Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kazura JW | Yaws eradication--a goal finally within reach. | 2015 | N. Engl. J. Med. | pmid:25693007 |
Eberly MD et al. | Azithromycin in early infancy and pyloric stenosis. | 2015 | Pediatrics | pmid:25687145 |
Bissessor M et al. | Macrolide resistance and azithromycin failure in a Mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens. | 2015 | Clin. Infect. Dis. | pmid:25537875 |
Kerani RP et al. | Gonorrhea treatment practices in the STD Surveillance Network, 2010-2012. | 2015 | Sex Transm Dis | pmid:25504294 |
Yadav S et al. | Orofacial granulomatosis responding to weekly azithromycin pulse therapy. | 2015 | JAMA Dermatol | pmid:25494221 |
Beigelman A et al. | Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. | 2015 | J. Allergy Clin. Immunol. | pmid:25458910 |
Kirkcaldy RD et al. | Analysis of Neisseria gonorrhoeae azithromycin susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013. | 2015 | Antimicrob. Agents Chemother. | pmid:25451056 |
Lahra MM and Enriquez RP | Australian Gonococcal Surveillance Programme, 1 April to 30 June 2015. | 2015 | Commun Dis Intell Q Rep | pmid:26779739 |
Yan M et al. | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. | 2015 | Eur J Med Chem | pmid:26402728 |
GarcÃa-Quintanilla M et al. | Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii. | 2015 | Int. J. Antimicrob. Agents | pmid:26391380 |
Muralidharan V and Striepen B | Teaching old drugs new tricks to stop malaria invasion in its tracks. | 2015 | BMC Biol. | pmid:26349580 |
Phoon YW et al. | Isolation of multidrug-resistant Salmonella in Singapore. | 2015 | Singapore Med J | pmid:26311915 |
Unemo M | Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. | 2015 | BMC Infect. Dis. | pmid:26293005 |
Arnež M and Ružić-Sabljić E | Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans. | 2015 | Pediatr. Infect. Dis. J. | pmid:26186104 |
Pérez-Doñate V et al. | [Is azithromycin really a therapeutic option in intestinal salmonellosis?]. | 2015 | An Pediatr (Barc) | pmid:26006271 |
Teo A et al. | Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission. | 2015 | Malar. J. | pmid:26006260 |
Chazan B et al. | Susceptibility of Group A Streptococcus to Antimicrobial Agents in Northern Israel: A Surveillance Study. | 2015 | Microb. Drug Resist. | pmid:26430943 |
Brusselle GG | Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? | 2015 | Thorax | pmid:25870311 |
Gose SO et al. | Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California. | 2015 | Sex Transm Dis | pmid:25868141 |
He X et al. | Synergistic combination of marine oligosaccharides and azithromycin against Pseudomonas aeruginosa. | 2014 Sep-Oct | Microbiol. Res. | pmid:24529598 |
Rai S | Azithromycin zone interpretation for Salmonella: time to adopt BSAC's zone diameters? | 2014 Oct-Dec | Indian J Med Microbiol | pmid:25297045 |
Toledo Junior A et al. | Poor response to azithromycin in cutaneous leishmaniasis leading to a premature interruption of a multicentric phase III clinical trial in Brazil. | 2014 Nov-Dec | Rev. Soc. Bras. Med. Trop. | pmid:25626655 |
Rajaii RM et al. | Acute generalized exanthematous pustulosis reported due to loxosceles envenomation may be secondary to azithromycin therapy. | 2014 May-Jun | Mo Med | pmid:25011333 |
Mueller M | Dr. Mueller and fellow authors reply. | 2014 May-Jun | Mo Med | pmid:25011334 |
Rao GA et al. | Azithromycin and levofloxacin use and increased risk of cardiac arrhythmia and death. | 2014 Mar-Apr | Ann Fam Med | pmid:24615307 |
Mori F et al. | Azithromycin anaphylaxis in children. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674687 |
Pandhi D et al. | The efficacy of azithromycin in pityriasis rosea: a randomized, double-blind, placebo-controlled trial. | 2014 Jan-Feb | Indian J Dermatol Venereol Leprol | pmid:24448121 |
Lis G et al. | Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure. | 2014 Jan-Feb | J Bras Pneumol | pmid:24626275 |
Lahra MM | Australian gonococcal surveillance programme, 1 April to 30 June 2014. | 2014 | Commun Dis Intell Q Rep | pmid:25631604 |
Dumke R et al. | Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia. | 2014 | Int. J. Infect. Dis. | pmid:25449256 |
Sagara I et al. | Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults. | 2014 | Malar. J. | pmid:25425434 |
van Bijnen EM et al. | Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureus in the community. | 2014 | BMC Fam Pract | pmid:25413920 |
Cole MJ et al. | Emerging cephalosporin and multidrug-resistant gonorrhoea in Europe. | 2014 | Euro Surveill. | pmid:25411689 |
Khoshnood A et al. | Replacement of clarithromycin with azithromycin in triple therapy regimens for the eradication of Helicobacter pylori: A randomized clinical trial. | 2014 | J Med Life | pmid:25408735 |
Burr SE et al. | Anthropometric indices of Gambian children after one or three annual rounds of mass drug administration with azithromycin for trachoma control. | 2014 | BMC Public Health | pmid:25407464 |
Glanville AR | CLAD: does the Emperor have new clothes? | 2014 | Am. J. Transplant. | pmid:25394597 |
Vos R et al. | Azithromycin and the treatment of lymphocytic airway inflammation after lung transplantation. | 2014 | Am. J. Transplant. | pmid:25394537 |
Nambudiri VE | More than skin deep--the costs of antibiotic overuse: a teachable moment. | 2014 | JAMA Intern Med | pmid:25178174 |
Filist M et al. | Simplified LC-MS/MS method enabling the determination of azithromycin in human plasma after a low 100mg dose administration. | 2014 | J Pharm Biomed Anal | pmid:25168217 |
Schuhfried G et al. | Gilles de la Tourette Syndrome caused by Mycoplasma pneumoniae successfully treated with macrolides. | 2014 | Klin Padiatr | pmid:25153913 |
de Barsy M et al. | Antibiotic susceptibility of Estrella lausannensis, a potential emerging pathogen. | 2014 | Microbes Infect. | pmid:25150688 |
Sundaramurthi P and Suryanarayanan R | Azithromycin hydrates-implications of processing-induced phase transformations. | 2014 | J Pharm Sci | pmid:25139082 |
Rams TE et al. | Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates. | 2014 | J. Periodontol. | pmid:25102269 |
Kavanagh KT | How I was prescribed an unnecessary antibiotic while traveling to a conference on antibiotic resistance. | 2014 | JAMA Intern Med | pmid:25089657 |
Lourdesamy Anthony AI and Muthukumaru U | Efficacy of azithromycin in the treatment of bronchiectasis. | 2014 | Respirology | pmid:25183304 |
Caceres SM et al. | Enhanced in vitro formation and antibiotic resistance of nonattached Pseudomonas aeruginosa aggregates through incorporation of neutrophil products. | 2014 | Antimicrob. Agents Chemother. | pmid:25182651 |
Tsai MS et al. | Jarisch-Herxheimer reaction among HIV-positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy. | 2014 | J Int AIDS Soc | pmid:25174641 |
Edwards T et al. | Non-participation during azithromycin mass treatment for trachoma in The Gambia: heterogeneity and risk factors. | 2014 | PLoS Negl Trop Dis | pmid:25165994 |
Pierson RC et al. | A retrospective comparison of antibiotic regimens for preterm premature rupture of membranes. | 2014 | Obstet Gynecol | pmid:25162251 |
Kemp MW et al. | Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy. | 2014 | Antimicrob. Agents Chemother. | pmid:25155606 |
Zheng S et al. | Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects. | 2014 | Antimicrob. Agents Chemother. | pmid:25155592 |
Simpson JL et al. | The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial. | 2014 | PLoS ONE | pmid:25148049 |
Oztürk K et al. | Diagnosis of helicobacter pylori infection. | 2014 | Turk J Gastroenterol | pmid:25141328 |
Ray WA | Azithromycin associated with a reduction in 90-day mortality among older pneumonia patients, although a true clinical benefit is uncertain. | 2014 | Evid Based Med | pmid:25121563 |
He S et al. | [Clinical analysis of scrub typhus-associated hemophagocytic syndrome]. | 2014 | Zhonghua Er Ke Za Zhi | pmid:25476431 |
Pocock JM et al. | Septic arthritis of the hip in a Cambodian child caused by multidrug-resistant Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin treated with ceftriaxone and azithromycin. | 2014 | Paediatr Int Child Health | pmid:24749773 |
Uzun S et al. | Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): a randomised, double-blind, placebo-controlled trial. | 2014 | Lancet Respir Med | pmid:24746000 |
Wong C and Herath S | Azithromycin for patients with frequent COPD exacerbations. | 2014 | Lancet Respir Med | pmid:24745999 |
Rodgers S et al. | Challenges in implementing the new BASHH guidelines for the management of gonorrhoea. | 2014 | Int J STD AIDS | pmid:23970641 |
Kong FY et al. | Azithromycin versus doxycycline for the treatment of genital chlamydia infection: a meta-analysis of randomized controlled trials. | 2014 | Clin. Infect. Dis. | pmid:24729507 |
Lechtenberg RJ et al. | Variation in adherence to the treatment guidelines for Neisseria gonorrhoeae by clinical practice setting, California, 2009 to 2011. | 2014 | Sex Transm Dis | pmid:24722391 |
McColley SA | Practice guidelines, clinical trials, and unexpected results in cystic fibrosis. | 2014 | Ann Am Thorac Soc | pmid:24673695 |
Kawamura K et al. | Efficacy of azithromycin for treatment of acute exacerbation of chronic fibrosing interstitial pneumonia: a prospective, open-label study with historical controls. | 2014 | Respiration | pmid:24802885 |
Geisler WM et al. | Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women. | 2014 | Antimicrob. Agents Chemother. | pmid:24798277 |
Assani K et al. | IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. | 2014 | PLoS ONE | pmid:24798083 |
Chu DJ et al. | Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer. | 2014 | Genet. Mol. Res. | pmid:24782093 |
Mukherjee P et al. | Emergence of high-level azithromycin resistance in Campylobacter jejuni isolates from pediatric diarrhea patients in Kolkata, India. | 2014 | Antimicrob. Agents Chemother. | pmid:24777098 |
Goodhew EB et al. | Longitudinal analysis of antibody responses to trachoma antigens before and after mass drug administration. | 2014 | BMC Infect. Dis. | pmid:24755001 |
Zasowski E et al. | Relationship between time to clinical response and outcomes among Pneumonia Outcomes Research Team (PORT) risk class III and IV hospitalized patients with community-acquired pneumonia who received ceftriaxone and azithromycin. | 2014 | Antimicrob. Agents Chemother. | pmid:24752270 |
Wong MH et al. | Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin. | 2014 | Antimicrob. Agents Chemother. | pmid:24752251 |
Gaudreau C et al. | Shigella spp. with reduced azithromycin susceptibility, Quebec, Canada, 2012-2013. | 2014 | Emerging Infect. Dis. | pmid:24750584 |
Gaubert A et al. | Preliminary pharmaceutical development of antimalarial-antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas. | 2014 | Int J Pharm | pmid:24726300 |
Milić A et al. | A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24114177 |
Belibasakis GN and Thurnheer T | Validation of antibiotic efficacy on in vitro subgingival biofilms. | 2014 | J. Periodontol. | pmid:23659420 |
Luo Z et al. | Effects of prednisolone on refractory mycoplasma pneumoniae pneumonia in children. | 2014 | Pediatr. Pulmonol. | pmid:23401275 |
Anstead M et al. | Pulmonary exacerbations in CF patients with early lung disease. | 2014 | J. Cyst. Fibros. | pmid:24029220 |
Cory TJ et al. | Impact of azithromycin treatment on macrophage gene expression in subjects with cystic fibrosis. | 2014 | J. Cyst. Fibros. | pmid:24018177 |
Liu YL et al. | Pediatric round pneumonia. | 2014 | Pediatr Neonatol | pmid:23597522 |
Abera B and Kibret M | Azithromycin, fluoroquinolone and chloramphenicol resistance of non-chlamydia conjunctival bacteria in rural community of Ethiopia. | 2014 | Indian J Ophthalmol | pmid:23571246 |
Yangco BG et al. | Is primary mycobacterium avium complex prophylaxis necessary in patients with CD4 <50 cells/μL who are virologically suppressed on cART? | 2014 | AIDS Patient Care STDS | pmid:24833016 |
Murray S and Marshall L | Empiric NSU treatment needs updating. | 2014 | Sex Transm Infect | pmid:25028712 |
Serwin AB et al. | Gonorrhoea in 21st century--international and Polish situation. | 2014 | Przegl Epidemiol | pmid:25004630 |
Panduranga V and Kumar A | Severe babesiosis presenting as acute respiratory distress syndrome in an immunocompetent patient. | 2014 | Conn Med | pmid:24974563 |
Restrepo MI and Anzueto A | Macrolide antibiotics for prevention of chronic obstructive pulmonary disease exacerbations: are we there yet? | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24983214 |
Oud EV et al. | Pitfalls in the diagnosis and management of inguinal lymphogranuloma venereum: important lessons from a case series. | 2014 | Sex Transm Infect | pmid:24787368 |
Noguchi S et al. | [Efficacy and safety of azithromycin infusion in patients with mild or moderate community-acquired pneumonia]. | 2014 | Jpn J Antibiot | pmid:25163252 |
Boleda MR et al. | Survey of the occurrence of pharmaceuticals in Spanish finished drinking waters. | 2014 | Environ Sci Pollut Res Int | pmid:24756682 |
De Groote MA et al. | GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus. | 2014 | J. Antimicrob. Chemother. | pmid:24222613 |
Heriot WJ et al. | Ocular involvement in a patient with Legionella longbeachae 1 infection. | 2014 | Clin. Experiment. Ophthalmol. | pmid:24650007 |
Thakur R et al. | Development and optimization of controlled release bioerodable anti infective ophthalmic insert. | 2014 | Curr Drug Deliv | pmid:22283654 |
Verleden GM et al. | A new classification system for chronic lung allograft dysfunction. | 2014 | J. Heart Lung Transplant. | pmid:24374027 |
Liu Y et al. | Effect of azithromycin on lipid accumulation in immortalized human meibomian gland epithelial cells. | 2014 | JAMA Ophthalmol | pmid:24357250 |
Horner P et al. | Time to manage Mycoplasma genitalium as an STI: but not with azithromycin 1 g! | 2014 | Curr. Opin. Infect. Dis. | pmid:24322592 |
Yamashita H et al. | [Questionnaire survey on medical care for male urethritis in community clinics in Shiga prefecture]. | 2014 | Hinyokika Kiyo | pmid:24594766 |
Diezi L et al. | [Pharmacovigilance update]. | 2014 | Rev Med Suisse | pmid:24558915 |
Kaiser C | A coughing spell. | 2014 | JEMS | pmid:24724329 |
Khosropour CM et al. | Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: a prospective cohort study. | 2014 | Sex Transm Infect | pmid:24106340 |
Jang MO et al. | Outcome of intravenous azithromycin therapy in patients with complicated scrub typhus compared with that of doxycycline therapy using propensity-matched analysis. | 2014 | Antimicrob. Agents Chemother. | pmid:24366734 |
Han MK et al. | Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24779680 |
Khosropour CM et al. | Lack of association between azithromycin and death from cardiovascular causes. | 2014 | N. Engl. J. Med. | pmid:24827057 |