Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Southern KW and Smyth RL | Design of clinical trials in cystic fibrosis. | 2003 | Lancet | pmid:12559892 |
OÄŸuz F et al. | Etiology of acute otitis media in childhood and evaluation of two different protocols of antibiotic therapy: 10 days cefaclor vs. 3 days azitromycin. | 2003 | Int. J. Pediatr. Otorhinolaryngol. | pmid:12560149 |
Debremaeker D et al. | Analysis of unknown compounds in azithromycin bulk samples with liquid chromatography coupled to ion trap mass spectrometry. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12569445 |
Miyazaki S and Yamaguchi K | [In vitro and in vivo antibacterial activities of azithromycin]. | 2000 | Jpn J Antibiot | pmid:12572087 |
Shiba K | [Pharmacokinetics and tissue distribution of azithromycin in humans]. | 2000 | Jpn J Antibiot | pmid:12572088 |
Enogaki K | [Transport to an infected site of azithromycin by phagocyte cells]. | 2000 | Jpn J Antibiot | pmid:12572089 |
Oizumi K | [Clinical evaluation of azithromycin for respiratory infectious diseases]. | 2000 | Jpn J Antibiot | pmid:12572090 |
Nakayama I | [Clinical studies of azithromycin, a new macrolide antibiotic, for infections in the field of surgery]. | 2000 | Jpn J Antibiot | pmid:12572091 |
Sunakawa K | [Summary of the clinical studies with azithromycin in the pediatric fields]. | 2000 | Jpn J Antibiot | pmid:12572092 |
Naoya M | [The clinical study of azithromycin in otolaryngologic infection]. | 2000 | Jpn J Antibiot | pmid:12572093 |
Arata J | [Azithromycin in the field of dermatology]. | 2000 | Jpn J Antibiot | pmid:12572094 |
Sasaki J | [Azithromycin in dentistry and oral surgery]. | 2000 | Jpn J Antibiot | pmid:12572095 |
Higa F and Saito A | [Clinical safety of azithromycin]. | 2000 | Jpn J Antibiot | pmid:12572096 |
Woods GL et al. | Multisite reproducibility of results obtained by two broth dilution methods for susceptibility testing of Mycobacterium avium complex. | 2003 | J. Clin. Microbiol. | pmid:12574258 |
Dai G et al. | [Researching some sensitivity factor of bioassay method on the antibiotics pharmacokinetics]. | 2002 | Hunan Yi Ke Da Xue Xue Bao | pmid:12575254 |
Nagata T et al. | [Two cases successfully treated with long-term administration of low-dosage azithromycin]. | 2001 | Jpn J Antibiot | pmid:12575407 |
Ikegaya S et al. | [Effect of azithromycin on cytokine production by THP-1 cells]. | 2001 | Jpn J Antibiot | pmid:12575425 |
Kato T et al. | [Effect of azithromycin on cytokine production in human bronchial epithelial cell line, BEAS-2B]. | 2001 | Jpn J Antibiot | pmid:12575426 |
Pechère JC | Azithromycin reduces the production of virulence factors in Pseudomonas aeruginosa by inhibiting quorum sensing. | 2001 | Jpn J Antibiot | pmid:12575427 |
Tateda K et al. | [MIC, sub-MIC of macrolide resistant bacteria--special reference to their quorum-sensing system]. | 2001 | Jpn J Antibiot | pmid:12575433 |
Tanyuksel M et al. | Determination of intracellular efficacies of azithromycin against Leishmania major infection in human neutrophils in vitro. | 2003 | Cell Biochem. Funct. | pmid:12579528 |
Mehta CL | Arcanobacterium haemolyticum. | 2003 | J. Am. Acad. Dermatol. | pmid:12582410 |
Esteban J et al. | A comparison between disk diffusion and microdilution for susceptibility testing of Mycobacterium fortuitum complex. | 2002 | J Chemother | pmid:12583544 |
Dakdouki GK et al. | Azithromycin-induced rash in infectious mononucleosis. | 2002 | Scand. J. Infect. Dis. | pmid:12587634 |
Kwun WH et al. | Effect of azithromycin in the treartment of cyclosporine-induced gingival hyperplasia in renal transplant recipients. | 2003 | Transplant. Proc. | pmid:12591416 |
Dzelalija B et al. | Randomized trial of azithromycin in the prophylaxis of Mediterranean spotted fever. | 2002 | Acta Med Croatica | pmid:12596623 |
Khedr A and Sheha M | Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms. | 2003 | J Chromatogr Sci | pmid:12597590 |
Coke RL et al. | Pharmacokinetics and tissue concentrations of azithromycin in ball pythons (Python regius). | 2003 | Am. J. Vet. Res. | pmid:12602593 |
Peric M et al. | Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates. | 2003 | Antimicrob. Agents Chemother. | pmid:12604536 |
Seral C et al. | Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages. | 2003 | Antimicrob. Agents Chemother. | pmid:12604540 |
Roblin PM et al. | In vitro activities of rifamycin derivatives ABI-1648 (Rifalazil, KRM-1648), ABI-1657, and ABI-1131 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae. | 2003 | Antimicrob. Agents Chemother. | pmid:12604555 |
Schiedler V et al. | Pattern of antibiotic use in a trachoma-endemic region of Nepal: implications for mass azithromycin distribution. | 2003 | Ophthalmic Epidemiol | pmid:12607157 |
Aznabaev MT et al. | [Use of cycloferon in a combined treatment of chlamydial conjunctivitis]. | 2003 Jan-Feb | Vestn Oftalmol | pmid:12608044 |
Mesa FL et al. | Antibiotic treatment of incipient drug-induced gingival overgrowth in adult renal transplant patients. | 2003 | J. Periodont. Res. | pmid:12608908 |
Scheinfeld NS et al. | Macrolides in dermatology. | 2003 Jan-Feb | Clin. Dermatol. | pmid:12609587 |
Al-Belasy FA and Hairam AR | The efficacy of azithromycin in the treatment of acute infraorbital space infection. | 2003 | J. Oral Maxillofac. Surg. | pmid:12618970 |
[Uncomplicated community-acquired pneumonia. Under control in 3 treatment days]. | 2003 | MMW Fortschr Med | pmid:12619240 | |
Schlünzen F et al. | Structural basis for the antibiotic activity of ketolides and azalides. | 2003 | Structure | pmid:12623020 |
Hanada H et al. | Infection of human fibroblast-like synovial cells with Chlamydia trachomatis results in persistent infection and interleukin-6 production. | 2003 | Microb. Pathog. | pmid:12623273 |
Basilion EV et al. | Height as a proxy for weight in determining azithromycin treatment for paediatric trachoma. | 2002 Nov-Dec | Trans. R. Soc. Trop. Med. Hyg. | pmid:12625152 |
Salcedo Posadas A et al. | [Complementary therapies in cystic fibrosis: evidence of therapeutic benefits and treatment recommendations]. | 2003 | An Pediatr (Barc) | pmid:12628117 |
Amsden GW et al. | Efficacy and safety of azithromycin vs levofloxacin in the outpatient treatment of acute bacterial exacerbations of chronic bronchitis. | 2003 | Chest | pmid:12628877 |
Kuvin JT et al. | Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function. | 2003 | Am. J. Cardiol. | pmid:12633811 |
Ramsey PS et al. | Maternal and transplacental pharmacokinetics of azithromycin. | 2003 | Am. J. Obstet. Gynecol. | pmid:12634646 |
Bevan CD et al. | Efficacy and safety of azithromycin as monotherapy or combined with metronidazole compared with two standard multidrug regimens for the treatment of acute pelvic inflammatory disease. | 2003 Jan-Feb | J. Int. Med. Res. | pmid:12635534 |
Tajima T et al. | [Discussions on PRSP and BLNAR]. | 2001 | Jpn J Antibiot | pmid:12638161 |
Cercek B et al. | Effect of short-term treatment with azithromycin on recurrent ischaemic events in patients with acute coronary syndrome in the Azithromycin in Acute Coronary Syndrome (AZACS) trial: a randomised controlled trial. | 2003 | Lancet | pmid:12642046 |
Anagnostopoulos GK et al. | Omeprazole plus azithromycin and either amoxicillin or tinidazole for eradication of Helicobacter pylori infection. | 2003 | J. Clin. Gastroenterol. | pmid:12642739 |
Katusic D et al. | Azithromycin vs doxycycline in the treatment of inclusion conjunctivitis. | 2003 | Am. J. Ophthalmol. | pmid:12654359 |
Carryn S et al. | Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model. | 2003 | J. Antimicrob. Chemother. | pmid:12654747 |