Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Arrieta A et al. | High-dose azithromycin versus high-dose amoxicillin-clavulanate for treatment of children with recurrent or persistent acute otitis media. | 2003 | Antimicrob. Agents Chemother. | pmid:14506028 |
Suskova VS et al. | [Immuno-modulating properties of a macrolide antibiotic "Z-factor"]. | 2003 | Antibiot. Khimioter. | pmid:15002174 |
Pisarev VV et al. | [Comparative study of azithromycin pharmacokinetics in healthy volunteers in open cross randomized procedure]. | 2003 | Antibiot. Khimioter. | pmid:15004973 |
Mandić Z et al. | Electrochemical oxidation of azithromycin and its derivatives. | 2003 | J Pharm Biomed Anal | pmid:14623590 |
Muhlestein JB | Antibiotic treatment of atherosclerosis. | 2003 | Curr. Opin. Lipidol. | pmid:14624138 |
Schultz KD and Oermann CM | Treatment of cast bronchitis with low-dose oral azithromycin. | 2003 | Pediatr. Pulmonol. | pmid:12526076 |
Ewald DP et al. | An evaluation of a SAFE-style trachoma control program in Central Australia. | 2003 | Med. J. Aust. | pmid:12526724 |
Rodvold KA et al. | Steady-state plasma and bronchopulmonary concentrations of intravenous levofloxacin and azithromycin in healthy adults. | 2003 | Antimicrob. Agents Chemother. | pmid:12878504 |
Gryglicka B et al. | Evaluation of an anti-chlamydial antibiotic therapy influence on asthma patients. | 2003 | Ann Univ Mariae Curie Sklodowska Med | pmid:15315030 |
Dunne MW et al. | Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis. | 2003 | Antimicrob. Agents Chemother. | pmid:12878537 |
Crum NF et al. | Halting a pneumococcal pneumonia outbreak among United States Marine Corps trainees. | 2003 | Am J Prev Med | pmid:12880877 |
Enomoto T et al. | [Azithromycin therapy for patients with intractable diffuse panbronchiolitis]. | 2003 | Jpn J Antibiot | pmid:14679738 |
Tateda K et al. | [Effects of azithromycin on pathogenic bacteria]. | 2003 | Jpn J Antibiot | pmid:14679740 |
Shimizu T et al. | [Effect of azithromycin on mucus secretion from nasal epithelium]. | 2003 | Jpn J Antibiot | pmid:14679741 |
Taira M et al. | [Effect of azithromycin on Cl ion transport in airway epithelial cells]. | 2003 | Jpn J Antibiot | pmid:14679742 |
Sakata N et al. | [Influence of clarithromycin and azithromycin on cell cycle of neoplasms]. | 2003 | Jpn J Antibiot | pmid:14679743 |
Favre-Bonté S et al. | Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin. | 2003 | J. Antimicrob. Chemother. | pmid:12951348 |
Ramsey PS et al. | Maternal and transplacental pharmacokinetics of azithromycin. | 2003 | Am. J. Obstet. Gynecol. | pmid:12634646 |
Cercek B et al. | Effect of short-term treatment with azithromycin on recurrent ischaemic events in patients with acute coronary syndrome in the Azithromycin in Acute Coronary Syndrome (AZACS) trial: a randomised controlled trial. | 2003 | Lancet | pmid:12642046 |
Anagnostopoulos GK et al. | Omeprazole plus azithromycin and either amoxicillin or tinidazole for eradication of Helicobacter pylori infection. | 2003 | J. Clin. Gastroenterol. | pmid:12642739 |
Lynch M et al. | Azithromycin treatment coverage in Tanzanian children using community volunteers. | 2003 | Ophthalmic Epidemiol | pmid:12815491 |
Cone LA et al. | Delirium in the elderly resulting from azithromycin therapy. | 2003 | Surg Neurol | pmid:12826358 |
Sánchez F et al. | Is azithromycin the first-choice macrolide for treatment of community-acquired pneumonia? | 2003 | Clin. Infect. Dis. | pmid:12746768 |
Malcolm C and Marrie TJ | Antibiotic therapy for ambulatory patients with community-acquired pneumonia in an emergency department setting. | 2003 | Arch. Intern. Med. | pmid:12695270 |
Muñoz B et al. | Antibiotic dosage in trachoma control programs: height as a surrogate for weight in children. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12657580 |
Gibb AM et al. | Should we offer antibiotic prophylaxis post sexual assault? | 2003 | Int J STD AIDS | pmid:12662387 |
Putnam SD et al. | Antimicrobial susceptibility trends in Campylobacter jejuni and Campylobacter coli isolated from a rural Egyptian pediatric population with diarrhea. | 2003 | Diagn. Microbiol. Infect. Dis. | pmid:14711482 |
Jacks SS et al. | In vitro susceptibilities of Rhodococcus equi and other common equine pathogens to azithromycin, clarithromycin, and 20 other antimicrobials. | 2003 | Antimicrob. Agents Chemother. | pmid:12709351 |
Hoban DJ et al. | Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21232 clinical isolates from europe. | 2003 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:12709842 |
Faber M et al. | [Comparative analysis of the effectiveness and costs of azithromycin and cefoperazone treatment of patients during COPD exacerbation]. | 2003 | Pol. Merkur. Lekarski | pmid:12712826 |
Basualdo W and Arbo A | Randomized comparison of azithromycin versus cefixime for treatment of shigellosis in children. | 2003 | Pediatr. Infect. Dis. J. | pmid:12712971 |
Fernández-Cuenca F et al. | In vitro activity of azithromycin in combination with amikacin, ceftazidime, ciprofloxacin or imipenem against clinical isolates of Acinobacter baumannii. | 2003 | Chemotherapy | pmid:12714805 |
Tanyuksel M et al. | Determination of intracellular efficacies of azithromycin against Leishmania major infection in human neutrophils in vitro. | 2003 | Cell Biochem. Funct. | pmid:12579528 |
Khedr A and Sheha M | Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms. | 2003 | J Chromatogr Sci | pmid:12597590 |
Coke RL et al. | Pharmacokinetics and tissue concentrations of azithromycin in ball pythons (Python regius). | 2003 | Am. J. Vet. Res. | pmid:12602593 |
Rekart ML et al. | Targeted mass treatment for syphilis with oral azithromycin. | 2003 | Lancet | pmid:12559870 |
Southern KW and Smyth RL | Design of clinical trials in cystic fibrosis. | 2003 | Lancet | pmid:12559892 |
OÄŸuz F et al. | Etiology of acute otitis media in childhood and evaluation of two different protocols of antibiotic therapy: 10 days cefaclor vs. 3 days azitromycin. | 2003 | Int. J. Pediatr. Otorhinolaryngol. | pmid:12560149 |
Aznabaev MT et al. | [Use of cycloferon in a combined treatment of chlamydial conjunctivitis]. | 2003 Jan-Feb | Vestn Oftalmol | pmid:12608044 |
Scheinfeld NS et al. | Macrolides in dermatology. | 2003 Jan-Feb | Clin. Dermatol. | pmid:12609587 |
Bevan CD et al. | Efficacy and safety of azithromycin as monotherapy or combined with metronidazole compared with two standard multidrug regimens for the treatment of acute pelvic inflammatory disease. | 2003 Jan-Feb | J. Int. Med. Res. | pmid:12635534 |
Prata A et al. | Efficacy of azithromycin in the treatment of cutaneous leishmaniasis. | 2003 Jan-Feb | Rev. Soc. Bras. Med. Trop. | pmid:12715065 |
Knuf M et al. | [Lymphadenitis colli due to non-tuberculous mycobacteria (NTM): a case-series and review of the literature]. | 2003 Jan-Feb | Klin Padiatr | pmid:12545419 |
Bernstein JM | The farmer and the tractor. | 2003 Mar-Apr | Skinmed | pmid:14673307 |
Aktan B et al. | Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion. | 2003 Nov-Dec | Pol J Pharmacol | pmid:14730107 |
Khandekarf R and Mohammed AJ | Outcome of azithromycin treatment of active trachoma in Omani school children. | 2003 Sep-Nov | East. Mediterr. Health J. | pmid:16450533 |
Imamura Y et al. | Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells. | 2004 | Antimicrob. Agents Chemother. | pmid:15328111 |
Nielsen HU et al. | Nasopharyngeal pathogens in children with acute otitis media in a low-antibiotic use country. | 2004 | Int. J. Pediatr. Otorhinolaryngol. | pmid:15302145 |
Shrader SP et al. | Azithromycin and warfarin interaction. | 2004 | Pharmacotherapy | pmid:15303459 |
Melese M et al. | Feasibility of eliminating ocular Chlamydia trachomatis with repeat mass antibiotic treatments. | 2004 | JAMA | pmid:15304470 |
Zuckerman JM | Macrolides and ketolides: azithromycin, clarithromycin, telithromycin. | 2004 | Infect. Dis. Clin. North Am. | pmid:15308279 |
Kvien TK et al. | Three month treatment of reactive arthritis with azithromycin: a EULAR double blind, placebo controlled study. | 2004 | Ann. Rheum. Dis. | pmid:15308521 |
Ishimatsu Y et al. | Macrolide antibiotics induce apoptosis of human peripheral lymphocytes in vitro. | 2004 | Int. J. Antimicrob. Agents | pmid:15325428 |
Berquand A et al. | Real-time imaging of drug-membrane interactions by atomic force microscopy. | 2004 | Biochim. Biophys. Acta | pmid:15328052 |
Riska PF et al. | Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae. | 2004 | Antimicrob. Agents Chemother. | pmid:15328134 |
Faber M et al. | [Evaluation of clinical effectiveness and direct costs of azithromycin treatment for exacerbation of chronic obstructive pulmonary disease in hospitalized patients and ambulatory care]. | 2004 | Pol. Merkur. Lekarski | pmid:15524029 |
Bantar C et al. | An ex-vivo pharmacodynamic study comparing bactericidal activity of amoxicillin/sulbactam, azithromycin, doxycycline and levofloxacin against Streptococcus pneumoniae. | 2004 | J Chemother | pmid:15330320 |
Solomon AW et al. | Mass treatment with single-dose azithromycin for trachoma. | 2004 | N. Engl. J. Med. | pmid:15525721 |
[Brief antibiotic therapy. 3 swallows in suppurative bronchitis]. | 2004 | MMW Fortschr Med | pmid:15347057 | |
Mariotti SP | New steps toward eliminating blinding trachoma. | 2004 | N. Engl. J. Med. | pmid:15525727 |
Southern KW and Barker PM | Azithromycin for cystic fibrosis. | 2004 | Eur. Respir. J. | pmid:15516680 |
Smelov V et al. | In vitro activity of fluoroquinolones, azithromycin and doxycycline against chlamydia trachomatis cultured from men with chronic lower urinary tract symptoms. | 2004 | Eur. Urol. | pmid:15474277 |
Atasoy M et al. | Treatment of confluent and reticulated papillomatosis with azithromycin. | 2004 | J. Dermatol. | pmid:15492444 |
Chidambaram JD et al. | Mass antibiotic treatment and community protection in trachoma control programs. | 2004 | Clin. Infect. Dis. | pmid:15494901 |
Sugie M et al. | Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin. | 2004 | Antimicrob. Agents Chemother. | pmid:14982769 |
Kim YS et al. | A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus. | 2004 | Clin. Infect. Dis. | pmid:15494910 |
Panpanich R et al. | Azithromycin for acute lower respiratory tract infections. | 2004 | Cochrane Database Syst Rev | pmid:15497172 |
Koytchev R et al. | Assessment of the bioequivalence of different formulations containing azithromycin (tablets and suspension). | 2004 | Arzneimittelforschung | pmid:15497663 |
Michot JM et al. | Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter. | 2004 | Antimicrob. Agents Chemother. | pmid:15215125 |
Hoberman A and Paradise JL | Study design questions in treatment of children with acute otitis media. | 2004 | Antimicrob. Agents Chemother. | pmid:15215151 |
Drago L et al. | Selection of resistance of telithromycin against Haemophilus influenzae, Moraxella catarrhalis and streptococci in comparison with macrolides. | 2004 | J. Antimicrob. Chemother. | pmid:15215227 |
Hillis GS et al. | Effects of a brief course of azithromycin on soluble cell adhesion molecules and markers of inflammation in survivors of an acute coronary syndrome: A double-blind, randomized, placebo-controlled study. | 2004 | Am. Heart J. | pmid:15215794 |
Wu Y et al. | Studies on electrochemical oxidation of azithromycin and its interaction with bovine serum albumin. | 2004 | Bioelectrochemistry | pmid:15219252 |
Kaul R et al. | Monthly antibiotic chemoprophylaxis and incidence of sexually transmitted infections and HIV-1 infection in Kenyan sex workers: a randomized controlled trial. | 2004 | JAMA | pmid:15173146 |
Habib AR and Fernando R | Efficacy of azithromycin 1g single dose in the management of uncomplicated gonorrhoea. | 2004 | Int J STD AIDS | pmid:15075017 |
Sopena N et al. | Comparative study of the efficacy and tolerance of azithromycin versus clarithromycin in the treatment of community-acquired pneumonia in adults. | 2004 | J Chemother | pmid:15078008 |
Rao KB et al. | Enhanced hypoprothrombinemia with warfarin due to azithromycin. | 2004 | Ann Pharmacother | pmid:15084685 |
Wenzler S et al. | Comparative in vitro activities of three new quinolones and azithromycin against aerobic pathogens causing respiratory tract and abdominal wound infections. | 2004 | Chemotherapy | pmid:15084805 |
Kohlhoff SA et al. | In vitro activity of a novel diaminopyrimidine compound, iclaprim, against Chlamydia trachomatis and C. pneumoniae. | 2004 | Antimicrob. Agents Chemother. | pmid:15105151 |
Romanowska-Sarlej J et al. | Ultrastructure of the hepatocytes after application of azithromycin (Sumamed). | 2004 | Ann Univ Mariae Curie Sklodowska Med | pmid:16146049 |
Shibata Y et al. | [Evaluation of anti-inflammatory effect of macrolides on macrophages]. | 2004 | Jpn J Antibiot | pmid:16108591 |
Mizunoe T et al. | [The mechanism of apoptosis induction in lymphocytes by macrolide antibiotics and the related intra-cellular molecular structure]. | 2004 | Jpn J Antibiot | pmid:16108600 |
Mak DB et al. | Control of genital chlamydial infection in the Kimberley region of Western Australia. | 2004 | Med. J. Aust. | pmid:14709130 |
Aihara Y et al. | Stevens-Johnson syndrome associated with azithromycin followed by transient reactivation of herpes simplex virus infection. | 2004 | Allergy | pmid:14674950 |
Tiukinhoy SD et al. | Novel echogenic drug-immunoliposomes for drug delivery. | 2004 | Invest Radiol | pmid:14734925 |
Yang YZ | [Death of a case caused by anaphylaxis to azithromycin]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15733367 |
McLean CA et al. | The emergence of Neisseria gonorrhoeae with decreased susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000. | 2004 | Sex Transm Dis | pmid:14743069 |
Kyebambe P | Incomplete Reiter's arthritis in a 23 year old nursing mother. | 2004 | Afr Health Sci | pmid:15687073 |
Matic V et al. | Antipneumococcal activities of two novel macrolides, GW 773546 and GW 708408, compared with those of erythromycin, azithromycin, clarithromycin, clindamycin, and telithromycin. | 2004 | Antimicrob. Agents Chemother. | pmid:15504828 |
Kosowska K et al. | Activities of two novel macrolides, GW 773546 and GW 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against Haemophilus influenzae. | 2004 | Antimicrob. Agents Chemother. | pmid:15504829 |
Levy SB et al. | The misuse of antibiotics. | 2004 | Med Ethics (Burlingt Mass) | pmid:15915579 |
Fernandez AD et al. | Azithromycin modulates murine immune responses to pneumococcal conjugate vaccine and inhibits nasal clearance of bacteria. | 2004 | J. Infect. Dis. | pmid:15499531 |
Pokrovskaia EV | [Final confirmation of inefficiency of antibiotics in secondary prevention of coronary heart disease. Results of PROVE IT (gatifloxacin trial) and ACES]. | 2004 | Kardiologiia | pmid:15477798 |
Mueller M et al. | Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines. | 2004 | Immunobiology | pmid:15638128 |
Hyodo E et al. | Effect of azithromycin therapy on coronary circulation in patients with coronary artery disease. | 2004 | Am. J. Cardiol. | pmid:15566918 |
Khamitov RF et al. | [Significance of antibacterial therapy of Chlamydophila pneumoniae infection in patients with bronchial asthma]. | 2004 | Ter. Arkh. | pmid:15575487 |
Gillis RJ and Iglewski BH | Azithromycin retards Pseudomonas aeruginosa biofilm formation. | 2004 | J. Clin. Microbiol. | pmid:15583321 |
Tokgöz B et al. | Effects of azithromycin on cyclosporine-induced gingival hyperplasia in renal transplant patients. | 2004 | Transplant. Proc. | pmid:15621128 |
Chen GF et al. | [Follow up of 16 cases with congenital toxoplasmosis treated with azithromycin]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:14990100 |
Kasahara K et al. | Longterm azithromycin therapy for three patients with chronic lower respiratory tract infections. | 2004 | J. Infect. Chemother. | pmid:14991517 |