Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Salimi A et al. | Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. | 2016 | Xenobiotica | pmid:26068526 |
Martande SS et al. | Clinical and microbiological effects of systemic azithromycin in adjunct to nonsurgical periodontal therapy in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis: a randomized placebo-controlled clinical trial. | 2016 | J Investig Clin Dent | pmid:25044531 |
EmiralioÄŸlu N et al. | Long term azithromycin therapy in patients with cystic fibrosis. | 2016 | Turk. J. Pediatr. | pmid:27922234 |
Mougari F et al. | Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. | 2016 | Expert Rev Anti Infect Ther | pmid:27690688 |
Johnston SL et al. | Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial. | 2016 | JAMA Intern Med | pmid:27653939 |
Zhao X et al. | Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids. | 2016 | PLoS ONE | pmid:27907030 |
Mosquera RA et al. | Anti-inflammatory effect of prophylactic macrolides on children with chronic lung disease: a protocol for a double-blinded randomised controlled trial. | 2016 | BMJ Open | pmid:27638496 |
Kissinger PJ et al. | Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. | 2016 | Sex Transm Dis | pmid:27631353 |
Nielsen HL et al. | Azithromycin vs. Placebo for the Clinical Outcome in Campylobacter concisus Diarrhoea in Adults: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. | 2016 | PLoS ONE | pmid:27893820 |
Tepper M et al. | Mass Treatment with Single-Dose Azithromycin for Yaws. | 2016 | N. Engl. J. Med. | pmid:27626527 |
Phiri K et al. | Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. | 2016 | PLoS ONE | pmid:27861509 |
Eckhoff G et al. | Mass Treatment with Single-Dose Azithromycin for Yaws. | 2016 | N. Engl. J. Med. | pmid:27626526 |
Malhotra S et al. | Prevalence of Trachoma in Car-Nicobar Island, India after Three Annual Rounds of Mass Drug Administration with Azithromycin. | 2016 | PLoS ONE | pmid:27391274 |
Marks M | Yaws: towards the WHO eradication target. | 2016 | Trans. R. Soc. Trop. Med. Hyg. | pmid:27268712 |
Liu B et al. | Relationship between Community Drug Administration Strategy and Changes in Trachoma Prevalence, 2007 to 2013. | 2016 | PLoS Negl Trop Dis | pmid:27385309 |
Long SS | Optimizing antimicrobial therapy in children. | 2016 | J. Infect. | pmid:27263076 |
Katanami Y et al. | Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27352874 |
Mertens TC et al. | Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells. | 2016 | Pulm Pharmacol Ther | pmid:27246785 |
Wang X et al. | Increased therapeutic efficacy of combination of azithromycin and ceftazidime on Pseudomonas aeruginosa biofilm in an animal model of ureteral stent infection. | 2016 | BMC Microbiol. | pmid:27341798 |
Das S et al. | Revisit of fluoroquinolone and azithromycin susceptibility breakpoints for Salmonella enterica serovar Typhi. | 2016 | J. Med. Microbiol. | pmid:27221661 |
Fifer H et al. | Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea. | 2016 | N. Engl. J. Med. | pmid:27332921 |
Bacharier LB et al. | Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children--Reply. | 2016 | JAMA | pmid:27187309 |
Gesink D et al. | Mycoplasma genitalium in Toronto, Ont: Estimates of prevalence and macrolide resistance. | 2016 | Can Fam Physician | pmid:27331225 |
Fleming-Dutra KE et al. | Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children. | 2016 | JAMA | pmid:27187308 |
Yuan Z et al. | Randomized controlled clinical trial on the efficacy of fosfomycin trometamol for uncomplicated gonococcal urethritis in men. | 2016 | Clin. Microbiol. Infect. | pmid:27064136 |
Farrell DJ et al. | Results from the Solithromycin International Surveillance Program (2014). | 2016 | Antimicrob. Agents Chemother. | pmid:27044551 |
Mathew JL et al. | Oral Azithromycin for Acute Episodic Airway Symptoms in Young Children: Evidence-based Medicine Viewpoint. | 2016 | Indian Pediatr | pmid:27029689 |
Pavlović D and Mutak S | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. | 2016 | Bioorg. Med. Chem. | pmid:26860929 |
Roca A et al. | Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial. | 2016 | Clin. Microbiol. Infect. | pmid:27026482 |
Oey M and Malhotra P | Azithromycin and ceftriaxone combination treatment for relapsed Salmonella Paratyphi A bacteraemia. | 2016 | J Travel Med | pmid:26858276 |
DeCoster B et al. | Expedited Partner Therapy: Clinical Considerations and Public Health Explorations. | 2016 | AMA J Ethics | pmid:27002992 |
Zhou T et al. | Determination of azithromycin residue in pork using a molecularly imprinted monolithic microcolumn coupled to liquid chromatography with tandem mass spectrometry. | 2016 | J Sep Sci | pmid:26854282 |
Das MC et al. | Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. | 2016 | Sci Rep | pmid:27000525 |
Saleh A et al. | Comparison of adjunctive azithromycin and amoxicillin/metronidazole for patients with chronic periodontitis: preliminary randomized control trial. | 2016 | Aust Dent J | pmid:26836781 |
Topp E et al. | Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. | 2016 | Sci. Total Environ. | pmid:27096634 |
Liu H et al. | [A systematic review of the therapy for Mycoplasma pneumoniae infections in children]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:26875461 |
Arnold FW et al. | Macrolide Use and Neutrophil Function/Cytokine Levels in Hospitalized Patients with Community-Acquired Pneumonia: A Pilot Study. | 2016 | Lung | pmid:26553025 |
Olszewska-Sosińska O et al. | Persistence of non-typeable Haemophilus Influenzae in the pharynx of children with adenotonsillar hypertrophy after treatment with azithromycin. | 2016 | Pathog Dis | pmid:26546328 |
Wakiguchi H et al. | Multiple Renal and Splenic Lesions in Cat Scratch Disease. | 2016 | Jpn. J. Infect. Dis. | pmid:26567841 |
So W et al. | Poor outcomes of empiric ceftriaxone ± azithromycin for community-acquired pneumonia caused by methicillin-susceptible Staphylococcus aureus. | 2016 | Intern Emerg Med | pmid:26531307 |
VÃchová B et al. | First molecular identification of Babesia gibsoni in dogs from Slovakia, central Europe. | 2016 | Ticks Tick Borne Dis | pmid:26304014 |
Bhargava A et al. | Scrub typhus in Uttarakhand & adjoining Uttar Pradesh: Seasonality, clinical presentations & predictors of mortality. | 2016 | Indian J. Med. Res. | pmid:28474627 |
Fegan D et al. | Tropical leg ulcers in children: more than yaws. | 2016 | Trop Doct | pmid:26289420 |
Kasten G et al. | Development of low density azithromycin-loaded polycaprolactone microparticles for pulmonary delivery. | 2016 | Drug Dev Ind Pharm | pmid:26289002 |
Narayanasamy DK et al. | Clinico - Laboratory Profile of Scrub Typhus - An Emerging Rickettsiosis in India. | 2016 | Indian J Pediatr | pmid:27352842 |
Keenan JD et al. | Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma. | 2016 | J Pediatric Infect Dis Soc | pmid:27199475 |
Tous Romero F et al. | Acute Infection by Staphylococcus simulans in the Hand of a Man. | 2016 | JAMA Dermatol | pmid:27144675 |
Horner P et al. | 2015 UK National Guideline on the management of non-gonococcal urethritis. | 2016 | Int J STD AIDS | pmid:26002319 |
Ni C et al. | High prevalence of Neisseria gonorrhoeae with high-level resistance to azithromycin in Hangzhou, China. | 2016 | J. Antimicrob. Chemother. | pmid:27090631 |
Garnier C et al. | Intra-nodal injection of gentamicin for the treatment of suppurated cat scratch disease's lymphadenitis. | 2016 | Infection | pmid:26001741 |