Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Stomach Diseases D013272 7 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Lung Diseases D008171 37 associated lipids
Sarcoidosis D012507 13 associated lipids
Hyperglycemia D006943 21 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Genital Diseases, Male D005832 3 associated lipids
Sexually Transmitted Diseases D012749 4 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Abscess D000038 13 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Osteitis D010000 10 associated lipids
Dog Diseases D004283 5 associated lipids
Osteomyelitis D010019 10 associated lipids
Coronary Disease D003327 70 associated lipids
Pancreatitis D010195 10 associated lipids
Acne Vulgaris D000152 35 associated lipids
Skin Ulcer D012883 6 associated lipids
Eyelid Diseases D005141 4 associated lipids
Multiple Myeloma D009101 13 associated lipids
Pain, Postoperative D010149 13 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Corneal Opacity D003318 3 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Eye Diseases D005128 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Per page 10 20 50 100 | Total 276

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Azithramycine

Download all related citations
Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Lin C and Lietman T Trachoma control: is azithromycin the answer for trichiasis too? 2007 Arch. Ophthalmol. pmid:17562994
West SK et al. Single-dose azithromycin prevents trichiasis recurrence following surgery: randomized trial in Ethiopia. 2006 Arch. Ophthalmol. pmid:16534049
Miyagawa T et al. Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α. 2016 Arch. Oral Biol. pmid:26655749
Pawlowski KS et al. Ototoxicity of topical azithromycin solutions in the guinea pig. 2010 Arch. Otolaryngol. Head Neck Surg. pmid:20479380
Brook I and Hausfeld JN Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis. 2006 Arch. Otolaryngol. Head Neck Surg. pmid:16618915
Chan KH et al. Efficacy of a new macrolide (azithromycin). For acute otitis media in the chinchilla model. 1988 Arch. Otolaryngol. Head Neck Surg. pmid:2844210
Wu ML et al. Enterocolonic Mycobacterium avium-intracellulare. 2002 Arch. Pathol. Lab. Med. pmid:11860323
Fadlallah A et al. Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. 2012 May-Jun Arq Bras Oftalmol pmid:22872200
Frota LC et al. Helicobacter pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy: an open randomized clinical trial. 2005 Apr-Jun Arq Gastroenterol pmid:16127567
Assmann G et al. Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study. 2009 Arthritis Res. Ther. pmid:19772564
St Clair EW et al. The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. 2001 Arthritis Rheum. pmid:11357896
Carter JD et al. Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial. 2010 Arthritis Rheum. pmid:20155838
Jiang B et al. Quantification of azithromycin in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study. 2012 Arzneimittelforschung pmid:22344571
Wildfeuer A and Haberreiter A Intracellular activity of azithromycin against Mycobacterium avium complex in human macrophages. 1997 Arzneimittelforschung pmid:9272246
Sultana TA et al. Comparative pharmacokinetic and relative bioavailability study of coated and uncoated azithromycin powder for suspension in healthy Bangladeshi male volunteers. 2011 Arzneimittelforschung pmid:22164968
Koytchev R et al. Assessment of the bioequivalence of different formulations containing azithromycin (tablets and suspension). 2004 Arzneimittelforschung pmid:15497663
Setiawati E et al. Bioequivalence study of two azithromycin formulations in healthy subjects. 2009 Arzneimittelforschung pmid:19856795
Afghani T et al. Preventing Long-Term Ocular Complications of Trachoma With Topical Azithromycin: A 3-Year Follow-up Study. 2017 Jan-Feb Asia Pac J Ophthalmol (Phila) pmid:28161923
Magri V et al. Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction. 2011 Asian J. Androl. pmid:21765442
Karanth SS et al. A rare case of community acquired Burkholderia cepacia infection presenting as pyopneumothorax in an immunocompetent individual. 2012 Asian Pac J Trop Biomed pmid:23569891
Jirapongsananuruk O et al. Recurrent Campylobacter lari bacteremia in X-linked agammaglobulinemia: a case report and review. 2006 Jun-Sep Asian Pac. J. Allergy Immunol. pmid:17136884
Llor Vilà C [I'd rather give azithromycin for three days. That way the patient complies]. 2003 Aten Primaria pmid:12735886
Schriever C et al. Red wine, resveratrol, Chlamydia pneumoniae and the French connection. 2003 Atherosclerosis pmid:14644410
Hotomi M et al. Nontypeable Haemophilus influenzae isolated from intractable acute otitis media internalized into cultured human epithelial cells. 2010 Auris Nasus Larynx pmid:19505782
Shimizu T and Suzaki H Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan. 2016 Auris Nasus Larynx pmid:26441370
Hirsch R Periodontal healing and bone regeneration in response to azithromycin. 2010 Aust Dent J pmid:20604763
O'Rourke VJ Azithromycin as an adjunct to non-surgical periodontal therapy: a systematic review. 2017 Aust Dent J pmid:27492140
Higgins TJ Azithromycin. 2010 Aust Dent J pmid:21133950
Saleh A et al. Comparison of adjunctive azithromycin and amoxicillin/metronidazole for patients with chronic periodontitis: preliminary randomized control trial. 2016 Aust Dent J pmid:26836781
Fujise O et al. Regenerative effect of azithromycin on periodontitis with different levels of gingival inflammation: three case reports. 2014 Aust Dent J pmid:24861402
Pradeep AR et al. Local drug delivery of 0.5% azithromycin in the treatment of chronic periodontitis among smokers. 2013 Aust Dent J pmid:23441790
Gomi K et al. Full-mouth scaling and root planing combined with azithromycin to treat peri-implantitis. 2015 Aust Dent J pmid:25439282
Bowden FJ and Skov SJ Treating donovanosis. 1999 Aust Fam Physician pmid:10615749
Heal C et al. Genital Chlamydia trachomatis infection - a study of general practice management in northern Queensland. 2012 Aust Fam Physician pmid:22762073
Pereira A et al. Acute onset of widespread pustular eruption. 2015 Aust Fam Physician pmid:26209988
Redmond AM et al. Epidemic syphilis exhibits diverse manifestations. 2007 Aust Fam Physician pmid:17885710
SendaÄŸ F et al. Single dose oral azithromycin versus seven day doxycycline in the treatment of non-gonococcal mucopurulent endocervicitis. 2000 Aust N Z J Obstet Gynaecol pmid:10870778
van der Griend B et al. An uncommon cause of a destructive vulval lesion. 2001 Aust N Z J Obstet Gynaecol pmid:11787928
Tsubouchi K et al. Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. 2017 Autophagy pmid:28613983
Luo H et al. Identification of ribosomal RNA methyltransferase gene ermF in Riemerella anatipestifer. 2015 Avian Pathol. pmid:25690020
Juricic D et al. Vanishing bile duct syndrome associated with azithromycin in a 62-year-old man. 2010 Basic Clin. Pharmacol. Toxicol. pmid:19906050
Srivastava P et al. Azithromycin treatment modulates cytokine production in Chlamydia trachomatis infected women. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19389045
Mary N and Mahmood TA Preventing infective complications relating to induced abortion. 2010 Best Pract Res Clin Obstet Gynaecol pmid:20542471
Legrand T et al. An optimal LC-MS/MS method for determination of azithromycin in white blood cells: application to pediatric samples. 2014 Bioanalysis pmid:25383741
Cigana C et al. Anti-inflammatory effects of azithromycin in cystic fibrosis airway epithelial cells. 2006 Biochem. Biophys. Res. Commun. pmid:17045242
Berquand A et al. Real-time imaging of drug-membrane interactions by atomic force microscopy. 2004 Biochim. Biophys. Acta pmid:15328052
Fa N et al. Decrease of elastic moduli of DOPC bilayers induced by a macrolide antibiotic, azithromycin. 2007 Biochim. Biophys. Acta pmid:17537401
Kitsiouli E et al. Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells. 2015 Biochim. Biophys. Acta pmid:25791017
Wu Y et al. Studies on electrochemical oxidation of azithromycin and its interaction with bovine serum albumin. 2004 Bioelectrochemistry pmid:15219252
Saini H et al. Antimicrobial and antifouling efficacy of urinary catheters impregnated with a combination of macrolide and fluoroquinolone antibiotics against Pseudomonas aeruginosa. 2016 Biofouling pmid:26982572
Radhakrishnan SV et al. Preventive azithromycin treatment reduces noninfectious lung injury and acute graft-versus-host disease in a murine model of allogeneic hematopoietic cell transplantation. 2015 Biol. Blood Marrow Transplant. pmid:25445642
Williams KM et al. Fluticasone, Azithromycin, and Montelukast Treatment for New-Onset Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation. 2016 Biol. Blood Marrow Transplant. pmid:26475726
Yadav H et al. Azithromycin for the Treatment of Obliterative Bronchiolitis after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. 2016 Biol. Blood Marrow Transplant. pmid:27575542
Asano N et al. Limited Azithromycin Localization to Rabbit Meibomian Glands Revealed by LC-MS-Based Bioanalysis and DESI Imaging. 2017 Biol. Pharm. Bull. pmid:28867744
Togami K et al. Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro. 2013 Biol. Pharm. Bull. pmid:23995662
Gilbert D and Gerber MA Regarding "antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders". 2005 Biol. Psychiatry pmid:16242119
Budman C et al. Regarding "antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders". 2005 Biol. Psychiatry pmid:16242121
Snider LA et al. Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. 2005 Biol. Psychiatry pmid:15820236
Toti US et al. Targeted delivery of antibiotics to intracellular chlamydial infections using PLGA nanoparticles. 2011 Biomaterials pmid:21652065
Rivulgo V et al. Comparative plasma exposure and lung distribution of two human use commercial azithromycin formulations assessed in murine model: a preclinical study. 2013 Biomed Res Int pmid:24073402
Liu F et al. Sensitive liquid chromatography/mass spectrometry assay for the quantification of azithromycin in human plasma. 2007 Biomed. Chromatogr. pmid:17604364
Sharma K and Mullangi R A concise review of HPLC, LC-MS and LC-MS/MS methods for determination of azithromycin in various biological matrices. 2013 Biomed. Chromatogr. pmid:23553351
Ben-Eltriki M et al. A liquid chromatography-mass spectrometric method for the quantification of azithromycin in human plasma. 2013 Biomed. Chromatogr. pmid:23494651
Song Z and Wang C Ultrasensitive assay of azithromycin in medicine and bio-fluids based on its enhanced luminol-H(2)O(2) chemiluminescence reaction using flow injection technique. 2003 Bioorg. Med. Chem. pmid:14642581
Miura T et al. Novel azalides derived from 16-membered macrolides. Part II: Isolation of the linear 9-formylcarboxylic acid and its sequential macrocyclization with an amino alcohol or an azidoamine. 2008 Bioorg. Med. Chem. pmid:18986810
Jakopović IP et al. Synthesis and properties of macrolones characterized by two ether bonds in the linker. 2010 Bioorg. Med. Chem. pmid:20688524
Kapić S et al. 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. 2010 Bioorg. Med. Chem. pmid:20673633
Pavlović D and Mutak S Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. 2016 Bioorg. Med. Chem. pmid:26860929
Kapić S et al. Synthesis and activity of new macrolones: conjugates between 6(7)-(2'-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2'-hydroxyethyl) amides and 4″-propenoyl-azithromycin. 2011 Bioorg. Med. Chem. pmid:22041174
Maračić S et al. 1,2,3-Triazole pharmacophore-based benzofused nitrogen/sulfur heterocycles with potential anti-Moraxella catarrhalis activity. 2015 Bioorg. Med. Chem. pmid:26578325
Hutinec A et al. An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics. 2011 Bioorg. Med. Chem. pmid:21316974
Washington AZ et al. Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel. 2015 Bioorg. Med. Chem. pmid:26037612
Wang Y et al. Synthesis and antibacterial activity of novel 4″-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs. 2017 Bioorg. Med. Chem. Lett. pmid:28655423
Zhang L et al. Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. 2013 Bioorg. Med. Chem. Lett. pmid:23937982
Ma S et al. Synthesis and antibacterial activity of 4'',11-di-O-arylalkylcarbamoyl azithromycin derivatives. 2009 Bioorg. Med. Chem. Lett. pmid:19232491
Denis A and Agouridas C Synthesis of 6-O-methyl-azithromycin and its ketolide analogue via Beckmann rearrangement of 9(E)-6-O-methyl-erythromycin oxime. 1998 Bioorg. Med. Chem. Lett. pmid:9873555
Cheng H et al. Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent Gram-positive and Gram-negative antibacterial agents. 2002 Bioorg. Med. Chem. Lett. pmid:12161150
Ito S et al. Effect of macrolide antibiotics on uptake of digoxin into rat liver. 2007 Biopharm Drug Dispos pmid:17253595
Fuksa L et al. Amiodarone modulates pharmacokinetics of low-dose methotrexate in rats. 2008 Biopharm Drug Dispos pmid:18548509
Davila D et al. Pharmacokinetics of azithromycin after single oral dosing of experimental animals. 1991 Biopharm Drug Dispos pmid:1657238
Togami K et al. Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infections, in lung epithelial lining fluid and alveolar macrophages. 2011 Biopharm Drug Dispos pmid:21812004
Najib NM et al. Bioequivalence assessment of Azomycin (Julphar, UAE) as compared to Zithromax (Pfizer, USA)--two brands of azithromycin--in healthy human volunteers. 2001 Biopharm Drug Dispos pmid:11745903
Tayob N and Murray S Nonparametric tests of treatment effect based on combined endpoints for mortality and recurrent events. 2015 Biostatistics pmid:24719282
Cameron ST Patient-delivered partner therapy for chlamydia: a realistic public health measure in the UK. 2009 BJOG pmid:19187365
Melvin L et al. Preferred strategies of men and women for managing chlamydial infection. 2009 BJOG pmid:19187367
Cameron ST et al. Expedited partner therapy for Chlamydia trachomatis at the community pharmacy. 2010 BJOG pmid:20497415
Cameron ST et al. Willingness of gynaecologists, doctors in family planning, GPs, practice nurses and pharmacists to adopt novel interventions for treating sexual partners of women with chlamydia. 2007 BJOG pmid:17877773
Heikkinen T et al. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. 2000 BJOG pmid:10847234
Muralidharan V and Striepen B Teaching old drugs new tricks to stop malaria invasion in its tracks. 2015 BMC Biol. pmid:26349580
Wilson DW et al. Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum. 2015 BMC Biol. pmid:26187647
van Bijnen EM et al. Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureus in the community. 2014 BMC Fam Pract pmid:25413920
Silva FM et al. Short-term triple therapy with azithromycin for Helicobacter pylori eradication: low cost, high compliance, but low efficacy. 2008 BMC Gastroenterol pmid:18510773
Marumo S et al. Effectiveness of azithromycin in aspiration pneumonia: a prospective observational study. 2014 BMC Infect. Dis. pmid:25491126
Dukers-Muijrers NH et al. Design of the FemCure study: prospective multicentre study on the transmission of genital and extra-genital Chlamydia trachomatis infections in women receiving routine care. 2016 BMC Infect. Dis. pmid:27502928
Ab Rahman N et al. Antibiotic prescribing in public and private practice: a cross-sectional study in primary care clinics in Malaysia. 2016 BMC Infect. Dis. pmid:27188538
Kadota T et al. Analysis of drug treatment outcome in clarithromycin-resistant Mycobacterium avium complex lung disease. 2016 BMC Infect. Dis. pmid:26818764
Cole MJ et al. Overall Low Extended-Spectrum Cephalosporin Resistance but high Azithromycin Resistance in Neisseria gonorrhoeae in 24 European Countries, 2015. 2017 BMC Infect. Dis. pmid:28893203
Unemo M Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. 2015 BMC Infect. Dis. pmid:26293005
Jensen JS and Bradshaw C Management of Mycoplasma genitalium infections - can we hit a moving target? 2015 BMC Infect. Dis. pmid:26286546
Hoffmann K et al. Prevalence and resistance patterns of commensal S. aureus in community-dwelling GP patients and socio-demographic associations. A cross-sectional study in the framework of the APRES-project in Austria. 2015 BMC Infect. Dis. pmid:25981559