Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Cardiovascular Diseases D002318 24 associated lipids
Cat Diseases D002371 12 associated lipids
Cat-Scratch Disease D002372 4 associated lipids
Uterine Cervicitis D002575 3 associated lipids
Chancroid D002602 4 associated lipids
Chlamydia Infections D002690 7 associated lipids
Chlamydiaceae Infections D002694 2 associated lipids
Chronic Disease D002908 7 associated lipids
Ciliary Motility Disorders D002925 2 associated lipids
Colitis D003092 69 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Salimi A et al. Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. 2016 Xenobiotica pmid:26068526
Martande SS et al. Clinical and microbiological effects of systemic azithromycin in adjunct to nonsurgical periodontal therapy in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis: a randomized placebo-controlled clinical trial. 2016 J Investig Clin Dent pmid:25044531
Gong L et al. Clinical effect of treating secondary asthma attacks of children Mycoplasma pneumoniae with combined therapy of montelukast and azithromycin. 2016 Eur Rev Med Pharmacol Sci pmid:28051240
Alcaraz I et al. [Mycoplasma genitalium]. 2016 Ann Dermatol Venereol pmid:27773499
Lin SJ et al. Azithromycin modulates immune response of human monocyte-derived dendritic cells and CD4 T cells. 2016 Int. Immunopharmacol. pmid:27664570
Liu X et al. Novel antimicrobial peptide-modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus. 2016 Int J Nanomedicine pmid:28008253
van den Berg GF et al. Chlamydia screening and prophylactic treatment in termination of pregnancy clinics in the Netherlands and Great Britain: a qualitative study. 2016 Eur J Contracept Reprod Health Care pmid:27701927
Hirasawa K et al. Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. 2016 PLoS ONE pmid:27977675
EmiralioÄŸlu N et al. Long term azithromycin therapy in patients with cystic fibrosis. 2016 Turk. J. Pediatr. pmid:27922234
Mougari F et al. Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. 2016 Expert Rev Anti Infect Ther pmid:27690688
Johnston SL et al. Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial. 2016 JAMA Intern Med pmid:27653939
Zhao X et al. Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids. 2016 PLoS ONE pmid:27907030
Zeng J et al. Mechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa. 2016 Sci Rep pmid:27075730
Miyake H et al. Meibomian Gland Dysfunction Model in Hairless Mice Fed a Special Diet With Limited Lipid Content. 2016 Invest. Ophthalmol. Vis. Sci. pmid:27327582
Kobbernagel HE et al. Study protocol, rationale and recruitment in a European multi-centre randomized controlled trial to determine the efficacy and safety of azithromycin maintenance therapy for 6 months in primary ciliary dyskinesia. 2016 BMC Pulm Med pmid:27450411
Sacks HS In older adults, macrolide antibiotics were not linked to increased risk for ventricular arrhythmia. 2016 Ann. Intern. Med. pmid:27323264
Goh YS et al. Neutralizing Antibodies against Plasmodium falciparum Associated with Successful Cure after Drug Therapy. 2016 PLoS ONE pmid:27427762
Shah SA et al. Meibomian gland dysfunction: azithromycin and objective improvement in outcomes in posterior blepharitis. 2016 Clin. Experiment. Ophthalmol. pmid:27314917
Davido B et al. Why should 1 gram of ceftriaxone monotherapy be considered as a therapeutic option in gonococcal sexually transmitted diseases? 2016 Clin. Microbiol. Infect. pmid:27404364
Belkacem A et al. Molecular epidemiology and mechanisms of resistance of azithromycin-resistant Neisseria gonorrhoeae isolated in France during 2013-14. 2016 J. Antimicrob. Chemother. pmid:27301565
Malhotra S et al. Prevalence of Trachoma in Car-Nicobar Island, India after Three Annual Rounds of Mass Drug Administration with Azithromycin. 2016 PLoS ONE pmid:27391274
Marks M Yaws: towards the WHO eradication target. 2016 Trans. R. Soc. Trop. Med. Hyg. pmid:27268712
Liu B et al. Relationship between Community Drug Administration Strategy and Changes in Trachoma Prevalence, 2007 to 2013. 2016 PLoS Negl Trop Dis pmid:27385309
Long SS Optimizing antimicrobial therapy in children. 2016 J. Infect. pmid:27263076
Katanami Y et al. Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. 2016 Am. J. Trop. Med. Hyg. pmid:27352874
Mertens TC et al. Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells. 2016 Pulm Pharmacol Ther pmid:27246785
Das S et al. Revisit of fluoroquinolone and azithromycin susceptibility breakpoints for Salmonella enterica serovar Typhi. 2016 J. Med. Microbiol. pmid:27221661
Lahra MM and Enriquez RP Australian Gonococcal Surveillance Programme, 1 July to 30 September 2015. 2016 Commun Dis Intell Q Rep pmid:27080026
Ward E and Duff P A comparison of 3 antibiotic regimens for prevention of postcesarean endometritis: an historical cohort study. 2016 Am. J. Obstet. Gynecol. pmid:26901276
Yuan Z et al. Randomized controlled clinical trial on the efficacy of fosfomycin trometamol for uncomplicated gonococcal urethritis in men. 2016 Clin. Microbiol. Infect. pmid:27064136
Hathorn E et al. What is the most appropriate treatment for rectal Chlamydia trachomatis infection? 2016 Sex Transm Infect pmid:26892930
Farrell DJ et al. Results from the Solithromycin International Surveillance Program (2014). 2016 Antimicrob. Agents Chemother. pmid:27044551
Moore BR et al. Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women. 2016 Br J Clin Pharmacol pmid:26889763
Mathew JL et al. Oral Azithromycin for Acute Episodic Airway Symptoms in Young Children: Evidence-based Medicine Viewpoint. 2016 Indian Pediatr pmid:27029689
Pavlović D and Mutak S Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. 2016 Bioorg. Med. Chem. pmid:26860929
Roca A et al. Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial. 2016 Clin. Microbiol. Infect. pmid:27026482
Oey M and Malhotra P Azithromycin and ceftriaxone combination treatment for relapsed Salmonella Paratyphi A bacteraemia. 2016 J Travel Med pmid:26858276
Yang CJ et al. Comparison of serological responses to single-dose azithromycin (2 g) versus benzathine penicillin G in the treatment of early syphilis in HIV-infected patients in an area of low prevalence of macrolide-resistant Treponema pallidum infection. 2016 J. Antimicrob. Chemother. pmid:26604241
Chisholm SA et al. An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England. 2016 Sex Transm Infect pmid:26601852
Hood D et al. A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse. 2016 Dis Model Mech pmid:26611891
Liu H et al. [A systematic review of the therapy for Mycoplasma pneumoniae infections in children]. 2016 Zhonghua Er Ke Za Zhi pmid:26875461
Shunmugaperumal T and Kaur V In Vitro Anti-inflammatory and Antimicrobial Activities of Azithromycin After Loaded in Chitosan- and Tween 20-Based Oil-in-Water Macroemulsion for Acne Management. 2016 AAPS PharmSciTech pmid:26314246
Víchová B et al. First molecular identification of Babesia gibsoni in dogs from Slovakia, central Europe. 2016 Ticks Tick Borne Dis pmid:26304014
Bhargava A et al. Scrub typhus in Uttarakhand & adjoining Uttar Pradesh: Seasonality, clinical presentations & predictors of mortality. 2016 Indian J. Med. Res. pmid:28474627
Fegan D et al. Tropical leg ulcers in children: more than yaws. 2016 Trop Doct pmid:26289420
Dombrowski JC and Batteiger BE Reconsidering the Use of Azithromycin for Chlamydial Urethritis. 2016 Sex Transm Dis pmid:27626187
Yadav H et al. Azithromycin for the Treatment of Obliterative Bronchiolitis after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. 2016 Biol. Blood Marrow Transplant. pmid:27575542
Lemieux JE et al. A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse. 2016 Nat Microbiol pmid:27572973
Narayanasamy DK et al. Clinico - Laboratory Profile of Scrub Typhus - An Emerging Rickettsiosis in India. 2016 Indian J Pediatr pmid:27352842
Keenan JD et al. Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma. 2016 J Pediatric Infect Dis Soc pmid:27199475