Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vcev A et al. | Omeprazole, azithromycin and amoxicillin or amoxicillin plus clavulanic acid in eradication of Helicobacter pylori in duodenal ulcer disease. | 1998 | Acta Med Croatica | pmid:9988898 |
Wirnsberger GH et al. | Chronic bacterial inflammation of the gum: the main risk factor for posttransplant gingival hyperplasia? | 1999 | Clin. Nephrol. | pmid:9988152 |
Klapan I et al. | Azithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis. | 1999 Jan-Feb | Am J Otolaryngol | pmid:9950107 |
Principi N and Esposito S | Comparative tolerability of erythromycin and newer macrolide antibacterials in paediatric patients. | 1999 | Drug Saf | pmid:9935275 |
Oliva S et al. | Successful treatment of widely disseminated acanthamoebiasis. | 1999 | South. Med. J. | pmid:9932828 |
Adriaenssen CF | Comparison of the efficacy, safety and tolerability of azithromycin and co-amoxiclav in the treatment of acute periapical abscesses. | 1998 Oct-Nov | J. Int. Med. Res. | pmid:9924711 |
Rothova A et al. | Azithromycin for ocular toxoplasmosis. | 1998 | Br J Ophthalmol | pmid:9924338 |
Jakob-Sölder B et al. | Treatment of pediatric patients with acute group A beta-hemolytic streptococcal tonsillopharyngitis. | 1998 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9923529 |
Fera MT et al. | Bactericidal activity of lansoprazole and three macrolides against Helicobacter pylori strains tested by the time-kill kinetic method. | 1998 | Int. J. Antimicrob. Agents | pmid:9916902 |
Lacy MK et al. | Comparison of bactericidal activity after multidose administration of clarithromycin, azithromycin, and ceruroxime axetil against Streptococcus pneumoniae. | 1998 | Int. J. Antimicrob. Agents | pmid:9916901 |
Négrel AD and Mariotti SP | WHO alliance for the global elimination of blinding trachoma and the potential use of azithromycin. | 1998 | Int. J. Antimicrob. Agents | pmid:9916898 |
Gruber F et al. | Treatment of confluent and reticulated papillomatosis with azithromycin. | 1998 | Clin. Exp. Dermatol. | pmid:9894368 |
Trevisani L et al. | Evaluation of a new ultrashort triple therapy for Helicobacter pylori disease. | 1998 | Aliment. Pharmacol. Ther. | pmid:9882037 |
Chey WD et al. | Low- versus high-dose azithromycin triple therapy for Helicobacter pylori infection. | 1998 | Aliment. Pharmacol. Ther. | pmid:9882036 |
Ghirga G et al. | Inefficacy of a 3-day course of azithromycin in preventing acute rheumatic fever after group A streptococcal infection (scarlet fever) in an 8-year-old child. | 1999 | J. Pediatr. | pmid:9880464 |
Gruber F et al. | Azithromycin compared with minocycline in the treatment of acne comedonica and papulo-pustulosa. | 1998 | J Chemother | pmid:9876055 |
Denis A and Agouridas C | Synthesis of 6-O-methyl-azithromycin and its ketolide analogue via Beckmann rearrangement of 9(E)-6-O-methyl-erythromycin oxime. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873555 |
Tabbara KF et al. | Ocular levels of azithromycin. | 1998 | Arch. Ophthalmol. | pmid:9869792 |
Amsden GW et al. | Pharmacokinetics in serum and leukocyte exposures of oral azithromycin, 1,500 milligrams, given over a 3- or 5-day period in healthy subjects. | 1999 | Antimicrob. Agents Chemother. | pmid:9869584 |
Choi EK and Pai H | Azithromycin therapy for scrub typhus during pregnancy. | 1998 | Clin. Infect. Dis. | pmid:9868680 |
Dohmen W and Seelis RE | The role of azithromycin in the treatment of Helicobacter pylori infection - a retrospective report. | 1998 Jul-Aug | Infection | pmid:9867486 |
Schuster FL and Visvesvara GS | Efficacy of novel antimicrobials against clinical isolates of opportunistic amebas. | 1998 Nov-Dec | J. Eukaryot. Microbiol. | pmid:9864851 |
Tapsall JW et al. | Failure of azithromycin therapy in gonorrhea and discorrelation with laboratory test parameters. | 1998 | Sex Transm Dis | pmid:9858344 |
Raines DA et al. | Simultaneous high-performance liquid chromatography analysis of azithromycin and two of its metabolites in human tears and plasma. | 1998 | Ther Drug Monit | pmid:9853988 |
Hammerschlag MR et al. | Treatment of neonatal chlamydial conjunctivitis with azithromycin. | 1998 | Pediatr. Infect. Dis. J. | pmid:9849993 |
Bonoan JT et al. | Life-threatening babesiosis in an asplenic patient treated with exchange transfusion, azithromycin, and atovaquone. | 1998 Nov-Dec | Heart Lung | pmid:9835673 |
Hogan PA and Sheehan DJ | Macrolide susceptibility and beta-lactamase production among haemophilus influenzae isolates in the United States, 1996-1997. | 1998 | Antimicrob. Agents Chemother. | pmid:9835536 |
Berry V et al. | Bacteriological efficacies of three macrolides compared with those of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae. | 1998 | Antimicrob. Agents Chemother. | pmid:9835514 |
Sackoff J et al. | Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care. | 1998 | J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. | pmid:9833748 |
Karcioglu ZA et al. | Pharmacokinetics of azithromycinin rabbit lacrimal glands and conjunctiv a. | 1999 | Ophthalmic Res. | pmid:9831822 |
Shafran SD | Prevention and treatment of disseminated Mycobacterium avium complex infection in human immunodeficiency virus-infected individuals. | 1998 Jul-Sep | Int. J. Infect. Dis. | pmid:9831675 |
Gascón A et al. | Cryptosporidiosis in a haemodialysis patient with depressed CD4+ T cell count: successful treatment with azithromycin. | 1998 | Nephrol. Dial. Transplant. | pmid:9829506 |
Ward TT et al. | Randomized, open-label trial of azithromycin plus ethambutol vs. clarithromycin plus ethambutol as therapy for Mycobacterium avium complex bacteremia in patients with human immunodeficiency virus infection. Veterans Affairs HIV Research Consortium. | 1998 | Clin. Infect. Dis. | pmid:9827282 |
Bauriedel G et al. | Azithromycin, Chlamydia pneumoniae, and intimal thickening. | 1998 | Circulation | pmid:9826328 |
Champney WS and Burdine R | Macrolide antibiotic inhibition of translation and 50S ribosomal subunit assembly in methicillin-resistant Staphylococcus aureus cells. | 1998 | Microb. Drug Resist. | pmid:9818968 |
Johnson DM et al. | Antimicrobial interactions of trovafloxacin and extended-spectrum cephalosporins or azithromycin tested against clinical isolates of Pseudomonas aeruginosa and Stenotrophomonas maltophilia. | 1998 | J. Antimicrob. Chemother. | pmid:9818765 |
Dagan R et al. | Dynamics of pneumococcal nasopharyngeal colonization during the first days of antibiotic treatment in pediatric patients. | 1998 | Pediatr. Infect. Dis. J. | pmid:9802628 |
Harris JA et al. | Safety and efficacy of azithromycin in the treatment of community-acquired pneumonia in children. | 1998 | Pediatr. Infect. Dis. J. | pmid:9802626 |
Pankuch GA et al. | In vitro selection of resistance to four beta-lactams and azithromycin in Streptococcus pneumoniae. | 1998 | Antimicrob. Agents Chemother. | pmid:9797225 |
Sánchez F et al. | [Treatment of pneumonia caused by Legionella with azithromycin]. | 1998 | Rev Esp Quimioter | pmid:9795300 |
Davis TM | Adverse effects of antimalarial prophylactic drugs: an important consideration in the risk-benefit equation. | 1998 | Ann Pharmacother | pmid:9793605 |
Shih CM and Wang CC | Ability of azithromycin in combination with quinine for the elimination of babesial infection in humans. | 1998 | Am. J. Trop. Med. Hyg. | pmid:9790419 |
Girgis N et al. | Azithromycin compared with rifampin for eradication of nasopharyngeal colonization by Neisseria meningitidis. | 1998 | Pediatr. Infect. Dis. J. | pmid:9779768 |
Dagan R et al. | Early eradication of pathogens from middle ear fluid during antibiotic treatment of acute otitis media is associated with improved clinical outcome. | 1998 | Pediatr. Infect. Dis. J. | pmid:9779760 |
Pontani D et al. | Susceptibility of European respiratory tract isolates to trovafloxacin, ciprofloxacin, clarithromycin, azithromycin and ampicillin. | 1998 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9758284 |
Greenblatt DJ et al. | Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. | 1998 | Clin. Pharmacol. Ther. | pmid:9757151 |
Apseloff G et al. | Comparison of azithromycin and clarithromycin in their interactions with rifabutin in healthy volunteers. | 1998 | J Clin Pharmacol | pmid:9753212 |
Mainardi JL et al. | Cat scratch disease due to Bartonella henselae serotype Marseille (Swiss cat) in a seronegative patient. | 1998 | J. Clin. Microbiol. | pmid:9742017 |
Yeo AE et al. | Indirect inhibition by antibiotics of nucleotide and deoxynucleotide biosynthesis in Plasmodium falciparum. | 1998 | Southeast Asian J. Trop. Med. Public Health | pmid:9740262 |
Alder JD et al. | Dynamics of clarithromycin and azithromycin efficacies against experimental Haemophilus influenzae pulmonary infection. | 1998 | Antimicrob. Agents Chemother. | pmid:9736568 |