children. 2017 Clin. Infect. Dis. pmid:27956455
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Hirasawa K et al. Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. 2016 PLoS ONE pmid:27977675
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Marks M et al. Mathematical Modeling of Programmatic Requirements for Yaws Eradication. 2017 Emerging Infect. Dis. pmid:27983500
Seyama S et al. Emergence and molecular characterization of Haemophilus influenzae harbouring mef(A). 2017 J. Antimicrob. Chemother. pmid:27999037
Shapiro ED and Wormser GP Prophylaxis with topical azithromycin against Lyme borreliosis. 2017 Lancet Infect Dis pmid:28007427
Schwameis M et al. Topical azithromycin for the prevention of Lyme borreliosis: a randomised, placebo-controlled, phase 3 efficacy trial. 2017 Lancet Infect Dis pmid:28007428
Liu X et al. Novel antimicrobial peptide-modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus. 2016 Int J Nanomedicine pmid:28008253
Read TR et al. Azithromycin 1.5g Over 5 Days Compared to 1g Single Dose in Urethral Mycoplasma genitalium: Impact on Treatment Outcome and Resistance. 2017 Clin. Infect. Dis. pmid:28011607
Park J et al. Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense. 2017 Clin. Infect. Dis. pmid:28011609
Nichols DP et al. Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis. 2017 J. Cyst. Fibros. pmid:28025037
Saini H et al. Azithromycin-Ciprofloxacin-Impregnated Urinary Catheters Avert Bacterial Colonization, Biofilm Formation, and Inflammation in a Murine Model of Foreign-Body-Associated Urinary Tract Infections Caused by Pseudomonas aeruginosa. 2017 Antimicrob. Agents Chemother. pmid:28031194
Sutton SS Is cardiovascular risk a concern when prescribing azithromycin? 2017 JAAPA pmid:28033168
Allen G Evidence appraisal of Tita ATN, Szychowski JM, Boggess K, et al. Adjunctive azithromycin prophylaxis for cesarean delivery.: N Engl J Med. 2016;375:1231-1241. 2017 AORN J pmid:28034388
Johnson SR et al. Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance. 2017 Int. J. Antimicrob. Agents pmid:28038960
Gong L et al. Clinical effect of treating secondary asthma attacks of children Mycoplasma pneumoniae with combined therapy of montelukast and azithromycin. 2016 Eur Rev Med Pharmacol Sci pmid:28051240
Gensel JC et al. Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. 2017 Sci Rep pmid:28057928
Lau A et al. Treatment efficacy of azithromycin 1 g single dose versus doxycycline 100 mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. 2017 BMC Infect. Dis. pmid:28061753
Llop CJ et al. Antibiotic treatment patterns, costs, and resource utilization among patients with community acquired pneumonia: a US cohort study. 2017 Hosp Pract (1995) pmid:28064542
Descours G et al. Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila. 2017 Antimicrob. Agents Chemother. pmid:28069647
Kwakye-Maclean C et al. A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. 2017 PLoS Negl Trop Dis pmid:28072863
Idkaidek N et al. Saliva Versus Plasma Bioequivalence of Azithromycin in Humans: Validation of Class I Drugs of the Salivary Excretion Classification System. 2017 Drugs R D pmid:28074334
Tita ATN et al. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28076707
Bellon H et al. Interleukin-1α induced release of interleukin-8 by human bronchial epithelial cells in vitro: assessing mechanisms and possible treatment options. 2017 Transpl. Int. pmid:28078769
Greig JR and Jones L Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079334
Ragusa A and Svelato A Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079335
Wind CM et al. Trends in antimicrobial susceptibility for azithromycin and ceftriaxone in Neisseria gonorrhoeae isolates in Amsterdam, the Netherlands, between 2012 and 2015. 2017 Euro Surveill. pmid:28079519
Okah E et al. Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. 2017 Sex Transm Dis pmid:28079746
Gawin A et al. Mildly pruritic palmar rash. 2016 J Fam Pract pmid:28087868
Kibuule D et al. An analysis of policies for cotrimoxazole, amoxicillin and azithromycin use in Namibia's public sector: Findings and therapeutic implications. 2017 Int. J. Clin. Pract. pmid:28090718
Bulman ZP et al. Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin. 2017 Antimicrob. Agents Chemother. pmid:28096154
Liao YS et al. Azithromycin-Nonsusceptible Shigella flexneri 3a in Men Who Have Sex with Men, Taiwan, 2015-2016. 2016 Emerging Infect. Dis. pmid:28098533
Murray K et al. Increasing Antibiotic Resistance in Shigella spp. from Infected New York City Residents, New York, USA. 2017 Emerging Infect. Dis. pmid:28098543
Diniz LM et al. Bacillary angiomatosis with bone invasion. 2016 Nov-Dec An Bras Dermatol pmid:28099606
Haque F et al. Evaluation of a Smartphone Decision-Support Tool for Diarrheal Disease Management in a Resource-Limited Setting. 2017 PLoS Negl Trop Dis pmid:28103233
Koop AH et al. 56-Year-Old Woman With Cough and Fatigue for 1 Week. 2017 Mayo Clin. Proc. pmid:28110893
Cramer CL et al. Immunomodulatory indications of azithromycin in respiratory disease: a concise review for the clinician. 2017 Postgrad Med pmid:28116959
Cogen JD et al. Characterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations. 2017 Pediatrics pmid:28126911