Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Sexually Transmitted Diseases, Bacterial D015231 5 associated lipids
Fever of Unknown Origin D005335 3 associated lipids
Conjunctivitis, Bacterial D003234 3 associated lipids
Psittacosis D009956 4 associated lipids
Conjunctivitis, Inclusion D003235 4 associated lipids
Typhus, Endemic Flea-Borne D014437 3 associated lipids
Urethral Diseases D014522 4 associated lipids
Chlamydiaceae Infections D002694 2 associated lipids
Lymphogranuloma Venereum D008219 4 associated lipids
Superinfection D015163 3 associated lipids
Otitis Media, Suppurative D010035 4 associated lipids
Serum Sickness D012713 7 associated lipids
Bites, Human D001734 2 associated lipids
Rickettsia Infections D012282 5 associated lipids
Pharyngeal Diseases D010608 4 associated lipids
Granuloma Inguinale D006100 2 associated lipids
Erythema Chronicum Migrans D015787 3 associated lipids
Elephantiasis, Filarial D004605 4 associated lipids
Hearing Loss, Conductive D006314 2 associated lipids
Granuloma, Pyogenic D017789 2 associated lipids
Bartonella Infections D001474 3 associated lipids
Ethmoid Sinusitis D015521 2 associated lipids
Otorhinolaryngologic Diseases D010038 3 associated lipids
Dry Socket D004368 3 associated lipids
Nasopharyngeal Diseases D009302 2 associated lipids
Furunculosis D005667 2 associated lipids
Elephantiasis D004604 2 associated lipids
Lymphangitis D008205 4 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Herpes Genitalis D006558 2 associated lipids
Pericoronitis D010497 2 associated lipids
Tuberculosis, Urogenital D014401 2 associated lipids
Moraxellaceae Infections D045828 3 associated lipids
Abdominal Abscess D018784 2 associated lipids
Pyloric Stenosis, Hypertrophic D046248 2 associated lipids
Hoarseness D006685 2 associated lipids
Scrub Typhus D012612 3 associated lipids
Tuberculosis, Avian D014379 2 associated lipids
Pneumocystis Infections D016720 1 associated lipids
Frontal Sinusitis D015522 1 associated lipids
Toxoplasmosis, Ocular D014126 2 associated lipids
Typhoid Fever D014435 2 associated lipids
Acquired Hyperostosis Syndrome D020083 1 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Syncope, Vasovagal D019462 1 associated lipids
Leishmaniasis, Mucocutaneous D007897 1 associated lipids
Trichiasis D058457 1 associated lipids
Paratyphoid Fever D010284 1 associated lipids
Ectodermal Dysplasia D004476 1 associated lipids
Tooth Erosion D014077 2 associated lipids
Epiglottitis D004826 1 associated lipids
Furcation Defects D017823 1 associated lipids
Pseudolymphoma D019310 1 associated lipids
Tenosynovitis D013717 3 associated lipids
Corneal Endothelial Cell Loss D055954 1 associated lipids
Asymptomatic Infections D058345 1 associated lipids
Aphasia, Broca D001039 1 associated lipids
Heartburn D006356 2 associated lipids
Eisenmenger Complex D004541 1 associated lipids
Focal Nodular Hyperplasia D020518 1 associated lipids
Splenic Diseases D013158 5 associated lipids
Trismus D014313 1 associated lipids
Male Urogenital Diseases D052801 1 associated lipids
Hyper-IgM Immunodeficiency Syndrome D053306 1 associated lipids
T-Lymphocytopenia, Idiopathic CD4-Positive D018344 1 associated lipids
Pyomyositis D052880 2 associated lipids
Myelitis, Transverse D009188 1 associated lipids
Hernia, Hiatal D006551 3 associated lipids
Achondroplasia D000130 1 associated lipids
Tracheobronchomalacia D055089 1 associated lipids
Reproductive Tract Infections D060737 1 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Protozoan Infections D011528 6 associated lipids
Tick Bites D064927 1 associated lipids
Granulomatous Mastitis D058890 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

Download all related citations
Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Bermudez LE et al. Stimulation with cytokines enhances penetration of azithromycin into human macrophages. 1991 Antimicrob. Agents Chemother. pmid:1667256
Moellering RC Introduction: revolutionary changes in the macrolide and azalide antibiotics. 1991 Am. J. Med. pmid:1656735
Hopkins S Clinical toleration and safety of azithromycin. 1991 Am. J. Med. pmid:1656742
Schentag JJ and Ballow CH Tissue-directed pharmacokinetics. 1991 Am. J. Med. pmid:1656743
Perronne C et al. Activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine compared with that of clarithromycin against multiplication of Mycobacterium avium complex within human macrophages. 1991 Antimicrob. Agents Chemother. pmid:1656860
Araujo FG and Remington JS Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis. 1991 Antimicrob. Agents Chemother. pmid:1656872
Davila D et al. Pharmacokinetics of azithromycin after single oral dosing of experimental animals. 1991 Biopharm Drug Dispos pmid:1657238
Taylor DE and Chang N In vitro susceptibilities of Campylobacter jejuni and Campylobacter coli to azithromycin and erythromycin. 1991 Antimicrob. Agents Chemother. pmid:1659309
Goldman RC et al. Role of protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria. 1990 Antimicrob. Agents Chemother. pmid:2159256
Gladue RP and Snider ME Intracellular accumulation of azithromycin by cultured human fibroblasts. 1990 Antimicrob. Agents Chemother. pmid:2168141
Capobianco JO and Goldman RC Erythromycin and azithromycin transport into Haemophilus influenzae ATCC 19418 under conditions of depressed proton motive force (delta mu H). 1990 Antimicrob. Agents Chemother. pmid:2178338
Gorby GL and McGee ZA Antimicrobial interference with bacterial mechanisms of pathogenicity: effect of sub-MIC azithromycin on gonococcal piliation and attachment to human epithelial cells. 1990 Antimicrob. Agents Chemother. pmid:1982402
Goldman RC and Capobianco JO Role of an energy-dependent efflux pump in plasmid pNE24-mediated resistance to 14- and 15-membered macrolides in Staphylococcus epidermidis. 1990 Antimicrob. Agents Chemother. pmid:1963291
Børsum T et al. Chlamydia trachomatis: in vitro susceptibility of genital and ocular isolates to some quinolones, amoxicillin and azithromycin. 1990 Chemotherapy pmid:1963393
Pascual A et al. Effect of azithromycin, roxithromycin and erythromycin on human polymorphonuclear leukocyte function against Staphylococcus aureus. 1990 Chemotherapy pmid:1963394
Ravdin JI and Skilogiannis J In vitro susceptibilities of Entamoeba histolytica to azithromycin, CP-63,956, erythromycin, and metronidazole. 1989 Antimicrob. Agents Chemother. pmid:2548442
Gladue RP et al. In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. 1989 Antimicrob. Agents Chemother. pmid:2543276
Bermudez LE and Young LS Activities of amikacin, roxithromycin, and azithromycin alone or in combination with tumor necrosis factor against Mycobacterium avium complex. 1988 Antimicrob. Agents Chemother. pmid:2847644
Araujo FG et al. Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii. 1988 Antimicrob. Agents Chemother. pmid:2840017
Yourassowsky E et al. Rate of bactericidal activity for Branhamella catarrhalis of a new macrolide, CP-62,993, compared with that of amoxicillin-clavulanic acid. 1988 Chemotherapy pmid:2843324