Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Bartonella Infections D001474 3 associated lipids
Ethmoid Sinusitis D015521 2 associated lipids
Otorhinolaryngologic Diseases D010038 3 associated lipids
Dry Socket D004368 3 associated lipids
Nasopharyngeal Diseases D009302 2 associated lipids
Furunculosis D005667 2 associated lipids
Elephantiasis D004604 2 associated lipids
Lymphangitis D008205 4 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Herpes Genitalis D006558 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Martin DL et al. Serology for trachoma surveillance after cessation of mass drug administration. 2015 PLoS Negl Trop Dis pmid:25714363
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Doyle CJ et al. Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro. 2015 Clin Oral Investig pmid:24806810
Willekens J et al. How long should we maintain long-term azithromycin treatment in cystic fibrosis patients? 2015 Pediatr. Pulmonol. pmid:24464958
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Siekmeier R et al. Inhalation of macrolides: a novel approach to treatment of pulmonary infections. 2015 Adv. Exp. Med. Biol. pmid:25252902
Méndez Abad P et al. Idiopathic plastic bronchitis as an uncommon cause of massive pulmonary atelectasis. 2015 Arch. Bronconeumol. pmid:24495947
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Hemmige V et al. Recurrent skin and soft tissue infections in HIV-infected patients during a 5-year period: incidence and risk factors in a retrospective cohort study. 2015 BMC Infect. Dis. pmid:26503616
Su XH et al. Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914). 2015 Antimicrob. Agents Chemother. pmid:26482313
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Jesus FP et al. In Vitro and In Vivo Antimicrobial Activities of Minocycline in Combination with Azithromycin, Clarithromycin, or Tigecycline against Pythium insidiosum. 2015 Antimicrob. Agents Chemother. pmid:26459895
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ACOG Committee Opinion No. 645: Dual Therapy for Gonococcal Infections. 2015 Obstet Gynecol pmid:26488526
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ACOG Committee Opinion No. 645 Summary: Dual Therapy for Gonococcal Infections. 2015 Obstet Gynecol pmid:26488518
Wei HX et al. A Systematic Review and Meta-Analysis of the Efficacy of Anti-Toxoplasma gondii Medicines in Humans. 2015 PLoS ONE pmid:26394212
Babics A and Roussellier P Gardnerella vaginalis: An overlooked pathogen in male patients? 2015 Med Mal Infect pmid:26472061
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Fonseca DC et al. Clinical and Microbiologic Evaluation of Scaling and Root Planing per Quadrant and One-Stage Full-Mouth Disinfection Associated With Azithromycin or Chlorhexidine: A Clinical Randomized Controlled Trial. 2015 J. Periodontol. pmid:26252751
Pereira A et al. Acute onset of widespread pustular eruption. 2015 Aust Fam Physician pmid:26209988
O'Beirne SL et al. Severe Cavitary, Fistulating Mycobacterium avium-intracellulare Complex Disease in an Immunocompetent Host. 2015 Am. J. Respir. Crit. Care Med. pmid:26244303
Zhang L et al. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. 2015 JAMA Ophthalmol pmid:26204109
Wilson DW et al. Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum. 2015 BMC Biol. pmid:26187647
Zhanel GG et al. Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data-authors' response. 2015 J. Antimicrob. Chemother. pmid:26242414
Brill SE et al. Effects of different antibiotic classes on airway bacteria in stable COPD using culture and molecular techniques: a randomised controlled trial. 2015 Thorax pmid:26179246
Horner PJ Editorial Commentary: Mycoplasma genitalium and Declining Treatment Efficacy of Azithromycin 1 g: What Can We Do? 2015 Clin. Infect. Dis. pmid:26240204
Medina AM et al. Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru. 2015 Trans. R. Soc. Trop. Med. Hyg. pmid:26175267
Lau A et al. The Efficacy of Azithromycin for the Treatment of Genital Mycoplasma genitalium: A Systematic Review and Meta-analysis. 2015 Clin. Infect. Dis. pmid:26240201
West SK et al. Risk of Infection with Chlamydia trachomatis from Migrants to Communities Undergoing Mass Drug Administration for Trachoma Control. 2015 Ophthalmic Epidemiol pmid:26158574
Goldstein LH et al. Azithromycin is not associated with QT prolongation in hospitalized patients with community-acquired pneumonia. 2015 Pharmacoepidemiol Drug Saf pmid:26238864
Gebresillasie S et al. Inter-Rater Agreement between Trachoma Graders: Comparison of Grades Given in Field Conditions versus Grades from Photographic Review. 2015 Ophthalmic Epidemiol pmid:26158573
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Unemo M et al. High in vitro susceptibility to the novel spiropyrimidinetrione ETX0914 (AZD0914) among 873 contemporary clinical Neisseria gonorrhoeae isolates from 21 European countries from 2012 to 2014. 2015 Antimicrob. Agents Chemother. pmid:26077246
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Escalante MG et al. Comparison of Azithromycin and Amoxicillin Before Dental Implant Placement: An Exploratory Study of Bioavailability and Resolution of Postoperative Inflammation. 2015 J. Periodontol. pmid:26252749
Carter N and Horner P Treatment regimens in non-gonococcal urethritis. 2015 Sex Transm Infect pmid:25990780
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Gomi K et al. Full-mouth scaling and root planing combined with azithromycin to treat peri-implantitis. 2015 Aust Dent J pmid:25439282
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Singh AE et al. Gonorrhea Treatment Failures With Oral and Injectable Expanded Spectrum Cephalosporin Monotherapy vs Dual Therapy at 4 Canadian Sexually Transmitted Infection Clinics, 2010-2013. 2015 Sex Transm Dis pmid:25970311
Waites KB et al. In vitro antibacterial activity of AZD0914 against human Mycoplasmas and Ureaplasmas. 2015 Antimicrob. Agents Chemother. pmid:25824220
Unemo M et al. Five-day Azithromycin Treatment Regimen for Mycoplasma genitalium Infection Also Effectively Eradicates Chlamydia trachomatis. 2015 Acta Derm. Venereol. pmid:25823977
Nakamura M et al. Cat-scratch disease presenting as a solitary splenic abscess in an elderly man. 2015 BMJ Case Rep pmid:25804947
Baker KS et al. Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study. 2015 Lancet Infect Dis pmid:25936611
Phelan VV et al. Mass Spectrometry Analysis of Pseudomonas aeruginosa Treated with Azithromycin. 2015 J. Am. Soc. Mass Spectrom. pmid:25801585
Agaisse H Shigella flexneri serotype 3a: the rise of a superbug. 2015 Lancet Infect Dis pmid:25936610
Jimenez V et al. Mass drug administration for trachoma: how long is not long enough? 2015 PLoS Negl Trop Dis pmid:25799168
Rice LB Will use of combination cephalosporin/azithromycin therapy forestall resistance to cephalosporins in Neisseria gonorrhoeae? 2015 Sex Transm Infect pmid:25926405
Kitsiouli E et al. Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells. 2015 Biochim. Biophys. Acta pmid:25791017
Lynagh Y et al. Detailed characterization of the first high-level azithromycin-resistant Neisseria gonorrhoeae cases in Ireland. 2015 J. Antimicrob. Chemother. pmid:25907073
Prohl A et al. Enrofloxacin and macrolides alone or in combination with rifampicin as antimicrobial treatment in a bovine model of acute Chlamydia psittaci infection. 2015 PLoS ONE pmid:25768665
Coolen N et al. Reduced risk of nontuberculous mycobacteria in cystic fibrosis adults receiving long-term azithromycin. 2015 J. Cyst. Fibros. pmid:25735458
Soares GM et al. Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model. 2015 Antimicrob. Agents Chemother. pmid:25733510
Parry CM et al. Clinically and microbiologically derived azithromycin susceptibility breakpoints for Salmonella enterica serovars Typhi and Paratyphi A. 2015 Antimicrob. Agents Chemother. pmid:25733500
Shoaib A et al. Determining the role of a probiotic in the restoration of intestinal microbial balance by molecular and cultural techniques. 2015 Genet. Mol. Res. pmid:25730092
Corris PA et al. A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation. 2015 Thorax pmid:25714615