Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tomazic J et al. | Ex vivo effect of azithromycin in human leukocyte bactericidal functions. | 1995 | Antimicrob. Agents Chemother. | pmid:7486947 |
Gill CJ et al. | In vivo evaluation of three acid-stable azalide compounds, L-701,677, L-708,299 and L-708,365 compared to erythromycin, azithromycin and clarithromycin. | 1995 | J. Antibiot. | pmid:7490222 |
Zuckerman JM and Kaye KM | The newer macrolides. Azithromycin and clarithromycin. | 1995 | Infect. Dis. Clin. North Am. | pmid:7490441 |
Haddix AC et al. | The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women. | 1995 Sep-Oct | Sex Transm Dis | pmid:7502180 |
Genç M and Mårdh A | A cost-effectiveness analysis of screening and treatment for Chlamydia trachomatis infection in asymptomatic women. | 1996 | Ann. Intern. Med. | pmid:7503471 |
Harris S et al. | Azithromycin and terfenadine: lack of drug interaction. | 1995 | Clin. Pharmacol. Ther. | pmid:7554704 |
Qadri SM et al. | Antibacterial activity of azithromycin against Brucella melitensis. | 1995 Jul-Aug | Chemotherapy | pmid:7555205 |
Bokemeyer B | [Combined therapy with azithromycin and omeprazole for the eradication of Helicobacter pylori]. | 1995 | Dtsch. Med. Wochenschr. | pmid:7555645 |
Carlier MB et al. | Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture. | 1994 | Int J Tissue React | pmid:7558665 |
Van Asselt GJ et al. | Susceptibility of Streptococcus pyogenes to azithromycin, clarithromycin, erythromycin and roxithromycin in vitro. | 1995 | J. Med. Microbiol. | pmid:7563004 |
Sadiq ST et al. | Effects of azithromycin on malariometric indices in The Gambia. | 1995 | Lancet | pmid:7564674 |
Wawer MJ et al. | AIDS intervention in Uganda. | 1995 | Science | pmid:7570005 |
Anderson SL et al. | Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers. | 1995 | Ann. Intern. Med. | pmid:7574195 |
Backman JT et al. | Azithromycin does not increase plasma concentrations of oral midazolam. | 1995 | Int J Clin Pharmacol Ther | pmid:7582388 |
Worm AM and Osterlind A | Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis. | 1995 | Genitourin Med | pmid:7590717 |
Bamberger DM et al. | Azithromycin in an experimental Staphylococcus aureus abscess model. | 1995 | J. Antimicrob. Chemother. | pmid:7592175 |
Adegbola RA et al. | Effect of azithromycin on pharyngeal microflora. | 1995 | Pediatr. Infect. Dis. J. | pmid:7603826 |
Vartiovaara I | Living with Lyme. | 1995 | Lancet | pmid:7605437 |
Spangler SK et al. | Susceptibilities of 201 anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin by oxyrase agar dilution and E test methodologies. | 1995 | J. Clin. Microbiol. | pmid:7615756 |
Kobayashi H et al. | [Study on azithromycin in treatment of diffuse panbronchiolitis]. | 1995 | Kansenshogaku Zasshi | pmid:7616016 |
Ljutić D and Rumboldt Z | Possible interaction between azithromycin and cyclosporin: a case report. | 1995 | Nephron | pmid:7617103 |
Fouda HG and Schneider RP | Quantitative determination of the antibiotic azithromycin in human serum by high-performance liquid chromatography (HPLC)-atmospheric pressure chemical ionization mass spectrometry: correlation with a standard HPLC-electrochemical method. | 1995 | Ther Drug Monit | pmid:7624907 |
Goldstein EJ et al. | Comparative in vitro activities of azithromycin, Bay y 3118, levofloxacin, sparfloxacin, and 11 other oral antimicrobial agents against 194 aerobic and anaerobic bite wound isolates. | 1995 | Antimicrob. Agents Chemother. | pmid:7625795 |
Barry AL et al. | Relative potencies of azithromycin, clarithromycin and five other orally administered antibiotics. | 1995 | J. Antimicrob. Chemother. | pmid:7628991 |
Stamm WE et al. | Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study. | 1995 | JAMA | pmid:7629982 |
Schmid GP and Fontanarosa PB | Evolving strategies for management of the nongonococcal urethritis syndrome. | 1995 | JAMA | pmid:7629989 |
Péc J et al. | [Treatment of chlamydia infections and a brief review of the problems]. | 1995 | Bratisl Lek Listy | pmid:7633932 |
Management of genital Chlamydia trachomatis infections. | 1994 | Drug Ther Bull | pmid:7635012 | |
Bowden FJ et al. | Azithromycin and syphilis. | 1995 | Genitourin Med | pmid:7635501 |
Yeo AE and Rieckmann KH | Increased antimalarial activity of azithromycin during prolonged exposure of Plasmodium falciparum in vitro. | 1995 | Int. J. Parasitol. | pmid:7635629 |
Debets-Ossenkopp YJ et al. | Effect of an acidic environment on the susceptibility of Helicobacter pylori to trospectomycin and other antimicrobial agents. | 1995 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:7649202 |
Onyeji CO et al. | Activities of clarithromycin, azithromycin, and ofloxacin in combination with liposomal or unencapsulated granulocyte-macrophage colony-stimulating factor against intramacrophage Mycobacterium avium-Mycobacterium intracellulare. | 1995 | J. Infect. Dis. | pmid:7658075 |
Hashisaki GT | Update on macrolide antibiotics. | 1995 May-Jun | Am J Otolaryngol | pmid:7661309 |
Beghi G et al. | Efficacy and tolerability of azithromycin versus amoxicillin/clavulanic acid in acute purulent exacerbation of chronic bronchitis. | 1995 | J Chemother | pmid:7666122 |
Amacher DE et al. | Preclinical toxicology studies with azithromycin: genetic toxicology evaluation. | 1993 | Mutat. Res. | pmid:7685497 |
Odenholt-Tornqvist I et al. | Postantibiotic effects and postantibiotic sub-MIC effects of roxithromycin, clarithromycin, and azithromycin on respiratory tract pathogens. | 1995 | Antimicrob. Agents Chemother. | pmid:7695310 |
Malinverni R et al. | Effects of two antibiotic regimens on course and persistence of experimental Chlamydia pneumoniae TWAR pneumonitis. | 1995 | Antimicrob. Agents Chemother. | pmid:7695327 |
Sher AA et al. | [Interactions in the system of copper ion-azalide (azithromycin)]. | 1994 Sep-Oct | Antibiot. Khimioter. | pmid:7695446 |
Nuovo J et al. | Cost-effectiveness analysis of five different antibiotic regimens for the treatment of uncomplicated Chlamydia trachomatis cervicitis. | 1995 Jan-Feb | J Am Board Fam Pract | pmid:7701965 |
O'Day DM et al. | Ocular pharmacokinetics of orally administered azithromycin in rabbits. | 1994 | J Ocul Pharmacol | pmid:7714407 |
Adal KA et al. | Photo quiz. Bacillary angiomatosis. | 1995 | Clin. Infect. Dis. | pmid:7727641 |
Tuffrey M et al. | The effect of a single oral dose of azithromycin on chlamydial infertility and oviduct ultrastructure in mice. | 1994 | J. Antimicrob. Chemother. | pmid:7730241 |
Schönwald S et al. | Three-day azithromycin compared with ten-day roxithromycin treatment of atypical pneumonia. | 1994 | Scand. J. Infect. Dis. | pmid:7747094 |
Ramadan MA et al. | Post-antibiotic effect of azithromycin and erythromycin on streptococcal susceptibility to phagocytosis. | 1995 | J. Med. Microbiol. | pmid:7752216 |
Hunter RP et al. | Pharmacokinetics, oral bioavailability and tissue distribution of azithromycin in cats. | 1995 | J. Vet. Pharmacol. Ther. | pmid:7752305 |
Ives DV et al. | Impact of clarithromycin and azithromycin on patterns of treatment and survival among AIDS patients with disseminated Mycobacterium avium complex. | 1995 | AIDS | pmid:7755914 |
Pascual A et al. | Factors affecting the intracellular accumulation and activity of azithromycin. | 1995 | J. Antimicrob. Chemother. | pmid:7768786 |
Nilsen OG | Pharmacokinetics of macrolides. Comparison of plasma, tissue and free concentrations with special reference to roxithromycin. | 1995 | Infection | pmid:7782117 |
Rizzato G et al. | Efficacy of a three day course of azithromycin in moderately severe community-acquired pneumonia. | 1995 | Eur. Respir. J. | pmid:7789484 |
Schlossberg D | Azithromycin and clarithromycin. | 1995 | Med. Clin. North Am. | pmid:7791424 |
Weber JT and Johnson RE | New treatments for Chlamydia trachomatis genital infection. | 1995 | Clin. Infect. Dis. | pmid:7795110 |
Rakita RM et al. | Intracellular activity of azithromycin against bacterial enteric pathogens. | 1994 | Antimicrob. Agents Chemother. | pmid:7810998 |
Beale AS and Upshon PA | Characteristics of murine model of genital infection with Chlamydia trachomatis and effects of therapy with tetracyclines, amoxicillin-clavulanic acid, or azithromycin. | 1994 | Antimicrob. Agents Chemother. | pmid:7811001 |
Verdon MS et al. | Pilot study of azithromycin for treatment of primary and secondary syphilis. | 1994 | Clin. Infect. Dis. | pmid:7811868 |
Raszka WV et al. | Multifocal M. intracellulare osteomyelitis in an immunocompetent child. | 1994 | Clin Pediatr (Phila) | pmid:7813141 |
Beckers CJ et al. | Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics. | 1995 | J. Clin. Invest. | pmid:7814637 |
Chiarini F et al. | Chlamydia trachomatis genitourinary infections: laboratory diagnosis and therapeutic aspects. Evaluation of in vitro and in vivo effectiveness of azithromycin. | 1994 | J Chemother | pmid:7830100 |
Friis HM | [Azithromycin--an exciting new antibiotic]. | 1995 | Ugeskr. Laeg. | pmid:7831724 |
Dessau RB | [Azithromycin]. | 1995 | Ugeskr. Laeg. | pmid:7831733 |
Niki Y et al. | In vitro and in vivo activities of azithromycin, a new azalide antibiotic, against chlamydia. | 1994 | Antimicrob. Agents Chemother. | pmid:7840560 |
Freeman CD et al. | Intracellular and extracellular penetration of azithromycin into inflammatory and noninflammatory blister fluid. | 1994 | Antimicrob. Agents Chemother. | pmid:7840585 |
Rapp RP et al. | New macrolide antibiotics: usefulness in infections caused by mycobacteria other than Mycobacterium tuberculosis. | 1994 | Ann Pharmacother | pmid:7849341 |
Wahlstrom E et al. | Improvement in cyclosporine-associated gingival hyperplasia with azithromycin therapy. | 1995 | N. Engl. J. Med. | pmid:7854392 |
Wang JH et al. | Azithromycin in the treatment of pneumonia caused by Chlamydia pneumoniae: report of a case. | 1994 | J. Formos. Med. Assoc. | pmid:7866068 |
al-Assi MT et al. | Azithromycin triple therapy for Helicobacter pylori infection: azithromycin, tetracycline, and bismuth. | 1995 | Am. J. Gastroenterol. | pmid:7872278 |
Andersen SL et al. | Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. | 1995 | Am. J. Trop. Med. Hyg. | pmid:7872444 |
Donowitz GR | Tissue-directed antibiotics and intracellular parasites: complex interaction of phagocytes, pathogens, and drugs. | 1994 | Clin. Infect. Dis. | pmid:7893881 |
Wallace MR et al. | Ototoxicity with azithromycin. | 1994 | Lancet | pmid:7904701 |
Kuschner RA et al. | Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum. | 1994 | Lancet | pmid:7910886 |
Wallace MR et al. | Azithromycin and typhoid. | 1994 | Lancet | pmid:7911192 |
Jones RN et al. | Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus test medium. National Committee for Clinical Laboratory Standards. | 1994 | Diagn. Microbiol. Infect. Dis. | pmid:7924221 |
Klepser ME et al. | Treatment of uncomplicated infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae. | 1994 | Conn Med | pmid:7924316 |
Hughes WT et al. | Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model. | 1994 | J. Infect. Dis. | pmid:7930735 |
Rehg JE | A comparison of anticryptosporidial activity of paromomycin with that of other aminoglycosides and azithromycin in immunosuppressed rats. | 1994 | J. Infect. Dis. | pmid:7930738 |
Wildfeuer A et al. | Distribution of orally administered azithromycin in various blood compartments. | 1994 | Int J Clin Pharmacol Ther | pmid:7952797 |
Bottaro G et al. | [Evaluation of the clinical efficacy of azithromycin in acute respiratory infections in children]. | 1994 | Clin Ter | pmid:7955949 |
Sifrim D et al. | Comparison of the effects of midecamycin acetate and azithromycin on gastrointestinal motility in man. | 1994 | Drugs Exp Clin Res | pmid:7956719 |
Dumas JL et al. | Evaluation of the efficacy of prolonged administration of azithromycin in a murine model of chronic toxoplasmosis. | 1994 | J. Antimicrob. Chemother. | pmid:7961197 |
Tyndall MW et al. | Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin. | 1994 Jul-Aug | Sex Transm Dis | pmid:7974076 |
[Newly approved specialty drugs in Austria and new knowledge about currently available specialty drugs. Zithromax capsules, dried syrup]. | 1994 | Wien. Klin. Wochenschr. | pmid:7975673 | |
Cynamon MH et al. | Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7979270 |
Klemens SP and Cynamon MH | Activities of azithromycin and clarithromycin against nontuberculous mycobacteria in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7979271 |
Schwab JC et al. | Localization of azithromycin in Toxoplasma gondii-infected cells. | 1994 | Antimicrob. Agents Chemother. | pmid:7979295 |
[Azithromycin--an innovative macrolide antibiotic for 3-day-therapy]. | 1994 | Immun. Infekt. | pmid:7982710 | |
Klemens SP and Cynamon MH | Intermittent azithromycin for treatment of Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7986001 |
Andersen SL et al. | Efficacy of azithromycin as a causal prophylactic agent against murine malaria. | 1994 | Antimicrob. Agents Chemother. | pmid:7986022 |
Pacor ML et al. | [Safety of azithromycin in patients allergic to penicillin and cephalosporin]. | 1994 | Clin Ter | pmid:8001336 |
Cazzola M et al. | Evaluation of lung tissue and hilar lymph node concentrations of azithromycin. | 1994 | Int J Clin Pharmacol Ther | pmid:8004364 |
Bush MR and Rosa C | Azithromycin and erythromycin in the treatment of cervical chlamydial infection during pregnancy. | 1994 | Obstet Gynecol | pmid:8008325 |
Steven N et al. | Corticosteroid therapy for AIDS patients with Mycobacterium avium-intracellulare infection. | 1994 | AIDS | pmid:8011231 |
Dorrell L et al. | Intravenous azithromycin as salvage therapy in a patient with Legionnaire's disease. | 1994 | Thorax | pmid:8016806 |
Ishida K et al. | In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. | 1994 | Antimicrob. Agents Chemother. | pmid:8031048 |
Heifets L et al. | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8031351 |
Wolinsky E | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1994 | Antimicrob. Agents Chemother. | pmid:8031406 |
Trevisi P et al. | Toxic pustuloderma associated with azithromycin. | 1994 | Clin. Exp. Dermatol. | pmid:8033402 |
Katelaris PH et al. | Activity of metronidazole, azithromycin and three benzimidazoles on Giardia lamblia growth and attachment to a human intestinal cell line. | 1994 | Aliment. Pharmacol. Ther. | pmid:8038350 |
Rehg J | New potential therapies for cryptosporidiosis: an analysis of variables affecting drug efficacy. | 1994 | Folia Parasitol. | pmid:8050751 |
Gomberg MA and MashkilleÄson AL | [Use of azithromycin in long existing urogenital chlamydia infections and its association with primary syphilis]. | 1993 | Antibiot. Khimioter. | pmid:8060178 |
Sidorenko SV | [Azithromycin--an antibiotic of the azalide group]. | 1993 | Antibiot. Khimioter. | pmid:8060181 |
Lopatkin NA et al. | [Use of azithromycin ("Sumamded") in the treatment of infectious-inflammatory diseases of the lower urinary tract and male genitalia]. | 1993 | Antibiot. Khimioter. | pmid:8060189 |