Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Tuberculosis, Pulmonary D014397 18 associated lipids
Peptic Ulcer D010437 19 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Hyperglycemia D006943 21 associated lipids
Bacterial Infections D001424 21 associated lipids
Vomiting D014839 21 associated lipids
Malaria, Falciparum D016778 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Bloch EM et al. Antibiotic Resistance in Young Children in Kilosa District, Tanzania 4 Years after Mass Distribution of Azithromycin for Trachoma Control. 2017 Am. J. Trop. Med. Hyg. pmid:28722638
O'Brien KS et al. Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. 2017 Am. J. Trop. Med. Hyg. pmid:28722569
Stoney RJ et al. Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. 2017 Am. J. Trop. Med. Hyg. pmid:28719282
Harper LM et al. Economic Evaluation of Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 Obstet Gynecol pmid:28697108
Fan LC et al. Macrolides protect against infection via inhibition of inflammasomes. 2017 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:28684545
Wang Y et al. Synthesis and antibacterial activity of novel 4″-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs. 2017 Bioorg. Med. Chem. Lett. pmid:28655423
Kirk SK et al. Efficacy of Azithromycin and Compounded Atovaquone for Treatment of Babesia gibsoni in Dogs. 2017 J. Vet. Intern. Med. pmid:28625019
Vajpayee S et al. Scrub typhus causing neonatal hepatitis with acute liver failure-A case series. 2017 Indian J Gastroenterol pmid:28612320
Kimura S et al. Azithromycin Modulates 3',5'-cyclic Diguanylic Acid Signaling in Pseudomonas aeruginosa. 2017 J. Infect. Chemother. pmid:28579350
Dixit S et al. Carbamoylated azithromycin incorporated zirconia hybrid monolith for enantioseparation of acidic chiral drugs using non-aqueous capillary electrochromatography. 2017 J Chromatogr A pmid:28558906
Jordan SJ et al. Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women. 2017 J. Infect. Dis. pmid:28520912
Bystrzycka W et al. Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release. 2017 Int J Mol Sci pmid:29292737
Lopes Dos Santos Santiago G et al. Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma. 2017 BMC Microbiol. pmid:28486933
Pavlinac PB et al. Azithromycin to prevent post-discharge morbidity and mortality in Kenyan children: a protocol for a randomised, double-blind, placebo-controlled trial (the Toto Bora trial). 2017 BMJ Open pmid:29289941
Savaris RF et al. Antibiotic therapy for pelvic inflammatory disease. 2017 Cochrane Database Syst Rev pmid:28436019
Last AR et al. The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa. 2017 Parasit Vectors pmid:29282126
Snelling PJ et al. Rhabdomyolysis Complicating Typhoid Fever in A Child and Review of the Literature. 2017 Pediatr. Infect. Dis. J. pmid:28430751
Koštrun S et al. Around the macrolide - Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation. 2017 Eur J Med Chem pmid:28410508
Dolezelova E et al. Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. 2017 World J. Gastroenterol. pmid:29209109
Wang CM et al. Synthesis and Antibacterial Evaluation of a Series of 11,12-Cyclic Carbonate Azithromycin-3-O-descladinosyl-3-O-carbamoyl Glycosyl Derivatives. 2017 Molecules pmid:29207567
Rasmussen LD et al. Follicular bronchiolitis in an HIV-infected individual on combination antiretroviral therapy with low CD4+ cell count but sustained viral suppression. 2017 BMJ Case Rep pmid:29191821
Emmanuel R et al. Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from Justicia glauca against oral pathogens: A nanoantibiotic approach. 2017 Microb. Pathog. pmid:29101061
Giguère S et al. Antimicrobial Resistance in . 2017 Microbiol Spectr pmid:29052538
Ullah S et al. Creatinine-based non-phospholipid vesicular carrier for improved oral bioavailability of Azithromycin. 2017 Drug Dev Ind Pharm pmid:28157445
Mohammed H et al. First line dual therapy for gonorrhoea to limit the spread of antimicrobial resistance. 2017 BMJ pmid:28153820
Oluwalana C et al. Azithromycin in Labor Lowers Clinical Infections in Mothers and Newborns: A Double-Blind Trial. 2017 Pediatrics pmid:28130432
Gerber JS and Zaoutis TE Azithromycin Prophylaxis for Laboring Mothers. 2017 Pediatrics pmid:28130431
Cogen JD et al. Characterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations. 2017 Pediatrics pmid:28126911
Cramer CL et al. Immunomodulatory indications of azithromycin in respiratory disease: a concise review for the clinician. 2017 Postgrad Med pmid:28116959
Liu D et al. Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2. 2017 PLoS ONE pmid:28976984
Lee S et al. The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis. 2017 PLoS ONE pmid:28973041
Kibuule D et al. An analysis of policies for cotrimoxazole, amoxicillin and azithromycin use in Namibia's public sector: Findings and therapeutic implications. 2017 Int. J. Clin. Pract. pmid:28090718
Lee SC et al. Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis. 2017 Medicine (Baltimore) pmid:28885357
Mandhane PJ et al. Treatment of preschool children presenting to the emergency department with wheeze with azithromycin: A placebo-controlled randomized trial. 2017 PLoS ONE pmid:28771627
Okah E et al. Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. 2017 Sex Transm Dis pmid:28079746
Gibson PG et al. Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial. 2017 Lancet pmid:28687413
Gifford J et al. Decision support during electronic prescription to stem antibiotic overuse for acute respiratory infections: a long-term, quasi-experimental study. 2017 BMC Infect. Dis. pmid:28760143
Ragusa A and Svelato A Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079335
Molefe NI et al. Oral administration of azithromycin ameliorates trypanosomosis in Trypanosoma congolense-infected mice. 2017 Parasitol. Res. pmid:28674747
Upadhyay K et al. Combination therapy with ampicillin and azithromycin improved outcomes in a mouse model of group B streptococcal sepsis. 2017 PLoS ONE pmid:28759625
Greig JR and Jones L Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079334
Li R et al. Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice. 2017 PLoS ONE pmid:28742883
Bellon H et al. Interleukin-1α induced release of interleukin-8 by human bronchial epithelial cells in vitro: assessing mechanisms and possible treatment options. 2017 Transpl. Int. pmid:28078769
Batteiger BE Azithromycin Efficacy in Asymptomatic Rectal Chlamydial Infection in Men Who Have Sex With Men: A More Definitive Answer Soon? 2017 Sex Transm Dis pmid:28604482
Llop CJ et al. Antibiotic treatment patterns, costs, and resource utilization among patients with community acquired pneumonia: a US cohort study. 2017 Hosp Pract (1995) pmid:28064542
Sonavane AD and Rathi PM Fitz-Hugh-Curtis syndrome. 2017 Indian J. Med. Res. pmid:28574030
Ra SW et al. Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori. 2017 Respir. Res. pmid:28558695
Campanón-Toro MV et al. Acute generalized exanthematous pustulosis (AGEP) induced by azithromycin. 2017 Contact Derm. pmid:28497632
Shastay A The Absence of a Drug-Disease Interaction Alert Leads to a Child's Death. 2017 Home Healthc Now pmid:28471797
Varano GP et al. Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat. 2017 Mol. Vis. pmid:29296071
Lahra MM and Enriquez RP Australian Gonococcal Surveillance Programme, 1 July to 30 September 2016
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Pokharel S et al. Co-trimoxazole versus azithromycin for the treatment of undifferentiated febrile illness in Nepal: study protocol for a randomized controlled trial. 2017 Trials pmid:28969659
White AC Treatment of Early Syphilis in HIV: What Do We Really Know? 2017 Clin. Infect. Dis. pmid:28362951
Brown JD et al. Shigella species epidemiology and antimicrobial susceptibility: the implications of emerging azithromycin resistance for guiding treatment, guidelines and breakpoints. 2017 J. Antimicrob. Chemother. pmid:28961759
Jacobsson S et al. Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae. 2017 Antimicrob. Agents Chemother. pmid:28893785
Sharpton R et al. Do cystic fibrosis patients on azithromycin need electrocardiogram monitoring? 2017 Pulm Pharmacol Ther pmid:28219728
Tribble DR Antibiotic Therapy for Acute Watery Diarrhea and Dysentery. 2017 Mil Med pmid:28885920
Braam JF et al. High prevalence of the A2058T macrolide resistance-associated mutation in Mycoplasma genitalium strains from the Netherlands. 2017 J. Antimicrob. Chemother. pmid:28158595
Pavlova A et al. Toward the rational design of macrolide antibiotics to combat resistance. 2017 Chem Biol Drug Des pmid:28419786
Asano N et al. Limited Azithromycin Localization to Rabbit Meibomian Glands Revealed by LC-MS-Based Bioanalysis and DESI Imaging. 2017 Biol. Pharm. Bull. pmid:28867744
Seyama S et al. Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae. 2017 Antimicrob. Agents Chemother. pmid:28848006
Yoon HY et al. Clinical significance of QT-prolonging drug use in patients with MDR-TB or NTM disease. 2017 Int. J. Tuberc. Lung Dis. pmid:28826448
Whiley DM et al. Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia. 2017 Emerging Infect. Dis. pmid:28820128
Fage C et al. The combination of oseltamivir with azithromycin does not show additional benefits over oseltamivir monotherapy in mice infected with influenza A(H1N1)pdm2009 virus. 2017 J. Med. Virol. pmid:28792077
Ginouvès M et al. In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs. 2017 Am. J. Trop. Med. Hyg. pmid:28167598
Koetsveld J et al. Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. 2017 Antimicrob. Agents Chemother. pmid:28674060
Haque F et al. Evaluation of a Smartphone Decision-Support Tool for Diarrheal Disease Management in a Resource-Limited Setting. 2017 PLoS Negl Trop Dis pmid:28103233
Bulman ZP et al. Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin. 2017 Antimicrob. Agents Chemother. pmid:28096154
Wind CM et al. Trends in antimicrobial susceptibility for azithromycin and ceftriaxone in Neisseria gonorrhoeae isolates in Amsterdam, the Netherlands, between 2012 and 2015. 2017 Euro Surveill. pmid:28079519
Tita ATN et al. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28076707
Idkaidek N et al. Saliva Versus Plasma Bioequivalence of Azithromycin in Humans: Validation of Class I Drugs of the Salivary Excretion Classification System. 2017 Drugs R D pmid:28074334
Gomes C et al. Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin. 2017 Crit. Rev. Microbiol. pmid:27786586
Kwakye-Maclean C et al. A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. 2017 PLoS Negl Trop Dis pmid:28072863
Fu L et al. Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action. 2017 Chemosphere pmid:27783962
Descours G et al. Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila. 2017 Antimicrob. Agents Chemother. pmid:28069647
Lau A et al. Treatment efficacy of azithromycin 1 g single dose versus doxycycline 100 mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. 2017 BMC Infect. Dis. pmid:28061753
Saini H et al. Azithromycin-Ciprofloxacin-Impregnated Urinary Catheters Avert Bacterial Colonization, Biofilm Formation, and Inflammation in a Murine Model of Foreign-Body-Associated Urinary Tract Infections Caused by Pseudomonas aeruginosa. 2017 Antimicrob. Agents Chemother. pmid:28031194
Bouklouze A et al. Azithromycin assay in drug formulations: Validation of a HPTLC method with a quadratic polynomial calibration model using the accuracy profile approach. 2017 Ann Pharm Fr pmid:27692351
Collins SA et al. Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms. 2017 Antimicrob. Agents Chemother. pmid:27919896
Björnelius E et al. macrolide resistance in Stockholm, Sweden. 2017 Sex Transm Infect pmid:27502694
O'Rourke VJ Azithromycin as an adjunct to non-surgical periodontal therapy: a systematic review. 2017 Aust Dent J pmid:27492140
Xue Y et al. An in vitro model of azithromycin-induced persistent Chlamydia trachomatis infection. 2017 FEMS Microbiol. Lett. pmid:28854672
Barberá MJ et al. Mycoplasma genitalium Macrolide and Fluoroquinolone Resistance: Prevalence and Risk Factors Among a 2013-2014 Cohort of Patients in Barcelona, Spain. 2017 Sex Transm Dis pmid:28703723
Brusselle G and Pavord I Azithromycin in uncontrolled asthma. 2017 Lancet pmid:28687412
Xiao Z et al. Comparison of the ameliorative effects of Qingfei Tongluo formula and azithromycin on Mycoplasma pneumoniae pneumonia. 2017 J Nat Med pmid:28664473
Lendermon EA et al. Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation. 2017 Respir. Res. pmid:28659178
Turner KM et al. Analysis of the potential for point-of-care test to enable individualised treatment of infections caused by antimicrobial-resistant and susceptible strains of : a modelling study. 2017 BMJ Open pmid:28615273
Katz AR et al. Cluster of Neisseria gonorrhoeae Isolates With High-level Azithromycin Resistance and Decreased Ceftriaxone Susceptibility, Hawaii, 2016. 2017 Clin. Infect. Dis. pmid:28549097
Lee N et al. Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: A randomized controlled trial. 2017 Antiviral Res. pmid:28535933
Allen GP and Harris KA Resistance Selection in Shigella flexneri by Azithromycin, Ceftriaxone, Ciprofloxacin, Levofloxacin, and Moxifloxacin. 2017 Antimicrob. Agents Chemother. pmid:28483960
Waetzig V et al. Neurodegenerative effects of azithromycin in differentiated PC12 cells. 2017 Eur. J. Pharmacol. pmid:28479141
Park HS et al. Subantibiotic dose of azithromycin attenuates alveolar bone destruction and improves trabecular microarchitectures in a rat model of experimental periodontitis: A study using micro-computed tomography. 2017 Int. Immunopharmacol. pmid:28432937
Fohner AE et al. PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. 2017 Pharmacogenet. Genomics pmid:28146011
Murray K et al. Increasing Antibiotic Resistance in Shigella spp. from Infected New York City Residents, New York, USA. 2017 Emerging Infect. Dis. pmid:28098543
Nichols DP et al. Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis. 2017 J. Cyst. Fibros. pmid:28025037
Marks M et al. Mathematical Modeling of Programmatic Requirements for Yaws Eradication. 2017 Emerging Infect. Dis. pmid:27983500
Zhang C et al. Decreased Susceptibility to Azithromycin Among Clinical Shigella Isolates from China. 2017 Microb. Drug Resist. pmid:27841958
Segal LN et al. Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. 2017 Thorax pmid:27486204
Horner P and Saunders J Should azithromycin 1 g be abandoned as a treatment for bacterial STIs? The case for and against. 2017 Sex Transm Infect pmid:27418572
Bergeron A et al. Azithromycin and Survival After Hematopoietic Stem Cell Transplant-Reply. 2017 JAMA pmid:29279924