Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Respiratory Tract Infections D012141 4 associated lipids
Agammaglobulinemia D000361 4 associated lipids
Corneal Edema D015715 3 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
HIV Seropositivity D006679 15 associated lipids
Endophthalmitis D009877 12 associated lipids
Enteritis D004751 8 associated lipids
Leprosy D007918 8 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Rivero-Sánchez L et al. Fitz-Hugh-Curtis syndrome: abdominal pain in women of 26 years old. 2011 Rev Esp Enferm Dig pmid:22054272
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Cofré Guerra J [Pertussis chemoprophylaxis: a sterile effort?]. 2006 Rev Chilena Infectol pmid:16462967
Ruíz del Olmo I et al. [Severe neutropenia as side effect of medical treatment in nontuberculous mycobacterial adenitis]. 2015 Rev Chilena Infectol pmid:26633119
Aires FT et al. Efficacy of azithromycin on the treatment of syphilis. 2010 Sep-Oct Rev Assoc Med Bras (1992) pmid:21152813
Bowen BE et al. Diagnostic and therapeutic challenges. 2011 Retina (Philadelphia, Pa.) pmid:21866076
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Diego AD et al. Effects of long-term azithromycin therapy on airway oxidative stress markers in non-cystic fibrosis bronchiectasis. 2013 Respirology pmid:23714268
Karabay O Is azithromycin prophylaxis a rational approach for bronchoscopic biopsy? 2007 Respirology pmid:17587436
Singh N All generalizations are false including this one. 2007 Respirology pmid:17587437
Hodge S et al. Increased CD8 T-cell granzyme B in COPD is suppressed by treatment with low-dose azithromycin. 2015 Respirology pmid:25308201
Lourdesamy Anthony AI and Muthukumaru U Efficacy of azithromycin in the treatment of bronchiectasis. 2014 Respirology pmid:25183304
Kanazawa H Efficacy of azithromycin administration in prevention of respiratory tract infection after bronchoscopic biopsy: a randomized, controlled trial. 2007 Respirology pmid:17207028
Smith DJ et al. Pseudomonas aeruginosa antibiotic resistance in Australian cystic fibrosis centres. 2016 Respirology pmid:26711802
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Hansbro PM and Jarnicki AG Macrolides for macrophages in chronic obstructive pulmonary disease. 2012 Respirology pmid:22563902
Hodge S and Reynolds PN Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophages in chronic obstructive pulmonary disease subjects. 2012 Respirology pmid:22288725
Hanon S et al. Evidence of improved small airways function after azithromycin treatment in diffuse panbronchiolitis. 2012 Respiration pmid:22759949
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Ballard HO et al. Azithromycin in the extremely low birth weight infant for the prevention of bronchopulmonary dysplasia: a pilot study. 2007 Respir. Res. pmid:17550598
Persson HL et al. Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage. 2012 Respir. Res. pmid:23006592
Ra SW et al. Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori. 2017 Respir. Res. pmid:28558695
Beigelman A et al. Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis. 2010 Respir. Res. pmid:20591166
Berkhof FF et al. Azithromycin and cough-specific health status in patients with chronic obstructive pulmonary disease and chronic cough: a randomised controlled trial. 2013 Respir. Res. pmid:24229360
Lendermon EA et al. Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation. 2017 Respir. Res. pmid:28659178
Legssyer R et al. Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice. 2006 Respir. Res. pmid:17064416
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Equi AC et al. Exploring the mechanisms of macrolides in cystic fibrosis. 2006 Respir Med pmid:16185859
DeAbate CA et al. The safety and efficacy of short course (5-day) moxifloxacin vs. azithromycin in the treatment of patients with acute exacerbation of chronic bronchitis. 2000 Respir Med pmid:11127487
Cazzola M et al. Treatment of acute exacerbation of severe-to-very severe COPD with azithromycin in patients vaccinated against Streptococcus pneumoniae. 2005 Respir Med pmid:15878482
Anwar GA et al. Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis. 2008 Respir Med pmid:18653323
Steinkamp G et al. Once-weekly azithromycin in cystic fibrosis with chronic Pseudomonas aeruginosa infection. 2008 Respir Med pmid:18701270
Simoens S et al. Preventing COPD exacerbations with macrolides: a review and budget impact analysis. 2013 Respir Med pmid:23352223
de Wall C et al. Home spirometry as early detector of azithromycin refractory bronchiolitis obliterans syndrome in lung transplant recipients. 2014 Respir Med pmid:24445061
Naderi N et al. Long-term azithromycin therapy to reduce acute exacerbations in patients with severe chronic obstructive pulmonary disease. 2018 Respir Med pmid:29724384
Kamio K and Azuma A Diffuse panbronchiolitis: A fine road from the discovery of a disease to the establishment of treatment. 2018 Respir Investig pmid:30049592
Wan YF et al. Azithromycin attenuates pulmonary inflammation and emphysema in smoking-induced COPD model in rats. 2015 Respir Care pmid:25249648
Escudero E et al. Pharmacokinetics and tissue tolerance of azithromycin after intramuscular administration to rabbits. 2006 Res. Vet. Sci. pmid:16530237
Ramalho VL et al. Comparison of azithromycin and oral hygiene program in the treatment of cyclosporine-induced gingival hyperplasia. 2007 Ren Fail pmid:17497438
Krásny J et al. The role of Chlamydia pneumoniae in the etiology of keratoconjunctivitis sicca (KCS). 2014 Recent Pat Inflamm Allergy Drug Discov pmid:25395268
Debremaeker D et al. Analysis of unknown compounds in azithromycin bulk samples with liquid chromatography coupled to ion trap mass spectrometry. 2003 Rapid Commun. Mass Spectrom. pmid:12569445
Zhou F et al. High accuracy mass measurement of peptides with internal calibration using a dual electrospray ionization sprayer system for protein identification. 2002 Rapid Commun. Mass Spectrom. pmid:11870887
Bascones-Martinez A et al. Prevention of alveolar osteitis with azithromycin in women according to use of tobacco and oral contraceptives. 2007 Quintessence Int pmid:17432784
Kikuchi Y et al. Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia. 2009 Pulm Pharmacol Ther pmid:19162211
Mertens TC et al. Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells. 2016 Pulm Pharmacol Ther pmid:27246785
Blasi F et al. Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy. 2010 Pulm Pharmacol Ther pmid:20025989
Kai T et al. A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa. 2009 Pulm Pharmacol Ther pmid:19393329