Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Birth Weight D001724 23 associated lipids
Bites, Human D001734 2 associated lipids
Blister D001768 16 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Bronchiolitis D001988 6 associated lipids
Bronchiolitis Obliterans D001989 8 associated lipids
Burns D002056 34 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Zheng H et al. Association of the in vitro susceptibility of clinical isolates of chlamydia trachomatis with serovar and duration of antibiotic exposure. 2015 Sex Transm Dis pmid:25668641
Hublikar S et al. Disseminated gonococcal infection and eculizumab--a "high risk" connection? 2014 Sex Transm Dis pmid:25581812
Cole MJ et al. Risk factors for antimicrobial-resistant Neisseria gonorrhoeae in Europe. 2014 Sex Transm Dis pmid:25581808
Prevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007 to 2009. 2012 Sex Transm Dis pmid:23001267
Starnino S et al. Retrospective analysis of antimicrobial susceptibility trends (2000-2009) in Neisseria gonorrhoeae isolates from countries in Latin America and the Caribbean shows evolving resistance to ciprofloxacin, azithromycin and decreased susceptibility to ceftriaxone. 2012 Sex Transm Dis pmid:23001269
Thakur SD et al. Resistance to Ceftriaxone and Azithromycin in Neisseria gonorrhoeae Isolates From 7 Countries of South America and the Caribbean: 2010-2011. 2017 Sex Transm Dis pmid:28178114
Asbel LE et al. School-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae among Philadelphia public high school students. 2006 Sex Transm Dis pmid:16614587
Katz KA et al. Molecular epidemiology of syphilis--San Francisco, 2004-2007. 2010 Sex Transm Dis pmid:20601928
Lavoué V et al. Screening for Chlamydia trachomatis using self-collected vaginal swabs at a public pregnancy termination clinic in France: results of a screen-and-treat policy. 2012 Sex Transm Dis pmid:22801345
Holman KM et al. Rapid plasma reagin titer variation in the 2 weeks after syphilis therapy. 2012 Sex Transm Dis pmid:22801348
Bornstein M et al. Factors Associated With Primary Care Physician Knowledge of the Recommended Regimen for Treating Gonorrhea. 2017 Sex Transm Dis pmid:27898574
Tapsall JW et al. Failure of azithromycin therapy in gonorrhea and discorrelation with laboratory test parameters. 1998 Sex Transm Dis pmid:9858344
Farley TA et al. The acceptability and behavioral effects of antibiotic prophylaxis for syphilis prevention. 2003 Sex Transm Dis pmid:14603093
Peters RP et al. Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. 2016 Sex Transm Dis pmid:26760182
Gratrix J et al. A Retrospective Review of Treatment Failures Using Azithromycin and Doxycycline in the Treatment of Rectal Chlamydia Infections in Women and Men Who Have Sex With Men. 2016 Sex Transm Dis pmid:26760180
Blandford JM and Gift TL The cost-effectiveness of single-dose azithromycin for treatment of incubating syphilis. 2003 Sex Transm Dis pmid:12782951
Dillon JA et al. Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from three Caribbean countries: Trinidad, Guyana, and St. Vincent. 2001 Sex Transm Dis pmid:11518867
Dillon JA et al. Reduced susceptibility to azithromycin and high percentages of penicillin and tetracycline resistance in Neisseria gonorrhoeae isolates from Manaus, Brazil, 1998. 2001 Sex Transm Dis pmid:11518869
Steingrímsson O et al. Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men. 1994 Jan-Feb Sex Transm Dis pmid:8140488
Yuan LF et al. Resistance to azithromycin of Neisseria gonorrhoeae isolates from 2 cities in China. 2011 Sex Transm Dis pmid:21844727
Boix V et al. Polyostotic osteitis in secondary syphilis in an HIV-infected patient. 2013 Sex Transm Dis pmid:23859912
Khosropour CM et al. Comparing azithromycin and doxycycline for the treatment of rectal chlamydial infection: a retrospective cohort study. 2014 Sex Transm Dis pmid:24413484
Jordan SJ and Geisler WM Azithromycin for rectal chlamydia: is it time to leave azithromycin on the shelf?...Not yet. 2014 Sex Transm Dis pmid:24413485
Lau CY and Qureshi AK Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. 2002 Sex Transm Dis pmid:12218839
Singh AE et al. Gonorrhea Treatment Failures With Oral and Injectable Expanded Spectrum Cephalosporin Monotherapy vs Dual Therapy at 4 Canadian Sexually Transmitted Infection Clinics, 2010-2013. 2015 Sex Transm Dis pmid:25970311
Nieuwenhuis RF et al. Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin. 2003 Sex Transm Infect pmid:14663119
Niccolai LM et al. Behavioural sources of repeat Chlamydia trachomatis infections: importance of different sex partners. 2011 Sex Transm Infect pmid:21212380
Bowden FJ and Savage J Azithromycin for the treatment of donovanosis. 1998 Sex Transm Infect pmid:9634320
Khosropour CM et al. Efficacy of standard therapies against Ureaplasma species and persistence among men with non-gonococcal urethritis enrolled in a randomised controlled trial. 2015 Sex Transm Infect pmid:25616607
Magbanua JP et al. Chlamydia trachomatis variant not detected by plasmid based nucleic acid amplification tests: molecular characterisation and failure of single dose azithromycin. 2007 Sex Transm Infect pmid:17567684
Gundevia Z et al. Positivity at test of cure following first-line treatment for genital Mycoplasma genitalium: follow-up of a clinical cohort. 2015 Sex Transm Infect pmid:25096921
National guideline for the management of donovanosis (granuloma inguinale). Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). 1999 Sex Transm Infect pmid:10616381
Pasternack R et al. Follow up of treatment: an integral part of the control of Chlamydia trachomatis infections. 1999 Sex Transm Infect pmid:10448353
Romoren M et al. Costs and health consequences of chlamydia management strategies among pregnant women in sub-Saharan Africa. 2007 Sex Transm Infect pmid:17932126
Björnelius E et al. macrolide resistance in Stockholm, Sweden. 2017 Sex Transm Infect pmid:27502694
Horner PJ Azithromycin antimicrobial resistance and genital Chlamydia trachomatis infection: duration of therapy may be the key to improving efficacy. 2012 Sex Transm Infect pmid:22416272
Thompson C Azithromycin v oxytetracycline for the treatment of non-specific urethritis. 2000 Sex Transm Infect pmid:10961211
Hathorn E et al. What is the most appropriate treatment for rectal Chlamydia trachomatis infection? 2016 Sex Transm Infect pmid:26892930
Bartelsman M et al. Comparison of two Gram stain point-of-care systems for urogenital gonorrhoea among high-risk patients: diagnostic accuracy and cost-effectiveness before and after changing the screening algorithm at an STI clinic in Amsterdam. 2014 Sex Transm Infect pmid:24860102
Hathorn E et al. What is the appropriate treatment for the management of rectal Chlamydia trachomatis in men and women? 2012 Sex Transm Infect pmid:22517887
Murray S and Marshall L Empiric NSU treatment needs updating. 2014 Sex Transm Infect pmid:25028712
Oud EV et al. Pitfalls in the diagnosis and management of inguinal lymphogranuloma venereum: important lessons from a case series. 2014 Sex Transm Infect pmid:24787368
Gayet-Ageron A et al. Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples. 2009 Sex Transm Infect pmid:19155240
Chisholm SA et al. An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England. 2016 Sex Transm Infect pmid:26601852
Ito S et al. Selection of Mycoplasma genitalium strains harbouring macrolide resistance-associated 23S rRNA mutations by treatment with a single 1 g dose of azithromycin. 2011 Sex Transm Infect pmid:21653933
Fifer H et al. Gonorrhoea treatment position statement. 2015 Sex Transm Infect pmid:26195472
Khosropour CM et al. Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: a prospective cohort study. 2014 Sex Transm Infect pmid:24106340
Horner P and Saunders J Should azithromycin 1 g be abandoned as a treatment for bacterial STIs? The case for and against. 2017 Sex Transm Infect pmid:27418572
Horner P The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection. 2006 Sex Transm Infect pmid:16877590
Rice LB Will use of combination cephalosporin/azithromycin therapy forestall resistance to cephalosporins in Neisseria gonorrhoeae? 2015 Sex Transm Infect pmid:25926405