Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bala M et al. | Trends of resistance to antimicrobials recommended currently and in the past for management of gonorrhea in the Apex STD center in India and comparison of antimicrobial resistance profile between 2002-2006 and 2007-2012. | 2015 | Sex Transm Dis | pmid:25763675 |
Schillinger JA et al. | Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women: a randomized, controlled trial. | 2003 | Sex Transm Dis | pmid:12514443 |
Martin DH | The US Chlamydia trachomatis control program: successes, shortcomings and ideas for the future. | 2012 | Sex Transm Dis | pmid:23169170 |
Okah E et al. | Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. | 2017 | Sex Transm Dis | pmid:28079746 |
Katz KA et al. | Molecular epidemiology of syphilis--San Francisco, 2004-2007. | 2010 | Sex Transm Dis | pmid:20601928 |
Labbé AC et al. | Periodical antibiotic treatment for the control of gonococcal and chlamydial infections among sex workers in Benin and Ghana: a cluster-randomized placebo-controlled trial. | 2012 | Sex Transm Dis | pmid:22421690 |
Lechtenberg RJ et al. | Variation in adherence to the treatment guidelines for Neisseria gonorrhoeae by clinical practice setting, California, 2009 to 2011. | 2014 | Sex Transm Dis | pmid:24722391 |
Campos-Outcalt D et al. | Use of directly observed azithromycin treatment for syphilis in a homeless woman. | 2002 | Sex Transm Dis | pmid:12035029 |
Tapsall JW et al. | Failure of azithromycin therapy in gonorrhea and discorrelation with laboratory test parameters. | 1998 | Sex Transm Dis | pmid:9858344 |
Farley TA et al. | The acceptability and behavioral effects of antibiotic prophylaxis for syphilis prevention. | 2003 | Sex Transm Dis | pmid:14603093 |
O'Farrell N et al. | Periodic presumptive treatment for cervical infections in service women in 3 border provinces of Laos. | 2006 | Sex Transm Dis | pmid:16645552 |
Levy V et al. | A Case of Persistent and Possibly Treatment Resistant Pharyngeal Gonorrhea. | 2016 | Sex Transm Dis | pmid:26967304 |
Mmeje O and Coleman JS | Concurrent patient-partner treatment in pregnancy: an alternative to expedited partner therapy? | 2012 | Sex Transm Dis | pmid:22902661 |
Blandford JM and Gift TL | The cost-effectiveness of single-dose azithromycin for treatment of incubating syphilis. | 2003 | Sex Transm Dis | pmid:12782951 |
Dillon JA et al. | Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from three Caribbean countries: Trinidad, Guyana, and St. Vincent. | 2001 | Sex Transm Dis | pmid:11518867 |
Dillon JA et al. | Reduced susceptibility to azithromycin and high percentages of penicillin and tetracycline resistance in Neisseria gonorrhoeae isolates from Manaus, Brazil, 1998. | 2001 | Sex Transm Dis | pmid:11518869 |
Yuan LF et al. | Resistance to azithromycin of Neisseria gonorrhoeae isolates from 2 cities in China. | 2011 | Sex Transm Dis | pmid:21844727 |
Dan M et al. | Pharyngeal Gonorrhea in female sex workers: Response to a single 2-g dose of azithromycin. | 2006 | Sex Transm Dis | pmid:16572040 |
Tabidze IL et al. | Adherence to Centers for Disease Control and Prevention Gonococcal Treatment Guidelines Among Chicago Health Care Providers, 2011-2012. | 2015 | Sex Transm Dis | pmid:26165433 |
Dombrowski JC and Batteiger BE | Reconsidering the Use of Azithromycin for Chlamydial Urethritis. | 2016 | Sex Transm Dis | pmid:27626187 |
Handsfield HH | Questioning azithromycin for chlamydial infection. | 2011 | Sex Transm Dis | pmid:21992978 |
Lau CY and Qureshi AK | Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. | 2002 | Sex Transm Dis | pmid:12218839 |
Weinstein SA and Stiles BG | A review of the epidemiology, diagnosis and evidence-based management of Mycoplasma genitalium. | 2011 | Sex Health | pmid:21592428 |
McCormick DF et al. | Prevention and control of sexually transmissible infections among hotel-based female sex workers in Dhaka, Bangladesh. | 2013 | Sex Health | pmid:24262217 |
Robertson A et al. | Case report: lymphogranuloma venereum in New Zealand. | 2008 | Sex Health | pmid:19061558 |
Stratov I et al. | Azithromycin: more lethal than chloramphenicol? | 2013 | Sex Health | pmid:23448962 |
Renault CA et al. | Time to clearance of Chlamydia trachomatis ribosomal RNA in women treated for chlamydial infection. | 2011 | Sex Health | pmid:21371385 |
Jones S et al. | The tip of the iceberg: opportunistic screening for Chlamydia trachomatis in asymptomatic patients attending a young people's health clinic reveals a high prevalence--a pilot study. | 2004 | Sex Health | pmid:16334993 |
Suriawinata A and Min AD | A 33-year-old woman with jaundice after azithromycin use. | 2002 | Semin. Liver Dis. | pmid:12016551 |
Pedro-Botet ML and Sabrià M | Legionellosis. | 2005 | Semin Respir Crit Care Med | pmid:16388431 |
Berger BW | Lyme disease. | 1993 | Semin Dermatol | pmid:8312152 |
Seguà DÃaz M | [What is the best treatment for urogenital Chlamydia trachomatis infection?] | Semergen | pmid:27068255 | |
Wawer MJ et al. | AIDS intervention in Uganda. | 1995 | Science | pmid:7570005 |
Topp E et al. | Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. | 2016 | Sci. Total Environ. | pmid:27096634 |
Sidhu H et al. | Risk assessment of biosolids-borne ciprofloxacin and azithromycin. | 2019 | Sci. Total Environ. | pmid:30463165 |
Sidhu H et al. | Plant toxicity and accumulation of biosolids-borne ciprofloxacin and azithromycin. | 2019 | Sci. Total Environ. | pmid:30340267 |
Sidhu H et al. | Retention-release of ciprofloxacin and azithromycin in biosolids and biosolids-amended soils. | 2019 | Sci. Total Environ. | pmid:30196217 |
Sidhu H et al. | Bioavailability of biosolids-borne ciprofloxacin and azithromycin to terrestrial organisms: Microbial toxicity and earthworm responses. | 2019 | Sci. Total Environ. | pmid:30195128 |
Friesen J et al. | Natural immunization against malaria: causal prophylaxis with antibiotics. | 2010 | Sci Transl Med | pmid:20630856 |
Ratzinger F et al. | Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity. | 2014 | Sci Rep | pmid:25500904 |
Gensel JC et al. | Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. | 2017 | Sci Rep | pmid:28057928 |
Wang A et al. | Effects of Fluoroquinolones and Azithromycin on Biofilm Formation of Stenotrophomonas maltophilia. | 2016 | Sci Rep | pmid:27405358 |
Menzel M et al. | Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients. | 2016 | Sci Rep | pmid:27350308 |
Zeng J et al. | Mechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa. | 2016 | Sci Rep | pmid:27075730 |
Pansieri C et al. | Ureaplasma, bronchopulmonary dysplasia, and azithromycin in European neonatal intensive care units: a survey. | 2014 | Sci Rep | pmid:24518104 |
Das MC et al. | Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. | 2016 | Sci Rep | pmid:27000525 |
Gualdoni GA et al. | Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation. | 2015 | Sci Rep | pmid:26152605 |
Feary DJ et al. | Lawsonia intracellularis proliferative enteropathy in a foal. | 2007 | Schweiz. Arch. Tierheilkd. | pmid:17410971 |
Dickerson FB et al. | A double-blind trial of adjunctive azithromycin in individuals with schizophrenia who are seropositive for Toxoplasma gondii. | 2009 | Schizophr. Res. | pmid:19464853 |
Batieha A et al. | No advantage of treating acute respiratory tract infections with azithromycin in a placebo-controlled study. | 2002 | Scand. J. Infect. Dis. | pmid:12064684 |