Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Stout JE and Floto RA | Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:23118083 |
Hayes D et al. | ABCA3 transporter deficiency. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:23071193 |
Verleden GM et al. | Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. | 2006 | Am. J. Respir. Crit. Care Med. | pmid:16741151 |
Williams TJ and Verleden GM | Azithromycin: a plea for multicenter randomized studies in lung transplantation. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16148194 |
Saiman L et al. | Heterogeneity of treatment response to azithromycin in patients with cystic fibrosis. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16040785 |
Kunisaki KM et al. | Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22077070 |
Restrepo MI and Anzueto A | Macrolide antibiotics for prevention of chronic obstructive pulmonary disease exacerbations: are we there yet? | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24983214 |
Lococo F et al. | Hemoptysis and Progressive Dyspnea in a 67-Year-Old Woman with History of Renal Transplantation. | 2016 | Am. J. Respir. Crit. Care Med. | pmid:26681504 |
Yates B et al. | Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15976371 |
Hodge S et al. | Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. | 2008 | Am. J. Respir. Crit. Care Med. | pmid:18420960 |
Gerhardt SG et al. | Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12672648 |
Albert RK and Schuller JL | Macrolide antibiotics and the risk of cardiac arrhythmias. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24707986 |
Han MK et al. | Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24779680 |
Mertens V et al. | Bile acids aspiration reduces survival in lung transplant recipients with BOS despite azithromycin. | 2011 | Am. J. Transplant. | pmid:21272237 |
Glanville AR | CLAD: does the Emperor have new clothes? | 2014 | Am. J. Transplant. | pmid:25394597 |
Verleden SE et al. | Lymphocytic bronchiolitis after lung transplantation is associated with daily changes in air pollution. | 2012 | Am. J. Transplant. | pmid:22682332 |
Vanaudenaerde BM et al. | Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. | 2007 | Am. J. Transplant. | pmid:17061983 |
Greer M et al. | Phenotyping established chronic lung allograft dysfunction predicts extracorporeal photopheresis response in lung transplant patients. | 2013 | Am. J. Transplant. | pmid:23406373 |
Robertson AG et al. | Targeting allograft injury and inflammation in the management of post-lung transplant bronchiolitis obliterans syndrome. | 2009 | Am. J. Transplant. | pmid:19459806 |
Ruttens D et al. | Prophylactic Azithromycin Therapy After Lung Transplantation: Post hoc Analysis of a Randomized Controlled Trial. | 2016 | Am. J. Transplant. | pmid:26372728 |