Azithramycine
Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
Cross Reference
Introduction
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azithramycine?
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (156)
- Clin. Infect. Dis. (64)
- J. Antimicrob. Chemother. (50)
- Others (435)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azithramycine
PubChem Associated disorders and diseases
What pathways are associated with Azithramycine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azithramycine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (66)
- J. Antimicrob. Chemother. (25)
- Clin. Infect. Dis. (13)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Azithramycine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Azithramycine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Azithramycine?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (44)
- J. Antimicrob. Chemother. (18)
- Clin. Infect. Dis. (10)
- Others (126)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Azithramycine?
Mouse Model
Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Azithramycine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Anderson SL et al. | Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers. | 1995 | Ann. Intern. Med. | pmid:7574195 |
| Nuovo J et al. | Cost-effectiveness analysis of five different antibiotic regimens for the treatment of uncomplicated Chlamydia trachomatis cervicitis. | 1995 Jan-Feb | J Am Board Fam Pract | pmid:7701965 |
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| Amin NM and Breadon G | An open-label, noncomparative study to evaluate the efficacy, safety, and tolerability of azithromycin in the treatment of patients with acute sinusitis. | 1995 Jul-Aug | Clin Ther | pmid:8565033 |
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| Hulten K et al. | In-vitro activity of azithromycin in against intracellular Helicobacter pylori. | 1996 | J. Antimicrob. Chemother. | pmid:9182105 |
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| Girard D et al. | Influence of immunosuppression on the pharmacokinetics and pharmacodynamics of azithromycin in infected mouse tissues. | 1996 | J. Antimicrob. Chemother. | pmid:8818843 |
| Foulds G et al. | The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension. | 1996 | J. Antimicrob. Chemother. | pmid:8818844 |
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| Pukander J and Rautianen M | Penetration of azithromycin into middle ear effusions in acute and secretory otitis media in children. | 1996 | J. Antimicrob. Chemother. | pmid:8818846 |
| Rodriguez AF | An open study to compare azithromycin with cefaclor in the treatment of children with acute otitis media. | 1996 | J. Antimicrob. Chemother. | pmid:8818847 |
| O'Doherty B | An open comparative study of azithromycin versus cefaclor in the treatment of patients with upper respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818848 |
| Müller O | An open comparative study of azithromycin and roxithromycin in the treatment of acute upper respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818849 |
| Gris P | Once-daily, 3-day azithromycin versus a three-times-daily, 10-day course of co-amoxiclav in the treatment of adults with lower respiratory tract infections: results of a randomized, double-blind comparative study. | 1996 | J. Antimicrob. Chemother. | pmid:8818850 |
| Zachariah J | A randomized, comparative study to evaluate the efficacy and tolerability of a 3-day course of azithromycin versus a 10-day course of co-amoxiclav as treatment of adult patients with lower respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818851 |
| Laurent K | Efficacy, safety and tolerability of azithromycin versus roxithromycin in the treatment of acute lower respiratory tract infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818852 |
| Montero L | A comparative study of the efficacy, safety and tolerability of azithromycin and cefaclor in the treatment of children with acute skin and/or soft tissue infections. | 1996 | J. Antimicrob. Chemother. | pmid:8818853 |
| Nahata M | Drug interactions with azithromycin and the macrolides: an overview. | 1996 | J. Antimicrob. Chemother. | pmid:8818854 |
| Ednie LM et al. | Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. | 1996 | Antimicrob. Agents Chemother. | pmid:8843313 |
| Treadway G and Pontani D | Paediatric safety of azithromycin: worldwide experience. | 1996 | J. Antimicrob. Chemother. | pmid:8818855 |
| Carbon C et al. | Economic analysis of antibiotic regimens used in the treatment pharyngitis: a prospective comparison of azithromycin versus roxithromycin. | 1996 | J. Antimicrob. Chemother. | pmid:8818856 |
| Worth S et al. | Quality control guidelines for amoxicillin, amoxicillin-clavulanate, azithromycin, piperacillin-tazobactam, roxithromycin, ticarcillin, ticarcillin-clavulanate, trovafloxacin (CP 99,219), U-100592, and U-100766 for various National Committee for Clinical Laboratory Standards susceptibility testing methods. Results from multicenter trials. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:9147914 |
| Gerbaux C et al. | Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation. | 1996 | FEBS Lett. | pmid:8830663 |
| Hultén K et al. | New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. | 1996 | Antimicrob. Agents Chemother. | pmid:9124830 |
| Domingo S and Gamazo C | Inadequate azithromycin activity against Brucella melitensis in mice with acute or chronic infections. | 1996 | J Chemother | pmid:8835110 |
| Marchisio P et al. | Comparative study of once-weekly azithromycin and once-daily amoxicillin treatments in prevention of recurrent acute otitis media in children. | 1996 | Antimicrob. Agents Chemother. | pmid:9124831 |
| Conte JE et al. | Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects. | 1996 | Antimicrob. Agents Chemother. | pmid:8807050 |
| Xu G et al. | Effect of macrolide antibiotics on macrophage functions. | 1996 | Microbiol. Immunol. | pmid:8865152 |
| Meloni G and Meloni T | Azithromycin vs. doxycycline for Mediterranean spotted fever. | 1996 | Pediatr. Infect. Dis. J. | pmid:8933556 |
| Jackson MA et al. | Breakthrough sepsis in macrolide-resistant pneumococcal infection. | 1996 | Pediatr. Infect. Dis. J. | pmid:8933560 |
| Tateda K et al. | Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. | 1996 | Antimicrob. Agents Chemother. | pmid:8891128 |
| Hunt Gerardo S et al. | Comparison of Etest to broth microdilution method for testing Streptococcus pneumoniae susceptibility to levofloxacin and three macrolides. | 1996 | Antimicrob. Agents Chemother. | pmid:8891154 |
| Wintermeyer SM et al. | Dirithromycin: a new macrolide. | 1996 | Ann Pharmacother | pmid:8893122 |
| Akita H et al. | [Bacteriological, pharmacokinetic and clinical evaluation of azithromycin in the pediatric field]. | 1996 | Jpn J Antibiot | pmid:8986553 |
| Nishimura T et al. | [Clinical evaluation of azithromycin in pediatric infections]. | 1996 | Jpn J Antibiot | pmid:8986554 |
| Haruta T and Kobayashi Y | [Therapeutic efficacy of azithromycin in pediatrics]. | 1996 | Jpn J Antibiot | pmid:8986555 |
| Hoepelman IM | Human cryptosporidiosis. | 1996 | Int J STD AIDS | pmid:8652725 |
| McCutchan JA | Azithromycin in the prophylaxis of opportunistic infections in AIDS. | 1996 | Int J STD AIDS | pmid:8652726 |
| Ridgway GL | Azithromycin in the management of Chlamydia trachomatis infections. | 1996 | Int J STD AIDS | pmid:8652727 |
| Ballard RC et al. | Treatment of chancroid with azithromycin. | 1996 | Int J STD AIDS | pmid:8652728 |
| Bowden FJ et al. | Pilot study of azithromycin in the treatment of genital donovanosis. | 1996 | Genitourin Med | pmid:8655160 |
| Kohl PK et al. | Gonorrhoea: single-dose oral treatment. | 1996 | Curr. Probl. Dermatol. | pmid:8743257 |
| Nickel P and Näher H | Nongonococcal urethritis. | 1996 | Curr. Probl. Dermatol. | pmid:8743259 |
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| Murphy GS et al. | Ciprofloxacin- and azithromycin-resistant Campylobacter causing traveler's diarrhea in U.S. troops deployed to Thailand in 1994. | 1996 | Clin. Infect. Dis. | pmid:8722958 |
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| Olsen KM et al. | Intrapulmonary pharmacokinetics of azithromycin in healthy volunteers given five oral doses. | 1996 | Antimicrob. Agents Chemother. | pmid:8913469 |
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| Tursi A et al. | The use of azithromycin in short-term low-dose triple therapies for Helicobacter pylori infection. | 1996 | Am. J. Gastroenterol. | pmid:8677967 |
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| Pacifico L et al. | Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children. | 1996 | Antimicrob. Agents Chemother. | pmid:8849215 |
| Wilton LV et al. | A comparison of ciprofloxacin, norfloxacin, ofloxacin, azithromycin and cefixime examined by observational cohort studies. | 1996 | Br J Clin Pharmacol | pmid:8730972 |
| Jaruratanasirikul S et al. | Distribution of azithromycin into brain tissue, cerebrospinal fluid, and aqueous humor of the eye. | 1996 | Antimicrob. Agents Chemother. | pmid:8851625 |
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| Zuck P | [Efficacy of a 5-day treatment with an azalide (azithromycin) in superinfections of chronic bronchitis]. | 1996 | Rev Pneumol Clin | pmid:9033919 |
| Hayle R et al. | Efficacy and safety of azithromycin versus phenoxymethylpenicillin in the treatment of acute maxillary sinusitis. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8997555 |
| Magid D et al. | Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis. | 1996 | Ann. Intern. Med. | pmid:8554247 |
| Genç M and Mårdh A | A cost-effectiveness analysis of screening and treatment for Chlamydia trachomatis infection in asymptomatic women. | 1996 | Ann. Intern. Med. | pmid:7503471 |
| Roord JJ et al. | Prospective open randomized study comparing efficacies and safeties of a 3-day course of azithromycin and a 10-day course of erythromycin in children with community-acquired acute lower respiratory tract infections. | 1996 | Antimicrob. Agents Chemother. | pmid:9124837 |
| Aronovitz G | A multicenter, open label trial of azithromycin vs. amoxicillin/ clavulanate for the management of acute otitis media in children. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878241 |
| McLinn S | A multicenter, double blind comparison of azithromycin and amoxicillin/ clavulanate for the treatment of acute otitis media in children. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878242 |
| Cellesi C et al. | Susceptibility of macrolide and beta-lactam antibiotics of Streptococcus pyogenes strains isolated over a four-year period in central Italy. | 1996 | J Chemother | pmid:8808714 |
| Khurana CM | A multicenter, randomized, open label comparison of azithromycin and amoxicillin/clavulanate in acute otitis media among children attending day care or school. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878243 |
| Powers JL | Properties of azithromycin that enhance the potential for compliance in children with upper respiratory tract infections. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878244 |
| Wenisch C et al. | Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. | 1996 | Antimicrob. Agents Chemother. | pmid:8878577 |
| Yeates RA et al. | Interaction between midazolam and clarithromycin: comparison with azithromycin. | 1996 | Int J Clin Pharmacol Ther | pmid:8880291 |
| Dunn CJ and Barradell LB | Azithromycin. A review of its pharmacological properties and use as 3-day therapy in respiratory tract infections. | 1996 | Drugs | pmid:8882383 |
| Gnarpe J et al. | In vitro activities of azithromycin and doxycycline against 15 isolates of Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8843291 |
| Welsh L et al. | In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8787907 |
| Mehaffey PC et al. | Evaluation of in vitro spectra of activity of azithromycin, clarithromycin, and erythromycin tested against strains of Neisseria gonorrhoeae by reference agar dilution, disk diffusion, and Etest methods. | 1996 | J. Clin. Microbiol. | pmid:8789046 |
| Keysary A et al. | The in-vitro anti-rickettsial activity of macrolides. | 1996 | J. Antimicrob. Chemother. | pmid:8937968 |
| Mein J et al. | Donovanosis: sequelae of severe disease and successful azithromycin treatment. | 1996 | Int J STD AIDS | pmid:8940677 |
| Hoque S et al. | Rhodococcus equi in CAPD-associated peritonitis treated with azithromycin. | 1996 | Nephrol. Dial. Transplant. | pmid:8941608 |
| Wiselka MJ et al. | Response to oral and intravenous azithromycin in a patient with toxoplasma encephalitis and AIDS. | 1996 | J. Infect. | pmid:8945715 |
| Gómez E et al. | Interaction between azithromycin and cyclosporin? | 1996 | Nephron | pmid:8856287 |
| Delmée M et al. | In vitro susceptibilities of 180 clinical isolates of Haemophilus influenzae to ampicillin, amoxycillin/clavulanate, cefaclor, cefuroxime, cefotaxime, clarithromycin, and azithromycin. | 1996 | Acta Clin Belg | pmid:8858889 |
| Watt B et al. | Comparative activity of azithromycin against clinical isolates of mycobacteria. | 1996 | J. Antimicrob. Chemother. | pmid:8889727 |
| Patel KB et al. | Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. | 1996 | Antimicrob. Agents Chemother. | pmid:8891147 |