Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Epiglottitis D004826 1 associated lipids
Furcation Defects D017823 1 associated lipids
Pseudolymphoma D019310 1 associated lipids
Tenosynovitis D013717 3 associated lipids
Corneal Endothelial Cell Loss D055954 1 associated lipids
Asymptomatic Infections D058345 1 associated lipids
Aphasia, Broca D001039 1 associated lipids
Heartburn D006356 2 associated lipids
Eisenmenger Complex D004541 1 associated lipids
Focal Nodular Hyperplasia D020518 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Authors Title Published Journal PubMed Link
Jones RN and Biedenbach DJ Antimicrobial activity of RU-66647, a new ketolide. 1997 Jan-Feb Diagn. Microbiol. Infect. Dis. pmid:9127099
Roord JJ et al. Prospective open randomized study comparing efficacies and safeties of a 3-day course of azithromycin and a 10-day course of erythromycin in children with community-acquired acute lower respiratory tract infections. 1996 Antimicrob. Agents Chemother. pmid:9124837
Marchisio P et al. Comparative study of once-weekly azithromycin and once-daily amoxicillin treatments in prevention of recurrent acute otitis media in children. 1996 Antimicrob. Agents Chemother. pmid:9124831
Hultén K et al. New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. 1996 Antimicrob. Agents Chemother. pmid:9124830
Kavukçu S et al. Hypothermia from azithromycin. 1997 J. Toxicol. Clin. Toxicol. pmid:9120898
Dawson CR et al. A comparison of oral azithromycin with topical oxytetracycline/polymyxin for the treatment of trachoma in children. 1997 Clin. Infect. Dis. pmid:9114186
Tarlow MJ et al. Future indications for macrolides. 1997 Pediatr. Infect. Dis. J. pmid:9109159
Block SL Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. 1997 Pediatr. Infect. Dis. J. pmid:9109158
Tarlow MJ Macrolides in the management of streptococcal pharyngitis/tonsillitis. 1997 Pediatr. Infect. Dis. J. pmid:9109157
Nightingale CH Pharmacokinetics and pharmacodynamics of newer macrolides. 1997 Pediatr. Infect. Dis. J. pmid:9109156
McCracken GH Microbiologic activity of the newer macrolide antibiotics. 1997 Pediatr. Infect. Dis. J. pmid:9109155
Klein JO History of macrolide use in pediatrics. 1997 Pediatr. Infect. Dis. J. pmid:9109154
Ficnar B et al. Azithromycin: 3-day versus 5-day course in the treatment of respiratory tract infections in children. Croatian Azithromycin Study Group. 1997 J Chemother pmid:9106016
Fietta A et al. Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. 1997 J Chemother pmid:9106014
Fietta A et al. Inhibition of intracellular growth of Staphylococcus aureus by exposure of infected human monocytes to clarithromycin and azithromycin. 1997 J Chemother pmid:9106013
Kitamura K et al. [Pharmacokinetic and clinical evaluation of azithromycin in the pediatric field]. 1997 Jpn J Antibiot pmid:9100081
Tajima T et al. [Pharmacokinetic, bacteriological and clinical studies on azithromycin in children]. 1997 Jpn J Antibiot pmid:9100080
Handsfield HH et al. Multicenter trial of single-dose azithromycin vs. ceftriaxone in the treatment of uncomplicated gonorrhea. Azithromycin Gonorrhea Study Group. 1994 Mar-Apr Sex Transm Dis pmid:9071422
Pascual A et al. Azithromycin uptake by tissue cultured epithelial cells. 1997 J. Antimicrob. Chemother. pmid:9069561
Herrera-Insúa I et al. Synergistic effect of azithromycin on the phagocytic killing of Staphylococcus aureus by human polymorphonuclear leukocytes. 1997 Eur. J. Clin. Microbiol. Infect. Dis. pmid:9063667