Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Birth Weight D001724 23 associated lipids
Bites, Human D001734 2 associated lipids
Blister D001768 16 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Bronchiolitis D001988 6 associated lipids
Bronchiolitis Obliterans D001989 8 associated lipids
Burns D002056 34 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Gawin A et al. Mildly pruritic palmar rash. 2016 J Fam Pract pmid:28087868
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Lin SJ et al. Azithromycin modulates immune response of human monocyte-derived dendritic cells and CD4 T cells. 2016 Int. Immunopharmacol. pmid:27664570
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Hirasawa K et al. Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. 2016 PLoS ONE pmid:27977675
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Huang SW et al. Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice. 2016 J. Dermatol. Sci. pmid:27449383
Yoshioka D et al. Efficacy of β-Lactam-plus-Macrolide Combination Therapy in a Mouse Model of Lethal Pneumococcal Pneumonia. 2016 Antimicrob. Agents Chemother. pmid:27480866
Jacobsson S et al. WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014. 2016 J. Antimicrob. Chemother. pmid:27432597
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Sacks HS In older adults, macrolide antibiotics were not linked to increased risk for ventricular arrhythmia. 2016 Ann. Intern. Med. pmid:27323264
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Vermeersch K et al. The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebo-controlled trial. 2016 Int J Chron Obstruct Pulmon Dis pmid:27099485
Levy V et al. A Case of Persistent and Possibly Treatment Resistant Pharyngeal Gonorrhea. 2016 Sex Transm Dis pmid:26967304
Guo Y et al. Chlamydiaphage φCPG1 Capsid Protein Vp1 Inhibits Chlamydia trachomatis Growth via the Mitogen-Activated Protein Kinase Pathway. 2016 Viruses pmid:27089359
Gülses A and Ayna M Re: Comparison of Azithromycin and Amoxicillin Before Dental Implant Placement: An Exploratory Study of Bioavailability and Resolution of Postoperative Inflammation. 2016 J. Periodontol. pmid:26962889
Hu J et al. Streptococcus pneumoniae and Haemophilus influenzae type b carriage in Chinese children aged 12-18 months in Shanghai, China: a cross-sectional study. 2016 BMC Infect. Dis. pmid:27080523
McClure KS and Cameron ST An audit of expedited treatment for uncomplicated Chlamydia trachomatis index cases at the community pharmacy. 2016 Int J STD AIDS pmid:26945591
Liang JY et al. Azithromycin-resistant Neisseria gonorrhoeae isolates in Guangzhou, China (2009-2013): coevolution with decreased susceptibilities to ceftriaxone and genetic characteristics. 2016 BMC Infect. Dis. pmid:27080231
McCarthy M No link between macrolide antibiotics and ventricular arrhythmias, study finds. 2016 BMJ pmid:26905692
Lahra MM and Enriquez RP Australian Gonococcal Surveillance Programme, 1 July to 30 September 2015. 2016 Commun Dis Intell Q Rep pmid:27080026
Ward E and Duff P A comparison of 3 antibiotic regimens for prevention of postcesarean endometritis: an historical cohort study. 2016 Am. J. Obstet. Gynecol. pmid:26901276
Yuan Z et al. Randomized controlled clinical trial on the efficacy of fosfomycin trometamol for uncomplicated gonococcal urethritis in men. 2016 Clin. Microbiol. Infect. pmid:27064136
Hathorn E et al. What is the most appropriate treatment for rectal Chlamydia trachomatis infection? 2016 Sex Transm Infect pmid:26892930
Moore BR et al. Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women. 2016 Br J Clin Pharmacol pmid:26889763
Smith DJ et al. Pseudomonas aeruginosa antibiotic resistance in Australian cystic fibrosis centres. 2016 Respirology pmid:26711802
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Lee SJ et al. Maternal azithromycin administration eradicates intra-amniotic Ureaplasma infection: The first human case report. 2016 J Obstet Gynaecol pmid:26634623
Martin I et al. Decline in Decreased Cephalosporin Susceptibility and Increase in Azithromycin Resistance in Neisseria gonorrhoeae, Canada. 2016 Emerging Infect. Dis. pmid:26689114
Höh H et al. [MALT Lymphoma of the Conjunctiva in a 13-year old Child--5-Year Relapse-free Follow-up Following Antibiotic Treatment]. 2016 Klin Monbl Augenheilkd pmid:26609671
Yang CJ et al. Comparison of serological responses to single-dose azithromycin (2 g) versus benzathine penicillin G in the treatment of early syphilis in HIV-infected patients in an area of low prevalence of macrolide-resistant Treponema pallidum infection. 2016 J. Antimicrob. Chemother. pmid:26604241
Chisholm SA et al. An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England. 2016 Sex Transm Infect pmid:26601852
Hood D et al. A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse. 2016 Dis Model Mech pmid:26611891
Luo Q et al. Surface plasmon resonance sensor for antibiotics detection based on photo-initiated polymerization molecularly imprinted array. 2016 Talanta pmid:27769483
Chang Y et al. Factors Influencing the HPLC Determination for Related Substances of Azithromycin. 2016 J Chromatogr Sci pmid:26324196
Shunmugaperumal T and Kaur V In Vitro Anti-inflammatory and Antimicrobial Activities of Azithromycin After Loaded in Chitosan- and Tween 20-Based Oil-in-Water Macroemulsion for Acne Management. 2016 AAPS PharmSciTech pmid:26314246
Caspi M et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents. 2016 J. Mol. Med. pmid:26620677
Libois A and De Wit S Which empiric syndromic treatment for urethritis? 2016 Int J STD AIDS pmid:27794143
Gaudreau C et al. Shigella flexneri with Ciprofloxacin Resistance and Reduced Azithromycin Susceptibility, Canada, 2015. 2016 Emerging Infect. Dis. pmid:27767915
Narita M et al. Antimicrobial Susceptibility of Microorganisms Isolated from Periapical Periodontitis Lesions. 2016 Bull. Tokyo Dent. Coll. pmid:27665691
Dombrowski JC and Batteiger BE Reconsidering the Use of Azithromycin for Chlamydial Urethritis. 2016 Sex Transm Dis pmid:27626187
Yadav H et al. Azithromycin for the Treatment of Obliterative Bronchiolitis after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. 2016 Biol. Blood Marrow Transplant. pmid:27575542
Lemieux JE et al. A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse. 2016 Nat Microbiol pmid:27572973
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Das S and Mohanty M Comparative evaluation of 2 g single dose versus conventional dose azithromycin in uncomplicated skin and skin structure infections. 2016 Jan-Feb Indian J Pharmacol pmid:26997734
Das A et al. Azithromycin induced bullous fixed drug eruption. 2016 Jan-Feb Indian J Pharmacol pmid:26997729
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Oliveira IS et al. Evaluation of the improvement of quality of life with Azithromycin in the treatment of eosinophilic nasal polyposis. 2016 Mar-Apr Braz J Otorhinolaryngol pmid:26601998
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Zhang M et al. Electrophysiologic Studies on the Risks and Potential Mechanism Underlying the Proarrhythmic Nature of Azithromycin. 2017 Cardiovasc. Toxicol. pmid:28213753
Lahra MM et al. Treatment guidelines after an outbreak of azithromycin-resistant Neisseria gonorrhoeae in South Australia. 2017 Lancet Infect Dis pmid:28134103
Koštrun S et al. Around the macrolide - Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation. 2017 Eur J Med Chem pmid:28410508
Yang Z et al. Azithromycin Causes a Novel Proarrhythmic Syndrome. 2017 Circ Arrhythm Electrophysiol pmid:28408648
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Bellon H et al. Interleukin-1α induced release of interleukin-8 by human bronchial epithelial cells in vitro: assessing mechanisms and possible treatment options. 2017 Transpl. Int. pmid:28078769
Li Y et al. Synergistic Activity of Berberine with Azithromycin against Pseudomonas Aeruginosa Isolated from Patients with Cystic Fibrosis of Lung In Vitro and In Vivo. 2017 Cell. Physiol. Biochem. pmid:28738346
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Johnson SR et al. Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance. 2017 Int. J. Antimicrob. Agents pmid:28038960
Sanders AM et al. Burden of trachoma in five counties of Eastern Equatoria state, South Sudan: Results from population-based surveys. 2017 PLoS Negl Trop Dis pmid:28614375
Allen G Evidence appraisal of Tita ATN, Szychowski JM, Boggess K, et al. Adjunctive azithromycin prophylaxis for cesarean delivery.: N Engl J Med. 2016;375:1231-1241. 2017 AORN J pmid:28034388
Pavlova A et al. Toward the rational design of macrolide antibiotics to combat resistance. 2017 Chem Biol Drug Des pmid:28419786
Fage C et al. The combination of oseltamivir with azithromycin does not show additional benefits over oseltamivir monotherapy in mice infected with influenza A(H1N1)pdm2009 virus. 2017 J. Med. Virol. pmid:28792077
Koetsveld J et al. Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. 2017 Antimicrob. Agents Chemother. pmid:28674060
Kawamura K et al. Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study. 2017 BMC Pulm Med pmid:28629448
Nozawa H et al. Pertussis without apparent cough in a disabled girl with a tracheostomy. 2017 J. Infect. Chemother. pmid:28623110
Bouklouze A et al. Azithromycin assay in drug formulations: Validation of a HPTLC method with a quadratic polynomial calibration model using the accuracy profile approach. 2017 Ann Pharm Fr pmid:27692351
Collins SA et al. Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms. 2017 Antimicrob. Agents Chemother. pmid:27919896
Jover-García J et al. [In-vitro activity of azithromycin in faecal isolates of Aeromonas hydrophila]. 2017 An Pediatr (Barc) pmid:27686393
Han B et al. Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. 2017 Medicine (Baltimore) pmid:29384912
Park HS et al. Subantibiotic dose of azithromycin attenuates alveolar bone destruction and improves trabecular microarchitectures in a rat model of experimental periodontitis: A study using micro-computed tomography. 2017 Int. Immunopharmacol. pmid:28432937
Menzel M et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. 2017 Oncotarget pmid:28415826
Kneidinger N et al. Lung volumes predict survival in patients with chronic lung allograft dysfunction. 2017 Eur. Respir. J. pmid:28404648
Horner P and Saunders J Should azithromycin 1 g be abandoned as a treatment for bacterial STIs? The case for and against. 2017 Sex Transm Infect pmid:27418572
Quinn KL et al. Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. 2017 Drug Saf pmid:28421551
Bergeron A et al. Azithromycin and Survival After Hematopoietic Stem Cell Transplant-Reply. 2017 JAMA pmid:29279924
Fuji S Azithromycin and Survival After Hematopoietic Stem Cell Transplant. 2017 JAMA pmid:29279920
Castelli G et al. PURLs: Does azithromycin have a role in cesarean sections? 2017 J Fam Pract pmid:29202146