Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Shaio MF and Yang KD | Response of babesiosis to a combined regimen of quinine and azithromycin. | 1997 Mar-Apr | Trans. R. Soc. Trop. Med. Hyg. | pmid:9196774 |
Ramos JT et al. | Cryptosporidium in patients infected with human immunodeficiency virus: azithromycin revisited. | 1997 | J. Pediatr. | pmid:9202631 |
Nachbaur D et al. | Cryptosporidiosis after CD34-selected autologous peripheral blood stem cell transplantation (PBSCT). Treatment with paromomycin, azithromycin and recombinant human interleukin-2. | 1997 | Bone Marrow Transplant. | pmid:9208124 |
Luke DR and Foulds G | Disposition of oral azithromycin in humans. | 1997 | Clin. Pharmacol. Ther. | pmid:9209246 |
Longo G et al. | Azithromycin-induced intrahepatic cholestasis. | 1997 | Am. J. Med. | pmid:9217574 |
Hoppe JE and Tschirner T | Comparison of Etest and agar dilution for testing the activity of three macrolides against Bordetella parapertussis. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9218920 |
Grunden JW and Fisher KA | Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin. | 1997 Jul-Aug | Ann Pharmacother | pmid:9220046 |
Handsfield HH | Azithromycin in gonorrhoea. | 1997 | Int J STD AIDS | pmid:9228599 |
Nasta P and Chiodera S | Azithromycin for relapsing cerebral toxoplasmosis in AIDS. | 1997 | AIDS | pmid:9233470 |
Charoenwatanachokchai A et al. | Azithromycin in the treatment of chlamydial cervicitis and eradication of Ureaplasma urealyticum in female lower genital tract. | 1997 | J Med Assoc Thai | pmid:9240007 |
Gupta S et al. | Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. | 1997 | Circulation | pmid:9244203 |
Pollak PT and Slayter KL | Reduced serum theophylline concentrations after discontinuation of azithromycin: evidence for an unusual interaction. | 1997 Jul-Aug | Pharmacotherapy | pmid:9250566 |
New DL et al. | Vertically transmitted babesiosis. | 1997 | J. Pediatr. | pmid:9255211 |
Rouse MS et al. | Efficacy of azithromycin or clarithromycin for prophylaxis of viridans group streptococcus experimental endocarditis. | 1997 | Antimicrob. Agents Chemother. | pmid:9257739 |
Marone P et al. | Rapid drug susceptibility of Mycobacterium avium complex using a fluorescence quenching method. | 1997 | J Chemother | pmid:9269603 |
Gruber F et al. | Comparative trial of azithromycin and ciprofloxacin in the treatment of gonorrhea. | 1997 | J Chemother | pmid:9269606 |
Puig JM et al. | Treatment of gingival hyperplasia secondary to cyclosporine by the new macrolide azithromycin. | 1997 | Transplant. Proc. | pmid:9270772 |
Wildfeuer A and Haberreiter A | Intracellular activity of azithromycin against Mycobacterium avium complex in human macrophages. | 1997 | Arzneimittelforschung | pmid:9272246 |
De Sole G | Elimination of trachoma. | 1997 | Br J Ophthalmol | pmid:9274426 |
Charoenwatanachokchai A et al. | Azithromycin in non-gonococcal urethritis. | 1997 | J Med Assoc Thai | pmid:9277073 |
Walson PD | Hypothermia from azithromycin? | 1997 | J. Toxicol. Clin. Toxicol. | pmid:9279302 |
Visalli MA et al. | Susceptibility of twenty penicillin-susceptible and -resistant pneumococci to levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin by MIC and time-kill. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9294703 |
Luke DR and Foulds G | Toleration of intravenous azithromycin. | 1997 | Ann Pharmacother | pmid:9296232 |
Brettle RP | Mycobacterium avium intracellulare infection in patients with HIV or AIDS. | 1997 | J. Antimicrob. Chemother. | pmid:9301979 |
Visalli MA et al. | Susceptibility of penicillin-susceptible and -resistant pneumococci to dirithromycin compared with susceptibilities to erythromycin, azithromycin, clarithromycin, roxithromycin, and clindamycin. | 1997 | Antimicrob. Agents Chemother. | pmid:9303375 |
Jepras RI et al. | Rapid assessment of antibiotic effects on Escherichia coli by bis-(1,3-dibutylbarbituric acid) trimethine oxonol and flow cytometry. | 1997 | Antimicrob. Agents Chemother. | pmid:9303401 |
Ednie LM et al. | Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004). | 1997 | Antimicrob. Agents Chemother. | pmid:9303406 |
Roblin PM et al. | In vitro activity of trovafloxacin against Chlamydia pneumoniae. | 1997 | Antimicrob. Agents Chemother. | pmid:9303410 |
RodrÃguez-Bano J et al. | [Penetration of azithromycin into human neutrophils: effect of hydrogen peroxide production]. | 1997 | Enferm. Infecc. Microbiol. Clin. | pmid:9312278 |
Stevens RC et al. | Pharmacokinetics of azithromycin after single- and multiple-doses in children. | 1997 Sep-Oct | Pharmacotherapy | pmid:9324176 |
Destache CJ et al. | Microbiologic effect of bovine cerebrospinal fluid and azithromycin against Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. | 1997 Sep-Oct | Pharmacotherapy | pmid:9324186 |
Buehring I et al. | Chronic sinusitis refractory to standard management in patients with humoral immunodeficiencies. | 1997 | Clin. Exp. Immunol. | pmid:9328124 |
Vazifeh D et al. | Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin. | 1997 | Antimicrob. Agents Chemother. | pmid:9333032 |
Rajyaguru JM and Muszynski MJ | Enhancement of Burkholderia cepacia antimicrobial susceptibility by cationic compounds. | 1997 | J. Antimicrob. Chemother. | pmid:9338485 |
Pendland SL et al. | Comparison of charcoal- and starch-based media for testing susceptibilities of Legionella species to macrolides, azalides, and fluoroquinolones. | 1997 | J. Clin. Microbiol. | pmid:9350781 |
Dautzenberg B | Rationale for the prevention of disseminated Mycobacterium avium-intracellulare complex disease. | 1997 | Drugs | pmid:9358194 |
Cohn DL | Prevention strategies for Mycobacterium avium-intracellulare complex (MAC) infection. A review of recent studies in patients with AIDS. | 1997 | Drugs | pmid:9358195 |
Lauvau DV and Verbist L | An open, multicentre, comparative study of the efficacy and safety of azithromycin and co-amoxiclav in the treatment of upper and lower respiratory tract infections in children. The Paediatric Azithromycin Study Group. | 1997 Sep-Oct | J. Int. Med. Res. | pmid:9364291 |
Scaramuzza A et al. | Case of the month: a girl with oedema and purpuric eruption. Diagnosis: acute haemorrhagic oedema of infancy. | 1997 | Eur. J. Pediatr. | pmid:9365076 |
Odenholt I et al. | Studies of the killing kinetics of benzylpenicillin, cefuroxime, azithromycin, and sparfloxacin on bacteria in the postantibiotic phase. | 1997 | Antimicrob. Agents Chemother. | pmid:9371360 |
Tartaglione T | Treatment of nontuberculous mycobacterial infections: role of clarithromycin and azithromycin. | 1997 Jul-Aug | Clin Ther | pmid:9377608 |
Dudle G et al. | [Meningitis after acute Borrelia burgdorferi infection in HIV infection]. | 1997 | Dtsch. Med. Wochenschr. | pmid:9378035 |
Obando Santaella I et al. | [Cat scratch disease. Diagnostic and therapeutic considerations]. | 1997 | An. Esp. Pediatr. | pmid:9382360 |
Reed MD and Blumer JL | Azithromycin: a critical review of the first azilide antibiotic and its role in pediatric practice. | 1997 | Pediatr. Infect. Dis. J. | pmid:9384342 |
Kränke B and Aberer W | Macrolide-induced Churg-Strauss syndrome in patient with atopy. | 1997 | Lancet | pmid:9388427 |
Fichera ME and Roos DS | A plastid organelle as a drug target in apicomplexan parasites. | 1997 | Nature | pmid:9389481 |
Cadle RM et al. | Symptomatic syndrome of inappropriate antidiuretic hormone secretion associated with azithromycin. | 1997 | Ann Pharmacother | pmid:9391684 |
Barry AL et al. | In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9405952 |
Cohen DA et al. | A school-based Chlamydia control program using DNA amplification technology. | 1998 | Pediatrics | pmid:9417165 |
Klausner JD et al. | Enhanced control of an outbreak of Mycoplasma pneumoniae pneumonia with azithromycin prophylaxis. | 1998 | J. Infect. Dis. | pmid:9419183 |
Lo Bue AM et al. | Antimicrobial interference of a subinhibitory concentration of azithromycin on fimbrial production of Porphyromonas gingivalis. | 1997 | J. Antimicrob. Chemother. | pmid:9421312 |
Kobayashi I et al. | A new semi-solid agar dilution method for determining amoxycillin, clarithromycin and azithromycin MICs for Helicobacter pylori isolates. | 1997 | J. Antimicrob. Chemother. | pmid:9421321 |
Champney WS and Burdine R | Azithromycin and clarithromycin inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells. | 1998 | Curr. Microbiol. | pmid:9425251 |
Feldman C et al. | Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. | 1997 | Inflammation | pmid:9429912 |
Gómez E et al. | Treatment of cyclosporin-induced gingival hyperplasia with azithromycin. | 1997 | Nephrol. Dial. Transplant. | pmid:9430874 |
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Nyström-Rosander C et al. | Susceptibility of Chlamydia pneumoniae to azithromycin and doxycycline: methodological aspects on the determination of minimal inhibitory and minimal bactericidal concentrations. | 1997 | Scand. J. Infect. Dis. | pmid:9435043 |
Hillis SD et al. | Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women. A use-effectiveness study in public health settings. | 1998 | Sex Transm Dis | pmid:9437777 |
Edelstein PH | Legionnaires' disease. | 1998 | N. Engl. J. Med. | pmid:9441231 |
Kalenić S et al. | Helicobacter pylori: in vitro induction of resistance to azithromycin. | 1998 Jan-Feb | Chemotherapy | pmid:9444404 |
Malizia T et al. | Periodontal tissue disposition of azithromycin. | 1997 | J. Periodontol. | pmid:9444596 |
Nguyen MH et al. | Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447909 |
Bermudez LE et al. | Emergence of Mycobacterium avium populations resistant to macrolides during experimental chemotherapy. | 1998 | Antimicrob. Agents Chemother. | pmid:9449283 |
Roblin PM and Hammerschlag MR | Microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community-acquired pneumonia. | 1998 | Antimicrob. Agents Chemother. | pmid:9449287 |
Diculencu D et al. | [The postantibiotic effect of azithromycin on respiratory pathogens]. | 1996 Jul-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:9455450 |
Gray GC et al. | Weekly oral azithromycin as prophylaxis for agents causing acute respiratory disease. | 1998 | Clin. Infect. Dis. | pmid:9455517 |
Andersen SL et al. | Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. | 1998 | Clin. Infect. Dis. | pmid:9455524 |
Chia JK et al. | Azithromycin for the treatment of cat-scratch disease. | 1998 | Clin. Infect. Dis. | pmid:9455538 |
Peterson J and Treadway G | Impact of community-based azithromycin treatment of trachoma on carriage and resistance of Streptococcus pneumoniae. | 1998 | Clin. Infect. Dis. | pmid:9455579 |
Holmberg SD et al. | Possible effectiveness of clarithromycin and rifabutin for cryptosporidiosis chemoprophylaxis in HIV disease. HIV Outpatient Study (HOPS) Investigators. | 1998 | JAMA | pmid:9459473 |
Gaydos CA et al. | Molecular amplification assays to detect chlamydial infections in urine specimens from high school female students and to monitor the persistence of chlamydial DNA after therapy. | 1998 | J. Infect. Dis. | pmid:9466530 |
Adair CD et al. | Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin. | 1998 | Obstet Gynecol | pmid:9469269 |
Vcev A et al. | [Omeprazole and azithromycin with and without metronidazole in the eradication of Helicobacter pylori in duodenal ulcer disease]. | 1997 | Lijec Vjesn | pmid:9471481 |
Lilley LL and Guanci R | Distraction delays a dose. | 1998 | Am J Nurs | pmid:9473978 |
Hahn DL et al. | Evidence for Chlamydia pneumoniae infection in steroid-dependent asthma. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9475566 |
Jaffé A et al. | Long-term azithromycin may improve lung function in children with cystic fibrosis. | 1998 | Lancet | pmid:9482305 |
Russell TS et al. | Eradication of Cryptosporidium in a child undergoing maintenance chemotherapy for leukemia using high dose azithromycin therapy. | 1998 Jan-Feb | J. Pediatr. Hematol. Oncol. | pmid:9482419 |
Seelis RE and Dohmen W | [Short-term (6 days) eradication of Helicobacter pylori infection in the practice of a health insurance physician]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9487294 |
Thalhammer F et al. | Azithromycin-related toxic effects of digitoxin. | 1998 | Br J Clin Pharmacol | pmid:9489601 |
Muhlestein JB et al. | Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. | 1998 | Circulation | pmid:9495296 |
Woldtvedt BR et al. | Possible increased anticoagulation effect of warfarin induced by azithromycin. | 1998 | Ann Pharmacother | pmid:9496419 |
Hoge CW et al. | Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. | 1998 | Clin. Infect. Dis. | pmid:9502453 |
Clancy CJ and Nguyen MH | The combination of amphotericin B and azithromycin as a potential new therapeutic approach to fusariosis. | 1998 | J. Antimicrob. Chemother. | pmid:9511049 |
Trevisani L et al. | A four-day low dose triple therapy regimen for the treatment of Helicobacter pylori infection. | 1998 | Am. J. Gastroenterol. | pmid:9517646 |
Bowden FJ and Savage J | Donovanosis: treatment with azithromycin. | 1998 | Int J STD AIDS | pmid:9518024 |
Oldfield EC et al. | Once weekly azithromycin therapy for prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial. | 1998 | Clin. Infect. Dis. | pmid:9524832 |
den Hollander JG et al. | Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo. | 1998 | Antimicrob. Agents Chemother. | pmid:9527789 |
Fuentes F et al. | Postanitbiotic and sub-MIC effects of azithromycin and isepamicin against Staphylococcus aureus and Escherichia coli. | 1998 | Antimicrob. Agents Chemother. | pmid:9527796 |
Kashuba AD and Amsden GW | Bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. | 1998 | Antimicrob. Agents Chemother. | pmid:9527816 |
Leri O et al. | [Effects of the triple therapy in the eradication of Helicobacter pylori: comparison of 3 different antibiotics]. | 1997 | Clin Ter | pmid:9528197 |
Socan M | Treatment of atypical pneumonia with azithromycin: comparison of a 5-day and a 3-day course. | 1998 | J Chemother | pmid:9531077 |
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Rajyaguru JM and Muszynski MJ | Sensitization of Burkholderia cepacia to antibiotics by cationic drugs. | 1998 | J. Antimicrob. Chemother. | pmid:9533472 |
Kemper CA et al. | Immunomodulatory treatment of Mycobacterium avium complex bacteremia in patients with AIDS by use of recombinant granulocyte-macrophage colony-stimulating factor. | 1998 | J. Infect. Dis. | pmid:9534963 |
Jucglà A et al. | The use of azithromycin for cyclosporin-induced gingival overgrowth. | 1998 | Br. J. Dermatol. | pmid:9536254 |
Karcioglu ZA et al. | Pharmacokinetics of azithromycin in trachoma patients: serum and tear levels. | 1998 | Ophthalmology | pmid:9544640 |
Mizutani S | [Nontuberculous mycobacteriosis; the present status and in the future. Infection with human immunodeficiency virus (HIV) and nontuberculous mycobacteriosis]. | 1998 | Kekkaku | pmid:9545702 |
Walsh T et al. | Randomised controlled trial of prophylactic antibiotics before insertion of intrauterine devices. IUD Study Group. | 1998 | Lancet | pmid:9546505 |
Chakrabarti MK et al. | Evaluation of different antibiotics in inhibiting colonization of Vibrio cholerae O1 and O139 in the rabbit intestine. | 1998 Mar-Apr | Chemotherapy | pmid:9551241 |
Hoepelman IM et al. | A short (3-day) course of azithromycin tablets versus a 10-day course of amoxycillin-clavulanic acid (co-amoxiclav) in the treatment of adults with lower respiratory tract infections and effects on long-term outcome. | 1997 | Int. J. Antimicrob. Agents | pmid:9552709 |