Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hayle R et al. | Efficacy and safety of azithromycin versus phenoxymethylpenicillin in the treatment of acute maxillary sinusitis. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8997555 |
Carlin EM and Barton SE | Azithromycin as a cost-effective treatment for nongonococcal urethritis in men. | 1997 | Sex Transm Dis | pmid:9018784 |
Berg-Candolfi M and Candolfi E | Depression of the N-demethylation of erythromycin, azithromycin, clarithromycin and clindamycin in murine Toxoplasma infection. | 1996 | Int. J. Parasitol. | pmid:9024879 |
Caselli M et al. | Short-term low-dose triple therapy with azithromycin, metronidazole and lansoprazole appears highly effective for the eradication of Helicobacter pylori. | 1997 | Eur J Gastroenterol Hepatol | pmid:9031898 |
Bedos JP and Veber B | [Lower respiratory infections: predictive factors of therapeutic response]. | 1996 | Rev Pneumol Clin | pmid:9033917 |
Zuck P | [Efficacy of a 5-day treatment with an azalide (azithromycin) in superinfections of chronic bronchitis]. | 1996 | Rev Pneumol Clin | pmid:9033919 |
Arévalo Morles C et al. | Donovanosis: treatment with azithromycin. | 1997 | Int J STD AIDS | pmid:9043983 |
Fuchs PC et al. | Effect of minor pH changes on the in-vitro activity of azithromycin and clarithromycin. | 1997 | J. Antimicrob. Chemother. | pmid:9044039 |
Tursi A et al. | What is the best azithromycin-based therapy for Helicobacter pylori infection? | 1997 | J. Antimicrob. Chemother. | pmid:9044040 |
MashkilleÄson AL | [The treatment of early syphilis today]. | 1996 | Ter. Arkh. | pmid:9045378 |
Mosby JA | Treating acute bronchitis with azithromycin. | 1997 | Am Fam Physician | pmid:9054218 |
Adhikari P et al. | Evaluation of safety and efficacy of azithromycin in lower respiratory tract infections (LRTI) | 1996 | Indian J Med Sci | pmid:9057364 |
Thylefors B | Trachoma--new opportunities to tackle an old problem. | 1996 | Br J Ophthalmol | pmid:9059262 |
Blanshard C et al. | Pilot studies of azithromycin, letrazuril and paromomycin in the treatment of cryptosporidiosis. | 1997 | Int J STD AIDS | pmid:9061412 |
Herrera-Insúa I et al. | Synergistic effect of azithromycin on the phagocytic killing of Staphylococcus aureus by human polymorphonuclear leukocytes. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9063667 |
Pascual A et al. | Azithromycin uptake by tissue cultured epithelial cells. | 1997 | J. Antimicrob. Chemother. | pmid:9069561 |
Handsfield HH et al. | Multicenter trial of single-dose azithromycin vs. ceftriaxone in the treatment of uncomplicated gonorrhea. Azithromycin Gonorrhea Study Group. | 1994 Mar-Apr | Sex Transm Dis | pmid:9071422 |
Tajima T et al. | [Pharmacokinetic, bacteriological and clinical studies on azithromycin in children]. | 1997 | Jpn J Antibiot | pmid:9100080 |
Kitamura K et al. | [Pharmacokinetic and clinical evaluation of azithromycin in the pediatric field]. | 1997 | Jpn J Antibiot | pmid:9100081 |
Fietta A et al. | Inhibition of intracellular growth of Staphylococcus aureus by exposure of infected human monocytes to clarithromycin and azithromycin. | 1997 | J Chemother | pmid:9106013 |
Fietta A et al. | Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. | 1997 | J Chemother | pmid:9106014 |
Ficnar B et al. | Azithromycin: 3-day versus 5-day course in the treatment of respiratory tract infections in children. Croatian Azithromycin Study Group. | 1997 | J Chemother | pmid:9106016 |
Klein JO | History of macrolide use in pediatrics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109154 |
McCracken GH | Microbiologic activity of the newer macrolide antibiotics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109155 |
Nightingale CH | Pharmacokinetics and pharmacodynamics of newer macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109156 |
Tarlow MJ | Macrolides in the management of streptococcal pharyngitis/tonsillitis. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109157 |
Block SL | Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109158 |
Tarlow MJ et al. | Future indications for macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109159 |
Dawson CR et al. | A comparison of oral azithromycin with topical oxytetracycline/polymyxin for the treatment of trachoma in children. | 1997 | Clin. Infect. Dis. | pmid:9114186 |
Kavukçu S et al. | Hypothermia from azithromycin. | 1997 | J. Toxicol. Clin. Toxicol. | pmid:9120898 |
Hultén K et al. | New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. | 1996 | Antimicrob. Agents Chemother. | pmid:9124830 |
Marchisio P et al. | Comparative study of once-weekly azithromycin and once-daily amoxicillin treatments in prevention of recurrent acute otitis media in children. | 1996 | Antimicrob. Agents Chemother. | pmid:9124831 |
Roord JJ et al. | Prospective open randomized study comparing efficacies and safeties of a 3-day course of azithromycin and a 10-day course of erythromycin in children with community-acquired acute lower respiratory tract infections. | 1996 | Antimicrob. Agents Chemother. | pmid:9124837 |
Jones RN and Biedenbach DJ | Antimicrobial activity of RU-66647, a new ketolide. | 1997 Jan-Feb | Diagn. Microbiol. Infect. Dis. | pmid:9127099 |
Khan WA et al. | Treatment of shigellosis: V. Comparison of azithromycin and ciprofloxacin. A double-blind, randomized, controlled trial. | 1997 | Ann. Intern. Med. | pmid:9139555 |
Brown BA et al. | Relationship of adverse events to serum drug levels in patients receiving high-dose azithromycin for mycobacterial lung disease. | 1997 | Clin. Infect. Dis. | pmid:9142801 |
Littlewood-Evans AJ et al. | Effect of combination therapy of rifampicin and azithromycin on TNF levels during a rat model of chronic osteomyelitis. | 1997 | J. Antimicrob. Chemother. | pmid:9145822 |
Worth S et al. | Quality control guidelines for amoxicillin, amoxicillin-clavulanate, azithromycin, piperacillin-tazobactam, roxithromycin, ticarcillin, ticarcillin-clavulanate, trovafloxacin (CP 99,219), U-100592, and U-100766 for various National Committee for Clinical Laboratory Standards susceptibility testing methods. Results from multicenter trials. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:9147914 |
Trotta M et al. | [Azithromycin combined with pyrimethamine in the treatment of neurotoxoplasmosis, in an AIDS patient]. | 1997 | Minerva Med. | pmid:9148227 |
Yasin RM et al. | Comparison of E-test with agar dilution methods in testing susceptibility of N. gonorrhoeae to azithromycin. | 1997 | Sex Transm Dis | pmid:9153733 |
Pacifico L and Chiesa C | Efficacy of three-day azithromycin vs. ten-day penicillin V in the treatment of streptococcal pharyngitis. | 1997 | Pediatr. Infect. Dis. J. | pmid:9154566 |
Fernandez-Obregon AC | Azithromycin for the treatment of acne. | 1997 | Int. J. Dermatol. | pmid:9159021 |
Nilius AM et al. | Variability in susceptibilities of Haemophilus influenzae to clarithromycin and azithromycin due to medium pH. | 1997 | J. Clin. Microbiol. | pmid:9163435 |
Kuzman I et al. | Azithromycin in the treatment of pneumonias caused by Chlamydia spp: a retrospective study. | 1996 | Int J Clin Pharmacol Res | pmid:9172008 |
Rodvold KA et al. | Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers. | 1997 | Antimicrob. Agents Chemother. | pmid:9174209 |
Young H et al. | Azithromycin and erythromycin resistant Neisseria gonorrhoeae following treatment with azithromycin. | 1997 | Int J STD AIDS | pmid:9175650 |
Hulten K et al. | In-vitro activity of azithromycin in against intracellular Helicobacter pylori. | 1996 | J. Antimicrob. Chemother. | pmid:9182105 |
Paul TR et al. | Delivery of azithromycin to Chlamydia trachomatis-infected polarized human endometrial epithelial cells by polymorphonuclear leucocytes. | 1997 | J. Antimicrob. Chemother. | pmid:9184362 |
Na-Bangchang K et al. | Activity of artemether-azithromycin versus artemether-doxycycline in the treatment of multiple drug resistant falciparum malaria. | 1996 | Southeast Asian J. Trop. Med. Public Health | pmid:9185262 |
Waites K et al. | In vitro activities of oral antimicrobial agents against penicillin-resistant Streptococcus pneumoniae: implications for outpatient treatment. | 1997 | South. Med. J. | pmid:9191739 |