Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Amsden GW et al. | Pharmacokinetics of azithromycin and the combination of ivermectin and albendazole when administered alone and concurrently in healthy volunteers. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17556628 |
Bloch EM et al. | Antibiotic Resistance in Young Children in Kilosa District, Tanzania 4 Years after Mass Distribution of Azithromycin for Trachoma Control. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28722638 |
O'Brien KS et al. | Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28722569 |
Stoney RJ et al. | Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28719282 |
Miller RS et al. | Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging study. | 2006 | Am. J. Trop. Med. Hyg. | pmid:16525097 |
Chetchotisakd P et al. | Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycycline. | 2001 Jan-Feb | Am. J. Trop. Med. Hyg. | pmid:11425157 |
González-Beiras C et al. | Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28193743 |
Heppner DG et al. | Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. | 2005 | Am. J. Trop. Med. Hyg. | pmid:16282291 |
Gao D et al. | Optimal seasonal timing of oral azithromycin for malaria. | 2014 | Am. J. Trop. Med. Hyg. | pmid:25223942 |
Ginouvès M et al. | In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28167598 |
Rosenthal PJ | Azithromycin for Malaria? | 2016 | Am. J. Trop. Med. Hyg. | pmid:27215296 |
Layegh P et al. | Efficacy of azithromycin versus systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17620637 |
Mikals K et al. | Campylobacter fetus bacteremia in an immunocompetent traveler. | 2014 | Am. J. Trop. Med. Hyg. | pmid:25071002 |
Katanami Y et al. | Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27352874 |
Kumaresan JA and Mecaskey JW | The global elimination of blinding trachoma: progress and promise. | 2003 | Am. J. Trop. Med. Hyg. | pmid:14692677 |
Phong NC et al. | In Vivo Efficacy and Tolerability of Artesunate-Azithromycin for the Treatment of Falciparum Malaria in Vietnam. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27215294 |
Krolewiecki A et al. | Activity of azithromycin against Leishmania major in vitro and in vivo. | 2002 | Am. J. Trop. Med. Hyg. | pmid:12408666 |
Luntamo M et al. | Effect of repeated treatment of pregnant women with sulfadoxine-pyrimethamine and azithromycin on preterm delivery in Malawi: a randomized controlled trial. | 2010 | Am. J. Trop. Med. Hyg. | pmid:21118924 |
Haile M et al. | The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial. | 2013 | Am. J. Trop. Med. Hyg. | pmid:24002488 |
See CW et al. | The Effect of Mass Azithromycin Distribution on Childhood Mortality: Beliefs and Estimates of Efficacy. | 2015 | Am. J. Trop. Med. Hyg. | pmid:26392160 |
Ayele B et al. | Adverse events after mass azithromycin treatments for trachoma in Ethiopia. | 2011 | Am. J. Trop. Med. Hyg. | pmid:21813850 |
Gaynor BD et al. | Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. | 2014 | Am. J. Trop. Med. Hyg. | pmid:24615132 |
Gebre T et al. | Latrine promotion for trachoma: assessment of mortality from a cluster-randomized trial in Ethiopia. | 2011 | Am. J. Trop. Med. Hyg. | pmid:21896815 |
Gingras BA and Jensen JB | Antimalarial activity of azithromycin and erythromycin against Plasmodium berghei. | 1993 | Am. J. Trop. Med. Hyg. | pmid:8394660 |
Å majs D et al. | Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains? | 2015 | Am. J. Trop. Med. Hyg. | pmid:26217043 |
Shih CM and Wang CC | Ability of azithromycin in combination with quinine for the elimination of babesial infection in humans. | 1998 | Am. J. Trop. Med. Hyg. | pmid:9790419 |
Amza A et al. | A cluster-randomized controlled trial evaluating the effects of mass azithromycin treatment on growth and nutrition in Niger. | 2013 | Am. J. Trop. Med. Hyg. | pmid:23208876 |
Krolewiecki AJ et al. | A randomized clinical trial comparing oral azithromycin and meglumine antimoniate for the treatment of American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17978064 |
Richards FO et al. | No depletion of Wolbachia from Onchocerca volvulus after a short course of rifampin and/or azithromycin. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17984346 |
Fossa AA et al. | Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17984356 |
Keenan JD et al. | Clinical activity and polymerase chain reaction evidence of chlamydial infection after repeated mass antibiotic treatments for trachoma. | 2010 | Am. J. Trop. Med. Hyg. | pmid:20207878 |
Coles CL et al. | Association of mass treatment with azithromycin in trachoma-endemic communities with short-term reduced risk of diarrhea in young children. | 2011 | Am. J. Trop. Med. Hyg. | pmid:21976574 |
Dunne MW et al. | A double-blind, randomized study of azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India. | 2005 | Am. J. Trop. Med. Hyg. | pmid:16354821 |
Mertens V et al. | Bile acids aspiration reduces survival in lung transplant recipients with BOS despite azithromycin. | 2011 | Am. J. Transplant. | pmid:21272237 |
Glanville AR | CLAD: does the Emperor have new clothes? | 2014 | Am. J. Transplant. | pmid:25394597 |
Vos R et al. | Azithromycin and the treatment of lymphocytic airway inflammation after lung transplantation. | 2014 | Am. J. Transplant. | pmid:25394537 |
Verleden SE et al. | Lymphocytic bronchiolitis after lung transplantation is associated with daily changes in air pollution. | 2012 | Am. J. Transplant. | pmid:22682332 |
Vanaudenaerde BM et al. | Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. | 2007 | Am. J. Transplant. | pmid:17061983 |
Greer M et al. | Phenotyping established chronic lung allograft dysfunction predicts extracorporeal photopheresis response in lung transplant patients. | 2013 | Am. J. Transplant. | pmid:23406373 |
Robertson AG et al. | Targeting allograft injury and inflammation in the management of post-lung transplant bronchiolitis obliterans syndrome. | 2009 | Am. J. Transplant. | pmid:19459806 |
Ruttens D et al. | Prophylactic Azithromycin Therapy After Lung Transplantation: Post hoc Analysis of a Randomized Controlled Trial. | 2016 | Am. J. Transplant. | pmid:26372728 |
Jeong BH et al. | Intermittent antibiotic therapy for nodular bronchiectatic Mycobacterium avium complex lung disease. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25393520 |
Verleden GM et al. | Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. | 2006 | Am. J. Respir. Crit. Care Med. | pmid:16741151 |
Barker PM et al. | Effect of macrolides on in vivo ion transport across cystic fibrosis nasal epithelium. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15657462 |
Choi GE et al. | Macrolide treatment for Mycobacterium abscessus and Mycobacterium massiliense infection and inducible resistance. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878281 |
Restrepo MI and Anzueto A | Macrolide antibiotics for prevention of chronic obstructive pulmonary disease exacerbations: are we there yet? | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24983214 |
Binder AM et al. | Epidemiology of nontuberculous mycobacterial infections and associated chronic macrolide use among persons with cystic fibrosis. | 2013 | Am. J. Respir. Crit. Care Med. | pmid:23927602 |
Lococo F et al. | Hemoptysis and Progressive Dyspnea in a 67-Year-Old Woman with History of Renal Transplantation. | 2016 | Am. J. Respir. Crit. Care Med. | pmid:26681504 |
Hodge S et al. | Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. | 2008 | Am. J. Respir. Crit. Care Med. | pmid:18420960 |
Han MK et al. | Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24779680 |