Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Superinfection D015163 3 associated lipids
Pouchitis D019449 3 associated lipids
Conjunctivitis, Bacterial D003234 3 associated lipids
Digestive System Diseases D004066 3 associated lipids
Tendinopathy D052256 3 associated lipids
Retinal Hemorrhage D012166 3 associated lipids
Pemphigus D010392 3 associated lipids
Corneal Edema D015715 3 associated lipids
Cryptosporidiosis D003457 3 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Hernia, Hiatal D006551 3 associated lipids
Trichomonas Infections D014245 3 associated lipids
Genital Diseases, Male D005832 3 associated lipids
Uterine Cervicitis D002575 3 associated lipids
Mitral Valve Stenosis D008946 3 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Corneal Opacity D003318 3 associated lipids
Scrub Typhus D012612 3 associated lipids
Bartonella Infections D001474 3 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

Download all related citations
Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Uy HS et al. Infectious crystalline keratopathy and endophthalmitis secondary to Mycobacterium abscessus in a monocular patient with Stevens-Johnson syndrome. 1999 Am. J. Ophthalmol. pmid:10030567
Wolle MA et al. Impact of Trichiasis surgery on physical functioning in Ethiopian patients: STAR trial. 2011 Am. J. Ophthalmol. pmid:21333268
Fan LC et al. Macrolides protect against infection via inhibition of inflammasomes. 2017 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:28684545
Shinkai M et al. Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16085674
Blau H et al. Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2, JNK, and NF-kappaB activation in a cystic fibrosis epithelial cell line. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17012372
Tarran R et al. Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23542952
Kadova Z et al. IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats. 2015 Am. J. Physiol. Renal Physiol. pmid:25503728
Meyer M et al. Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19244203
Halldorsson S et al. Azithromycin maintains airway epithelial integrity during Pseudomonas aeruginosa infection. 2010 Am. J. Respir. Cell Mol. Biol. pmid:19372247
Bergamini G et al. Effects of azithromycin on glutathione S-transferases in cystic fibrosis airway cells. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19097986