Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bergeron A et al. | Azithromycin and Survival After Hematopoietic Stem Cell Transplant-Reply. | 2017 | JAMA | pmid:29279924 |
Burr SE et al. | Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial. | 2017 | BMC Infect. Dis. | pmid:29282015 |
Last AR et al. | The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa. | 2017 | Parasit Vectors | pmid:29282126 |
Pavlinac PB et al. | Azithromycin to prevent post-discharge morbidity and mortality in Kenyan children: a protocol for a randomised, double-blind, placebo-controlled trial (the Toto Bora trial). | 2017 | BMJ Open | pmid:29289941 |
Bystrzycka W et al. | Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release. | 2017 | Int J Mol Sci | pmid:29292737 |
Varano GP et al. | Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat. | 2017 | Mol. Vis. | pmid:29296071 |
Sardana K et al. | An observational study of the efficacy of azithromycin in erythema annulare centrifugum. | 2018 | Clin. Exp. Dermatol. | pmid:29297941 |
Gibson PG | How does azithromycin improve asthma exacerbations? - Author's reply. | 2018 | Lancet | pmid:29323652 |
Crooks MG et al. | How does azithromycin improve asthma exacerbations? | 2018 | Lancet | pmid:29323653 |
Sarathchandran P et al. | infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement. | 2018 | BMJ Case Rep | pmid:29326371 |
Jenson A et al. | Patient-centered communication of community treatment assistants in Tanzania predicts coverage of future mass drug administration for trachoma. | 2018 | Patient Educ Couns | pmid:29329726 |
Buder S et al. | Antimicrobial resistance of Neisseria gonorrhoeae in Germany: low levels of cephalosporin resistance, but high azithromycin resistance. | 2018 | BMC Infect. Dis. | pmid:29343220 |
Jakubů V et al. | Trends in the Minimum Inhibitory Concentrations of Erythromycin, Clarithromycin, Azithromycin, Ciprofloxacin, and Trimethoprim/Sulfamethoxazole for Strains of Bordetella pertussis isolated in the Czech Republic in 1967-2015. | 2017 | Cent. Eur. J. Public Health | pmid:29346850 |
Huang S et al. | Human babesiosis in Southeast China: A case report. | 2018 | Int. J. Infect. Dis. | pmid:29355731 |
Morales A et al. | Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up. | 2018 | J Appl Oral Sci | pmid:29364340 |
Yang D et al. | The timing of azithromycin treatment is not associated with the clinical prognosis of childhood Mycoplasma pneumoniae pneumonia in high macrolide-resistant prevalence settings. | 2018 | PLoS ONE | pmid:29377957 |
Ting CY and Shahdadpuri R | Fuchs syndrome: a case of fever, mucositis and conjunctivitis. | 2018 | BMJ Case Rep | pmid:29378740 |
Han B et al. | Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. | 2017 | Medicine (Baltimore) | pmid:29384912 |
Brereton CJ et al. | Is gentamicin safe and effective for severe community-acquired pneumonia? An 8-year retrospective cohort study. | 2018 | Int. J. Antimicrob. Agents | pmid:29410326 |
Mitjà O et al. | Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study. | 2018 | Lancet | pmid:29428183 |
Å majs D and PospÃÅ¡ilová P | Macrolide resistance in yaws. | 2018 | Lancet | pmid:29428184 |
Chen QF and Zhang YW | [Clinical effect of Saccharomyces boulardii powder combined with azithromycin sequential therapy in treatment of children with diarrhea secondary to Mycoplasma pneumoniae pneumonia]. | 2018 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:29429459 |
Feng X and Liu J | A combination of irsogladine maleate and azithromycin exhibits addictive protective effects in LPS-induced human gingival epithelial cells. | 2017 | Pharmazie | pmid:29441859 |
Stieger N et al. | Solution-mediated crystallization of amorphous azithromycin. | 2017 | Pharmazie | pmid:29441902 |
Cai X et al. | Anti-N-methyl-D-aspartate receptor encephalitis associated with acute Toxoplasma gondii infection: A case report. | 2018 | Medicine (Baltimore) | pmid:29443773 |
Astale T et al. | Population-based coverage survey results following the mass drug administration of azithromycin for the treatment of trachoma in Amhara, Ethiopia. | 2018 | PLoS Negl Trop Dis | pmid:29451881 |
Marks M et al. | Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea. | 2018 | Lancet Glob Health | pmid:29456191 |
Mikalová L and Šmajs D | Low-dose versus standard-dose azithromycin for treatment of yaws. | 2018 | Lancet Glob Health | pmid:29456192 |
de Oliveira Alves A et al. | Young Boy With Roughening in the Inner Eyelids. | 2018 | Ann Emerg Med | pmid:29458812 |
Mannelli VK et al. | . | 2018 | BMJ Case Rep | pmid:29472421 |
Liu YH et al. | Antimicrobial susceptibilities and molecular typing of neisseria gonorrhoeae isolates at a medical centre in Taiwan, 2001-2013 with an emphasis on high rate of azithromycin resistance among the isolates. | 2018 | Int. J. Antimicrob. Agents | pmid:29477549 |
Atkin PA and Simms ML | Orofacial granulomatosis: an unsuccessful response to weekly azithromycin pulse therapy. | 2018 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:29477603 |
Mulugeta A et al. | Coverage, social mobilization and challenges of mass Zithromax administration campaign in South and South East zones of Tigray, Northern Ethiopia: A cross sectional study. | 2018 | PLoS Negl Trop Dis | pmid:29481558 |
Bandyopadhyay R et al. | Effectiveness of treatment regimens for Typhoid fever in the nalidixic acid-resistant S. typhi (NARST) era in South India. | 2018 | Trop Doct | pmid:29495943 |
Kawamura K et al. | Adjunctive therapy with azithromycin for moderate and severe acute respiratory distress syndrome: a retrospective, propensity score-matching analysis of prospectively collected data at a single center. | 2018 | Int. J. Antimicrob. Agents | pmid:29501821 |
Xu L et al. | Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review. | 2018 | Medicine (Baltimore) | pmid:29505509 |
Agarwal P et al. | susceptibility of Indian isolates to different antimalarial drugs & antibiotics. | 2017 | Indian J. Med. Res. | pmid:29512604 |
Luo H et al. | Clinical characteristics from co-infection with avian influenza A H7N9 and Mycoplasma pneumoniae: a case report. | 2018 | J Med Case Rep | pmid:29540219 |
Kelly C et al. | Macrolide antibiotics for bronchiectasis. | 2018 | Cochrane Database Syst Rev | pmid:29543980 |
Azmanis P et al. | First detection of Cryptosporidium parvum in falcons (Falconiformes): Diagnosis, molecular sequencing, therapeutic trial and epidemiological assessment of a possible emerging disease in captive falcons. | 2018 | Vet. Parasitol. | pmid:29559142 |
Abdulai AA et al. | Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. | 2018 | PLoS Negl Trop Dis | pmid:29566044 |
Hong D et al. | [Atopic keratoconjunctivitis: One allergy may mask another. A clinical observation with two types of hypersensitivity reactions: IgE-mediated and non-IgE-mediated]. | 2018 | J Fr Ophtalmol | pmid:29567021 |
Pu Y et al. | Azithromycin ameliorates OVA-induced airway remodeling in Balb/c mice via suppression of epithelial-to-mesenchymal transition. | 2018 | Int. Immunopharmacol. | pmid:29567590 |
Rim JH et al. | Recent Increase in the Incidence of TEM-135 β-Lactamase-harboring Neisseria gonorrhoeae in Korea. | 2018 | Ann Lab Med | pmid:29611382 |
Li JG et al. | [Eperythrozoonosis complicated with hemophagocytic syndrome: report of four cases and review of literature]. | 2018 | Zhonghua Er Ke Za Zhi | pmid:29614573 |
Smith-Norowitz TA et al. | Doxycycline suppresses Chlamydia pneumoniae induced interferon-gamma responses in peripheral blood mononuclear cells in children with allergic asthma. | 2018 | J. Infect. Chemother. | pmid:29615379 |
Deguchi T et al. | Macrolide and fluoroquinolone resistance is uncommon in clinical strains of Chlamydia trachomatis. | 2018 | J. Infect. Chemother. | pmid:29627327 |
Ganesh R et al. | Clinical profile and outcome of children with scrub typhus from Chennai, South India. | 2018 | Eur. J. Pediatr. | pmid:29637374 |
Baker KS et al. | Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species. | 2018 | Nat Commun | pmid:29654279 |
Barge L et al. | Transient immune-mediated agranulocytosis following infection. | 2018 | BMJ Case Rep | pmid:29669774 |
Wei W et al. | MPEG-PCL Copolymeric Micelles for Encapsulation of Azithromycin. | 2018 | AAPS PharmSciTech | pmid:29675667 |
Singh M et al. | Sunray appearance in lacrimal canaliculitis. | Indian J Pathol Microbiol | pmid:29676385 | |
Zmora N et al. | Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults. | 2018 | PLoS Negl Trop Dis | pmid:29684022 |
Keenan JD et al. | Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa. | 2018 | N. Engl. J. Med. | pmid:29694816 |
Weston EJ et al. | Adherence to CDC Recommendations for the Treatment of Uncomplicated Gonorrhea - STD Surveillance Network, United States, 2016. | 2018 | MMWR Morb. Mortal. Wkly. Rep. | pmid:29698384 |
Speer EM et al. | Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. | 2018 | PLoS ONE | pmid:29715306 |
Naderi N et al. | Long-term azithromycin therapy to reduce acute exacerbations in patients with severe chronic obstructive pulmonary disease. | 2018 | Respir Med | pmid:29724384 |
Sharma P et al. | Changing trends of culture-positive typhoid fever and antimicrobial susceptibility in a tertiary care North Indian Hospital over the last decade. | Indian J Med Microbiol | pmid:29735830 | |
Williams PCM and Berkley JA | Guidelines for the management of paediatric cholera infection: a systematic review of the evidence. | 2018 | Paediatr Int Child Health | pmid:29790841 |
Saita MG et al. | pH-Dependent stability of azithromycin in aqueous solution and structure identification of two new degradation products. | 2018 | J Pharm Biomed Anal | pmid:29860178 |
Lam-Franco L et al. | IL-1α and MMP-9 Tear Levels of Patients with Active Ocular Rosacea before and after Treatment with Systemic Azithromycin or Doxycycline. | 2018 | Ophthalmic Res. | pmid:29874670 |
Lendermon EA et al. | Azithromycin Fails to Prevent Accelerated Airway Obliteration in T-bet Mouse Lung Allograft Recipients. | 2018 | Transplant. Proc. | pmid:29880387 |
Iguidbashian JP et al. | and coinfection in the setting of ulcerative colitis. | 2018 | BMJ Case Rep | pmid:29880626 |
Nüesch-Inderbinen M et al. | Genetic characterization of Shiga toxin producing Escherichia coli belonging to the emerging hybrid pathotype O80:H2 isolated from humans 2010-2017 in Switzerland. | 2018 | Int. J. Med. Microbiol. | pmid:29884331 |
Smotrys M et al. | Babesiosis as a cause of false-positive HIV serology. | 2018 | BMJ Case Rep | pmid:29884713 |
Ersoy B et al. | The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. | 2018 | J Laryngol Otol | pmid:29888693 |
Kalua K et al. | One round of azithromycin MDA adequate to interrupt transmission in districts with prevalence of trachomatous inflammation-follicular of 5.0-9.9%: Evidence from Malawi. | 2018 | PLoS Negl Trop Dis | pmid:29897902 |
Lanz J and Lautenschlager S | [CME Dermatology 16/Answer: Fever, Pustules and Joint Pain as Vacation Mementoes]. | 2018 | Praxis (Bern 1994) | pmid:29921188 |
Valor C and Huber K | Atypical presentation of cat scratch disease: Parinaud's oculoglandular syndrome with facial nerve paresis. | 2018 | BMJ Case Rep | pmid:29982178 |
Al-Darraji A et al. | Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. | 2018 | PLoS ONE | pmid:30001416 |
Lederhandler MH et al. | Severe Oral Mucositis: A Rare Adverse Event of Pembrolizumab. | 2018 | J Drugs Dermatol | pmid:30005106 |
Celma A et al. | Development of a Retention Time Interpolation scale (RTi) for liquid chromatography coupled to mass spectrometry in both positive and negative ionization modes. | 2018 | J Chromatogr A | pmid:30005941 |
Zikic A et al. | Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis. | 2018 | J Pediatric Infect Dis Soc | pmid:30007329 |
Lundin MS et al. | Lemierre's syndrome and 2016 American College of Physician guidelines for pharyngitis: no to empiric coverage for bacterial pharyngitis. While no role for routine Fusobacterium PCR, keep suspicion for this pathogen. | 2018 | BMJ Case Rep | pmid:30030249 |
Kamio K and Azuma A | Diffuse panbronchiolitis: A fine road from the discovery of a disease to the establishment of treatment. | 2018 | Respir Investig | pmid:30049592 |
Tilahun Z and Fenta TG | Coverage of azithromycin mass treatment for trachoma elimination in Northwestern Ethiopia: a community based cross-sectional study. | 2018 | BMC Ophthalmol | pmid:30081851 |
Montazeri M et al. | Activities of anti-Toxoplasma drugs and compounds against tissue cysts in the last three decades (1987 to 2017), a systematic review. | 2018 | Parasitol. Res. | pmid:30088074 |
Grewal TK et al. | Therapeutic implications of nano-encapsulated rifabutin, azithromycin & ethambutol against experimental infection in mice. | 2018 | Indian J. Med. Res. | pmid:30168492 |
Thapa A et al. | Typhoid fever with isolated left lateral rectus palsy. | 2018 | BMJ Case Rep | pmid:30181402 |
Sidhu H et al. | Bioavailability of biosolids-borne ciprofloxacin and azithromycin to terrestrial organisms: Microbial toxicity and earthworm responses. | 2019 | Sci. Total Environ. | pmid:30195128 |
Sidhu H et al. | Retention-release of ciprofloxacin and azithromycin in biosolids and biosolids-amended soils. | 2019 | Sci. Total Environ. | pmid:30196217 |
Hassan KS and Al-Khadouri G | Pneumonia with Worsening Pleural Effusion Despite Treatment with Appropriate Antimicrobials: Case report. | 2018 | Sultan Qaboos Univ Med J | pmid:30210860 |
Goyal V et al. | Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial. | 2018 | Lancet | pmid:30241722 |
El Sayed I et al. | Antibiotics for treating scrub typhus. | 2018 | Cochrane Database Syst Rev | pmid:30246875 |
Keenan JD et al. | Azithromycin and Childhood Mortality in Africa. | 2018 | N. Engl. J. Med. | pmid:30281987 |
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