Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Vaginosis, Bacterial D016585 10 associated lipids
Amebiasis D000562 2 associated lipids
Lung Diseases, Parasitic D008174 2 associated lipids
Aortic Aneurysm, Abdominal D017544 5 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Tooth Mobility D014086 2 associated lipids
Mitral Valve Stenosis D008946 3 associated lipids
Prostatitis D011472 5 associated lipids
Meningoencephalitis D008590 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Authors Title Published Journal PubMed Link
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Foster DR and Milan NL Potential interaction between azithromycin and warfarin. 1999 Pharmacotherapy pmid:10417043
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Khan AA et al. Effect of clarithromycin and azithromycin on production of cytokines by human monocytes. 1999 Int. J. Antimicrob. Agents pmid:10221415
Ogasawara KK and Goodwin TM Efficacy of azithromycin in reducing lower genital Ureaplasma urealyticum colonization in women at risk for preterm delivery. 1999 Jan-Feb J Matern Fetal Med pmid:10052839
Klapan I et al. Azithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis. 1999 Jan-Feb Am J Otolaryngol pmid:9950107
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Paavonen J and Eggert-Kruse W Chlamydia trachomatis: impact on human reproduction. 1999 Sep-Oct Hum. Reprod. Update pmid:10582782
From the Centers for Disease Control and Prevention. Fluoroquinolone resistance in Neisseria gonorrhoeae, Hawaii, 1999, and decreased susceptibility to azithromycin in N. gonorrhoeae, Missouri, 1999. 2000 JAMA pmid:11183745
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McNabb J et al. Comparison of azithromycin leukocyte disposition in healthy volunteers and volunteers with AIDS. 2000 Int. J. Antimicrob. Agents pmid:11185411
Amsden GW et al. A study of the pharmacokinetics of azithromycin and nelfinavir when coadministered in healthy volunteers. 2000 J Clin Pharmacol pmid:11185676
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Bujanda L et al. Ranitidine bismuth citrate plus azithromycin for Helicobacter pylori eradication. 2000 J. Clin. Gastroenterol. pmid:10777206
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Miller SA et al. Chlamydia pneumoniae activates nuclear factor kappaB and activator protein 1 in human vascular smooth muscle and induces cellular proliferation. 2000 J. Surg. Res. pmid:10781378
Skerk V et al. Comparative analysis of azithromycin and doxycycline efficacy in the treatment of female patients with acute urethral syndrome caused by Ureaplasma urealyticum. 2000 J Chemother pmid:10789560
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Semaan HB et al. The effect of chronic azithromycin therapy on soluble endothelium-derived adhesion molecules in patients with coronary artery disease. 2000 J. Cardiovasc. Pharmacol. pmid:11026657
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McBroom JW Medical management of interstitial pregnancy with a retained IUD. A case report. 2000 J Reprod Med pmid:10900583
Koch CC et al. Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae. 2000 J. Antimicrob. Chemother. pmid:10882684
Herrera D et al. The periodontal abscess (II). Short-term clinical and microbiological efficacy of 2 systemic antibiotic regimes. 2000 J. Clin. Periodontol. pmid:10883868
Anderson JL and Muhlestein JB The ACADEMIC study in perspective (Azithromycin in coronary artery disease: elimination of myocardial infection with Chlamydia). 2000 J. Infect. Dis. pmid:10839761
Dunne MW Rationale and design of a secondary prevention trial of antibiotic use in patients after myocardial infarction: the WIZARD (weekly intervention with zithromax [azithromycin] for atherosclerosis and its related disorders) trial. 2000 J. Infect. Dis. pmid:10839762
Jackson LA Description and status of the azithromycin and coronary events study (ACES). 2000 J. Infect. Dis. pmid:10839763
Raja Babu KK et al. Confluent and reticulate papillomatosis: successful treatment with azithromycin. 2000 Br. J. Dermatol. pmid:10848767
SendaÄŸ F et al. Single dose oral azithromycin versus seven day doxycycline in the treatment of non-gonococcal mucopurulent endocervicitis. 2000 Aust N Z J Obstet Gynaecol pmid:10870778
Gruber F et al. Treatment of early syphilis with azithromycin. 2000 J Chemother pmid:10877520
Tateda K et al. Potential of macrolide antibiotics to inhibit protein synthesis of Pseudomonas aeruginosa: suppression of virulence factors and stress response. 2000 J. Infect. Chemother. pmid:11810524
Vcev A et al. Pantoprazole, amoxycillin and either azithromycin or clarithromycin for eradication of Helicobacter pylori in duodenal ulcer. 2000 Aliment. Pharmacol. Ther. pmid:10632647
Steen R et al. Evidence of declining STD prevalence in a South African mining community following a core-group intervention. 2000 Sex Transm Dis pmid:10654860
Miyazaki S and Yamaguchi K [In vitro and in vivo antibacterial activities of azithromycin]. 2000 Jpn J Antibiot pmid:12572087
Shiba K [Pharmacokinetics and tissue distribution of azithromycin in humans]. 2000 Jpn J Antibiot pmid:12572088
Enogaki K [Transport to an infected site of azithromycin by phagocyte cells]. 2000 Jpn J Antibiot pmid:12572089
Oizumi K [Clinical evaluation of azithromycin for respiratory infectious diseases]. 2000 Jpn J Antibiot pmid:12572090
Nakayama I [Clinical studies of azithromycin, a new macrolide antibiotic, for infections in the field of surgery]. 2000 Jpn J Antibiot pmid:12572091
Sunakawa K [Summary of the clinical studies with azithromycin in the pediatric fields]. 2000 Jpn J Antibiot pmid:12572092
Naoya M [The clinical study of azithromycin in otolaryngologic infection]. 2000 Jpn J Antibiot pmid:12572093
Grayston JT Secondary prevention antibiotic treatment trials for coronary artery disease. 2000 Circulation pmid:11023925
Muhlestein JB et al. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease: primary clinical results of the ACADEMIC study. 2000 Circulation pmid:11023928