Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hypersensitivity, Delayed D006968 43 associated lipids
Hypotension D007022 41 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Infectious Mononucleosis D007244 5 associated lipids
Inflammation D007249 119 associated lipids
Keratitis D007634 7 associated lipids
Keratosis D007642 9 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leishmaniasis, Mucocutaneous D007897 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
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Old drug approved for MAC prevention. 1996 AIDS Alert pmid:11363659
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Azithromycin effective in preventing MAC. 1996 AIDS Alert pmid:11363857
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Bertoni G et al. Triple therapy with azithromycin, omeprazole, and amoxicillin is highly effective in the eradication of Helicobacter pylori: a controlled trial versus omeprazole plus amoxicillin. 1996 Am. J. Gastroenterol. pmid:8607489
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Apseloff G et al. Severe neutropenia caused by recommended prophylactic doses of rifabutin. 1996 Lancet pmid:8782773
Ednie LM et al. Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. 1996 Antimicrob. Agents Chemother. pmid:8843313
Treadway G and Pontani D Paediatric safety of azithromycin: worldwide experience. 1996 J. Antimicrob. Chemother. pmid:8818855
Carbon C et al. Economic analysis of antibiotic regimens used in the treatment pharyngitis: a prospective comparison of azithromycin versus roxithromycin. 1996 J. Antimicrob. Chemother. pmid:8818856
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Gerbaux C et al. Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation. 1996 FEBS Lett. pmid:8830663
Domingo S and Gamazo C Inadequate azithromycin activity against Brucella melitensis in mice with acute or chronic infections. 1996 J Chemother pmid:8835110
Conte JE et al. Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects. 1996 Antimicrob. Agents Chemother. pmid:8807050
Nash KA and Inderlied CB Rapid detection of mutations associated with macrolide resistance in Mycobacterium avium complex. 1996 Antimicrob. Agents Chemother. pmid:8807078
Dupont C et al. Microbiological findings about pulmonary cryptosporidiosis in two AIDS patients. 1996 J. Clin. Microbiol. pmid:8748314
Xu G et al. Effect of macrolide antibiotics on macrophage functions. 1996 Microbiol. Immunol. pmid:8865152
Wildfeuer A et al. Uptake of azithromycin by various cells and its intracellular activity under in vivo conditions. 1996 Antimicrob. Agents Chemother. pmid:8787883
Hicks P et al. Azithromycin therapy for Cryptosporidium parvum infection in four children infected with human immunodeficiency virus. 1996 J. Pediatr. pmid:8765631
Tateda K et al. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891128
Boran M et al. Improvement in cyclosporine A associated gingival hyperplasia with azithromycin therapy. 1996 Transplant. Proc. pmid:8769234
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Three new studies expand understanding of MAC therapy. 1996 Am J Health Syst Pharm pmid:8899122
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Vasil'ev MM and Gazarian IIu [Clinico-laboratory evaluation of the effectiveness of azithromycin in the treatment of patients with Chlamydia and mixed Chlamydia-gonorrhea infections]. 1996 Antibiot. Khimioter. pmid:8929122
Schaad UB and Heynen G Evaluation of the efficacy, safety and toleration of azithromycin vs. penicillin V in the treatment of acute streptococcal pharyngitis in children: results of a multicenter, open comparative study. The Swiss Tonsillopharyngitis Study Group. 1996 Pediatr. Infect. Dis. J. pmid:8878223
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Roord JJ et al. Prospective open randomized study comparing efficacies and safeties of a 3-day course of azithromycin and a 10-day course of erythromycin in children with community-acquired acute lower respiratory tract infections. 1996 Antimicrob. Agents Chemother. pmid:9124837
McCarty J A multicenter, open label trial of azithromycin for the treatment of children with acute otitis media. 1996 Pediatr. Infect. Dis. J. pmid:8878240
Aronovitz G A multicenter, open label trial of azithromycin vs. amoxicillin/ clavulanate for the management of acute otitis media in children. 1996 Pediatr. Infect. Dis. J. pmid:8878241
Cellesi C et al. Susceptibility of macrolide and beta-lactam antibiotics of Streptococcus pyogenes strains isolated over a four-year period in central Italy. 1996 J Chemother pmid:8808714
Welsh L et al. In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. 1996 Antimicrob. Agents Chemother. pmid:8787907
Mehaffey PC et al. Evaluation of in vitro spectra of activity of azithromycin, clarithromycin, and erythromycin tested against strains of Neisseria gonorrhoeae by reference agar dilution, disk diffusion, and Etest methods. 1996 J. Clin. Microbiol. pmid:8789046
Mashkilleyson AL et al. Treatment of syphilis with azithromycin. 1996 Int J STD AIDS pmid:8652720