Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Desnica B et al. | Myalgia and swelling of interphalangeal joints as side-effect of prolonged azithromycin therapy in patient with pelvic actinomycosis: case report. | 2007 | Scand. J. Infect. Dis. | pmid:17366044 |
Dakdouki GK et al. | Azithromycin-induced rash in infectious mononucleosis. | 2002 | Scand. J. Infect. Dis. | pmid:12587634 |
Batieha A et al. | No advantage of treating acute respiratory tract infections with azithromycin in a placebo-controlled study. | 2002 | Scand. J. Infect. Dis. | pmid:12064684 |
Schönwald S et al. | Three-day azithromycin compared with ten-day roxithromycin treatment of atypical pneumonia. | 1994 | Scand. J. Infect. Dis. | pmid:7747094 |
Brandén E et al. | Intermittent azithromycin treatment for respiratory symptoms in patients with chronic Chlamydia pneumoniae infection. | 2004 | Scand. J. Infect. Dis. | pmid:15764166 |
Dickerson FB et al. | A double-blind trial of adjunctive azithromycin in individuals with schizophrenia who are seropositive for Toxoplasma gondii. | 2009 | Schizophr. Res. | pmid:19464853 |
Feary DJ et al. | Lawsonia intracellularis proliferative enteropathy in a foal. | 2007 | Schweiz. Arch. Tierheilkd. | pmid:17410971 |
Ratzinger F et al. | Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity. | 2014 | Sci Rep | pmid:25500904 |
Gensel JC et al. | Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. | 2017 | Sci Rep | pmid:28057928 |
Wang A et al. | Effects of Fluoroquinolones and Azithromycin on Biofilm Formation of Stenotrophomonas maltophilia. | 2016 | Sci Rep | pmid:27405358 |
Menzel M et al. | Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients. | 2016 | Sci Rep | pmid:27350308 |
Zeng J et al. | Mechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa. | 2016 | Sci Rep | pmid:27075730 |
Pansieri C et al. | Ureaplasma, bronchopulmonary dysplasia, and azithromycin in European neonatal intensive care units: a survey. | 2014 | Sci Rep | pmid:24518104 |
Das MC et al. | Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. | 2016 | Sci Rep | pmid:27000525 |
Gualdoni GA et al. | Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation. | 2015 | Sci Rep | pmid:26152605 |
Friesen J et al. | Natural immunization against malaria: causal prophylaxis with antibiotics. | 2010 | Sci Transl Med | pmid:20630856 |
Topp E et al. | Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. | 2016 | Sci. Total Environ. | pmid:27096634 |
Sidhu H et al. | Risk assessment of biosolids-borne ciprofloxacin and azithromycin. | 2019 | Sci. Total Environ. | pmid:30463165 |
Sidhu H et al. | Plant toxicity and accumulation of biosolids-borne ciprofloxacin and azithromycin. | 2019 | Sci. Total Environ. | pmid:30340267 |
Sidhu H et al. | Retention-release of ciprofloxacin and azithromycin in biosolids and biosolids-amended soils. | 2019 | Sci. Total Environ. | pmid:30196217 |
Sidhu H et al. | Bioavailability of biosolids-borne ciprofloxacin and azithromycin to terrestrial organisms: Microbial toxicity and earthworm responses. | 2019 | Sci. Total Environ. | pmid:30195128 |
Wawer MJ et al. | AIDS intervention in Uganda. | 1995 | Science | pmid:7570005 |
Seguà DÃaz M | [What is the best treatment for urogenital Chlamydia trachomatis infection?] | Semergen | pmid:27068255 | |
Berger BW | Lyme disease. | 1993 | Semin Dermatol | pmid:8312152 |
Pedro-Botet ML and Sabrià M | Legionellosis. | 2005 | Semin Respir Crit Care Med | pmid:16388431 |
Suriawinata A and Min AD | A 33-year-old woman with jaundice after azithromycin use. | 2002 | Semin. Liver Dis. | pmid:12016551 |
Weinstein SA and Stiles BG | A review of the epidemiology, diagnosis and evidence-based management of Mycoplasma genitalium. | 2011 | Sex Health | pmid:21592428 |
McCormick DF et al. | Prevention and control of sexually transmissible infections among hotel-based female sex workers in Dhaka, Bangladesh. | 2013 | Sex Health | pmid:24262217 |
Robertson A et al. | Case report: lymphogranuloma venereum in New Zealand. | 2008 | Sex Health | pmid:19061558 |
Stratov I et al. | Azithromycin: more lethal than chloramphenicol? | 2013 | Sex Health | pmid:23448962 |
Renault CA et al. | Time to clearance of Chlamydia trachomatis ribosomal RNA in women treated for chlamydial infection. | 2011 | Sex Health | pmid:21371385 |
Jones S et al. | The tip of the iceberg: opportunistic screening for Chlamydia trachomatis in asymptomatic patients attending a young people's health clinic reveals a high prevalence--a pilot study. | 2004 | Sex Health | pmid:16334993 |
Grimes M et al. | Two mutations associated with macrolide resistance in Treponema pallidum: increasing prevalence and correlation with molecular strain type in Seattle, Washington. | 2012 | Sex Transm Dis | pmid:23191949 |
Mabey D | Azithromycin resistance in Treponema pallidum. | 2009 | Sex Transm Dis | pmid:19801961 |
Zheng H et al. | Association of the in vitro susceptibility of clinical isolates of chlamydia trachomatis with serovar and duration of antibiotic exposure. | 2015 | Sex Transm Dis | pmid:25668641 |
Hublikar S et al. | Disseminated gonococcal infection and eculizumab--a "high risk" connection? | 2014 | Sex Transm Dis | pmid:25581812 |
Bianchi A et al. | Kinetics of Chlamydia trachomatis clearance in patients with azithromycin, as assessed by first void urine testing by PCR and transcription-mediated amplification. | 1998 | Sex Transm Dis | pmid:9713917 |
Cole MJ et al. | Risk factors for antimicrobial-resistant Neisseria gonorrhoeae in Europe. | 2014 | Sex Transm Dis | pmid:25581808 |
Kerani RP et al. | Gonorrhea treatment practices in the STD Surveillance Network, 2010-2012. | 2015 | Sex Transm Dis | pmid:25504294 |
Zhou P et al. | Occurrence of congenital syphilis after maternal treatment with azithromycin during pregnancy. | 2007 | Sex Transm Dis | pmid:17589329 |
Muldoon EG et al. | Treponema pallidum azithromycin resistance in Dublin, Ireland. | 2012 | Sex Transm Dis | pmid:23001265 |
Prevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007 to 2009. | 2012 | Sex Transm Dis | pmid:23001267 | |
Starnino S et al. | Retrospective analysis of antimicrobial susceptibility trends (2000-2009) in Neisseria gonorrhoeae isolates from countries in Latin America and the Caribbean shows evolving resistance to ciprofloxacin, azithromycin and decreased susceptibility to ceftriaxone. | 2012 | Sex Transm Dis | pmid:23001269 |
Thakur SD et al. | Resistance to Ceftriaxone and Azithromycin in Neisseria gonorrhoeae Isolates From 7 Countries of South America and the Caribbean: 2010-2011. | 2017 | Sex Transm Dis | pmid:28178114 |
Handsfield HH et al. | Multicenter trial of single-dose azithromycin vs. ceftriaxone in the treatment of uncomplicated gonorrhea. Azithromycin Gonorrhea Study Group. | 1994 Mar-Apr | Sex Transm Dis | pmid:9071422 |
Yasin RM et al. | Comparison of E-test with agar dilution methods in testing susceptibility of N. gonorrhoeae to azithromycin. | 1997 | Sex Transm Dis | pmid:9153733 |
Asbel LE et al. | School-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae among Philadelphia public high school students. | 2006 | Sex Transm Dis | pmid:16614587 |
Sosa J et al. | High percentages of resistance to tetracycline and penicillin and reduced susceptibility to azithromycin characterize the majority of strain types of Neisseria gonorrhoeae isolates in Cuba, 1995-1998. | 2003 | Sex Transm Dis | pmid:12916137 |
Okah E et al. | Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. | 2017 | Sex Transm Dis | pmid:28079746 |
Hook EW et al. | A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. | 2002 | Sex Transm Dis | pmid:12172535 |
Sahin-Hodoglugil NN et al. | A comparison of cost-effectiveness of three protocols for diagnosis and treatment of gonococcal and chlamydial infections in women in Africa. | 2003 | Sex Transm Dis | pmid:12916139 |
Howell MR et al. | Control of Chlamydia trachomatis infections in female army recruits: cost-effective screening and treatment in training cohorts to prevent pelvic inflammatory disease. | 1999 | Sex Transm Dis | pmid:10534206 |
Beymer MR et al. | Evaluation of gonorrhea test of cure at 1 week in a Los Angeles community-based clinic serving men who have sex with men. | 2014 | Sex Transm Dis | pmid:25211254 |
Beyda RM et al. | Azithromycin efficacy in the treatment of Chlamydia trachomatis among detained youth. | 2014 | Sex Transm Dis | pmid:25211253 |
Tyndall MW et al. | Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin. | 1994 Jul-Aug | Sex Transm Dis | pmid:7974076 |
Katz KA et al. | Molecular epidemiology of syphilis--San Francisco, 2004-2007. | 2010 | Sex Transm Dis | pmid:20601928 |
Chen S et al. | Universal screening or prophylactic treatment for Chlamydia trachomatis infection among women seeking induced abortions: which strategy is more cost-effective? | 2007 | Sex Transm Dis | pmid:17414068 |
Lavoué V et al. | Screening for Chlamydia trachomatis using self-collected vaginal swabs at a public pregnancy termination clinic in France: results of a screen-and-treat policy. | 2012 | Sex Transm Dis | pmid:22801345 |
Holman KM et al. | Rapid plasma reagin titer variation in the 2 weeks after syphilis therapy. | 2012 | Sex Transm Dis | pmid:22801348 |
Bornstein M et al. | Factors Associated With Primary Care Physician Knowledge of the Recommended Regimen for Treating Gonorrhea. | 2017 | Sex Transm Dis | pmid:27898574 |
Martin IE et al. | Molecular typing of Treponema pallidum strains in western Canada: predominance of 14d subtypes. | 2010 | Sex Transm Dis | pmid:20539263 |
Lechtenberg RJ et al. | Variation in adherence to the treatment guidelines for Neisseria gonorrhoeae by clinical practice setting, California, 2009 to 2011. | 2014 | Sex Transm Dis | pmid:24722391 |
Molini BJ et al. | Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains. | 2016 | Sex Transm Dis | pmid:27513385 |
Xiridou M et al. | Cost-Effectiveness of Dual Antimicrobial Therapy for Gonococcal Infections Among Men Who Have Sex With Men in the Netherlands. | 2016 | Sex Transm Dis | pmid:27513379 |
Tapsall JW et al. | Failure of azithromycin therapy in gonorrhea and discorrelation with laboratory test parameters. | 1998 | Sex Transm Dis | pmid:9858344 |
Carlin EM and Barton SE | Azithromycin as a cost-effective treatment for nongonococcal urethritis in men. | 1997 | Sex Transm Dis | pmid:9018784 |
Schumacher CM and Ghanem KG | Retreatment rates for uncomplicated gonorrhea infection: comparing ceftriaxone and azithromycin versus ceftriaxone and doxycycline. | 2013 | Sex Transm Dis | pmid:23965767 |
Lázaro MJ et al. | A case of late-stage lymphogranuloma venereum in a woman in Europe. | 2013 | Sex Transm Dis | pmid:24275729 |
Abdolrasouli A and Roushan A | Corynebacterium propinquum associated with acute, nongonococcal urethritis. | 2013 | Sex Transm Dis | pmid:24275738 |
McLean CA et al. | The emergence of Neisseria gonorrhoeae with decreased susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000. | 2004 | Sex Transm Dis | pmid:14743069 |
Farley TA et al. | The acceptability and behavioral effects of antibiotic prophylaxis for syphilis prevention. | 2003 | Sex Transm Dis | pmid:14603093 |
Rahangdale L et al. | An observational cohort study of Chlamydia trachomatis treatment in pregnancy. | 2006 | Sex Transm Dis | pmid:16432482 |
Manhart LE | Has the time come to systematically test for Mycoplasma genitalium? | 2009 | Sex Transm Dis | pmid:19734818 |
Noda AA et al. | First Report of the 23S rRNA Gene A2058G Point Mutation Associated With Macrolide Resistance in Treponema pallidum From Syphilis Patients in Cuba. | 2016 | Sex Transm Dis | pmid:27100771 |
Galarza PG et al. | Emergence of high level azithromycin-resistant Neisseria gonorrhoeae strain isolated in Argentina. | 2009 | Sex Transm Dis | pmid:19734823 |
Levy V et al. | A Case of Persistent and Possibly Treatment Resistant Pharyngeal Gonorrhea. | 2016 | Sex Transm Dis | pmid:26967304 |
Mmeje O and Coleman JS | Concurrent patient-partner treatment in pregnancy: an alternative to expedited partner therapy? | 2012 | Sex Transm Dis | pmid:22902661 |
Gratrix J et al. | Retrospective review of pharyngeal gonorrhea treatment failures in Alberta, Canada. | 2013 | Sex Transm Dis | pmid:24113412 |
Haddix AC et al. | The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women. | 1995 Sep-Oct | Sex Transm Dis | pmid:7502180 |
Peters RP et al. | Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. | 2016 | Sex Transm Dis | pmid:26760182 |
Gratrix J et al. | A Retrospective Review of Treatment Failures Using Azithromycin and Doxycycline in the Treatment of Rectal Chlamydia Infections in Women and Men Who Have Sex With Men. | 2016 | Sex Transm Dis | pmid:26760180 |
Blandford JM and Gift TL | The cost-effectiveness of single-dose azithromycin for treatment of incubating syphilis. | 2003 | Sex Transm Dis | pmid:12782951 |
Dillon JA et al. | Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from three Caribbean countries: Trinidad, Guyana, and St. Vincent. | 2001 | Sex Transm Dis | pmid:11518867 |
Dillon JA et al. | Reduced susceptibility to azithromycin and high percentages of penicillin and tetracycline resistance in Neisseria gonorrhoeae isolates from Manaus, Brazil, 1998. | 2001 | Sex Transm Dis | pmid:11518869 |
Meltzer MC et al. | Association of Mobiluncus curtisii with recurrence of bacterial vaginosis. | 2008 | Sex Transm Dis | pmid:18418301 |
Steen R et al. | Evidence of declining STD prevalence in a South African mining community following a core-group intervention. | 2000 | Sex Transm Dis | pmid:10654860 |
Barberá MJ et al. | Mycoplasma genitalium Macrolide and Fluoroquinolone Resistance: Prevalence and Risk Factors Among a 2013-2014 Cohort of Patients in Barcelona, Spain. | 2017 | Sex Transm Dis | pmid:28703723 |
Yuan LF et al. | Resistance to azithromycin of Neisseria gonorrhoeae isolates from 2 cities in China. | 2011 | Sex Transm Dis | pmid:21844727 |
Boix V et al. | Polyostotic osteitis in secondary syphilis in an HIV-infected patient. | 2013 | Sex Transm Dis | pmid:23859912 |
Khosropour CM et al. | Comparing azithromycin and doxycycline for the treatment of rectal chlamydial infection: a retrospective cohort study. | 2014 | Sex Transm Dis | pmid:24413484 |
Jordan SJ and Geisler WM | Azithromycin for rectal chlamydia: is it time to leave azithromycin on the shelf?...Not yet. | 2014 | Sex Transm Dis | pmid:24413485 |
Kiddugavu MG et al. | Effectiveness of syphilis treatment using azithromycin and/or benzathine penicillin in Rakai, Uganda. | 2005 | Sex Transm Dis | pmid:15614114 |
Hillis SD et al. | Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women. A use-effectiveness study in public health settings. | 1998 | Sex Transm Dis | pmid:9437777 |
Llata E et al. | Management of Pelvic Inflammatory Disease in Selected U.S. Sexually Transmitted Disease Clinics: Sexually Transmitted Disease Surveillance Network, January 2010-December 2011. | 2015 | Sex Transm Dis | pmid:26165434 |
Tabidze IL et al. | Adherence to Centers for Disease Control and Prevention Gonococcal Treatment Guidelines Among Chicago Health Care Providers, 2011-2012. | 2015 | Sex Transm Dis | pmid:26165433 |
Dombrowski JC and Batteiger BE | Reconsidering the Use of Azithromycin for Chlamydial Urethritis. | 2016 | Sex Transm Dis | pmid:27626187 |
Lau CY and Qureshi AK | Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. | 2002 | Sex Transm Dis | pmid:12218839 |
Singh AE et al. | Gonorrhea Treatment Failures With Oral and Injectable Expanded Spectrum Cephalosporin Monotherapy vs Dual Therapy at 4 Canadian Sexually Transmitted Infection Clinics, 2010-2013. | 2015 | Sex Transm Dis | pmid:25970311 |
Stamm WE et al. | A randomized, double-blind study comparing single-dose rifalazil with single-dose azithromycin for the empirical treatment of nongonococcal urethritis in men. | 2007 | Sex Transm Dis | pmid:17297383 |
Gose SO et al. | Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California. | 2015 | Sex Transm Dis | pmid:25868141 |