Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Berg-Candolfi M and Candolfi E | Depression of the N-demethylation of erythromycin, azithromycin, clarithromycin and clindamycin in murine Toxoplasma infection. | 1996 | Int. J. Parasitol. | pmid:9024879 |
Segreti J et al. | In vitro activity of macrolides against intracellular Legionella pneumophila. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:8902407 |
Wondrack L et al. | Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides. | 1996 | Antimicrob. Agents Chemother. | pmid:8849266 |
Tabbara KF et al. | Single-dose azithromycin in the treatment of trachoma. A randomized, controlled study. | 1996 | Ophthalmology | pmid:8637698 |
Hulten K et al. | In-vitro activity of azithromycin in against intracellular Helicobacter pylori. | 1996 | J. Antimicrob. Chemother. | pmid:9182105 |
Na-Bangchang K et al. | Activity of artemether-azithromycin versus artemether-doxycycline in the treatment of multiple drug resistant falciparum malaria. | 1996 | Southeast Asian J. Trop. Med. Public Health | pmid:9185262 |
Rodriguez AF | An open study to compare azithromycin with cefaclor in the treatment of children with acute otitis media. | 1996 | J. Antimicrob. Chemother. | pmid:8818847 |
O'Doherty B | An open comparative study of azithromycin versus cefaclor in the treatment of patients with upper respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818848 |
Müller O | An open comparative study of azithromycin and roxithromycin in the treatment of acute upper respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818849 |
Gris P | Once-daily, 3-day azithromycin versus a three-times-daily, 10-day course of co-amoxiclav in the treatment of adults with lower respiratory tract infections: results of a randomized, double-blind comparative study. | 1996 | J. Antimicrob. Chemother. | pmid:8818850 |
Zachariah J | A randomized, comparative study to evaluate the efficacy and tolerability of a 3-day course of azithromycin versus a 10-day course of co-amoxiclav as treatment of adult patients with lower respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818851 |
Laurent K | Efficacy, safety and tolerability of azithromycin versus roxithromycin in the treatment of acute lower respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818852 |
Montero L | A comparative study of the efficacy, safety and tolerability of azithromycin and cefaclor in the treatment of children with acute skin and/or soft tissue infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818853 |
Nahata M | Drug interactions with azithromycin and the macrolides: an overview. | 1996 | J. Antimicrob. Chemother. | pmid:8818854 |
Ednie LM et al. | Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. | 1996 | Antimicrob. Agents Chemother. | pmid:8843313 |
Treadway G and Pontani D | Paediatric safety of azithromycin: worldwide experience. | 1996 | J. Antimicrob. Chemother. | pmid:8818855 |
Carbon C et al. | Economic analysis of antibiotic regimens used in the treatment pharyngitis: a prospective comparison of azithromycin versus roxithromycin. | 1996 | J. Antimicrob. Chemother. | pmid:8818856 |
Gerbaux C et al. | Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation. | 1996 | FEBS Lett. | pmid:8830663 |
Domingo S and Gamazo C | Inadequate azithromycin activity against Brucella melitensis in mice with acute or chronic infections. | 1996 | J Chemother | pmid:8835110 |
Marchisio P et al. | Comparative study of once-weekly azithromycin and once-daily amoxicillin treatments in prevention of recurrent acute otitis media in children. | 1996 | Antimicrob. Agents Chemother. | pmid:9124831 |
Xu G et al. | Effect of macrolide antibiotics on macrophage functions. | 1996 | Microbiol. Immunol. | pmid:8865152 |
Meloni G and Meloni T | Azithromycin vs. doxycycline for Mediterranean spotted fever. | 1996 | Pediatr. Infect. Dis. J. | pmid:8933556 |
Jackson MA et al. | Breakthrough sepsis in macrolide-resistant pneumococcal infection. | 1996 | Pediatr. Infect. Dis. J. | pmid:8933560 |
Tateda K et al. | Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. | 1996 | Antimicrob. Agents Chemother. | pmid:8891128 |
Hunt Gerardo S et al. | Comparison of Etest to broth microdilution method for testing Streptococcus pneumoniae susceptibility to levofloxacin and three macrolides. | 1996 | Antimicrob. Agents Chemother. | pmid:8891154 |
Wintermeyer SM et al. | Dirithromycin: a new macrolide. | 1996 | Ann Pharmacother | pmid:8893122 |
Akita H et al. | [Bacteriological, pharmacokinetic and clinical evaluation of azithromycin in the pediatric field]. | 1996 | Jpn J Antibiot | pmid:8986553 |
Nishimura T et al. | [Clinical evaluation of azithromycin in pediatric infections]. | 1996 | Jpn J Antibiot | pmid:8986554 |
Bowden FJ et al. | Pilot study of azithromycin in the treatment of genital donovanosis. | 1996 | Genitourin Med | pmid:8655160 |
Kohl PK et al. | Gonorrhoea: single-dose oral treatment. | 1996 | Curr. Probl. Dermatol. | pmid:8743257 |
Nickel P and Näher H | Nongonococcal urethritis. | 1996 | Curr. Probl. Dermatol. | pmid:8743259 |
Johnson RB | Azithromycin. | 1996 | Curr. Probl. Dermatol. | pmid:8743269 |
Caselli M et al. | A comparative trial of short term therapy with omeprazole plus either amoxycillin or azithromycin for Helicobacter pylori eradication. | 1996 | J. Antimicrob. Chemother. | pmid:8722557 |
Falagas ME and Klempner MS | Babesiosis in patients with AIDS: a chronic infection presenting as fever of unknown origin. | 1996 | Clin. Infect. Dis. | pmid:8722936 |
Murphy GS et al. | Ciprofloxacin- and azithromycin-resistant Campylobacter causing traveler's diarrhea in U.S. troops deployed to Thailand in 1994. | 1996 | Clin. Infect. Dis. | pmid:8722958 |
Scorneaux B et al. | Effect of recombinant human gamma interferon on intracellular activities of antibiotics against Listeria monocytogenes in the human macrophage cell line THP-1. | 1996 | Antimicrob. Agents Chemother. | pmid:8723471 |
Havlir DV et al. | Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. California Collaborative Treatment Group. | 1996 | N. Engl. J. Med. | pmid:8676932 |
Kuo CC et al. | In vitro activities of azithromycin, clarithromycin, and other antibiotics against Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8913488 |
Tursi A et al. | The use of azithromycin in short-term low-dose triple therapies for Helicobacter pylori infection. | 1996 | Am. J. Gastroenterol. | pmid:8677967 |
Aoyama T et al. | Efficacy of short-term treatment of pertussis with clarithromycin and azithromycin. | 1996 | J. Pediatr. | pmid:8917247 |
Thorpe EM et al. | Chlamydial cervicitis and urethritis: single dose treatment compared with doxycycline for seven days in community based practises. | 1996 | Genitourin Med | pmid:8698374 |
Pacifico L et al. | Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children. | 1996 | Antimicrob. Agents Chemother. | pmid:8849215 |
Wilton LV et al. | A comparison of ciprofloxacin, norfloxacin, ofloxacin, azithromycin and cefixime examined by observational cohort studies. | 1996 | Br J Clin Pharmacol | pmid:8730972 |
Jaruratanasirikul S et al. | Distribution of azithromycin into brain tissue, cerebrospinal fluid, and aqueous humor of the eye. | 1996 | Antimicrob. Agents Chemother. | pmid:8851625 |
Bedos JP and Veber B | [Lower respiratory infections: predictive factors of therapeutic response]. | 1996 | Rev Pneumol Clin | pmid:9033917 |
Zuck P | [Efficacy of a 5-day treatment with an azalide (azithromycin) in superinfections of chronic bronchitis]. | 1996 | Rev Pneumol Clin | pmid:9033919 |
Hayle R et al. | Efficacy and safety of azithromycin versus phenoxymethylpenicillin in the treatment of acute maxillary sinusitis. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8997555 |
Magid D et al. | Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis. | 1996 | Ann. Intern. Med. | pmid:8554247 |
Genç M and Mårdh A | A cost-effectiveness analysis of screening and treatment for Chlamydia trachomatis infection in asymptomatic women. | 1996 | Ann. Intern. Med. | pmid:7503471 |
Roord JJ et al. | Prospective open randomized study comparing efficacies and safeties of a 3-day course of azithromycin and a 10-day course of erythromycin in children with community-acquired acute lower respiratory tract infections. | 1996 | Antimicrob. Agents Chemother. | pmid:9124837 |
Cellesi C et al. | Susceptibility of macrolide and beta-lactam antibiotics of Streptococcus pyogenes strains isolated over a four-year period in central Italy. | 1996 | J Chemother | pmid:8808714 |
Wenisch C et al. | Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. | 1996 | Antimicrob. Agents Chemother. | pmid:8878577 |
Yeates RA et al. | Interaction between midazolam and clarithromycin: comparison with azithromycin. | 1996 | Int J Clin Pharmacol Ther | pmid:8880291 |
Dunn CJ and Barradell LB | Azithromycin. A review of its pharmacological properties and use as 3-day therapy in respiratory tract infections. | 1996 | Drugs | pmid:8882383 |
Gnarpe J et al. | In vitro activities of azithromycin and doxycycline against 15 isolates of Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8843291 |
Welsh L et al. | In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8787907 |
Mehaffey PC et al. | Evaluation of in vitro spectra of activity of azithromycin, clarithromycin, and erythromycin tested against strains of Neisseria gonorrhoeae by reference agar dilution, disk diffusion, and Etest methods. | 1996 | J. Clin. Microbiol. | pmid:8789046 |
Keysary A et al. | The in-vitro anti-rickettsial activity of macrolides. | 1996 | J. Antimicrob. Chemother. | pmid:8937968 |
Mein J et al. | Donovanosis: sequelae of severe disease and successful azithromycin treatment. | 1996 | Int J STD AIDS | pmid:8940677 |
Hoque S et al. | Rhodococcus equi in CAPD-associated peritonitis treated with azithromycin. | 1996 | Nephrol. Dial. Transplant. | pmid:8941608 |
Wiselka MJ et al. | Response to oral and intravenous azithromycin in a patient with toxoplasma encephalitis and AIDS. | 1996 | J. Infect. | pmid:8945715 |
Gómez E et al. | Interaction between azithromycin and cyclosporin? | 1996 | Nephron | pmid:8856287 |
Delmée M et al. | In vitro susceptibilities of 180 clinical isolates of Haemophilus influenzae to ampicillin, amoxycillin/clavulanate, cefaclor, cefuroxime, cefotaxime, clarithromycin, and azithromycin. | 1996 | Acta Clin Belg | pmid:8858889 |
Watt B et al. | Comparative activity of azithromycin against clinical isolates of mycobacteria. | 1996 | J. Antimicrob. Chemother. | pmid:8889727 |
Patel KB et al. | Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. | 1996 | Antimicrob. Agents Chemother. | pmid:8891147 |
Amsden GW | Erythromycin, clarithromycin, and azithromycin: are the differences real? | 1996 Jan-Feb | Clin Ther | pmid:8851453 |
Preac Mursic V et al. | Kill kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of Lyme borreliosis. | 1996 Jan-Feb | Infection | pmid:8852456 |
Baradaran-Dilmaghani R and Stanek G | In vitro susceptibility of thirty Borrelia strains from various sources against eight antimicrobial chemotherapeutics. | 1996 Jan-Feb | Infection | pmid:8852472 |
Strle F et al. | Azithromycin and doxycycline for treatment of Borrelia culture-positive erythema migrans. | 1996 Jan-Feb | Infection | pmid:8852473 |
Fontán PA et al. | Haemophilus influenzae type b exoproducts induce chemotaxis and macrolide antibiotic release by human polymorphonuclear leukocytes. | 1996 Jan-Feb | Chemotherapy | pmid:8751269 |
Ehret JM et al. | A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin. | 1996 Jul-Aug | Sex Transm Dis | pmid:8836018 |
Lane G | Increased hypoprothrombinemic effect of warfarin possibly induced by azithromycin. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826581 |
Diculencu D et al. | [The postantibiotic effect of azithromycin on respiratory pathogens]. | 1996 Jul-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:9455450 |
Carlin EM and Barton SE | Azithromycin as the first-line treatment of non-gonococcal urethritis (NGU): a study of follow-up rates, contact attendance and patients' treatment preference. | 1996 May-Jun | Int J STD AIDS | pmid:8799780 |
Shanks GD et al. | Azithromycin prophylaxis prevents epidemic dysentery. | 1996 May-Jun | Trans. R. Soc. Trop. Med. Hyg. | pmid:8758091 |
Adam D et al. | Re: A. Bauernfeind et al.: Comparative pharmacodynamics of clarithromycin and azithromycin against respiratory pathogens (Infection 23 [1995] 316-321) | 1996 May-Jun | Infection | pmid:8811372 |
Vranes J | Effect of subinhibitory concentrations of ceftazidime, ciprofloxacin, and azithromycin on the hemagglutination and adherence of uropathogenic Escherichia coli strains. | 1996 May-Jun | Chemotherapy | pmid:8983884 |
Ichimiya T et al. | The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro. | 1996 May-Jun | Chemotherapy | pmid:8983885 |
Galova K et al. | Multicenter randomized study of two once daily regimens in the initial management of community-acquired respiratory tract infections in 163 children: azithromycin versus ceftibuten. | 1996 May-Jun | Chemotherapy | pmid:8983893 |
Burke SM | Azithromycin: only once a day. | 1996 May-Jun | MCN Am J Matern Child Nurs | pmid:8857402 |
Ripa S et al. | A linear model for the pharmacokinetics of azithromycin in healthy volunteers. | 1996 Nov-Dec | Chemotherapy | pmid:8957574 |
D'Amico R | ICAAC update on opportunistic infections. | 1996 Nov-Dec | Posit Aware | pmid:11363974 |
Wendel TD | 1-day azithromycin was as effective as 7-day doxycycline for nongonococcal urethritis syndrome in men. | 1996 Nov-Dec | ACP J. Club | pmid:8912627 |
Peeling RW and Brunham RC | Chlamydiae as pathogens: new species and new issues. | 1996 Oct-Dec | Emerging Infect. Dis. | pmid:8969247 |
Biebuyck XA | Comparison of azithromycin and co-amoxiclav in the treatment of acute tracheobronchitis and acute infectious exacerbations of chronic bronchitis in adults. Azithromycin Study Group. | 1996 Sep-Oct | J. Int. Med. Res. | pmid:8895044 |
Motohiro T et al. | [Clinical study on azithromycin in 10% fine granules and 100mg capsules in the field of pediatrics]. | 1997 | Jpn J Antibiot | pmid:9634360 |
Luke DR and Foulds G | Disposition of oral azithromycin in humans. | 1997 | Clin. Pharmacol. Ther. | pmid:9209246 |
Herrera-Insúa I et al. | Synergistic effect of azithromycin on the phagocytic killing of Staphylococcus aureus by human polymorphonuclear leukocytes. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9063667 |
Pascual A et al. | Azithromycin uptake by tissue cultured epithelial cells. | 1997 | J. Antimicrob. Chemother. | pmid:9069561 |
Khan WA et al. | Treatment of shigellosis: V. Comparison of azithromycin and ciprofloxacin. A double-blind, randomized, controlled trial. | 1997 | Ann. Intern. Med. | pmid:9139555 |
Yasin RM et al. | Comparison of E-test with agar dilution methods in testing susceptibility of N. gonorrhoeae to azithromycin. | 1997 | Sex Transm Dis | pmid:9153733 |
Blanshard C et al. | Pilot studies of azithromycin, letrazuril and paromomycin in the treatment of cryptosporidiosis. | 1997 | Int J STD AIDS | pmid:9061412 |
Dautzenberg B | Rationale for the prevention of disseminated Mycobacterium avium-intracellulare complex disease. | 1997 | Drugs | pmid:9358194 |
Cohn DL | Prevention strategies for Mycobacterium avium-intracellulare complex (MAC) infection. A review of recent studies in patients with AIDS. | 1997 | Drugs | pmid:9358195 |
Marone P et al. | Rapid drug susceptibility of Mycobacterium avium complex using a fluorescence quenching method. | 1997 | J Chemother | pmid:9269603 |
Gruber F et al. | Comparative trial of azithromycin and ciprofloxacin in the treatment of gonorrhea. | 1997 | J Chemother | pmid:9269606 |
Jepras RI et al. | Rapid assessment of antibiotic effects on Escherichia coli by bis-(1,3-dibutylbarbituric acid) trimethine oxonol and flow cytometry. | 1997 | Antimicrob. Agents Chemother. | pmid:9303401 |
RodrÃguez-Bano J et al. | [Penetration of azithromycin into human neutrophils: effect of hydrogen peroxide production]. | 1997 | Enferm. Infecc. Microbiol. Clin. | pmid:9312278 |
Malizia T et al. | Periodontal tissue disposition of azithromycin. | 1997 | J. Periodontol. | pmid:9444596 |
Nguyen MH et al. | Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447909 |