Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Tick Bites D064927 1 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Reproductive Tract Infections D060737 1 associated lipids
Granulomatous Mastitis D058890 1 associated lipids
Trichiasis D058457 1 associated lipids
Asymptomatic Infections D058345 1 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Neglected Diseases D058069 3 associated lipids
Corneal Endothelial Cell Loss D055954 1 associated lipids
Multiple Pulmonary Nodules D055613 2 associated lipids
Acute Lung Injury D055371 33 associated lipids
Failed Back Surgery Syndrome D055111 3 associated lipids
Tracheobronchomalacia D055089 1 associated lipids
Precursor Cell Lymphoblastic Leukemia-Lymphoma D054198 10 associated lipids
Hyper-IgM Immunodeficiency Syndrome D053306 1 associated lipids
Pyomyositis D052880 2 associated lipids
Male Urogenital Diseases D052801 1 associated lipids
Tendinopathy D052256 3 associated lipids
Mucositis D052016 7 associated lipids
Pyloric Stenosis, Hypertrophic D046248 2 associated lipids
Moraxellaceae Infections D045828 3 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Communicable Diseases, Emerging D021821 3 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Focal Nodular Hyperplasia D020518 1 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Acquired Hyperostosis Syndrome D020083 1 associated lipids
Syncope, Vasovagal D019462 1 associated lipids
Pouchitis D019449 3 associated lipids
Pseudolymphoma D019310 1 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Abdominal Abscess D018784 2 associated lipids
Parasitemia D018512 5 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
T-Lymphocytopenia, Idiopathic CD4-Positive D018344 1 associated lipids
Furcation Defects D017823 1 associated lipids
Granuloma, Pyogenic D017789 2 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Pelvic Pain D017699 7 associated lipids
Aortic Aneurysm, Abdominal D017544 5 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
Ureaplasma Infections D016869 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Yazdanbakhsh AR et al. Reduction of non-Betalactam Antibiotics COD by Combined Coagulation and Advanced Oxidation Processes. 2016 Water Environ. Res. pmid:28661328
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Martín JM et al. Azithromycin for the Treatment of Ciclosporin-Induced Gingival Hyperplasia. 2016 Actas Dermosifiliogr pmid:26996332
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Wang A et al. Effects of Fluoroquinolones and Azithromycin on Biofilm Formation of Stenotrophomonas maltophilia. 2016 Sci Rep pmid:27405358
Menzel M et al. Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients. 2016 Sci Rep pmid:27350308
O'Beirne SL et al. Trust Your Instincts. Surgical Lung Biopsy with Normal Chest Imaging in a 49-Year-Old Man with Progressive Dyspnea. 2016 Ann Am Thorac Soc pmid:27144798
Nair S et al. WGS for surveillance of antimicrobial resistance: a pilot study to detect the prevalence and mechanism of resistance to azithromycin in a UK population of non-typhoidal Salmonella. 2016 J. Antimicrob. Chemother. pmid:27585964
Mwingira UJ et al. Progress of Trachoma Mapping in Mainland Tanzania: Results of Baseline Surveys from 2012 to 2014. 2016 Ophthalmic Epidemiol pmid:27775455
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Yasuda M et al. Remarkable increase of Neisseria gonorrhoeae with decreased susceptibility of azithromycin and increase in the failure of azithromycin therapy in male gonococcal urethritis in Sendai in 2015. 2016 J. Infect. Chemother. pmid:27578029
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Committee Opinion No. 645: Dual Therapy for Gonococcal Infections. 2016 Obstet Gynecol pmid:27548425
Waites KB et al. In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas. 2016 Antimicrob. Agents Chemother. pmid:27671057
Committee Opinion No. 645 Summary: Dual Therapy for Gonococcal Infections. 2016 Obstet Gynecol pmid:27548417
Li S et al. Two case reports: Whole genome sequencing of two clinical macrolide-resistant Mycoplasma pneumoniae isolates with different responses to azithromycin. 2016 Medicine (Baltimore) pmid:27661056
Mustapha NA et al. Impact of different antibiotics on methane production using waste-activated sludge: mechanisms and microbial community dynamics. 2016 Appl. Microbiol. Biotechnol. pmid:27531514
Brunner A et al. Emerging azithromycin-resistance among the Neisseria gonorrhoeae strains isolated in Hungary. 2016 Ann. Clin. Microbiol. Antimicrob. pmid:27646968
Molini BJ et al. Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains. 2016 Sex Transm Dis pmid:27513385
Regnath T et al. Antimicrobial resistance of Neisseria gonorrhoeae isolates in south-west Germany, 2004 to 2015: increasing minimal inhibitory concentrations of tetracycline but no resistance to third-generation cephalosporins. 2016 Euro Surveill. pmid:27632642
Xiridou M et al. Cost-Effectiveness of Dual Antimicrobial Therapy for Gonococcal Infections Among Men Who Have Sex With Men in the Netherlands. 2016 Sex Transm Dis pmid:27513379
Mitjà O et al. Mass Treatment with Single-Dose Azithromycin for Yaws. 2016 N. Engl. J. Med. pmid:27626525
Cheng GS et al. Lung Function Trajectory in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplant. 2016 Ann Am Thorac Soc pmid:27513368
Kobuchi S et al. Transport of Azithromycin into Extravascular Space in Rats. 2016 Antimicrob. Agents Chemother. pmid:27600045
Marks M et al. Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. 2016 PLoS Negl Trop Dis pmid:27551787
Samson C et al. Long-term effects of azithromycin in patients with cystic fibrosis. 2016 Respir Med pmid:27492507
Akram FE et al. A combination of silver nanoparticles and visible blue light enhances the antibacterial efficacy of ineffective antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). 2016 Ann. Clin. Microbiol. Antimicrob. pmid:27530257
O'Farrell N Control of gonorrhoea and chlamydia in the UK. 2016 Lancet pmid:27477165
Zhu XH et al. Viral and Bacterial Etiology of Acute Diarrhea among Children under 5 Years of Age in Wuhan, China. 2016 Chin. Med. J. pmid:27503019
Zhao M et al. Comparison of minocycline and azithromycin for the treatment of mild scrub typhus in northern China. 2016 Int. J. Antimicrob. Agents pmid:27449540
Dukers-Muijrers NH et al. Design of the FemCure study: prospective multicentre study on the transmission of genital and extra-genital Chlamydia trachomatis infections in women receiving routine care. 2016 BMC Infect. Dis. pmid:27502928
Horner PJ et al. 2016 European guideline on the management of non-gonococcal urethritis. 2016 Int J STD AIDS pmid:27147267
El-Shitany NA and El-Desoky K Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression. 2016 Oxid Med Cell Longev pmid:27274777
Kreuter A and Wieland U Azithromycin versus Doxycycline for Chlamydia. 2016 N. Engl. J. Med. pmid:27144858
García-Quintanilla M et al. Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. 2016 Antimicrob. Agents Chemother. pmid:27270288
Schachter J Azithromycin versus Doxycycline for Chlamydia. 2016 N. Engl. J. Med. pmid:27144857
Zhou QT et al. How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder? 2016 AAPS J pmid:27255350
MUW researcher of the month Franz Ratzinger. 2016 Wien. Klin. Wochenschr. pmid:27113348
Yuan ZF et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with Mycoplasma pneumoniae infection. 2016 BMC Infect. Dis. pmid:27230114
Kloepfer KM Azithromycin may prevent severe respiratory-infection-induced wheezing. 2016 J. Pediatr. pmid:27112084
Liu Y et al. Influence of Omega 3 and 6 Fatty Acids on Human Meibomian Gland Epithelial Cells. 2016 Cornea pmid:27227397
Noda AA et al. First Report of the 23S rRNA Gene A2058G Point Mutation Associated With Macrolide Resistance in Treponema pallidum From Syphilis Patients in Cuba. 2016 Sex Transm Dis pmid:27100771
Haas AN et al. Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial. 2016 Braz Oral Res pmid:27223128
Itaqui SR et al. In Vitro Synergism between Azithromycin or Terbinafine and Topical Antimicrobial Agents against Pythium insidiosum. 2016 Antimicrob. Agents Chemother. pmid:27216049
Wang Z and Meenach SA Synthesis and Characterization of Nanocomposite Microparticles (nCmP) for the Treatment of Cystic Fibrosis-Related Infections. 2016 Pharm. Res. pmid:27091030
Phong NC et al. In Vivo Efficacy and Tolerability of Artesunate-Azithromycin for the Treatment of Falciparum Malaria in Vietnam. 2016 Am. J. Trop. Med. Hyg. pmid:27215294
Ab Rahman N et al. Antibiotic prescribing in public and private practice: a cross-sectional study in primary care clinics in Malaysia. 2016 BMC Infect. Dis. pmid:27188538
Brown J et al. Shigellosis: high rates of antibiotic resistance necessitate new treatment recommendations. 2016 Med. J. Aust. pmid:27078594
Ramaiah B et al. High azithromycin concentration in lungs by way of bovine serum albumin microspheres as targeted drug delivery: lung targeting efficiency in albino mice. 2016 Daru pmid:27150818
Rajabi O et al. Topical liposomal azithromycin in the treatment of acute cutaneous leishmaniasis. 2016 Dermatol Ther pmid:27073044
Geisler WM et al. Azithromycin versus Doxycycline for Chlamydia. 2016 N. Engl. J. Med. pmid:27144856
Dunn AL et al. Naegleria fowleri That Induces Primary Amoebic Meningoencephalitis: Rapid Diagnosis and Rare Case of Survival in a 12-Year-Old Caucasian Girl. 2016 Lab Med pmid:26984830
Trac MH et al. Macrolide antibiotics and the risk of ventricular arrhythmia in older adults. 2016 CMAJ pmid:26903359
Marks M et al. Mass drug administration of azithromycin for trachoma reduces the prevalence of genital Chlamydia trachomatis infection in the Solomon Islands. 2016 Sex Transm Infect pmid:26888658
Economopoulos KP et al. Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase. 2016 Diabetes Obes Metab pmid:26876427
Kang JY et al. Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma. 2016 Pulm Pharmacol Ther pmid:26778828
Sridhar S et al. High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study. 2016 BMC Infect. Dis. pmid:26861696
Peters RP et al. Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. 2016 Sex Transm Dis pmid:26760182
Hodgson D et al. The Effects of Azithromycin in Treatment-Resistant Cough: A Randomized, Double-Blind, Placebo-Controlled Trial. 2016 Chest pmid:26836927
Zheng Z et al. Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives. 2016 J. Antibiot. pmid:27118243
Gratrix J et al. A Retrospective Review of Treatment Failures Using Azithromycin and Doxycycline in the Treatment of Rectal Chlamydia Infections in Women and Men Who Have Sex With Men. 2016 Sex Transm Dis pmid:26760180
Kumaraswamy M et al. Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia. 2016 J. Antimicrob. Chemother. pmid:26832758
Arikan S et al. Effect of Topically Applied Azithromycin on Corneal Epithelial and Endothelial Apoptosis in a Rat Model of Corneal Alkali Burn. 2016 Cornea pmid:26751994
Zhou T et al. Fabrication of a Selective and Sensitive Sensor Based on Molecularly Imprinted Polymer/Acetylene Black for the Determination of Azithromycin in Pharmaceuticals and Biological Samples. 2016 PLoS ONE pmid:26820753
Russell DW et al. Disease phenotyping in chronic obstructive pulmonary disease: the neutrophilic endotype. 2016 Curr Opin Pulm Med pmid:26717512
Kadota T et al. Analysis of drug treatment outcome in clarithromycin-resistant Mycobacterium avium complex lung disease. 2016 BMC Infect. Dis. pmid:26818764
Wladis EJ et al. Oral Antibiotics for Meibomian Gland-Related Ocular Surface Disease: A Report by the American Academy of Ophthalmology. 2016 Ophthalmology pmid:26707417
Deshpande D et al. Azithromycin Dose To Maximize Efficacy and Suppress Acquired Drug Resistance in Pulmonary Mycobacterium avium Disease. 2016 Antimicrob. Agents Chemother. pmid:26810646
Stokholm J et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomised, double-blind, placebo-controlled trial. 2016 Lancet Respir Med pmid:26704020
Swatton JE et al. Impact of Azithromycin on the Quorum Sensing-Controlled Proteome of Pseudomonas aeruginosa. 2016 PLoS ONE pmid:26808156
Afshar M et al. Azithromycin use and outcomes in severe sepsis patients with and without pneumonia. 2016 J Crit Care pmid:26803186
Lenehan PJ et al. An evaluation strategy for potential QTc prolongation with chronic azithromycin therapy in cystic fibrosis. 2016 J. Cyst. Fibros. pmid:26698953
Lee H et al. New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae. 2016 Expert Rev Anti Infect Ther pmid:26690658
Nakajima T et al. Microbiological and Clinical Effects of Sitafloxacin and Azithromycin in Periodontitis Patients Receiving Supportive Periodontal Therapy. 2016 Antimicrob. Agents Chemother. pmid:26729495
Jentsch HF et al. Nonsurgical therapy of chronic periodontitis with adjunctive systemic azithromycin or amoxicillin/metronidazole. 2016 Clin Oral Investig pmid:26685849
Slade J et al. Chlamydial Pre-Infection Protects from Subsequent Herpes Simplex Virus-2 Challenge in a Murine Vaginal Super-Infection Model. 2016 PLoS ONE pmid:26726882
Lococo F et al. Hemoptysis and Progressive Dyspnea in a 67-Year-Old Woman with History of Renal Transplantation. 2016 Am. J. Respir. Crit. Care Med. pmid:26681504
Miyagawa T et al. Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α. 2016 Arch. Oral Biol. pmid:26655749
Nicholson TT et al. Assessing potential risks of treatment with long-term azithromycin in COPD patients: long-term oxygen users beware? 2016 Ir J Med Sci pmid:26502012
Deguchi T et al. Multidrug-Resistant Mycoplasma genitalium Is Increasing. 2016 Clin. Infect. Dis. pmid:26494825
Kong FY et al. Reply to Deguchi et al. 2016 Clin. Infect. Dis. pmid:26494824
Al-Hity A and Lockington D Oral azithromycin as the systemic treatment of choice in the treatment of meibomian gland disease. 2016 Clin. Experiment. Ophthalmol. pmid:26441357
Ruttens D et al. Prophylactic Azithromycin Therapy After Lung Transplantation: Post hoc Analysis of a Randomized Controlled Trial. 2016 Am. J. Transplant. pmid:26372728
Wu TS et al. Postcesarean section wound infection caused by Mycobacterium massiliense. 2016 J Microbiol Immunol Infect pmid:26350122
Unger HW et al. Azithromycin-containing intermittent preventive treatment in pregnancy affects gestational weight gain, an important predictor of birthweight in Papua New Guinea - an exploratory analysis. 2016 Matern Child Nutr pmid:26373537
Osborne LG et al. Enteric fever in a British soldier from Sierra Leone. 2016 J R Army Med Corps pmid:26243802
Li SQ et al. Establishment of a new animal model of azithromycin-induced liver injury and study the molecular pathological change during the process. 2016 Hum Exp Toxicol pmid:26205530
Nappe TM et al. Stevens-Johnson syndrome after treatment with azithromycin: an uncommon culprit. 2016 Am J Emerg Med pmid:26194400
Derad I et al. Hypertension and mild chronic kidney disease persist following severe haemolytic uraemic syndrome caused by Shiga toxin-producing Escherichia coli O104:H4 in adults. 2016 Nephrol. Dial. Transplant. pmid:26180049
Steeples LR et al. Real-time PCR using the 529 bp repeat element for the diagnosis of atypical ocular toxoplasmosis. 2016 Br J Ophthalmol pmid:26174811
Arora N et al. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. 2016 Nat Microbiol pmid:27918528
Retallack H et al. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:27911847
Brittain C et al. Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial. 2016 Trials pmid:27881151
Shimizu T and Suzaki H Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan. 2016 Auris Nasus Larynx pmid:26441370
Chang CC et al. Disseminated cat-scratch disease: case report and review of the literature. 2016 Paediatr Int Child Health pmid:25940800