Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Asymptomatic Infections D058345 1 associated lipids
Trichiasis D058457 1 associated lipids
Granulomatous Mastitis D058890 1 associated lipids
Reproductive Tract Infections D060737 1 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Tick Bites D064927 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Authors Title Published Journal PubMed Link
Gomi K et al. Drug concentration in inflamed periodontal tissues after systemically administered azithromycin. 2007 J. Periodontol. pmid:17470027
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Mvundura E et al. Good pregnancy outcome with emergent cerclage placed in the presence of intra-amniotic microbial invasion. 2007 Am J Perinatol pmid:17597442
Wilms EB et al. Pharmacokinetics and sputum penetration of azithromycin during once weekly dosing in cystic fibrosis patients. 2008 J. Cyst. Fibros. pmid:17599845
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Liu F et al. Sensitive liquid chromatography/mass spectrometry assay for the quantification of azithromycin in human plasma. 2007 Biomed. Chromatogr. pmid:17604364
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Karanth NV et al. Cryptosporidiosis in a relapsed case of Hodgkin's disease. 2007 Indian J Med Sci pmid:17611349
Boonleang J et al. Bioavailability and pharmacokinetic comparison between generic and branded azithromycin capsule: a randomized, double-blind, 2-way crossover in healthy male Thai volunteers. 2007 Clin Ther pmid:17617293
Pandori MW et al. Detection of azithromycin resistance in Treponema pallidum by real-time PCR. 2007 Antimicrob. Agents Chemother. pmid:17620374
Hoffmann N et al. Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice. 2007 Antimicrob. Agents Chemother. pmid:17620382
Yang JL and Lietman TM The return of trachoma in partially treated communities. 2007 Arch. Ophthalmol. pmid:17620592
Layegh P et al. Efficacy of azithromycin versus systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. 2007 Am. J. Trop. Med. Hyg. pmid:17620637
Rozmanic V et al. Role of magnetic resonance imaging and scintigraphy in the diagnosis and follow-up of osteomyelitis in cat-scratch disease. 2007 Jul-Aug J Paediatr Child Health pmid:17635689
Altunaiji S et al. Antibiotics for whooping cough (pertussis). 2007 Cochrane Database Syst Rev pmid:17636756
Phimda K et al. Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus. 2007 Antimicrob. Agents Chemother. pmid:17638700
Wang SA et al. Antimicrobial resistance for Neisseria gonorrhoeae in the United States, 1988 to 2003: the spread of fluoroquinolone resistance. 2007 Ann. Intern. Med. pmid:17638718
Protzko E et al. Phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops versus 0.3% tobramycin eye drops for bacterial conjunctivitis. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17652708
Matjila PT et al. Molecular characterisation of Babesia gibsoni infection from a pit-bull terrier pup recently imported into South Africa. 2007 J S Afr Vet Assoc pmid:17665757
Aghai ZH et al. Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. 2007 Pediatr. Res. pmid:17667842
Cummings JE et al. Drug-induced linear immunoglobulin A bullous dermatosis mimicking Stevens-Johnson syndrome: a case report. 2007 Cutis pmid:17674585
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Ohnsman C et al. Comparison of azithromycin and moxifloxacin against bacterial isolates causing conjunctivitis. 2007 Curr Med Res Opin pmid:17688706
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Miura T et al. Novel azalides derived from sixteen-membered macrolides. 2007 J. Antibiot. pmid:17721001
Amrol D Single-dose azithromycin microsphere formulation: a novel delivery system for antibiotics. 2007 Int J Nanomedicine pmid:17722506
Murphy DM et al. Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts. 2007 Thorax pmid:17726173
Sathia L et al. Pharyngeal gonorrhoea - is dual therapy the way forward? 2007 Int J STD AIDS pmid:17785013
Tomás I et al. Susceptibility of oral obligate anaerobes to telithromycin, moxifloxacin and a number of commonly used antibacterials. 2007 Oral Microbiol. Immunol. pmid:17803626
Teixeira AC et al. Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil. 2007 Jul-Aug Rev. Inst. Med. Trop. Sao Paulo pmid:17823753
Jernberg EJ and Moi H [Mycoplasma genitalium--aetiological agent of sexually transmitted infection]. 2007 Tidsskr. Nor. Laegeforen. pmid:17828317
Basta-Juzbasić A et al. A dose-finding study of azithromycin in the treatment of acne vulgaris. 2007 Acta Dermatovenerol Croat pmid:17868539
Ericson JF An evaluation of the OECD 308 water/sediment systems for investigating the biodegradation of pharmaceuticals. 2007 Environ. Sci. Technol. pmid:17874790
Clark CL et al. Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. 2007 Antimicrob. Agents Chemother. pmid:17876003
Köhler T et al. Ribosome protection prevents azithromycin-mediated quorum-sensing modulation and stationary-phase killing of Pseudomonas aeruginosa. 2007 Antimicrob. Agents Chemother. pmid:17876004
Cameron ST et al. Willingness of gynaecologists, doctors in family planning, GPs, practice nurses and pharmacists to adopt novel interventions for treating sexual partners of women with chlamydia. 2007 BJOG pmid:17877773
Ericsson CD et al. Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin alone. 2007 Sep-Oct J Travel Med pmid:17883462
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Schmidt EF and Bretz WA Benefits of additional courses of systemic azithromycin in periodontal disease case report. 2007 Jun-Jul N Y State Dent J pmid:17891880
Tita AT et al. Clinical trial of interconceptional antibiotics to prevent preterm birth: subgroup analyses and possible adverse antibiotic-microbial interaction. 2007 Am. J. Obstet. Gynecol. pmid:17904962
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Kirk CB Is the frequency of recurrent chest infections, in children with chronic neurological problems, reduced by prophylactic azithromycin? 2008 Arch. Dis. Child. pmid:17908711
Critchley IA et al. National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. 2007 Antimicrob. Agents Chemother. pmid:17908940
Binet R and Maurelli AT Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. 2007 Antimicrob. Agents Chemother. pmid:17908942
Dastoor SF et al. Effect of adjunctive systemic azithromycin with periodontal surgery in the treatment of chronic periodontitis in smokers: a pilot study. 2007 J. Periodontol. pmid:17915999
Glojnaric I et al. The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics. 2007 Int. Immunopharmacol. pmid:17920531
Dore J and Salisbury RE Morbidity and mortality of mucocutaneous diseases in the pediatric population at a tertiary care center. 2007 Nov-Dec J Burn Care Res pmid:17925657
Romoren M et al. Costs and health consequences of chlamydia management strategies among pregnant women in sub-Saharan Africa. 2007 Sex Transm Infect pmid:17932126
Björnelius E et al. Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial. 2008 Sex Transm Infect pmid:17932127
Ujházy A et al. Chlamydia prevalence and correlates among female adolescents in Hungary. 2007 J Adolesc Health pmid:17950173
Starner TD et al. Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilms. 2008 Antimicrob. Agents Chemother. pmid:17954687
Mick P and Westerberg BD Sensorineural hearing loss as a probable serious adverse drug reaction associated with low-dose oral azithromycin. 2007 J Otolaryngol pmid:17963663
Ballard HO et al. Azithromycin protects against hyperoxic lung injury in neonatal rats. 2007 J. Investig. Med. pmid:17963679
Capoor MR et al. In vitro activity of azithromycin, newer quinolones and cephalosporins in ciprofloxacin-resistant Salmonella causing enteric fever. 2007 J. Med. Microbiol. pmid:17965350
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Fujita J et al. [Overview of respiratory infection caused by nontuberculous mycobacteria]. 2007 Kekkaku pmid:17969990