Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Drug Eruptions D003875 30 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diarrhea D003967 32 associated lipids
Digestive System Diseases D004066 3 associated lipids
Dog Diseases D004283 5 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Dry Socket D004368 3 associated lipids
Dysentery, Bacillary D004405 6 associated lipids
Dyspnea D004417 10 associated lipids
Ectodermal Dysplasia D004476 1 associated lipids
Edema D004487 152 associated lipids
Eisenmenger Complex D004541 1 associated lipids
Elephantiasis D004604 2 associated lipids
Elephantiasis, Filarial D004605 4 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Enteritis D004751 8 associated lipids
Epiglottitis D004826 1 associated lipids
Erythema Nodosum D004893 5 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Exanthema D005076 11 associated lipids
Eye Diseases D005128 12 associated lipids
Eyelid Diseases D005141 4 associated lipids
Fatty Liver D005234 48 associated lipids
Fetal Membranes, Premature Rupture D005322 4 associated lipids
Fever D005334 35 associated lipids
Fever of Unknown Origin D005335 3 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Furunculosis D005667 2 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Genital Diseases, Male D005832 3 associated lipids
Giardiasis D005873 3 associated lipids
Gingival Hyperplasia D005885 3 associated lipids
Gonorrhea D006069 7 associated lipids
Granuloma Inguinale D006100 2 associated lipids
Haemophilus Infections D006192 3 associated lipids
Hearing Disorders D006311 10 associated lipids
Hearing Loss, Conductive D006314 2 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heartburn D006356 2 associated lipids
Hemolysis D006461 131 associated lipids
Hernia, Hiatal D006551 3 associated lipids
Herpes Genitalis D006558 2 associated lipids
HIV Seropositivity D006679 15 associated lipids
Hoarseness D006685 2 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Hyperglycemia D006943 21 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Desnica B et al. Myalgia and swelling of interphalangeal joints as side-effect of prolonged azithromycin therapy in patient with pelvic actinomycosis: case report. 2007 Scand. J. Infect. Dis. pmid:17366044
Dakdouki GK et al. Azithromycin-induced rash in infectious mononucleosis. 2002 Scand. J. Infect. Dis. pmid:12587634
Brihmer C et al. Efficacy and safety of azithromycin versus lymecyline in the treatment of genital chlamydial infections in women. 1996 Scand. J. Infect. Dis. pmid:8953672
Schönwald S et al. Three-day azithromycin compared with ten-day roxithromycin treatment of atypical pneumonia. 1994 Scand. J. Infect. Dis. pmid:7747094
Colakoglu S et al. Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Ankara, Turkey. 2006 Scand. J. Infect. Dis. pmid:16798693
Dickerson FB et al. A double-blind trial of adjunctive azithromycin in individuals with schizophrenia who are seropositive for Toxoplasma gondii. 2009 Schizophr. Res. pmid:19464853
Feary DJ et al. Lawsonia intracellularis proliferative enteropathy in a foal. 2007 Schweiz. Arch. Tierheilkd. pmid:17410971
Ratzinger F et al. Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity. 2014 Sci Rep pmid:25500904
Gensel JC et al. Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. 2017 Sci Rep pmid:28057928
Wang A et al. Effects of Fluoroquinolones and Azithromycin on Biofilm Formation of Stenotrophomonas maltophilia. 2016 Sci Rep pmid:27405358
Menzel M et al. Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients. 2016 Sci Rep pmid:27350308
Zeng J et al. Mechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa. 2016 Sci Rep pmid:27075730
Pansieri C et al. Ureaplasma, bronchopulmonary dysplasia, and azithromycin in European neonatal intensive care units: a survey. 2014 Sci Rep pmid:24518104
Das MC et al. Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. 2016 Sci Rep pmid:27000525
Gualdoni GA et al. Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation. 2015 Sci Rep pmid:26152605
Friesen J et al. Natural immunization against malaria: causal prophylaxis with antibiotics. 2010 Sci Transl Med pmid:20630856
Topp E et al. Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. 2016 Sci. Total Environ. pmid:27096634
Sidhu H et al. Risk assessment of biosolids-borne ciprofloxacin and azithromycin. 2019 Sci. Total Environ. pmid:30463165
Sidhu H et al. Plant toxicity and accumulation of biosolids-borne ciprofloxacin and azithromycin. 2019 Sci. Total Environ. pmid:30340267
Sidhu H et al. Retention-release of ciprofloxacin and azithromycin in biosolids and biosolids-amended soils. 2019 Sci. Total Environ. pmid:30196217
Sidhu H et al. Bioavailability of biosolids-borne ciprofloxacin and azithromycin to terrestrial organisms: Microbial toxicity and earthworm responses. 2019 Sci. Total Environ. pmid:30195128
Wawer MJ et al. AIDS intervention in Uganda. 1995 Science pmid:7570005
Seguí Díaz M [What is the best treatment for urogenital Chlamydia trachomatis infection?] Semergen pmid:27068255
Berger BW Lyme disease. 1993 Semin Dermatol pmid:8312152
Pedro-Botet ML and Sabrià M Legionellosis. 2005 Semin Respir Crit Care Med pmid:16388431
Suriawinata A and Min AD A 33-year-old woman with jaundice after azithromycin use. 2002 Semin. Liver Dis. pmid:12016551
Weinstein SA and Stiles BG A review of the epidemiology, diagnosis and evidence-based management of Mycoplasma genitalium. 2011 Sex Health pmid:21592428
McCormick DF et al. Prevention and control of sexually transmissible infections among hotel-based female sex workers in Dhaka, Bangladesh. 2013 Sex Health pmid:24262217
Robertson A et al. Case report: lymphogranuloma venereum in New Zealand. 2008 Sex Health pmid:19061558
Stratov I et al. Azithromycin: more lethal than chloramphenicol? 2013 Sex Health pmid:23448962
Renault CA et al. Time to clearance of Chlamydia trachomatis ribosomal RNA in women treated for chlamydial infection. 2011 Sex Health pmid:21371385
Jones S et al. The tip of the iceberg: opportunistic screening for Chlamydia trachomatis in asymptomatic patients attending a young people's health clinic reveals a high prevalence--a pilot study. 2004 Sex Health pmid:16334993
Grimes M et al. Two mutations associated with macrolide resistance in Treponema pallidum: increasing prevalence and correlation with molecular strain type in Seattle, Washington. 2012 Sex Transm Dis pmid:23191949
Bala M et al. Trends of resistance to antimicrobials recommended currently and in the past for management of gonorrhea in the Apex STD center in India and comparison of antimicrobial resistance profile between 2002-2006 and 2007-2012. 2015 Sex Transm Dis pmid:25763675
Mabey D Azithromycin resistance in Treponema pallidum. 2009 Sex Transm Dis pmid:19801961
Zheng H et al. Association of the in vitro susceptibility of clinical isolates of chlamydia trachomatis with serovar and duration of antibiotic exposure. 2015 Sex Transm Dis pmid:25668641
Hublikar S et al. Disseminated gonococcal infection and eculizumab--a "high risk" connection? 2014 Sex Transm Dis pmid:25581812
Cole MJ et al. Risk factors for antimicrobial-resistant Neisseria gonorrhoeae in Europe. 2014 Sex Transm Dis pmid:25581808
Schillinger JA et al. Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women: a randomized, controlled trial. 2003 Sex Transm Dis pmid:12514443
Martin DH The US Chlamydia trachomatis control program: successes, shortcomings and ideas for the future. 2012 Sex Transm Dis pmid:23169170
Chen XS Azithromycin versus penicillin G benzathine for early syphilis. 2012 Sex Transm Dis pmid:23060081
Soge OO et al. Emergence of increased azithromycin resistance during unsuccessful treatment of Neisseria gonorrhoeae infection with azithromycin (Portland, OR, 2011). 2012 Sex Transm Dis pmid:23064537
Leeyaphan C et al. Treatment Outcomes for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men Using Doxycycline, Azithromycin, or Both: A Review of Clinical Cases. 2017 Sex Transm Dis pmid:28282652
Ito S et al. Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. 2017 Sex Transm Dis pmid:28282645
Zhou P et al. Occurrence of congenital syphilis after maternal treatment with azithromycin during pregnancy. 2007 Sex Transm Dis pmid:17589329
Muldoon EG et al. Treponema pallidum azithromycin resistance in Dublin, Ireland. 2012 Sex Transm Dis pmid:23001265
Prevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007 to 2009. 2012 Sex Transm Dis pmid:23001267
Starnino S et al. Retrospective analysis of antimicrobial susceptibility trends (2000-2009) in Neisseria gonorrhoeae isolates from countries in Latin America and the Caribbean shows evolving resistance to ciprofloxacin, azithromycin and decreased susceptibility to ceftriaxone. 2012 Sex Transm Dis pmid:23001269
Thakur SD et al. Resistance to Ceftriaxone and Azithromycin in Neisseria gonorrhoeae Isolates From 7 Countries of South America and the Caribbean: 2010-2011. 2017 Sex Transm Dis pmid:28178114
Handsfield HH et al. Multicenter trial of single-dose azithromycin vs. ceftriaxone in the treatment of uncomplicated gonorrhea. Azithromycin Gonorrhea Study Group. 1994 Mar-Apr Sex Transm Dis pmid:9071422
Yasin RM et al. Comparison of E-test with agar dilution methods in testing susceptibility of N. gonorrhoeae to azithromycin. 1997 Sex Transm Dis pmid:9153733
Asbel LE et al. School-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae among Philadelphia public high school students. 2006 Sex Transm Dis pmid:16614587
Ehret JM et al. A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin. 1996 Jul-Aug Sex Transm Dis pmid:8836018
Hook EW et al. A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. 2002 Sex Transm Dis pmid:12172535
Howell MR et al. Control of Chlamydia trachomatis infections in female army recruits: cost-effective screening and treatment in training cohorts to prevent pelvic inflammatory disease. 1999 Sex Transm Dis pmid:10534206
Beymer MR et al. Evaluation of gonorrhea test of cure at 1 week in a Los Angeles community-based clinic serving men who have sex with men. 2014 Sex Transm Dis pmid:25211254
Beyda RM et al. Azithromycin efficacy in the treatment of Chlamydia trachomatis among detained youth. 2014 Sex Transm Dis pmid:25211253
Tyndall MW et al. Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin. 1994 Jul-Aug Sex Transm Dis pmid:7974076
Batteiger BE Azithromycin Efficacy in Asymptomatic Rectal Chlamydial Infection in Men Who Have Sex With Men: A More Definitive Answer Soon? 2017 Sex Transm Dis pmid:28604482
Chen S et al. Universal screening or prophylactic treatment for Chlamydia trachomatis infection among women seeking induced abortions: which strategy is more cost-effective? 2007 Sex Transm Dis pmid:17414068
Lavoué V et al. Screening for Chlamydia trachomatis using self-collected vaginal swabs at a public pregnancy termination clinic in France: results of a screen-and-treat policy. 2012 Sex Transm Dis pmid:22801345
Holman KM et al. Rapid plasma reagin titer variation in the 2 weeks after syphilis therapy. 2012 Sex Transm Dis pmid:22801348
Bornstein M et al. Factors Associated With Primary Care Physician Knowledge of the Recommended Regimen for Treating Gonorrhea. 2017 Sex Transm Dis pmid:27898574
Zhu BY et al. Surveillance of antimicrobial susceptibilities of Neisseria gonorrhoeae in Nanning, China, 2000 to 2012. 2014 Sex Transm Dis pmid:25013979
Zhou P et al. Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai. 2010 Sex Transm Dis pmid:20644500
Smith KS et al. Biological and Behavioral Factors Associated With Positive Chlamydia Retests. 2017 Sex Transm Dis pmid:28608791
Labbé AC et al. Periodical antibiotic treatment for the control of gonococcal and chlamydial infections among sex workers in Benin and Ghana: a cluster-randomized placebo-controlled trial. 2012 Sex Transm Dis pmid:22421690
Martin IE et al. Molecular typing of Treponema pallidum strains in western Canada: predominance of 14d subtypes. 2010 Sex Transm Dis pmid:20539263
Kissinger PJ et al. Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. 2016 Sex Transm Dis pmid:27631353
Vandepitte J et al. High prevalence of ciprofloxacin-resistant gonorrhea among female sex workers in Kampala, Uganda (2008-2009). 2014 Sex Transm Dis pmid:24622633
Molini BJ et al. Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains. 2016 Sex Transm Dis pmid:27513385
Xiridou M et al. Cost-Effectiveness of Dual Antimicrobial Therapy for Gonococcal Infections Among Men Who Have Sex With Men in the Netherlands. 2016 Sex Transm Dis pmid:27513379
Campos-Outcalt D et al. Use of directly observed azithromycin treatment for syphilis in a homeless woman. 2002 Sex Transm Dis pmid:12035029
Singh AE et al. Neisseria gonorrhoeae multiantigen sequence typing is beneficial in further characterizing gonococcal populations in Alberta, Canada. 2013 Sex Transm Dis pmid:23945428
Chaudhary C et al. A pilot study on antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Nepal. 2005 Sex Transm Dis pmid:16205307
Carlin EM and Barton SE Azithromycin as a cost-effective treatment for nongonococcal urethritis in men. 1997 Sex Transm Dis pmid:9018784
Lázaro MJ et al. A case of late-stage lymphogranuloma venereum in a woman in Europe. 2013 Sex Transm Dis pmid:24275729
Abdolrasouli A and Roushan A Corynebacterium propinquum associated with acute, nongonococcal urethritis. 2013 Sex Transm Dis pmid:24275738
Manhart LE Has the time come to systematically test for Mycoplasma genitalium? 2009 Sex Transm Dis pmid:19734818
Noda AA et al. First Report of the 23S rRNA Gene A2058G Point Mutation Associated With Macrolide Resistance in Treponema pallidum From Syphilis Patients in Cuba. 2016 Sex Transm Dis pmid:27100771
Galarza PG et al. Emergence of high level azithromycin-resistant Neisseria gonorrhoeae strain isolated in Argentina. 2009 Sex Transm Dis pmid:19734823
O'Farrell N et al. Periodic presumptive treatment for cervical infections in service women in 3 border provinces of Laos. 2006 Sex Transm Dis pmid:16645552
Gratrix J et al. Retrospective review of pharyngeal gonorrhea treatment failures in Alberta, Canada. 2013 Sex Transm Dis pmid:24113412
Haddix AC et al. The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women. 1995 Sep-Oct Sex Transm Dis pmid:7502180
Peters RP et al. Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. 2016 Sex Transm Dis pmid:26760182
Gratrix J et al. A Retrospective Review of Treatment Failures Using Azithromycin and Doxycycline in the Treatment of Rectal Chlamydia Infections in Women and Men Who Have Sex With Men. 2016 Sex Transm Dis pmid:26760180
Steingrímsson O et al. Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men. 1994 Jan-Feb Sex Transm Dis pmid:8140488
Steen R et al. Evidence of declining STD prevalence in a South African mining community following a core-group intervention. 2000 Sex Transm Dis pmid:10654860
Boix V et al. Polyostotic osteitis in secondary syphilis in an HIV-infected patient. 2013 Sex Transm Dis pmid:23859912
Khosropour CM et al. Comparing azithromycin and doxycycline for the treatment of rectal chlamydial infection: a retrospective cohort study. 2014 Sex Transm Dis pmid:24413484
Jordan SJ and Geisler WM Azithromycin for rectal chlamydia: is it time to leave azithromycin on the shelf?...Not yet. 2014 Sex Transm Dis pmid:24413485
Dan M et al. Pharyngeal Gonorrhea in female sex workers: Response to a single 2-g dose of azithromycin. 2006 Sex Transm Dis pmid:16572040
Kiddugavu MG et al. Effectiveness of syphilis treatment using azithromycin and/or benzathine penicillin in Rakai, Uganda. 2005 Sex Transm Dis pmid:15614114
Hillis SD et al. Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women. A use-effectiveness study in public health settings. 1998 Sex Transm Dis pmid:9437777
Hottes TS et al. Cephalosporin and azithromycin susceptibility in Neisseria gonorrhoeae isolates by site of infection, British Columbia, 2006 to 2011. 2013 Sex Transm Dis pmid:23250301
Handsfield HH Questioning azithromycin for chlamydial infection. 2011 Sex Transm Dis pmid:21992978
Singh AE et al. Gonorrhea Treatment Failures With Oral and Injectable Expanded Spectrum Cephalosporin Monotherapy vs Dual Therapy at 4 Canadian Sexually Transmitted Infection Clinics, 2010-2013. 2015 Sex Transm Dis pmid:25970311
Stamm WE et al. A randomized, double-blind study comparing single-dose rifalazil with single-dose azithromycin for the empirical treatment of nongonococcal urethritis in men. 2007 Sex Transm Dis pmid:17297383
Herchline TE and Inkrott BP Resistance trends in Neisseria gonorrhoeae in southwestern Ohio. 2010 Sex Transm Dis pmid:19901861
Van Damme K et al. Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar. 2009 Sex Transm Dis pmid:19901863