Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Stomach Diseases D013272 7 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Lung Diseases D008171 37 associated lipids
Sarcoidosis D012507 13 associated lipids
Hyperglycemia D006943 21 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Genital Diseases, Male D005832 3 associated lipids
Sexually Transmitted Diseases D012749 4 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Abscess D000038 13 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Osteitis D010000 10 associated lipids
Dog Diseases D004283 5 associated lipids
Osteomyelitis D010019 10 associated lipids
Coronary Disease D003327 70 associated lipids
Pancreatitis D010195 10 associated lipids
Acne Vulgaris D000152 35 associated lipids
Skin Ulcer D012883 6 associated lipids
Eyelid Diseases D005141 4 associated lipids
Multiple Myeloma D009101 13 associated lipids
Pain, Postoperative D010149 13 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Corneal Opacity D003318 3 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Eye Diseases D005128 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Per page 10 20 50 100 | Total 276

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Azithramycine

Download all related citations
Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Sidhu H et al. Risk assessment of biosolids-borne ciprofloxacin and azithromycin. 2019 Sci. Total Environ. pmid:30463165
Sidhu H et al. Plant toxicity and accumulation of biosolids-borne ciprofloxacin and azithromycin. 2019 Sci. Total Environ. pmid:30340267
Sidhu H et al. Retention-release of ciprofloxacin and azithromycin in biosolids and biosolids-amended soils. 2019 Sci. Total Environ. pmid:30196217
Sidhu H et al. Bioavailability of biosolids-borne ciprofloxacin and azithromycin to terrestrial organisms: Microbial toxicity and earthworm responses. 2019 Sci. Total Environ. pmid:30195128
Speer EM et al. Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. 2018 PLoS ONE pmid:29715306
Pu Y et al. Azithromycin ameliorates OVA-induced airway remodeling in Balb/c mice via suppression of epithelial-to-mesenchymal transition. 2018 Int. Immunopharmacol. pmid:29567590
Chen QF and Zhang YW [Clinical effect of Saccharomyces boulardii powder combined with azithromycin sequential therapy in treatment of children with diarrhea secondary to Mycoplasma pneumoniae pneumonia]. 2018 Zhongguo Dang Dai Er Ke Za Zhi pmid:29429459
Abdulai AA et al. Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. 2018 PLoS Negl Trop Dis pmid:29566044
Azmanis P et al. First detection of Cryptosporidium parvum in falcons (Falconiformes): Diagnosis, molecular sequencing, therapeutic trial and epidemiological assessment of a possible emerging disease in captive falcons. 2018 Vet. Parasitol. pmid:29559142
Luo H et al. Clinical characteristics from co-infection with avian influenza A H7N9 and Mycoplasma pneumoniae: a case report. 2018 J Med Case Rep pmid:29540219
Horner P et al. Which azithromycin regimen should be used for treating ? A meta-analysis. 2018 Sex Transm Infect pmid:28717050
Kawamura K et al. Adjunctive therapy with azithromycin for moderate and severe acute respiratory distress syndrome: a retrospective, propensity score-matching analysis of prospectively collected data at a single center. 2018 Int. J. Antimicrob. Agents pmid:29501821
Bandyopadhyay R et al. Effectiveness of treatment regimens for Typhoid fever in the nalidixic acid-resistant S. typhi (NARST) era in South India. 2018 Trop Doct pmid:29495943
Latif AS et al. Antimicrobial susceptibility in isolates from five sentinel surveillance sites in Zimbabwe, 2015-2016. 2018 Sex Transm Infect pmid:28476914
Mulugeta A et al. Coverage, social mobilization and challenges of mass Zithromax administration campaign in South and South East zones of Tigray, Northern Ethiopia: A cross sectional study. 2018 PLoS Negl Trop Dis pmid:29481558
Atkin PA and Simms ML Orofacial granulomatosis: an unsuccessful response to weekly azithromycin pulse therapy. 2018 Oral Surg Oral Med Oral Pathol Oral Radiol pmid:29477603
Liu YH et al. Antimicrobial susceptibilities and molecular typing of neisseria gonorrhoeae isolates at a medical centre in Taiwan, 2001-2013 with an emphasis on high rate of azithromycin resistance among the isolates. 2018 Int. J. Antimicrob. Agents pmid:29477549
Mannelli VK et al. . 2018 BMJ Case Rep pmid:29472421
de Oliveira Alves A et al. Young Boy With Roughening in the Inner Eyelids. 2018 Ann Emerg Med pmid:29458812
Astale T et al. Population-based coverage survey results following the mass drug administration of azithromycin for the treatment of trachoma in Amhara, Ethiopia. 2018 PLoS Negl Trop Dis pmid:29451881
Šmajs D and Pospíšilová P Macrolide resistance in yaws. 2018 Lancet pmid:29428184
Mitjà O et al. Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study. 2018 Lancet pmid:29428183
Brereton CJ et al. Is gentamicin safe and effective for severe community-acquired pneumonia? An 8-year retrospective cohort study. 2018 Int. J. Antimicrob. Agents pmid:29410326
Ting CY and Shahdadpuri R Fuchs syndrome: a case of fever, mucositis and conjunctivitis. 2018 BMJ Case Rep pmid:29378740
Huang S et al. Human babesiosis in Southeast China: A case report. 2018 Int. J. Infect. Dis. pmid:29355731
Jenson A et al. Patient-centered communication of community treatment assistants in Tanzania predicts coverage of future mass drug administration for trachoma. 2018 Patient Educ Couns pmid:29329726
Sarathchandran P et al. infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement. 2018 BMJ Case Rep pmid:29326371
Mascarenhas TR et al. Tick-borne illness after transplantation: Case and review. 2018 Transpl Infect Dis pmid:29277955
Oldenburg CE et al. Comparison of Mass Azithromycin Coverage Targets of Children in Niger: A Cluster-Randomized Trachoma Trial. 2018 Am. J. Trop. Med. Hyg. pmid:29260659
Medeiros PHQS et al. Molecular characterization of virulence and antimicrobial resistance profile of Shigella species isolated from children with moderate to severe diarrhea in northeastern Brazil. 2018 Diagn. Microbiol. Infect. Dis. pmid:29217418
Pan H and Ba-Thein W Diagnostic Accuracy of Global Pharma Health Fund Minilabâ„¢ in Assessing Pharmacopoeial Quality of Antimicrobials. 2018 Am. J. Trop. Med. Hyg. pmid:29141717
Chatterjee S and Agrawal D Azithromycin in the Management of Pythium insidiosum Keratitis. 2018 Cornea pmid:29095755
Thakur SD et al. High levels of susceptibility to new and older antibiotics in Neisseria gonorrhoeae isolates from Saskatchewan (2003-15): time to consider point-of-care or molecular testing for precision treatment? 2018 J. Antimicrob. Chemother. pmid:29029217
Kelly C et al. Macrolide antibiotics for bronchiectasis. 2018 Cochrane Database Syst Rev pmid:29543980
Li B et al. The efficacy of azithromycin and doxycycline treatment for rectal chlamydial infection: a retrospective cohort study in South Australia. 2018 Intern Med J pmid:28967178
Bogdan M et al. In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates. 2018 J Chemother pmid:28956494
Wang R et al. IncA/C plasmids conferring high azithromycin resistance in vibrio cholerae. 2018 Int. J. Antimicrob. Agents pmid:28919196
Casas-Maldonado F Bronchiectasis and Azithromycin. 2018 Arch. Bronconeumol. pmid:28757281
Zhao L et al. Trends in antimicrobial resistance in Neisseria gonorrhoeae and molecular characteristics of N. gonorrhoeae with decreased susceptibility to ceftriaxone in Shandong, China, 2007 to 2014. 2018 Int. J. Antimicrob. Agents pmid:28729124
Bakshi SS In reference to 'Therapeutic efficacy of azithromycin and acetylcysteine in chronic otitis media with effusion'. 2018 Eur Arch Otorhinolaryngol pmid:28612316
Weston EJ et al. Adherence to CDC Recommendations for the Treatment of Uncomplicated Gonorrhea - STD Surveillance Network, United States, 2016. 2018 MMWR Morb. Mortal. Wkly. Rep. pmid:29698384
Revello R et al. Prediction of chorioamnionitis in cases of intraamniotic infection by ureaplasma urealyticum in women with very preterm premature rupture of membranes or preterm labour. 2018 J. Matern. Fetal. Neonatal. Med. pmid:28502201
Keenan JD et al. Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa. 2018 N. Engl. J. Med. pmid:29694816
Marks M et al. Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea. 2018 Lancet Glob Health pmid:29456191
Sardana K et al. An observational study of the efficacy of azithromycin in erythema annulare centrifugum. 2018 Clin. Exp. Dermatol. pmid:29297941
Tung NT et al. Formulation and biopharmaceutical evaluation of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. 2018 Eur J Pharm Biopharm pmid:28359878
Kamio K and Azuma A Diffuse panbronchiolitis: A fine road from the discovery of a disease to the establishment of treatment. 2018 Respir Investig pmid:30049592
Zikic A et al. Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis. 2018 J Pediatric Infect Dis Soc pmid:30007329
Ersoy B et al. The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. 2018 J Laryngol Otol pmid:29888693
Lietman TM et al. Identifying a sufficient core group for trachoma transmission. 2018 PLoS Negl Trop Dis pmid:30296259
Hassan KS and Al-Khadouri G Pneumonia with Worsening Pleural Effusion Despite Treatment with Appropriate Antimicrobials: Case report. 2018 Sultan Qaboos Univ Med J pmid:30210860
Williams PCM and Berkley JA Guidelines for the management of paediatric cholera infection: a systematic review of the evidence. 2018 Paediatr Int Child Health pmid:29790841
Al-Darraji A et al. Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. 2018 PLoS ONE pmid:30001416
Glanternik JR et al. A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood. 2018 Pediatr. Infect. Dis. J. pmid:28945680
Li JG et al. [Eperythrozoonosis complicated with hemophagocytic syndrome: report of four cases and review of literature]. 2018 Zhonghua Er Ke Za Zhi pmid:29614573
Xu L et al. Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review. 2018 Medicine (Baltimore) pmid:29505509
Mikalová L and Šmajs D Low-dose versus standard-dose azithromycin for treatment of yaws. 2018 Lancet Glob Health pmid:29456192
Cai X et al. Anti-N-methyl-D-aspartate receptor encephalitis associated with acute Toxoplasma gondii infection: A case report. 2018 Medicine (Baltimore) pmid:29443773
Yang D et al. The timing of azithromycin treatment is not associated with the clinical prognosis of childhood Mycoplasma pneumoniae pneumonia in high macrolide-resistant prevalence settings. 2018 PLoS ONE pmid:29377957
Morales A et al. Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up. 2018 J Appl Oral Sci pmid:29364340
Buder S et al. Antimicrobial resistance of Neisseria gonorrhoeae in Germany: low levels of cephalosporin resistance, but high azithromycin resistance. 2018 BMC Infect. Dis. pmid:29343220
Crooks MG et al. How does azithromycin improve asthma exacerbations? 2018 Lancet pmid:29323653
Gibson PG How does azithromycin improve asthma exacerbations? - Author's reply. 2018 Lancet pmid:29323652
Sanchez Garcia D et al. Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs. 2018 Chem. Biol. Interact. pmid:29248446
Vermillion Maier ML and Tjeerdema RS Azithromycin sorption and biodegradation in a simulated California river system. 2018 Chemosphere pmid:29031188
Tada H et al. The effects of Lactobacillus reuteri probiotics combined with azithromycin on peri-implantitis: A randomized placebo-controlled study. 2018 J Prosthodont Res pmid:28756115
Fleming-Dutra KE et al. Variations in Antibiotic and Azithromycin Prescribing for Children by Geography and Specialty-United States, 2013. 2018 Pediatr. Infect. Dis. J. pmid:28746259
Balci O and Gulkilik G Assessment of efficacy of topical azithromycin 1.5 per cent ophthalmic solution for the treatment of meibomian gland dysfunction. 2018 Clin Exp Optom pmid:28677153
Hong D et al. [Atopic keratoconjunctivitis: One allergy may mask another. A clinical observation with two types of hypersensitivity reactions: IgE-mediated and non-IgE-mediated]. 2018 J Fr Ophtalmol pmid:29567021
Obaro S Azithromycin and Childhood Mortality in Africa. 2018 N. Engl. J. Med. pmid:30284804
Michelow IC and Sánchez PJ Azithromycin and Childhood Mortality in Africa. 2018 N. Engl. J. Med. pmid:30284803
Cutler T et al. Azithromycin and Childhood Mortality in Africa. 2018 N. Engl. J. Med. pmid:30284802
Keenan JD et al. Azithromycin and Childhood Mortality in Africa. 2018 N. Engl. J. Med. pmid:30281987
El Sayed I et al. Antibiotics for treating scrub typhus. 2018 Cochrane Database Syst Rev pmid:30246875
Goyal V et al. Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial. 2018 Lancet pmid:30241722
Grewal TK et al. Therapeutic implications of nano-encapsulated rifabutin, azithromycin & ethambutol against experimental infection in mice. 2018 Indian J. Med. Res. pmid:30168492
Montazeri M et al. Activities of anti-Toxoplasma drugs and compounds against tissue cysts in the last three decades (1987 to 2017), a systematic review. 2018 Parasitol. Res. pmid:30088074
Tilahun Z and Fenta TG Coverage of azithromycin mass treatment for trachoma elimination in Northwestern Ethiopia: a community based cross-sectional study. 2018 BMC Ophthalmol pmid:30081851
Lundin MS et al. Lemierre's syndrome and 2016 American College of Physician guidelines for pharyngitis: no to empiric coverage for bacterial pharyngitis. While no role for routine Fusobacterium PCR, keep suspicion for this pathogen. 2018 BMJ Case Rep pmid:30030249
Celma A et al. Development of a Retention Time Interpolation scale (RTi) for liquid chromatography coupled to mass spectrometry in both positive and negative ionization modes. 2018 J Chromatogr A pmid:30005941
Lederhandler MH et al. Severe Oral Mucositis: A Rare Adverse Event of Pembrolizumab. 2018 J Drugs Dermatol pmid:30005106
Valor C and Huber K Atypical presentation of cat scratch disease: Parinaud's oculoglandular syndrome with facial nerve paresis. 2018 BMJ Case Rep pmid:29982178
Lanz J and Lautenschlager S [CME Dermatology 16/Answer: Fever, Pustules and Joint Pain as Vacation Mementoes]. 2018 Praxis (Bern 1994) pmid:29921188
Kalua K et al. One round of azithromycin MDA adequate to interrupt transmission in districts with prevalence of trachomatous inflammation-follicular of 5.0-9.9%: Evidence from Malawi. 2018 PLoS Negl Trop Dis pmid:29897902
Smotrys M et al. Babesiosis as a cause of false-positive HIV serology. 2018 BMJ Case Rep pmid:29884713
Nüesch-Inderbinen M et al. Genetic characterization of Shiga toxin producing Escherichia coli belonging to the emerging hybrid pathotype O80:H2 isolated from humans 2010-2017 in Switzerland. 2018 Int. J. Med. Microbiol. pmid:29884331
Iguidbashian JP et al. and coinfection in the setting of ulcerative colitis. 2018 BMJ Case Rep pmid:29880626
Lendermon EA et al. Azithromycin Fails to Prevent Accelerated Airway Obliteration in T-bet Mouse Lung Allograft Recipients. 2018 Transplant. Proc. pmid:29880387
Lam-Franco L et al. IL-1α and MMP-9 Tear Levels of Patients with Active Ocular Rosacea before and after Treatment with Systemic Azithromycin or Doxycycline. 2018 Ophthalmic Res. pmid:29874670
Saita MG et al. pH-Dependent stability of azithromycin in aqueous solution and structure identification of two new degradation products. 2018 J Pharm Biomed Anal pmid:29860178
Naderi N et al. Long-term azithromycin therapy to reduce acute exacerbations in patients with severe chronic obstructive pulmonary disease. 2018 Respir Med pmid:29724384
Zmora N et al. Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults. 2018 PLoS Negl Trop Dis pmid:29684022
Wei W et al. MPEG-PCL Copolymeric Micelles for Encapsulation of Azithromycin. 2018 AAPS PharmSciTech pmid:29675667
Barge L et al. Transient immune-mediated agranulocytosis following infection. 2018 BMJ Case Rep pmid:29669774
Baker KS et al. Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species. 2018 Nat Commun pmid:29654279
Ganesh R et al. Clinical profile and outcome of children with scrub typhus from Chennai, South India. 2018 Eur. J. Pediatr. pmid:29637374
Papp JR et al. Accuracy and reproducibility of the Etest to detect drug-resistant Neisseria gonorrhoeae to contemporary treatment. 2018 J. Med. Microbiol. pmid:29219803
Deguchi T et al. Macrolide and fluoroquinolone resistance is uncommon in clinical strains of Chlamydia trachomatis. 2018 J. Infect. Chemother. pmid:29627327
Smith-Norowitz TA et al. Doxycycline suppresses Chlamydia pneumoniae induced interferon-gamma responses in peripheral blood mononuclear cells in children with allergic asthma. 2018 J. Infect. Chemother. pmid:29615379
Rim JH et al. Recent Increase in the Incidence of TEM-135 β-Lactamase-harboring Neisseria gonorrhoeae in Korea. 2018 Ann Lab Med pmid:29611382