Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Fetal Membranes, Premature Rupture D005322 4 associated lipids
Fatty Liver D005234 48 associated lipids
Eyelid Diseases D005141 4 associated lipids
Eye Diseases D005128 12 associated lipids
Exanthema D005076 11 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Erythema Nodosum D004893 5 associated lipids
Epiglottitis D004826 1 associated lipids
Enteritis D004751 8 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Elephantiasis, Filarial D004605 4 associated lipids
Elephantiasis D004604 2 associated lipids
Eisenmenger Complex D004541 1 associated lipids
Edema D004487 152 associated lipids
Ectodermal Dysplasia D004476 1 associated lipids
Dyspnea D004417 10 associated lipids
Dysentery, Bacillary D004405 6 associated lipids
Dry Socket D004368 3 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Dog Diseases D004283 5 associated lipids
Digestive System Diseases D004066 3 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Drug Eruptions D003875 30 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cryptosporidiosis D003457 3 associated lipids
Cross Infection D003428 9 associated lipids
Crohn Disease D003424 12 associated lipids
Corynebacterium Infections D003354 7 associated lipids
Coronary Disease D003327 70 associated lipids
Corneal Opacity D003318 3 associated lipids
Conjunctivitis, Inclusion D003235 4 associated lipids
Conjunctivitis, Bacterial D003234 3 associated lipids
Colitis D003092 69 associated lipids
Ciliary Motility Disorders D002925 2 associated lipids
Chronic Disease D002908 7 associated lipids
Chlamydiaceae Infections D002694 2 associated lipids
Chlamydia Infections D002690 7 associated lipids
Chancroid D002602 4 associated lipids
Uterine Cervicitis D002575 3 associated lipids
Cat-Scratch Disease D002372 4 associated lipids
Cat Diseases D002371 12 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Burns D002056 34 associated lipids
Bronchiolitis Obliterans D001989 8 associated lipids
Bronchiolitis D001988 6 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Body Weight D001835 333 associated lipids
Blister D001768 16 associated lipids
Bites, Human D001734 2 associated lipids
Birth Weight D001724 23 associated lipids
Bartonella Infections D001474 3 associated lipids
Bacterial Infections D001424 21 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Arthritis D001168 41 associated lipids
Arteriosclerosis D001161 86 associated lipids
Aphasia, Broca D001039 1 associated lipids
Angina, Unstable D000789 14 associated lipids
Anaplasmataceae Infections D000711 3 associated lipids
Anaphylaxis D000707 35 associated lipids
Amebiasis D000562 2 associated lipids
Airway Obstruction D000402 13 associated lipids
Agammaglobulinemia D000361 4 associated lipids
Actinomycetales Infections D000193 4 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acinetobacter Infections D000151 4 associated lipids
Achondroplasia D000130 1 associated lipids
Abscess D000038 13 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Kazura JW Yaws eradication--a goal finally within reach. 2015 N. Engl. J. Med. pmid:25693007
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Kerani RP et al. Gonorrhea treatment practices in the STD Surveillance Network, 2010-2012. 2015 Sex Transm Dis pmid:25504294
Yadav S et al. Orofacial granulomatosis responding to weekly azithromycin pulse therapy. 2015 JAMA Dermatol pmid:25494221
Beigelman A et al. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. 2015 J. Allergy Clin. Immunol. pmid:25458910
Kirkcaldy RD et al. Analysis of Neisseria gonorrhoeae azithromycin susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013. 2015 Antimicrob. Agents Chemother. pmid:25451056
Lahra MM and Enriquez RP Australian Gonococcal Surveillance Programme, 1 April to 30 June 2015. 2015 Commun Dis Intell Q Rep pmid:26779739
Yan M et al. Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. 2015 Eur J Med Chem pmid:26402728
García-Quintanilla M et al. Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii. 2015 Int. J. Antimicrob. Agents pmid:26391380
Muralidharan V and Striepen B Teaching old drugs new tricks to stop malaria invasion in its tracks. 2015 BMC Biol. pmid:26349580
Phoon YW et al. Isolation of multidrug-resistant Salmonella in Singapore. 2015 Singapore Med J pmid:26311915
Unemo M Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. 2015 BMC Infect. Dis. pmid:26293005
Arnež M and Ružić-Sabljić E Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans. 2015 Pediatr. Infect. Dis. J. pmid:26186104
Pérez-Doñate V et al. [Is azithromycin really a therapeutic option in intestinal salmonellosis?]. 2015 An Pediatr (Barc) pmid:26006271
Teo A et al. Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission. 2015 Malar. J. pmid:26006260
Chazan B et al. Susceptibility of Group A Streptococcus to Antimicrobial Agents in Northern Israel: A Surveillance Study. 2015 Microb. Drug Resist. pmid:26430943
Brusselle GG Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? 2015 Thorax pmid:25870311
Gose SO et al. Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California. 2015 Sex Transm Dis pmid:25868141
He X et al. Synergistic combination of marine oligosaccharides and azithromycin against Pseudomonas aeruginosa. 2014 Sep-Oct Microbiol. Res. pmid:24529598
Rai S Azithromycin zone interpretation for Salmonella: time to adopt BSAC's zone diameters? 2014 Oct-Dec Indian J Med Microbiol pmid:25297045
Toledo Junior A et al. Poor response to azithromycin in cutaneous leishmaniasis leading to a premature interruption of a multicentric phase III clinical trial in Brazil. 2014 Nov-Dec Rev. Soc. Bras. Med. Trop. pmid:25626655
Rajaii RM et al. Acute generalized exanthematous pustulosis reported due to loxosceles envenomation may be secondary to azithromycin therapy. 2014 May-Jun Mo Med pmid:25011333
Mueller M Dr. Mueller and fellow authors reply. 2014 May-Jun Mo Med pmid:25011334
Rao GA et al. Azithromycin and levofloxacin use and increased risk of cardiac arrhythmia and death. 2014 Mar-Apr Ann Fam Med pmid:24615307
Mori F et al. Azithromycin anaphylaxis in children. 2014 Jan-Mar Int J Immunopathol Pharmacol pmid:24674687
Pandhi D et al. The efficacy of azithromycin in pityriasis rosea: a randomized, double-blind, placebo-controlled trial. 2014 Jan-Feb Indian J Dermatol Venereol Leprol pmid:24448121
Lis G et al. Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure. 2014 Jan-Feb J Bras Pneumol pmid:24626275
Lahra MM Australian gonococcal surveillance programme, 1 April to 30 June 2014. 2014 Commun Dis Intell Q Rep pmid:25631604
Dumke R et al. Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia. 2014 Int. J. Infect. Dis. pmid:25449256
Sagara I et al. Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults. 2014 Malar. J. pmid:25425434
van Bijnen EM et al. Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureus in the community. 2014 BMC Fam Pract pmid:25413920
Cole MJ et al. Emerging cephalosporin and multidrug-resistant gonorrhoea in Europe. 2014 Euro Surveill. pmid:25411689
Khoshnood A et al. Replacement of clarithromycin with azithromycin in triple therapy regimens for the eradication of Helicobacter pylori: A randomized clinical trial. 2014 J Med Life pmid:25408735
Burr SE et al. Anthropometric indices of Gambian children after one or three annual rounds of mass drug administration with azithromycin for trachoma control. 2014 BMC Public Health pmid:25407464
Glanville AR CLAD: does the Emperor have new clothes? 2014 Am. J. Transplant. pmid:25394597
Vos R et al. Azithromycin and the treatment of lymphocytic airway inflammation after lung transplantation. 2014 Am. J. Transplant. pmid:25394537
Nambudiri VE More than skin deep--the costs of antibiotic overuse: a teachable moment. 2014 JAMA Intern Med pmid:25178174
Filist M et al. Simplified LC-MS/MS method enabling the determination of azithromycin in human plasma after a low 100mg dose administration. 2014 J Pharm Biomed Anal pmid:25168217
Schuhfried G et al. Gilles de la Tourette Syndrome caused by Mycoplasma pneumoniae successfully treated with macrolides. 2014 Klin Padiatr pmid:25153913
de Barsy M et al. Antibiotic susceptibility of Estrella lausannensis, a potential emerging pathogen. 2014 Microbes Infect. pmid:25150688
Sundaramurthi P and Suryanarayanan R Azithromycin hydrates-implications of processing-induced phase transformations. 2014 J Pharm Sci pmid:25139082
Rams TE et al. Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates. 2014 J. Periodontol. pmid:25102269
Kavanagh KT How I was prescribed an unnecessary antibiotic while traveling to a conference on antibiotic resistance. 2014 JAMA Intern Med pmid:25089657
Lourdesamy Anthony AI and Muthukumaru U Efficacy of azithromycin in the treatment of bronchiectasis. 2014 Respirology pmid:25183304
Caceres SM et al. Enhanced in vitro formation and antibiotic resistance of nonattached Pseudomonas aeruginosa aggregates through incorporation of neutrophil products. 2014 Antimicrob. Agents Chemother. pmid:25182651
Tsai MS et al. Jarisch-Herxheimer reaction among HIV-positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy. 2014 J Int AIDS Soc pmid:25174641
Edwards T et al. Non-participation during azithromycin mass treatment for trachoma in The Gambia: heterogeneity and risk factors. 2014 PLoS Negl Trop Dis pmid:25165994
Pierson RC et al. A retrospective comparison of antibiotic regimens for preterm premature rupture of membranes. 2014 Obstet Gynecol pmid:25162251
Kemp MW et al. Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy. 2014 Antimicrob. Agents Chemother. pmid:25155606
Zheng S et al. Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects. 2014 Antimicrob. Agents Chemother. pmid:25155592
Simpson JL et al. The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial. 2014 PLoS ONE pmid:25148049
Oztürk K et al. Diagnosis of helicobacter pylori infection. 2014 Turk J Gastroenterol pmid:25141328
Ray WA Azithromycin associated with a reduction in 90-day mortality among older pneumonia patients, although a true clinical benefit is uncertain. 2014 Evid Based Med pmid:25121563
He S et al. [Clinical analysis of scrub typhus-associated hemophagocytic syndrome]. 2014 Zhonghua Er Ke Za Zhi pmid:25476431
Pocock JM et al. Septic arthritis of the hip in a Cambodian child caused by multidrug-resistant Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin treated with ceftriaxone and azithromycin. 2014 Paediatr Int Child Health pmid:24749773
Uzun S et al. Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): a randomised, double-blind, placebo-controlled trial. 2014 Lancet Respir Med pmid:24746000
Wong C and Herath S Azithromycin for patients with frequent COPD exacerbations. 2014 Lancet Respir Med pmid:24745999
Rodgers S et al. Challenges in implementing the new BASHH guidelines for the management of gonorrhoea. 2014 Int J STD AIDS pmid:23970641
Kong FY et al. Azithromycin versus doxycycline for the treatment of genital chlamydia infection: a meta-analysis of randomized controlled trials. 2014 Clin. Infect. Dis. pmid:24729507
Lechtenberg RJ et al. Variation in adherence to the treatment guidelines for Neisseria gonorrhoeae by clinical practice setting, California, 2009 to 2011. 2014 Sex Transm Dis pmid:24722391
McColley SA Practice guidelines, clinical trials, and unexpected results in cystic fibrosis. 2014 Ann Am Thorac Soc pmid:24673695
Kawamura K et al. Efficacy of azithromycin for treatment of acute exacerbation of chronic fibrosing interstitial pneumonia: a prospective, open-label study with historical controls. 2014 Respiration pmid:24802885
Geisler WM et al. Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women. 2014 Antimicrob. Agents Chemother. pmid:24798277
Assani K et al. IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. 2014 PLoS ONE pmid:24798083
Chu DJ et al. Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer. 2014 Genet. Mol. Res. pmid:24782093
Mukherjee P et al. Emergence of high-level azithromycin resistance in Campylobacter jejuni isolates from pediatric diarrhea patients in Kolkata, India. 2014 Antimicrob. Agents Chemother. pmid:24777098
Goodhew EB et al. Longitudinal analysis of antibody responses to trachoma antigens before and after mass drug administration. 2014 BMC Infect. Dis. pmid:24755001
Zasowski E et al. Relationship between time to clinical response and outcomes among Pneumonia Outcomes Research Team (PORT) risk class III and IV hospitalized patients with community-acquired pneumonia who received ceftriaxone and azithromycin. 2014 Antimicrob. Agents Chemother. pmid:24752270
Wong MH et al. Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin. 2014 Antimicrob. Agents Chemother. pmid:24752251
Gaudreau C et al. Shigella spp. with reduced azithromycin susceptibility, Quebec, Canada, 2012-2013. 2014 Emerging Infect. Dis. pmid:24750584
Gaubert A et al. Preliminary pharmaceutical development of antimalarial-antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas. 2014 Int J Pharm pmid:24726300
Milić A et al. A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents. 2014 Eur J Drug Metab Pharmacokinet pmid:24114177
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Anstead M et al. Pulmonary exacerbations in CF patients with early lung disease. 2014 J. Cyst. Fibros. pmid:24029220
Cory TJ et al. Impact of azithromycin treatment on macrophage gene expression in subjects with cystic fibrosis. 2014 J. Cyst. Fibros. pmid:24018177
Liu YL et al. Pediatric round pneumonia. 2014 Pediatr Neonatol pmid:23597522
Abera B and Kibret M Azithromycin, fluoroquinolone and chloramphenicol resistance of non-chlamydia conjunctival bacteria in rural community of Ethiopia. 2014 Indian J Ophthalmol pmid:23571246
Yangco BG et al. Is primary mycobacterium avium complex prophylaxis necessary in patients with CD4 <50 cells/μL who are virologically suppressed on cART? 2014 AIDS Patient Care STDS pmid:24833016
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Panduranga V and Kumar A Severe babesiosis presenting as acute respiratory distress syndrome in an immunocompetent patient. 2014 Conn Med pmid:24974563
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Oud EV et al. Pitfalls in the diagnosis and management of inguinal lymphogranuloma venereum: important lessons from a case series. 2014 Sex Transm Infect pmid:24787368
Noguchi S et al. [Efficacy and safety of azithromycin infusion in patients with mild or moderate community-acquired pneumonia]. 2014 Jpn J Antibiot pmid:25163252
Boleda MR et al. Survey of the occurrence of pharmaceuticals in Spanish finished drinking waters. 2014 Environ Sci Pollut Res Int pmid:24756682
De Groote MA et al. GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus. 2014 J. Antimicrob. Chemother. pmid:24222613
Heriot WJ et al. Ocular involvement in a patient with Legionella longbeachae 1 infection. 2014 Clin. Experiment. Ophthalmol. pmid:24650007
Thakur R et al. Development and optimization of controlled release bioerodable anti infective ophthalmic insert. 2014 Curr Drug Deliv pmid:22283654
Verleden GM et al. A new classification system for chronic lung allograft dysfunction. 2014 J. Heart Lung Transplant. pmid:24374027
Liu Y et al. Effect of azithromycin on lipid accumulation in immortalized human meibomian gland epithelial cells. 2014 JAMA Ophthalmol pmid:24357250
Horner P et al. Time to manage Mycoplasma genitalium as an STI: but not with azithromycin 1 g! 2014 Curr. Opin. Infect. Dis. pmid:24322592
Yamashita H et al. [Questionnaire survey on medical care for male urethritis in community clinics in Shiga prefecture]. 2014 Hinyokika Kiyo pmid:24594766
Diezi L et al. [Pharmacovigilance update]. 2014 Rev Med Suisse pmid:24558915
Kaiser C A coughing spell. 2014 JEMS pmid:24724329
Khosropour CM et al. Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: a prospective cohort study. 2014 Sex Transm Infect pmid:24106340
Jang MO et al. Outcome of intravenous azithromycin therapy in patients with complicated scrub typhus compared with that of doxycycline therapy using propensity-matched analysis. 2014 Antimicrob. Agents Chemother. pmid:24366734
Han MK et al. Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. 2014 Am. J. Respir. Crit. Care Med. pmid:24779680
Khosropour CM et al. Lack of association between azithromycin and death from cardiovascular causes. 2014 N. Engl. J. Med. pmid:24827057