Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tuite AR et al. | Impact of Rapid Susceptibility Testing and Antibiotic Selection Strategy on the Emergence and Spread of Antibiotic Resistance in Gonorrhea. | 2017 | J. Infect. Dis. | pmid:28968710 |
Houinei W et al. | Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea. | 2017 | PLoS Negl Trop Dis | pmid:28489855 |
Afghani T et al. | Preventing Long-Term Ocular Complications of Trachoma With Topical Azithromycin: A 3-Year Follow-up Study. | 2017 Jan-Feb | Asia Pac J Ophthalmol (Phila) | pmid:28161923 |
Speer EM et al. | Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. | 2018 | PLoS ONE | pmid:29715306 |
Pu Y et al. | Azithromycin ameliorates OVA-induced airway remodeling in Balb/c mice via suppression of epithelial-to-mesenchymal transition. | 2018 | Int. Immunopharmacol. | pmid:29567590 |
Chen QF and Zhang YW | [Clinical effect of Saccharomyces boulardii powder combined with azithromycin sequential therapy in treatment of children with diarrhea secondary to Mycoplasma pneumoniae pneumonia]. | 2018 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:29429459 |
Abdulai AA et al. | Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. | 2018 | PLoS Negl Trop Dis | pmid:29566044 |
Azmanis P et al. | First detection of Cryptosporidium parvum in falcons (Falconiformes): Diagnosis, molecular sequencing, therapeutic trial and epidemiological assessment of a possible emerging disease in captive falcons. | 2018 | Vet. Parasitol. | pmid:29559142 |
Luo H et al. | Clinical characteristics from co-infection with avian influenza A H7N9 and Mycoplasma pneumoniae: a case report. | 2018 | J Med Case Rep | pmid:29540219 |
Horner P et al. | Which azithromycin regimen should be used for treating ? A meta-analysis. | 2018 | Sex Transm Infect | pmid:28717050 |
Kawamura K et al. | Adjunctive therapy with azithromycin for moderate and severe acute respiratory distress syndrome: a retrospective, propensity score-matching analysis of prospectively collected data at a single center. | 2018 | Int. J. Antimicrob. Agents | pmid:29501821 |
Bandyopadhyay R et al. | Effectiveness of treatment regimens for Typhoid fever in the nalidixic acid-resistant S. typhi (NARST) era in South India. | 2018 | Trop Doct | pmid:29495943 |
Latif AS et al. | Antimicrobial susceptibility in isolates from five sentinel surveillance sites in Zimbabwe, 2015-2016. | 2018 | Sex Transm Infect | pmid:28476914 |
Mulugeta A et al. | Coverage, social mobilization and challenges of mass Zithromax administration campaign in South and South East zones of Tigray, Northern Ethiopia: A cross sectional study. | 2018 | PLoS Negl Trop Dis | pmid:29481558 |
Atkin PA and Simms ML | Orofacial granulomatosis: an unsuccessful response to weekly azithromycin pulse therapy. | 2018 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:29477603 |
Liu YH et al. | Antimicrobial susceptibilities and molecular typing of neisseria gonorrhoeae isolates at a medical centre in Taiwan, 2001-2013 with an emphasis on high rate of azithromycin resistance among the isolates. | 2018 | Int. J. Antimicrob. Agents | pmid:29477549 |
Mannelli VK et al. | . | 2018 | BMJ Case Rep | pmid:29472421 |
de Oliveira Alves A et al. | Young Boy With Roughening in the Inner Eyelids. | 2018 | Ann Emerg Med | pmid:29458812 |
Astale T et al. | Population-based coverage survey results following the mass drug administration of azithromycin for the treatment of trachoma in Amhara, Ethiopia. | 2018 | PLoS Negl Trop Dis | pmid:29451881 |
Å majs D and PospÃÅ¡ilová P | Macrolide resistance in yaws. | 2018 | Lancet | pmid:29428184 |
Mitjà O et al. | Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study. | 2018 | Lancet | pmid:29428183 |
Brereton CJ et al. | Is gentamicin safe and effective for severe community-acquired pneumonia? An 8-year retrospective cohort study. | 2018 | Int. J. Antimicrob. Agents | pmid:29410326 |
Ting CY and Shahdadpuri R | Fuchs syndrome: a case of fever, mucositis and conjunctivitis. | 2018 | BMJ Case Rep | pmid:29378740 |
Huang S et al. | Human babesiosis in Southeast China: A case report. | 2018 | Int. J. Infect. Dis. | pmid:29355731 |
Jenson A et al. | Patient-centered communication of community treatment assistants in Tanzania predicts coverage of future mass drug administration for trachoma. | 2018 | Patient Educ Couns | pmid:29329726 |
Sarathchandran P et al. | infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement. | 2018 | BMJ Case Rep | pmid:29326371 |
Mascarenhas TR et al. | Tick-borne illness after transplantation: Case and review. | 2018 | Transpl Infect Dis | pmid:29277955 |
Oldenburg CE et al. | Comparison of Mass Azithromycin Coverage Targets of Children in Niger: A Cluster-Randomized Trachoma Trial. | 2018 | Am. J. Trop. Med. Hyg. | pmid:29260659 |
Medeiros PHQS et al. | Molecular characterization of virulence and antimicrobial resistance profile of Shigella species isolated from children with moderate to severe diarrhea in northeastern Brazil. | 2018 | Diagn. Microbiol. Infect. Dis. | pmid:29217418 |
Pan H and Ba-Thein W | Diagnostic Accuracy of Global Pharma Health Fund Minilabâ„¢ in Assessing Pharmacopoeial Quality of Antimicrobials. | 2018 | Am. J. Trop. Med. Hyg. | pmid:29141717 |
Chatterjee S and Agrawal D | Azithromycin in the Management of Pythium insidiosum Keratitis. | 2018 | Cornea | pmid:29095755 |
Thakur SD et al. | High levels of susceptibility to new and older antibiotics in Neisseria gonorrhoeae isolates from Saskatchewan (2003-15): time to consider point-of-care or molecular testing for precision treatment? | 2018 | J. Antimicrob. Chemother. | pmid:29029217 |
Kelly C et al. | Macrolide antibiotics for bronchiectasis. | 2018 | Cochrane Database Syst Rev | pmid:29543980 |
Li B et al. | The efficacy of azithromycin and doxycycline treatment for rectal chlamydial infection: a retrospective cohort study in South Australia. | 2018 | Intern Med J | pmid:28967178 |
Bogdan M et al. | In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates. | 2018 | J Chemother | pmid:28956494 |
Wang R et al. | IncA/C plasmids conferring high azithromycin resistance in vibrio cholerae. | 2018 | Int. J. Antimicrob. Agents | pmid:28919196 |
Casas-Maldonado F | Bronchiectasis and Azithromycin. | 2018 | Arch. Bronconeumol. | pmid:28757281 |
Zhao L et al. | Trends in antimicrobial resistance in Neisseria gonorrhoeae and molecular characteristics of N. gonorrhoeae with decreased susceptibility to ceftriaxone in Shandong, China, 2007 to 2014. | 2018 | Int. J. Antimicrob. Agents | pmid:28729124 |
Bakshi SS | In reference to 'Therapeutic efficacy of azithromycin and acetylcysteine in chronic otitis media with effusion'. | 2018 | Eur Arch Otorhinolaryngol | pmid:28612316 |
Weston EJ et al. | Adherence to CDC Recommendations for the Treatment of Uncomplicated Gonorrhea - STD Surveillance Network, United States, 2016. | 2018 | MMWR Morb. Mortal. Wkly. Rep. | pmid:29698384 |
Revello R et al. | Prediction of chorioamnionitis in cases of intraamniotic infection by ureaplasma urealyticum in women with very preterm premature rupture of membranes or preterm labour. | 2018 | J. Matern. Fetal. Neonatal. Med. | pmid:28502201 |
Keenan JD et al. | Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa. | 2018 | N. Engl. J. Med. | pmid:29694816 |
Marks M et al. | Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea. | 2018 | Lancet Glob Health | pmid:29456191 |
Sardana K et al. | An observational study of the efficacy of azithromycin in erythema annulare centrifugum. | 2018 | Clin. Exp. Dermatol. | pmid:29297941 |
Tung NT et al. | Formulation and biopharmaceutical evaluation of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. | 2018 | Eur J Pharm Biopharm | pmid:28359878 |
Kamio K and Azuma A | Diffuse panbronchiolitis: A fine road from the discovery of a disease to the establishment of treatment. | 2018 | Respir Investig | pmid:30049592 |
Zikic A et al. | Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis. | 2018 | J Pediatric Infect Dis Soc | pmid:30007329 |
Ersoy B et al. | The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. | 2018 | J Laryngol Otol | pmid:29888693 |
Lietman TM et al. | Identifying a sufficient core group for trachoma transmission. | 2018 | PLoS Negl Trop Dis | pmid:30296259 |
Hassan KS and Al-Khadouri G | Pneumonia with Worsening Pleural Effusion Despite Treatment with Appropriate Antimicrobials: Case report. | 2018 | Sultan Qaboos Univ Med J | pmid:30210860 |
Williams PCM and Berkley JA | Guidelines for the management of paediatric cholera infection: a systematic review of the evidence. | 2018 | Paediatr Int Child Health | pmid:29790841 |
Al-Darraji A et al. | Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. | 2018 | PLoS ONE | pmid:30001416 |
Glanternik JR et al. | A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood. | 2018 | Pediatr. Infect. Dis. J. | pmid:28945680 |
Li JG et al. | [Eperythrozoonosis complicated with hemophagocytic syndrome: report of four cases and review of literature]. | 2018 | Zhonghua Er Ke Za Zhi | pmid:29614573 |
Xu L et al. | Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review. | 2018 | Medicine (Baltimore) | pmid:29505509 |
Mikalová L and Šmajs D | Low-dose versus standard-dose azithromycin for treatment of yaws. | 2018 | Lancet Glob Health | pmid:29456192 |
Cai X et al. | Anti-N-methyl-D-aspartate receptor encephalitis associated with acute Toxoplasma gondii infection: A case report. | 2018 | Medicine (Baltimore) | pmid:29443773 |
Yang D et al. | The timing of azithromycin treatment is not associated with the clinical prognosis of childhood Mycoplasma pneumoniae pneumonia in high macrolide-resistant prevalence settings. | 2018 | PLoS ONE | pmid:29377957 |
Morales A et al. | Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up. | 2018 | J Appl Oral Sci | pmid:29364340 |
Buder S et al. | Antimicrobial resistance of Neisseria gonorrhoeae in Germany: low levels of cephalosporin resistance, but high azithromycin resistance. | 2018 | BMC Infect. Dis. | pmid:29343220 |
Crooks MG et al. | How does azithromycin improve asthma exacerbations? | 2018 | Lancet | pmid:29323653 |
Gibson PG | How does azithromycin improve asthma exacerbations? - Author's reply. | 2018 | Lancet | pmid:29323652 |
Sanchez Garcia D et al. | Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs. | 2018 | Chem. Biol. Interact. | pmid:29248446 |
Vermillion Maier ML and Tjeerdema RS | Azithromycin sorption and biodegradation in a simulated California river system. | 2018 | Chemosphere | pmid:29031188 |
Tada H et al. | The effects of Lactobacillus reuteri probiotics combined with azithromycin on peri-implantitis: A randomized placebo-controlled study. | 2018 | J Prosthodont Res | pmid:28756115 |
Fleming-Dutra KE et al. | Variations in Antibiotic and Azithromycin Prescribing for Children by Geography and Specialty-United States, 2013. | 2018 | Pediatr. Infect. Dis. J. | pmid:28746259 |
Balci O and Gulkilik G | Assessment of efficacy of topical azithromycin 1.5 per cent ophthalmic solution for the treatment of meibomian gland dysfunction. | 2018 | Clin Exp Optom | pmid:28677153 |
Hong D et al. | [Atopic keratoconjunctivitis: One allergy may mask another. A clinical observation with two types of hypersensitivity reactions: IgE-mediated and non-IgE-mediated]. | 2018 | J Fr Ophtalmol | pmid:29567021 |
Obaro S | Azithromycin and Childhood Mortality in Africa. | 2018 | N. Engl. J. Med. | pmid:30284804 |
Michelow IC and Sánchez PJ | Azithromycin and Childhood Mortality in Africa. | 2018 | N. Engl. J. Med. | pmid:30284803 |
Cutler T et al. | Azithromycin and Childhood Mortality in Africa. | 2018 | N. Engl. J. Med. | pmid:30284802 |
Keenan JD et al. | Azithromycin and Childhood Mortality in Africa. | 2018 | N. Engl. J. Med. | pmid:30281987 |
El Sayed I et al. | Antibiotics for treating scrub typhus. | 2018 | Cochrane Database Syst Rev | pmid:30246875 |
Goyal V et al. | Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial. | 2018 | Lancet | pmid:30241722 |
Thapa A et al. | Typhoid fever with isolated left lateral rectus palsy. | 2018 | BMJ Case Rep | pmid:30181402 |
Grewal TK et al. | Therapeutic implications of nano-encapsulated rifabutin, azithromycin & ethambutol against experimental infection in mice. | 2018 | Indian J. Med. Res. | pmid:30168492 |
Montazeri M et al. | Activities of anti-Toxoplasma drugs and compounds against tissue cysts in the last three decades (1987 to 2017), a systematic review. | 2018 | Parasitol. Res. | pmid:30088074 |
Tilahun Z and Fenta TG | Coverage of azithromycin mass treatment for trachoma elimination in Northwestern Ethiopia: a community based cross-sectional study. | 2018 | BMC Ophthalmol | pmid:30081851 |
Lundin MS et al. | Lemierre's syndrome and 2016 American College of Physician guidelines for pharyngitis: no to empiric coverage for bacterial pharyngitis. While no role for routine Fusobacterium PCR, keep suspicion for this pathogen. | 2018 | BMJ Case Rep | pmid:30030249 |
Celma A et al. | Development of a Retention Time Interpolation scale (RTi) for liquid chromatography coupled to mass spectrometry in both positive and negative ionization modes. | 2018 | J Chromatogr A | pmid:30005941 |
Lederhandler MH et al. | Severe Oral Mucositis: A Rare Adverse Event of Pembrolizumab. | 2018 | J Drugs Dermatol | pmid:30005106 |
Valor C and Huber K | Atypical presentation of cat scratch disease: Parinaud's oculoglandular syndrome with facial nerve paresis. | 2018 | BMJ Case Rep | pmid:29982178 |
Lanz J and Lautenschlager S | [CME Dermatology 16/Answer: Fever, Pustules and Joint Pain as Vacation Mementoes]. | 2018 | Praxis (Bern 1994) | pmid:29921188 |
Kalua K et al. | One round of azithromycin MDA adequate to interrupt transmission in districts with prevalence of trachomatous inflammation-follicular of 5.0-9.9%: Evidence from Malawi. | 2018 | PLoS Negl Trop Dis | pmid:29897902 |
Smotrys M et al. | Babesiosis as a cause of false-positive HIV serology. | 2018 | BMJ Case Rep | pmid:29884713 |
Nüesch-Inderbinen M et al. | Genetic characterization of Shiga toxin producing Escherichia coli belonging to the emerging hybrid pathotype O80:H2 isolated from humans 2010-2017 in Switzerland. | 2018 | Int. J. Med. Microbiol. | pmid:29884331 |
Iguidbashian JP et al. | and coinfection in the setting of ulcerative colitis. | 2018 | BMJ Case Rep | pmid:29880626 |
Lendermon EA et al. | Azithromycin Fails to Prevent Accelerated Airway Obliteration in T-bet Mouse Lung Allograft Recipients. | 2018 | Transplant. Proc. | pmid:29880387 |
Lam-Franco L et al. | IL-1α and MMP-9 Tear Levels of Patients with Active Ocular Rosacea before and after Treatment with Systemic Azithromycin or Doxycycline. | 2018 | Ophthalmic Res. | pmid:29874670 |
Saita MG et al. | pH-Dependent stability of azithromycin in aqueous solution and structure identification of two new degradation products. | 2018 | J Pharm Biomed Anal | pmid:29860178 |
Naderi N et al. | Long-term azithromycin therapy to reduce acute exacerbations in patients with severe chronic obstructive pulmonary disease. | 2018 | Respir Med | pmid:29724384 |
Zmora N et al. | Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults. | 2018 | PLoS Negl Trop Dis | pmid:29684022 |
Wei W et al. | MPEG-PCL Copolymeric Micelles for Encapsulation of Azithromycin. | 2018 | AAPS PharmSciTech | pmid:29675667 |
Barge L et al. | Transient immune-mediated agranulocytosis following infection. | 2018 | BMJ Case Rep | pmid:29669774 |
Baker KS et al. | Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species. | 2018 | Nat Commun | pmid:29654279 |
Ganesh R et al. | Clinical profile and outcome of children with scrub typhus from Chennai, South India. | 2018 | Eur. J. Pediatr. | pmid:29637374 |
Papp JR et al. | Accuracy and reproducibility of the Etest to detect drug-resistant Neisseria gonorrhoeae to contemporary treatment. | 2018 | J. Med. Microbiol. | pmid:29219803 |
Deguchi T et al. | Macrolide and fluoroquinolone resistance is uncommon in clinical strains of Chlamydia trachomatis. | 2018 | J. Infect. Chemother. | pmid:29627327 |
Smith-Norowitz TA et al. | Doxycycline suppresses Chlamydia pneumoniae induced interferon-gamma responses in peripheral blood mononuclear cells in children with allergic asthma. | 2018 | J. Infect. Chemother. | pmid:29615379 |
Rim JH et al. | Recent Increase in the Incidence of TEM-135 β-Lactamase-harboring Neisseria gonorrhoeae in Korea. | 2018 | Ann Lab Med | pmid:29611382 |