Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Motohiro T et al. | [Clinical study on azithromycin in 10% fine granules and 100mg capsules in the field of pediatrics]. | 1997 | Jpn J Antibiot | pmid:9634360 |
Nachbaur D et al. | Cryptosporidiosis after CD34-selected autologous peripheral blood stem cell transplantation (PBSCT). Treatment with paromomycin, azithromycin and recombinant human interleukin-2. | 1997 | Bone Marrow Transplant. | pmid:9208124 |
Luke DR and Foulds G | Disposition of oral azithromycin in humans. | 1997 | Clin. Pharmacol. Ther. | pmid:9209246 |
Herrera-Insúa I et al. | Synergistic effect of azithromycin on the phagocytic killing of Staphylococcus aureus by human polymorphonuclear leukocytes. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9063667 |
Pascual A et al. | Azithromycin uptake by tissue cultured epithelial cells. | 1997 | J. Antimicrob. Chemother. | pmid:9069561 |
Khan WA et al. | Treatment of shigellosis: V. Comparison of azithromycin and ciprofloxacin. A double-blind, randomized, controlled trial. | 1997 | Ann. Intern. Med. | pmid:9139555 |
Yasin RM et al. | Comparison of E-test with agar dilution methods in testing susceptibility of N. gonorrhoeae to azithromycin. | 1997 | Sex Transm Dis | pmid:9153733 |
Mosby JA | Treating acute bronchitis with azithromycin. | 1997 | Am Fam Physician | pmid:9054218 |
Blanshard C et al. | Pilot studies of azithromycin, letrazuril and paromomycin in the treatment of cryptosporidiosis. | 1997 | Int J STD AIDS | pmid:9061412 |
Dudle G et al. | [Meningitis after acute Borrelia burgdorferi infection in HIV infection]. | 1997 | Dtsch. Med. Wochenschr. | pmid:9378035 |
Dautzenberg B | Rationale for the prevention of disseminated Mycobacterium avium-intracellulare complex disease. | 1997 | Drugs | pmid:9358194 |
Cohn DL | Prevention strategies for Mycobacterium avium-intracellulare complex (MAC) infection. A review of recent studies in patients with AIDS. | 1997 | Drugs | pmid:9358195 |
Marone P et al. | Rapid drug susceptibility of Mycobacterium avium complex using a fluorescence quenching method. | 1997 | J Chemother | pmid:9269603 |
Gruber F et al. | Comparative trial of azithromycin and ciprofloxacin in the treatment of gonorrhea. | 1997 | J Chemother | pmid:9269606 |
Jepras RI et al. | Rapid assessment of antibiotic effects on Escherichia coli by bis-(1,3-dibutylbarbituric acid) trimethine oxonol and flow cytometry. | 1997 | Antimicrob. Agents Chemother. | pmid:9303401 |
RodrÃguez-Bano J et al. | [Penetration of azithromycin into human neutrophils: effect of hydrogen peroxide production]. | 1997 | Enferm. Infecc. Microbiol. Clin. | pmid:9312278 |
Malizia T et al. | Periodontal tissue disposition of azithromycin. | 1997 | J. Periodontol. | pmid:9444596 |
Nguyen MH et al. | Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447909 |
Nyström-Rosander C et al. | Susceptibility of Chlamydia pneumoniae to azithromycin and doxycycline: methodological aspects on the determination of minimal inhibitory and minimal bactericidal concentrations. | 1997 | Scand. J. Infect. Dis. | pmid:9435043 |
Biebuyck XA | Comparison of azithromycin and co-amoxiclav in the treatment of acute tracheobronchitis and acute infectious exacerbations of chronic bronchitis in adults. Azithromycin Study Group. | 1996 Sep-Oct | J. Int. Med. Res. | pmid:8895044 |
Peeling RW and Brunham RC | Chlamydiae as pathogens: new species and new issues. | 1996 Oct-Dec | Emerging Infect. Dis. | pmid:8969247 |
Ripa S et al. | A linear model for the pharmacokinetics of azithromycin in healthy volunteers. | 1996 Nov-Dec | Chemotherapy | pmid:8957574 |
D'Amico R | ICAAC update on opportunistic infections. | 1996 Nov-Dec | Posit Aware | pmid:11363974 |
Wendel TD | 1-day azithromycin was as effective as 7-day doxycycline for nongonococcal urethritis syndrome in men. | 1996 Nov-Dec | ACP J. Club | pmid:8912627 |
Carlin EM and Barton SE | Azithromycin as the first-line treatment of non-gonococcal urethritis (NGU): a study of follow-up rates, contact attendance and patients' treatment preference. | 1996 May-Jun | Int J STD AIDS | pmid:8799780 |
Shanks GD et al. | Azithromycin prophylaxis prevents epidemic dysentery. | 1996 May-Jun | Trans. R. Soc. Trop. Med. Hyg. | pmid:8758091 |
Adam D et al. | Re: A. Bauernfeind et al.: Comparative pharmacodynamics of clarithromycin and azithromycin against respiratory pathogens (Infection 23 [1995] 316-321) | 1996 May-Jun | Infection | pmid:8811372 |
Vranes J | Effect of subinhibitory concentrations of ceftazidime, ciprofloxacin, and azithromycin on the hemagglutination and adherence of uropathogenic Escherichia coli strains. | 1996 May-Jun | Chemotherapy | pmid:8983884 |
Ichimiya T et al. | The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro. | 1996 May-Jun | Chemotherapy | pmid:8983885 |
Galova K et al. | Multicenter randomized study of two once daily regimens in the initial management of community-acquired respiratory tract infections in 163 children: azithromycin versus ceftibuten. | 1996 May-Jun | Chemotherapy | pmid:8983893 |
Burke SM | Azithromycin: only once a day. | 1996 May-Jun | MCN Am J Matern Child Nurs | pmid:8857402 |
Diculencu D et al. | [The postantibiotic effect of azithromycin on respiratory pathogens]. | 1996 Jul-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:9455450 |
Ehret JM et al. | A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin. | 1996 Jul-Aug | Sex Transm Dis | pmid:8836018 |
Lane G | Increased hypoprothrombinemic effect of warfarin possibly induced by azithromycin. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826581 |
Amsden GW | Erythromycin, clarithromycin, and azithromycin: are the differences real? | 1996 Jan-Feb | Clin Ther | pmid:8851453 |
Preac Mursic V et al. | Kill kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of Lyme borreliosis. | 1996 Jan-Feb | Infection | pmid:8852456 |
Baradaran-Dilmaghani R and Stanek G | In vitro susceptibility of thirty Borrelia strains from various sources against eight antimicrobial chemotherapeutics. | 1996 Jan-Feb | Infection | pmid:8852472 |
Strle F et al. | Azithromycin and doxycycline for treatment of Borrelia culture-positive erythema migrans. | 1996 Jan-Feb | Infection | pmid:8852473 |
Fontán PA et al. | Haemophilus influenzae type b exoproducts induce chemotaxis and macrolide antibiotic release by human polymorphonuclear leukocytes. | 1996 Jan-Feb | Chemotherapy | pmid:8751269 |
Brihmer C et al. | Efficacy and safety of azithromycin versus lymecyline in the treatment of genital chlamydial infections in women. | 1996 | Scand. J. Infect. Dis. | pmid:8953672 |
Van Bambeke F et al. | Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity. | 1996 | Eur. J. Pharmacol. | pmid:8957238 |
Montenez JP et al. | Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies. | 1996 | Eur. J. Pharmacol. | pmid:8957239 |
Prescott LM | Macrolides, azalides, and streptogrammins. | 1996 | J Int Assoc Physicians AIDS Care | pmid:11363516 |
Currier J | Progress report: prophylaxis and therapy for MAC. | 1996 | AIDS Clin Care | pmid:11363599 |
Kuzman I et al. | Azithromycin in the treatment of pneumonias caused by Chlamydia spp: a retrospective study. | 1996 | Int J Clin Pharmacol Res | pmid:9172008 |
Old drug approved for MAC prevention. | 1996 | AIDS Alert | pmid:11363659 | |
Torres G | MAC prophylaxis revisited. | 1996 | GMHC Treat Issues | pmid:11363706 |
Antivirals key to MAC prevention regimen. | 1996 | AIDS Alert | pmid:11363722 | |
Marco M | Opportunistic infections in Vancouver. | 1996 | GMHC Treat Issues | pmid:11363841 |
Azithromycin effective in preventing MAC. | 1996 | AIDS Alert | pmid:11363857 | |
Schouten JT and Whittemore S | Recent development in the treatment and prevention of disseminated Mycobacterium avium complex (MAC). | 1996 | STEP Perspect | pmid:11364267 |
Wittner M et al. | Atovaquone in the treatment of Babesia microti infections in hamsters. | 1996 | Am. J. Trop. Med. Hyg. | pmid:8780464 |
Apseloff G et al. | Severe neutropenia caused by recommended prophylactic doses of rifabutin. | 1996 | Lancet | pmid:8782773 |
ZaÄtseva EA et al. | [Comparative study of the antimicrobial activity of pefloxacin, ciprofloxacin, norfloxacin and azithromycin with respect to Strains of Yersinia pseudotuberculosis]. | 1996 | Antibiot. Khimioter. | pmid:8762820 |
Lode H et al. | Azithromycin--review of key chemical, pharmacokinetic and microbiological features. | 1996 | J. Antimicrob. Chemother. | pmid:8818841 |
Girard AE et al. | Correlation of increased azithromycin concentrations with phagocyte infiltration into sites of localized infection. | 1996 | J. Antimicrob. Chemother. | pmid:8818842 |
Girard D et al. | Influence of immunosuppression on the pharmacokinetics and pharmacodynamics of azithromycin in infected mouse tissues. | 1996 | J. Antimicrob. Chemother. | pmid:8818843 |
Foulds G et al. | The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension. | 1996 | J. Antimicrob. Chemother. | pmid:8818844 |
Vaudaux BP et al. | Concentrations of azithromycin in tonsilar and/or adenoid tissue from paediatric patients. | 1996 | J. Antimicrob. Chemother. | pmid:8818845 |
Pukander J and Rautianen M | Penetration of azithromycin into middle ear effusions in acute and secretory otitis media in children. | 1996 | J. Antimicrob. Chemother. | pmid:8818846 |
Worth S et al. | Quality control guidelines for amoxicillin, amoxicillin-clavulanate, azithromycin, piperacillin-tazobactam, roxithromycin, ticarcillin, ticarcillin-clavulanate, trovafloxacin (CP 99,219), U-100592, and U-100766 for various National Committee for Clinical Laboratory Standards susceptibility testing methods. Results from multicenter trials. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:9147914 |
Hultén K et al. | New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. | 1996 | Antimicrob. Agents Chemother. | pmid:9124830 |
Hicks P et al. | Azithromycin therapy for Cryptosporidium parvum infection in four children infected with human immunodeficiency virus. | 1996 | J. Pediatr. | pmid:8765631 |
Boran M et al. | Improvement in cyclosporine A associated gingival hyperplasia with azithromycin therapy. | 1996 | Transplant. Proc. | pmid:8769234 |
Luft BJ et al. | Azithromycin compared with amoxicillin in the treatment of erythema migrans. A double-blind, randomized, controlled trial. | 1996 | Ann. Intern. Med. | pmid:8610947 |
Ridgway GL | Azithromycin in sexually transmitted diseases. | 1996 | Int J STD AIDS | pmid:8652719 |
Young LS | Azithromycin in the management of opportunistic infections. | 1996 | Int J STD AIDS | pmid:8652721 |
Chang HR | The potential role of azithromycin in the treatment of prophylaxis of toxoplasmosis. | 1996 | Int J STD AIDS | pmid:8652722 |
Waugh MA | Azithromycin in gonorrhoea. | 1996 | Int J STD AIDS | pmid:8652723 |
Young LS | Treatment and prophylaxis of Mycobacterium avium complex. | 1996 | Int J STD AIDS | pmid:8652724 |
Hoepelman IM | Human cryptosporidiosis. | 1996 | Int J STD AIDS | pmid:8652725 |
McCutchan JA | Azithromycin in the prophylaxis of opportunistic infections in AIDS. | 1996 | Int J STD AIDS | pmid:8652726 |
Ridgway GL | Azithromycin in the management of Chlamydia trachomatis infections. | 1996 | Int J STD AIDS | pmid:8652727 |
Furukawa S and Okada T | [A clinical evaluation of azithromycin in the treatment of pediatric infection]. | 1996 | Jpn J Antibiot | pmid:8988413 |
Ballard RC et al. | Treatment of chancroid with azithromycin. | 1996 | Int J STD AIDS | pmid:8652728 |
Okada T et al. | [Pharmacokinetic and clinical evaluations of azithromycin in the pediatric field]. | 1996 | Jpn J Antibiot | pmid:8988414 |
Ishida Y et al. | [Pharmacokinetic and clinical evaluation of azithromycin in pediatric infections]. | 1996 | Jpn J Antibiot | pmid:8988415 |
Ohtsuka Y et al. | [Pharmacokinetic and clinical studies on azithromycin in children]. | 1996 | Jpn J Antibiot | pmid:8988416 |
MashkilleÄson AL | [The treatment of early syphilis today]. | 1996 | Ter. Arkh. | pmid:9045378 |
Luke DR et al. | Safety, toleration, and pharmacokinetics of intravenous azithromycin. | 1996 | Antimicrob. Agents Chemother. | pmid:8913468 |
Olsen KM et al. | Intrapulmonary pharmacokinetics of azithromycin in healthy volunteers given five oral doses. | 1996 | Antimicrob. Agents Chemother. | pmid:8913469 |
Magid D et al. | Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis. | 1996 | Ann. Intern. Med. | pmid:8554247 |
Cammarota G et al. | Helicobacter pylori eradication using one-week low-dose lansoprazole plus amoxycillin and either clarithromycin or azithromycin. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971300 |
Pilotto A et al. | Cure of Helicobacter pylori infection in the elderly: effects of eradication on gastritis and serological markers. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971305 |
Andenaes K et al. | Preoperative bacterial colonization and its influence on postoperative wound infections in plastic surgery. | 1996 | J. Hosp. Infect. | pmid:8971618 |
Pozniak A and Nelson MR | Against the proposition: all patients with advanced HIV disease should be offered rifabutin prophylaxis. | 1996 | Genitourin Med | pmid:8976832 |
Schwartz RA et al. | Bacillary angiomatosis in an HIV seronegative patient on systemic steroid therapy. | 1996 | Br. J. Dermatol. | pmid:8977724 |
Griffith DE et al. | Azithromycin activity against Mycobacterium avium complex lung disease in patients who were not infected with human immunodeficiency virus. | 1996 | Clin. Infect. Dis. | pmid:8922790 |
Chulig I | [Pharmacokinetic profile of azithromycin. Role in the treatment of genital Chlamydia infections]. | 1996 | Antibiot. Khimioter. | pmid:8929112 |
Kuznetsova SM | ["Sumamed in the treatment of urogenital infections"]. | 1996 | Antibiot. Khimioter. | pmid:8929115 |
Skripkin IuK et al. | [The problem of diagnosis and treatment of urogenital chlamydiosis in Russia]. | 1996 | Antibiot. Khimioter. | pmid:8929120 |
Vasil'ev MM and Gazarian IIu | [Clinico-laboratory evaluation of the effectiveness of azithromycin in the treatment of patients with Chlamydia and mixed Chlamydia-gonorrhea infections]. | 1996 | Antibiot. Khimioter. | pmid:8929122 |
Schaad UB and Heynen G | Evaluation of the efficacy, safety and toleration of azithromycin vs. penicillin V in the treatment of acute streptococcal pharyngitis in children: results of a multicenter, open comparative study. The Swiss Tonsillopharyngitis Study Group. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878223 |
McLinn S and Williams D | Incidence of antibiotic-resistant Streptococcus pneumoniae and beta-lactamase-positive Haemophilus influenzae in clinical isolates from patients with otitis media. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878239 |
McCarty J | A multicenter, open label trial of azithromycin for the treatment of children with acute otitis media. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878240 |
Aronovitz G | A multicenter, open label trial of azithromycin vs. amoxicillin/ clavulanate for the management of acute otitis media in children. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878241 |
McLinn S | A multicenter, double blind comparison of azithromycin and amoxicillin/ clavulanate for the treatment of acute otitis media in children. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878242 |
Khurana CM | A multicenter, randomized, open label comparison of azithromycin and amoxicillin/clavulanate in acute otitis media among children attending day care or school. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878243 |
Powers JL | Properties of azithromycin that enhance the potential for compliance in children with upper respiratory tract infections. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878244 |
Wenisch C et al. | Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. | 1996 | Antimicrob. Agents Chemother. | pmid:8878577 |