Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lo Bue AM et al. | Antimicrobial interference of a subinhibitory concentration of azithromycin on fimbrial production of Porphyromonas gingivalis. | 1997 | J. Antimicrob. Chemother. | pmid:9421312 |
Kobayashi I et al. | A new semi-solid agar dilution method for determining amoxycillin, clarithromycin and azithromycin MICs for Helicobacter pylori isolates. | 1997 | J. Antimicrob. Chemother. | pmid:9421321 |
Champney WS and Burdine R | Azithromycin and clarithromycin inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells. | 1998 | Curr. Microbiol. | pmid:9425251 |
Feldman C et al. | Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. | 1997 | Inflammation | pmid:9429912 |
Gómez E et al. | Treatment of cyclosporin-induced gingival hyperplasia with azithromycin. | 1997 | Nephrol. Dial. Transplant. | pmid:9430874 |
[New ways of antibiotic therapy]. | 1995 | Internist (Berl) | pmid:9431354 | |
Nyström-Rosander C et al. | Susceptibility of Chlamydia pneumoniae to azithromycin and doxycycline: methodological aspects on the determination of minimal inhibitory and minimal bactericidal concentrations. | 1997 | Scand. J. Infect. Dis. | pmid:9435043 |
Hillis SD et al. | Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women. A use-effectiveness study in public health settings. | 1998 | Sex Transm Dis | pmid:9437777 |
Edelstein PH | Legionnaires' disease. | 1998 | N. Engl. J. Med. | pmid:9441231 |
Kalenić S et al. | Helicobacter pylori: in vitro induction of resistance to azithromycin. | 1998 Jan-Feb | Chemotherapy | pmid:9444404 |
Malizia T et al. | Periodontal tissue disposition of azithromycin. | 1997 | J. Periodontol. | pmid:9444596 |
Nguyen MH et al. | Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447909 |
Bermudez LE et al. | Emergence of Mycobacterium avium populations resistant to macrolides during experimental chemotherapy. | 1998 | Antimicrob. Agents Chemother. | pmid:9449283 |
Roblin PM and Hammerschlag MR | Microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community-acquired pneumonia. | 1998 | Antimicrob. Agents Chemother. | pmid:9449287 |
Diculencu D et al. | [The postantibiotic effect of azithromycin on respiratory pathogens]. | 1996 Jul-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:9455450 |
Gray GC et al. | Weekly oral azithromycin as prophylaxis for agents causing acute respiratory disease. | 1998 | Clin. Infect. Dis. | pmid:9455517 |
Andersen SL et al. | Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. | 1998 | Clin. Infect. Dis. | pmid:9455524 |
Chia JK et al. | Azithromycin for the treatment of cat-scratch disease. | 1998 | Clin. Infect. Dis. | pmid:9455538 |
Peterson J and Treadway G | Impact of community-based azithromycin treatment of trachoma on carriage and resistance of Streptococcus pneumoniae. | 1998 | Clin. Infect. Dis. | pmid:9455579 |
Holmberg SD et al. | Possible effectiveness of clarithromycin and rifabutin for cryptosporidiosis chemoprophylaxis in HIV disease. HIV Outpatient Study (HOPS) Investigators. | 1998 | JAMA | pmid:9459473 |
Gaydos CA et al. | Molecular amplification assays to detect chlamydial infections in urine specimens from high school female students and to monitor the persistence of chlamydial DNA after therapy. | 1998 | J. Infect. Dis. | pmid:9466530 |
Adair CD et al. | Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin. | 1998 | Obstet Gynecol | pmid:9469269 |
Vcev A et al. | [Omeprazole and azithromycin with and without metronidazole in the eradication of Helicobacter pylori in duodenal ulcer disease]. | 1997 | Lijec Vjesn | pmid:9471481 |
Lilley LL and Guanci R | Distraction delays a dose. | 1998 | Am J Nurs | pmid:9473978 |
Hahn DL et al. | Evidence for Chlamydia pneumoniae infection in steroid-dependent asthma. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9475566 |
Jaffé A et al. | Long-term azithromycin may improve lung function in children with cystic fibrosis. | 1998 | Lancet | pmid:9482305 |
Russell TS et al. | Eradication of Cryptosporidium in a child undergoing maintenance chemotherapy for leukemia using high dose azithromycin therapy. | 1998 Jan-Feb | J. Pediatr. Hematol. Oncol. | pmid:9482419 |
Seelis RE and Dohmen W | [Short-term (6 days) eradication of Helicobacter pylori infection in the practice of a health insurance physician]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9487294 |
Thalhammer F et al. | Azithromycin-related toxic effects of digitoxin. | 1998 | Br J Clin Pharmacol | pmid:9489601 |
Muhlestein JB et al. | Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. | 1998 | Circulation | pmid:9495296 |
Woldtvedt BR et al. | Possible increased anticoagulation effect of warfarin induced by azithromycin. | 1998 | Ann Pharmacother | pmid:9496419 |
Hoge CW et al. | Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. | 1998 | Clin. Infect. Dis. | pmid:9502453 |
Clancy CJ and Nguyen MH | The combination of amphotericin B and azithromycin as a potential new therapeutic approach to fusariosis. | 1998 | J. Antimicrob. Chemother. | pmid:9511049 |
Trevisani L et al. | A four-day low dose triple therapy regimen for the treatment of Helicobacter pylori infection. | 1998 | Am. J. Gastroenterol. | pmid:9517646 |
Bowden FJ and Savage J | Donovanosis: treatment with azithromycin. | 1998 | Int J STD AIDS | pmid:9518024 |
Oldfield EC et al. | Once weekly azithromycin therapy for prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial. | 1998 | Clin. Infect. Dis. | pmid:9524832 |
den Hollander JG et al. | Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo. | 1998 | Antimicrob. Agents Chemother. | pmid:9527789 |
Fuentes F et al. | Postanitbiotic and sub-MIC effects of azithromycin and isepamicin against Staphylococcus aureus and Escherichia coli. | 1998 | Antimicrob. Agents Chemother. | pmid:9527796 |
Kashuba AD and Amsden GW | Bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. | 1998 | Antimicrob. Agents Chemother. | pmid:9527816 |
Leri O et al. | [Effects of the triple therapy in the eradication of Helicobacter pylori: comparison of 3 different antibiotics]. | 1997 | Clin Ter | pmid:9528197 |
Socan M | Treatment of atypical pneumonia with azithromycin: comparison of a 5-day and a 3-day course. | 1998 | J Chemother | pmid:9531077 |
Dzelalija B et al. | [Azithromycin in the prevention of Mediterranean spotted fever]. | 1997 | Lijec Vjesn | pmid:9531759 |
Rajyaguru JM and Muszynski MJ | Sensitization of Burkholderia cepacia to antibiotics by cationic drugs. | 1998 | J. Antimicrob. Chemother. | pmid:9533472 |
Kemper CA et al. | Immunomodulatory treatment of Mycobacterium avium complex bacteremia in patients with AIDS by use of recombinant granulocyte-macrophage colony-stimulating factor. | 1998 | J. Infect. Dis. | pmid:9534963 |
Jucglà A et al. | The use of azithromycin for cyclosporin-induced gingival overgrowth. | 1998 | Br. J. Dermatol. | pmid:9536254 |
Karcioglu ZA et al. | Pharmacokinetics of azithromycin in trachoma patients: serum and tear levels. | 1998 | Ophthalmology | pmid:9544640 |
Mizutani S | [Nontuberculous mycobacteriosis; the present status and in the future. Infection with human immunodeficiency virus (HIV) and nontuberculous mycobacteriosis]. | 1998 | Kekkaku | pmid:9545702 |
Walsh T et al. | Randomised controlled trial of prophylactic antibiotics before insertion of intrauterine devices. IUD Study Group. | 1998 | Lancet | pmid:9546505 |
Chakrabarti MK et al. | Evaluation of different antibiotics in inhibiting colonization of Vibrio cholerae O1 and O139 in the rabbit intestine. | 1998 Mar-Apr | Chemotherapy | pmid:9551241 |
Hoepelman IM et al. | A short (3-day) course of azithromycin tablets versus a 10-day course of amoxycillin-clavulanic acid (co-amoxiclav) in the treatment of adults with lower respiratory tract infections and effects on long-term outcome. | 1997 | Int. J. Antimicrob. Agents | pmid:9552709 |