Azithramycine
Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
Cross Reference
Introduction
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azithramycine?
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (156)
- Clin. Infect. Dis. (64)
- J. Antimicrob. Chemother. (50)
- Others (435)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azithramycine
PubChem Associated disorders and diseases
What pathways are associated with Azithramycine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azithramycine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (66)
- J. Antimicrob. Chemother. (25)
- Clin. Infect. Dis. (13)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with Azithramycine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Azithramycine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with Azithramycine?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (44)
- J. Antimicrob. Chemother. (18)
- Clin. Infect. Dis. (10)
- Others (126)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azithramycine?
Mouse Model
Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with Azithramycine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Speer EM et al. | Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. | 2018 | PLoS ONE | pmid:29715306 |
| Laufer MK et al. | A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. | 2012 | PLoS ONE | pmid:22912697 |
| Liu D et al. | Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2. | 2017 | PLoS ONE | pmid:28976984 |
| Lee S et al. | The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis. | 2017 | PLoS ONE | pmid:28973041 |
| Mandhane PJ et al. | Treatment of preschool children presenting to the emergency department with wheeze with azithromycin: A placebo-controlled randomized trial. | 2017 | PLoS ONE | pmid:28771627 |
| Upadhyay K et al. | Combination therapy with ampicillin and azithromycin improved outcomes in a mouse model of group B streptococcal sepsis. | 2017 | PLoS ONE | pmid:28759625 |
| Li R et al. | Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice. | 2017 | PLoS ONE | pmid:28742883 |
| West SK et al. | Treating village newcomers and travelers for trachoma: Results from ASANTE cluster randomized trial. | 2017 | PLoS ONE | pmid:28662043 |
| Vodstrcil LA et al. | Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS). | 2017 | PLoS ONE | pmid:28498845 |
| Amran MY et al. | Investigation of encephalopathy caused by Shiga toxin 2c-producing Escherichia coli infection in mice. | 2013 | PLoS ONE | pmid:23516588 |
| Vandooren J et al. | Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. | 2017 | PLoS ONE | pmid:28369077 |
| Kong FY et al. | Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men. | 2017 | PLoS ONE | pmid:28350806 |
| Ishiguro N et al. | Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients. | 2017 | PLoS ONE | pmid:28288170 |
| Simpson JL et al. | The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial. | 2014 | PLoS ONE | pmid:25148049 |
| Dukers-Muijrers NH et al. | Chlamydia trachomatis test-of-cure cannot be based on a single highly sensitive laboratory test taken at least 3 weeks after treatment. | 2012 | PLoS ONE | pmid:22470526 |
| Hirasawa K et al. | Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. | 2016 | PLoS ONE | pmid:27977675 |
| Zhao X et al. | Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids. | 2016 | PLoS ONE | pmid:27907030 |
| Nielsen HL et al. | Azithromycin vs. Placebo for the Clinical Outcome in Campylobacter concisus Diarrhoea in Adults: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. | 2016 | PLoS ONE | pmid:27893820 |
| Phiri K et al. | Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. | 2016 | PLoS ONE | pmid:27861509 |
| Kalilani L et al. | A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women. | 2007 | PLoS ONE | pmid:18000538 |
| Bradshaw CS et al. | Persistence of Mycoplasma genitalium following azithromycin therapy. | 2008 | PLoS ONE | pmid:18978939 |
| Cui W et al. | The molecular mechanism of action of the CR6261-Azichromycin combination found through computational analysis. | 2012 | PLoS ONE | pmid:22693576 |
| Tong ML et al. | Factors associated with serological cure and the serofast state of HIV-negative patients with primary, secondary, latent, and tertiary syphilis. | 2013 | PLoS ONE | pmid:23894598 |
| Assani K et al. | IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. | 2014 | PLoS ONE | pmid:24798083 |
| Zhu B et al. | High Resistance to Azithromycin in Clinical Samples from Patients with Sexually Transmitted Diseases in Guangxi Zhuang Autonomous Region, China. | 2016 | PLoS ONE | pmid:27467164 |
| Goh YS et al. | Neutralizing Antibodies against Plasmodium falciparum Associated with Successful Cure after Drug Therapy. | 2016 | PLoS ONE | pmid:27427762 |
| Malhotra S et al. | Prevalence of Trachoma in Car-Nicobar Island, India after Three Annual Rounds of Mass Drug Administration with Azithromycin. | 2016 | PLoS ONE | pmid:27391274 |
| Kakeya H et al. | Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza: a multicenter, open-label, randomized study. | 2014 | PLoS ONE | pmid:24632748 |
| Kimani J et al. | Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial. | 2016 | PLoS ONE | pmid:27326859 |
| Dukers-Muijrers NH et al. | Detection of anorectal and cervicovaginal Chlamydia trachomatis infections following azithromycin treatment: prospective cohort study with multiple time-sequential measures of rRNA, DNA, quantitative load and symptoms. | 2013 | PLoS ONE | pmid:24278400 |
| Haussig JM et al. | Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway. | 2013 | PLoS ONE | pmid:23805304 |
| McCallum GB et al. | A single dose of azithromycin does not improve clinical outcomes of children hospitalised with bronchiolitis: a randomised, placebo-controlled trial. | 2013 | PLoS ONE | pmid:24086334 |
| Luntamo M et al. | The effect of monthly sulfadoxine-pyrimethamine, alone or with azithromycin, on PCR-diagnosed malaria at delivery: a randomized controlled trial. | 2012 | PLoS ONE | pmid:22829919 |
| Zhou T et al. | Fabrication of a Selective and Sensitive Sensor Based on Molecularly Imprinted Polymer/Acetylene Black for the Determination of Azithromycin in Pharmaceuticals and Biological Samples. | 2016 | PLoS ONE | pmid:26820753 |
| Slade J et al. | Chlamydial Pre-Infection Protects from Subsequent Herpes Simplex Virus-2 Challenge in a Murine Vaginal Super-Infection Model. | 2016 | PLoS ONE | pmid:26726882 |
| Al-Darraji A et al. | Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. | 2018 | PLoS ONE | pmid:30001416 |
| Coloma PM et al. | Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system. | 2013 | PLoS ONE | pmid:24015213 |
| Dolecek C et al. | A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. | 2008 | PLoS ONE | pmid:18493312 |
| Yang D et al. | The timing of azithromycin treatment is not associated with the clinical prognosis of childhood Mycoplasma pneumoniae pneumonia in high macrolide-resistant prevalence settings. | 2018 | PLoS ONE | pmid:29377957 |
| Wei HX et al. | A Systematic Review and Meta-Analysis of the Efficacy of Anti-Toxoplasma gondii Medicines in Humans. | 2015 | PLoS ONE | pmid:26394212 |
| Anagrius C et al. | Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic. | 2013 | PLoS ONE | pmid:23593483 |
| Hahn DL et al. | Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. | 2012 | PLoS ONE | pmid:22545149 |
| Banerjee B et al. | Regional differences in susceptibiity of bronchial epithelium to mesenchymal transition and inhibition by the macrolide antibiotic azithromycin. | 2012 | PLoS ONE | pmid:23284981 |
| Kaman WE et al. | Evaluation of a FRET-peptide substrate to predict virulence in Pseudomonas aeruginosa. | 2013 | PLoS ONE | pmid:24303047 |
| Twin J et al. | Transmission and selection of macrolide resistant Mycoplasma genitalium infections detected by rapid high resolution melt analysis. | 2012 | PLoS ONE | pmid:22532861 |
| Maher MC et al. | The fitness cost of antibiotic resistance in Streptococcus pneumoniae: insight from the field. | 2012 | PLoS ONE | pmid:22272234 |
| Prohl A et al. | Enrofloxacin and macrolides alone or in combination with rifampicin as antimicrobial treatment in a bovine model of acute Chlamydia psittaci infection. | 2015 | PLoS ONE | pmid:25768665 |
| Hao K et al. | The pharmacokinetic-pharmacodynamic model of azithromycin for lipopolysaccharide-induced depressive-like behavior in mice. | 2013 | PLoS ONE | pmid:23358536 |
| Martin DL et al. | Serology for trachoma surveillance after cessation of mass drug administration. | 2015 | PLoS Negl Trop Dis | pmid:25714363 |
| El-Tahtawy A et al. | The effect of azithromycin on ivermectin pharmacokinetics--a population pharmacokinetic model analysis. | 2008 | PLoS Negl Trop Dis | pmid:18478051 |