Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Asymptomatic Infections D058345 1 associated lipids
Trichiasis D058457 1 associated lipids
Granulomatous Mastitis D058890 1 associated lipids
Reproductive Tract Infections D060737 1 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Tick Bites D064927 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Authors Title Published Journal PubMed Link
Solomon AW et al. Mass treatment with single-dose azithromycin for trachoma. 2004 N. Engl. J. Med. pmid:15525721
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Neerja J and Puri SK Plasmodium yoelii: activity of azithromycin in combination with pyrimethamine or sulfadoxine against blood and sporozoite induced infections in Swiss mice. 2004 Jul-Aug Exp. Parasitol. pmid:15363937
Birkenheuer AJ et al. Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs. 2004 Jul-Aug J. Vet. Intern. Med. pmid:15320586
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Weiss K et al. Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults. 2004 Nov-Dec Can. Respir. J. pmid:15611810
Mahgoub A et al. Azithromycin and erythromycin ameliorate the extent of colonic damage induced by acetic acid in rats. 2005 Toxicol. Appl. Pharmacol. pmid:15885263
Tu D et al. Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. 2005 Cell pmid:15851032
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Tabbara KF et al. Effects of dehydration on corneal tissue absorption of topical azithromycin in rabbits. 2005 Curr. Eye Res. pmid:16251129
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Martinez FJ Acute exacerbation of chronic bronchitis: expanding short-course therapy. 2005 Int. J. Antimicrob. Agents pmid:16543077
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Beringer P et al. Absolute bioavailability and intracellular pharmacokinetics of azithromycin in patients with cystic fibrosis. 2005 Antimicrob. Agents Chemother. pmid:16304166
Shitrit D et al. Long-term azithromycin use for treatment of bronchiolitis obliterans syndrome in lung transplant recipients. 2005 J. Heart Lung Transplant. pmid:16143268
Salgado HR and Roncari AF Microbiological assay for the determination of azithromycin in ophthalmic solutions. 2005 Yao Xue Xue Bao pmid:16144322
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Marchisio P and Principi N Single dose azithromycin for treatment of uncomplicated acute otitis media. 2005 Pediatr. Infect. Dis. J. pmid:16148864
Verleden GM et al. Effect of azithromycin on bronchiectasis and pulmonary function in a heart-lung transplant patient with severe chronic allograft dysfunction: a case report. 2005 J. Heart Lung Transplant. pmid:16102464
Shinkai M and Rubin BK Macrolides and airway inflammation in children. 2005 Paediatr Respir Rev pmid:16153572
Rekart ML et al. The impact of syphilis mass treatment one year later: self-reported behaviour change among participants. 2005 Int J STD AIDS pmid:16105193
Ceccarini M et al. [Antibiotic prophylaxis in day surgery in dermatology]. 2005 Minerva Chir pmid:16166930
Labro MT et al. Accumulation of azithromycin and roxithromycin in tracheal epithelial fetal cell lines expressing wild type or mutated cystic fibrosis transmembrane conductance regulator protein (CFTR). 2005 J Chemother pmid:16167517
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Chidambaram JD and Lietman TM Trachoma. 2005 Br J Ophthalmol pmid:16170104
Gabrielli M et al. Azithromycin on soluble cell adhesion molecules and markers of inflammation in survivors of an acute coronary syndrome. 2005 Am. Heart J. pmid:16084141
Burton MJ et al. A randomised controlled trial of azithromycin following surgery for trachomatous trichiasis in the Gambia. 2005 Br J Ophthalmol pmid:16170117
Sharma S and El-Refaey H Vaginal azithromycin and misoprostol before surgical abortion. 2005 Fertil. Steril. pmid:16084904
Rodriguez CN et al. Quinolone and azithromycin-resistant Neisseria meningitidis serogroup C causing urethritis in a heterosexual man. 2005 Int J STD AIDS pmid:16176640
Riedner G et al. Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. 2005 N. Engl. J. Med. pmid:16177249
Murray JJ et al. Efficacy and safety of a novel, single-dose azithromycin microsphere formulation versus 10 days of levofloxacin for the treatment of acute bacterial sinusitis in adults. 2005 Otolaryngol Head Neck Surg pmid:16087013
Marple BF Editorial commentary: dilemma in trial design: do current study designs adequately evaluate effectiveness antibiotic in ABRS? 2005 Otolaryngol Head Neck Surg pmid:16087014
Trent M et al. Pelvic inflammatory disease in adolescents: care delivery in pediatric ambulatory settings. 2005 Pediatr Emerg Care pmid:16027575
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Rennie RP and Ibrahim KH Antimicrobial resistance in Haemophilus influenzae: how can we prevent the inevitable? Commentary on antimicrobial resistance in H. influenzae based on data from the TARGETed surveillance program. 2005 Clin. Infect. Dis. pmid:16032558
West ES et al. Surgery for Trichiasis, Antibiotics to prevent Recurrence (STAR) Clinical Trial methodology. 2005 Ophthalmic Epidemiol pmid:16033749
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Prahalad S et al. Fatal acute fibrinous and organizing pneumonia in a child with juvenile dermatomyositis. 2005 J. Pediatr. pmid:15689928
McCormack JG and Bell SC Has the time come to prescribe azithromycin in cystic fibrosis patients? 2005 Intern Med J pmid:15705133
Waters LJ et al. Efficacy of azithromycin 1 g single dose in the management of uncomplicated gonorrhoea. 2005 Int J STD AIDS pmid:15705283
O'Mahony C Blindingly obvious! 2005 Int J STD AIDS pmid:15705287
Carter JD et al. Antimicrobial treatment for Chlamydia induced reactive arthritis. 2005 Ann. Rheum. Dis. pmid:15708913
Bouchillon SK et al. Impact of carbon dioxide on the susceptibility of key respiratory tract pathogens to telithromycin and azithromycin. 2005 J. Antimicrob. Chemother. pmid:15890718
Dandekar PK et al. Assessment of the efficacy of telithromycin simulating human exposures against S. pneumoniae with ribosomal mutations in a murine pneumonia model. 2005 Int. J. Antimicrob. Agents pmid:15894464
Casey JR and Pichichero ME Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis. 2005 Clin. Infect. Dis. pmid:15909262
Kim DD et al. Neonatal group B streptococcus sepsis after negative screen in a patient taking oral antibiotics. 2005 Obstet Gynecol pmid:15863602
Zhang JX et al. [Resistant analysis and cultivation results of 3 160 blood specimen]. 2005 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:15871208
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Iacopini F et al. One-week once-daily triple therapy with esomeprazole, levofloxacin and azithromycin compared to a standard therapy for Helicobacter pylori eradication. 2005 Dig Liver Dis pmid:15996628
Girard D et al. Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models. 2005 J. Antimicrob. Chemother. pmid:16002421
Yates B et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. 2005 Am. J. Respir. Crit. Care Med. pmid:15976371
Prescott WA and Johnson CE Antiinflammatory therapies for cystic fibrosis: past, present, and future. 2005 Pharmacotherapy pmid:15977917
Eschenauer G et al. Azithromycin-warfarin interaction: are we fishing with a red herring? 2005 Pharmacotherapy pmid:15977924
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Parnham MJ et al. Modulation of neutrophil and inflammation markers in chronic obstructive pulmonary disease by short-term azithromycin treatment. 2005 Eur. J. Pharmacol. pmid:15964564
Krayenbuehl PA et al. Effect of macrolides on peripheral arterial disease depends on patient selection and adequate treatment. 2005 Eur J Vasc Endovasc Surg pmid:15967691
Wang JS et al. [Preparation of lung targeting azithromycin liposomes and its tissue distribution in mice]. 2005 Yao Xue Xue Bao pmid:15952603
Jain SK et al. Antimicrobial-resistant Shigella sonnei: limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility. 2005 Pediatr. Infect. Dis. J. pmid:15933557
Hoberman A et al. Large dosage amoxicillin/clavulanate, compared with azithromycin, for the treatment of bacterial acute otitis media in children. 2005 Pediatr. Infect. Dis. J. pmid:15933563
Sriram S et al. Pilot study to examine the effect of antibiotic therapy on MRI outcomes in RRMS. 2005 J. Neurol. Sci. pmid:15935383
Palmieri F et al. Pulmonary cryptosporidiosis in an AIDS patient: successful treatment with paromomycin plus azithromycin. 2005 Int J STD AIDS pmid:16004637
Kadota J et al. Antibiotic-induced apoptosis in human activated peripheral lymphocytes. 2005 Int. J. Antimicrob. Agents pmid:15737515
Bryant DH Obliterative bronchiolitis in haematopoietic stem cell transplantation: can it be treated? 2005 Eur. Respir. J. pmid:15738280
Khalid M et al. Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study. 2005 Eur. Respir. J. pmid:15738293
Snider LA et al. Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. 2005 Biol. Psychiatry pmid:15820236
Skrepnek GH et al. An economic and outcomes assessment of first-line monotherapy in the treatment of community-acquired pneumonia within managed care. 2005 Curr Med Res Opin pmid:15801997
García Vázquez E et al. Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a beta-lactam agent alone. 2005 Eur. J. Clin. Microbiol. Infect. Dis. pmid:15782278
Wilms E et al. Quantitative determination of azithromycin in plasma, blood and isolated neutrophils by liquid chromatography using pre-column derivatization with 9-fluorenylmethyloxycarbonyl-chloride and fluorescence detection. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15607705
Mumcu G et al. Clinical and immunological effects of azithromycin in Behçet's disease. 2005 J. Oral Pathol. Med. pmid:15610401
Kiddugavu MG et al. Effectiveness of syphilis treatment using azithromycin and/or benzathine penicillin in Rakai, Uganda. 2005 Sex Transm Dis pmid:15614114
Hughes WT et al. Comparison of atovaquone and azithromycin with trimethoprim-sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection. 2005 Clin. Infect. Dis. pmid:15614703
West ES et al. Mass treatment and the effect on the load of Chlamydia trachomatis infection in a trachoma-hyperendemic community. 2005 Invest. Ophthalmol. Vis. Sci. pmid:15623758
Halpern MT et al. Meta-analysis of bacterial resistance to macrolides. 2005 J. Antimicrob. Chemother. pmid:15772147
Yoshida K et al. Macrolides with promotive activity of monocyte to macrophage differentiation. 2005 J. Antibiot. pmid:15813186
Klochkov VA et al. [Effect of therapy with antibiotics on lipid metabolism and antioxidant reserve of patients with ischemic heart disease during Chlamydia pneumoniae infection]. 2005 Kardiologiia pmid:16353050
Dunne MW et al. A double-blind, randomized study of azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India. 2005 Am. J. Trop. Med. Hyg. pmid:16354821
Pavlica L et al. Successful treatment of postvenereal reactive arthritis with synovectomy and 3 months' azithromycin. 2005 J Clin Rheumatol pmid:16357772
Pedro-Botet ML and Sabrià M Legionellosis. 2005 Semin Respir Crit Care Med pmid:16388431