Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ritchlin CT | Treatment of reactive arthritis with azithromycin. | 2005 | Curr Rheumatol Rep | pmid:15918991 |
Máiz Carro L | [Long-term treatment with azithromycin in a patient with idiopathic bronchiectasis]. | 2005 | Arch. Bronconeumol. | pmid:15919012 |
Drago L et al. | In vitro selection of resistance to clarithromycin in Streptococcus pneumoniae clinical isolates. | 2005 | J Chemother | pmid:15920900 |
Fellerhoff B et al. | High risk of schizophrenia and other mental disorders associated with chlamydial infections: hypothesis to combine drug treatment and adoptive immunotherapy. | 2005 | Med. Hypotheses | pmid:15922095 |
Jain SK et al. | Antimicrobial-resistant Shigella sonnei: limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility. | 2005 | Pediatr. Infect. Dis. J. | pmid:15933557 |
Hoberman A et al. | Large dosage amoxicillin/clavulanate, compared with azithromycin, for the treatment of bacterial acute otitis media in children. | 2005 | Pediatr. Infect. Dis. J. | pmid:15933563 |
Sriram S et al. | Pilot study to examine the effect of antibiotic therapy on MRI outcomes in RRMS. | 2005 | J. Neurol. Sci. | pmid:15935383 |
Koch DE et al. | Azithromycin extraction from municipal wastewater and quantitation using liquid chromatography/mass spectrometry. | 2005 | J Chromatogr A | pmid:15941034 |
Patton DL et al. | Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment. | 2005 | J. Infect. Dis. | pmid:15942902 |
Handrick W et al. | [Pulmonary infection due to Mycobacterium malmoense]. | 2005 | Pneumologie | pmid:15944898 |
Barlam TF | Expedited treatment for partners of patients with gonorrhea and/or chlamydial infection: impact on rates of persistence or recurrence. | 2005 | Postgrad Med | pmid:15948359 |
Wang JS et al. | [Preparation of lung targeting azithromycin liposomes and its tissue distribution in mice]. | 2005 | Yao Xue Xue Bao | pmid:15952603 |
Floret D et al. | [Action to be taken when facing one or more cases of whooping-cough]. | 2005 | Arch Pediatr | pmid:15961299 |
Parnham MJ et al. | Modulation of neutrophil and inflammation markers in chronic obstructive pulmonary disease by short-term azithromycin treatment. | 2005 | Eur. J. Pharmacol. | pmid:15964564 |
Krayenbuehl PA et al. | Effect of macrolides on peripheral arterial disease depends on patient selection and adequate treatment. | 2005 | Eur J Vasc Endovasc Surg | pmid:15967691 |
Yates B et al. | Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15976371 |
Prescott WA and Johnson CE | Antiinflammatory therapies for cystic fibrosis: past, present, and future. | 2005 | Pharmacotherapy | pmid:15977917 |
Eschenauer G et al. | Azithromycin-warfarin interaction: are we fishing with a red herring? | 2005 | Pharmacotherapy | pmid:15977924 |
Desmond N et al. | Acceptability of azithromycin for the control of trachoma in Northern Tanzania. | 2005 | Trans. R. Soc. Trop. Med. Hyg. | pmid:15979657 |
Göbel A et al. | Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment. | 2005 | Environ. Sci. Technol. | pmid:15984773 |
Jover F et al. | Possible azithromycin-associated hiccups. | 2005 | J Clin Pharm Ther | pmid:15985056 |
Spiro DM et al. | Antibiotic-induced mesenteric adenopathy in an intussusception mouse model: a randomized, controlled trial. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:15990628 |
Iacopini F et al. | One-week once-daily triple therapy with esomeprazole, levofloxacin and azithromycin compared to a standard therapy for Helicobacter pylori eradication. | 2005 | Dig Liver Dis | pmid:15996628 |
Girard D et al. | Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models. | 2005 | J. Antimicrob. Chemother. | pmid:16002421 |
Palmieri F et al. | Pulmonary cryptosporidiosis in an AIDS patient: successful treatment with paromomycin plus azithromycin. | 2005 | Int J STD AIDS | pmid:16004637 |
Dinwiddie R | Anti-inflammatory therapy in cystic fibrosis. | 2005 | J. Cyst. Fibros. | pmid:16005266 |
Spooner K et al. | Azithromcyin might not protect against Treponema pallidum infection or reactivation in HIV type 1-infected patients. | 2005 | Clin. Infect. Dis. | pmid:16007551 |
Baltussen RM et al. | Cost-effectiveness of trachoma control in seven world regions. | 2005 | Ophthalmic Epidemiol | pmid:16019692 |
Trent M et al. | Pelvic inflammatory disease in adolescents: care delivery in pediatric ambulatory settings. | 2005 | Pediatr Emerg Care | pmid:16027575 |
Sirakov M and Ivanov S | [Sumamed--efficacy and convenience]. | 2005 | Akush Ginekol (Sofiia) | pmid:16028403 |
Rennie RP and Ibrahim KH | Antimicrobial resistance in Haemophilus influenzae: how can we prevent the inevitable? Commentary on antimicrobial resistance in H. influenzae based on data from the TARGETed surveillance program. | 2005 | Clin. Infect. Dis. | pmid:16032558 |
West ES et al. | Surgery for Trichiasis, Antibiotics to prevent Recurrence (STAR) Clinical Trial methodology. | 2005 | Ophthalmic Epidemiol | pmid:16033749 |
Bliziotis I et al. | Regression of subcorneal pustular dermatosis type of IgA pemphigus lesions with azithromycin. | 2005 | J. Infect. | pmid:16038746 |
Saiman L et al. | Heterogeneity of treatment response to azithromycin in patients with cystic fibrosis. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16040785 |
van Oosterhout JJ et al. | A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV. | 2005 | J. Acquir. Immune Defic. Syndr. | pmid:16044018 |
Kuper H et al. | Participatory evaluations of trachoma control programmes in eight countries. | 2005 | Trop. Med. Int. Health | pmid:16045463 |
Matsui H et al. | Azithromycin inhibits the formation of flagellar filaments without suppressing flagellin synthesis in Salmonella enterica serovar typhimurium. | 2005 | Antimicrob. Agents Chemother. | pmid:16048953 |
Glasheen JJ et al. | The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. | 2005 | J Gen Intern Med | pmid:16050864 |
Mitchell WM and Stratton CW | Chlamydia pneumoniae and acute coronary syndrome. | 2005 | N. Engl. J. Med. | pmid:16080250 |
Gabrielli M et al. | Azithromycin on soluble cell adhesion molecules and markers of inflammation in survivors of an acute coronary syndrome. | 2005 | Am. Heart J. | pmid:16084141 |
Sharma S and El-Refaey H | Vaginal azithromycin and misoprostol before surgical abortion. | 2005 | Fertil. Steril. | pmid:16084904 |
Shinkai M et al. | Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16085674 |
Murray JJ et al. | Efficacy and safety of a novel, single-dose azithromycin microsphere formulation versus 10 days of levofloxacin for the treatment of acute bacterial sinusitis in adults. | 2005 | Otolaryngol Head Neck Surg | pmid:16087013 |
Marple BF | Editorial commentary: dilemma in trial design: do current study designs adequately evaluate effectiveness antibiotic in ABRS? | 2005 | Otolaryngol Head Neck Surg | pmid:16087014 |
Barrett B et al. | Validated HPLC-MS-MS method for determination of azithromycin in human plasma. | 2005 | Anal Bioanal Chem | pmid:16091946 |
Elitok B et al. | Efficacy of azithromycin dihydrate in treatment of cryptosporidiosis in naturally infected dairy calves. | 2005 Jul-Aug | J. Vet. Intern. Med. | pmid:16095179 |
Taylor-Robinson D and Boman J | The failure of antibiotics to prevent heart attacks. | 2005 | BMJ | pmid:16096289 |
Silvers JA and Champney WS | Accumulation and turnover of 23S ribosomal RNA in azithromycin-inhibited ribonuclease mutant strains of Escherichia coli. | 2005 | Arch. Microbiol. | pmid:16096836 |
Rotschild M et al. | Autoantibodies against bactericidal/permeability-increasing protein (BPI-ANCA) in cystic fibrosis patients treated with azithromycin. | 2005 | Clin. Exp. Med. | pmid:16096858 |
Wagner T et al. | Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients. | 2005 | Chest | pmid:16100186 |
Verleden GM et al. | Effect of azithromycin on bronchiectasis and pulmonary function in a heart-lung transplant patient with severe chronic allograft dysfunction: a case report. | 2005 | J. Heart Lung Transplant. | pmid:16102464 |
Rekart ML et al. | The impact of syphilis mass treatment one year later: self-reported behaviour change among participants. | 2005 | Int J STD AIDS | pmid:16105193 |
Shibata Y et al. | [Evaluation of anti-inflammatory effect of macrolides on macrophages]. | 2004 | Jpn J Antibiot | pmid:16108591 |
Mizunoe T et al. | [The mechanism of apoptosis induction in lymphocytes by macrolide antibiotics and the related intra-cellular molecular structure]. | 2004 | Jpn J Antibiot | pmid:16108600 |
Gaynor BD et al. | Topical ocular antibiotics induce bacterial resistance at extraocular sites. | 2005 | Br J Ophthalmol | pmid:16113356 |
Ollivier V et al. | Modulation of tissue factor expression by rapamycin and FK-506 in lipopolysaccharide-stimulated human mononuclear cells and serum-stimulated aortic smooth muscle cells. | 2005 | Thromb. Haemost. | pmid:16113783 |
Block SL et al. | A comparison of 5 days of therapy with cefdinir or azithromycin in children with acute otitis media: a multicenter, prospective, single-blind study. | 2005 | Clin Ther | pmid:16117986 |
Milstone A et al. | Prospective observational study of patient-reported outcomes for azithromycin versus usual care in the treatment of bacterial acute exacerbation of chronic bronchitis. | 2005 | Clin Ther | pmid:16117993 |
Gillis RJ et al. | Molecular basis of azithromycin-resistant Pseudomonas aeruginosa biofilms. | 2005 | Antimicrob. Agents Chemother. | pmid:16127063 |
RÃos AM et al. | Microbiologic and immunologic evaluation of a single high dose of azithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia. | 2005 | Antimicrob. Agents Chemother. | pmid:16127085 |
Frota LC et al. | Helicobacter pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy: an open randomized clinical trial. | 2005 Apr-Jun | Arq Gastroenterol | pmid:16127567 |
Bouwman JJ et al. | Azithromycin reduces Chlamydia pneumoniae-induced attenuation of eNOS and cGMP production by endothelial cells. | 2005 | Eur. J. Clin. Invest. | pmid:16128864 |
Ioannidis J and Wilkinson D | HIV: prevention of opportunistic infections. | 2005 | Clin Evid | pmid:16135281 |
Graziani F et al. | Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction. | 2005 | Pharmacol. Res. | pmid:16140544 |
Shitrit D et al. | Long-term azithromycin use for treatment of bronchiolitis obliterans syndrome in lung transplant recipients. | 2005 | J. Heart Lung Transplant. | pmid:16143268 |
Salgado HR and Roncari AF | Microbiological assay for the determination of azithromycin in ophthalmic solutions. | 2005 | Yao Xue Xue Bao | pmid:16144322 |
Romanowska-Sarlej J et al. | Ultrastructure of the hepatocytes after application of azithromycin (Sumamed). | 2004 | Ann Univ Mariae Curie Sklodowska Med | pmid:16146049 |
Williams TJ and Verleden GM | Azithromycin: a plea for multicenter randomized studies in lung transplantation. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16148194 |
Dagan R et al. | Resistant organisms and otitis media. | 2005 | Pediatr. Infect. Dis. J. | pmid:16148862 |
Marchisio P and Principi N | Single dose azithromycin for treatment of uncomplicated acute otitis media. | 2005 | Pediatr. Infect. Dis. J. | pmid:16148864 |
Shinkai M and Rubin BK | Macrolides and airway inflammation in children. | 2005 | Paediatr Respir Rev | pmid:16153572 |
Rouquette-Loughlin CE et al. | Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae. | 2005 | J. Antimicrob. Chemother. | pmid:16162665 |
Ceccarini M et al. | [Antibiotic prophylaxis in day surgery in dermatology]. | 2005 | Minerva Chir | pmid:16166930 |
Labro MT et al. | Accumulation of azithromycin and roxithromycin in tracheal epithelial fetal cell lines expressing wild type or mutated cystic fibrosis transmembrane conductance regulator protein (CFTR). | 2005 | J Chemother | pmid:16167517 |
Pradal U et al. | Long-term azithromycin in cystic fibrosis: another possible mechanism of action? | 2005 | J Chemother | pmid:16167518 |
Chidambaram JD and Lietman TM | Trachoma. | 2005 | Br J Ophthalmol | pmid:16170104 |
Burton MJ et al. | A randomised controlled trial of azithromycin following surgery for trachomatous trichiasis in the Gambia. | 2005 | Br J Ophthalmol | pmid:16170117 |
Rodriguez CN et al. | Quinolone and azithromycin-resistant Neisseria meningitidis serogroup C causing urethritis in a heterosexual man. | 2005 | Int J STD AIDS | pmid:16176640 |
Riedner G et al. | Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. | 2005 | N. Engl. J. Med. | pmid:16177249 |
Holmes KK | Azithromycin versus penicillin G benzathine for early syphilis. | 2005 | N. Engl. J. Med. | pmid:16177256 |
Tripathi R et al. | Blood schizontocidal activity of azithromycin and its combination with alpha/beta arteether against multi-drug resistant Plasmodium yoelii nigeriensis, a novel MDR parasite model for antimalarial screening. | 2005 | Parasitology | pmid:16178350 |
Equi AC et al. | Exploring the mechanisms of macrolides in cystic fibrosis. | 2006 | Respir Med | pmid:16185859 |
Azithromycin extended-release (Zmax) for sinusitis and pneumonia. | 2005 | Med Lett Drugs Ther | pmid:16186790 | |
D'Ignazio J et al. | Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults. | 2005 | Antimicrob. Agents Chemother. | pmid:16189077 |
No value in antibiotic therapy for HD. | 2005 | Health News | pmid:16189853 | |
Valdes A and Johnson JR | Septic pleuritis and abdominal abscess formation caused by Rhodococcus equi in a foal. | 2005 | J. Am. Vet. Med. Assoc. | pmid:16190597 |
Biuk D et al. | Serum sickness and uveitis. | 2005 | Coll Antropol | pmid:16193694 |
Chaudhary C et al. | A pilot study on antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Nepal. | 2005 | Sex Transm Dis | pmid:16205307 |
Soley CA and Arguedas A | Single-dose azithromycin for the treatment of children with acute otitis media. | 2005 | Expert Rev Anti Infect Ther | pmid:16207162 |
Cárceles CM et al. | Pharmacokinetics of azithromycin after i.v. and i.m. administration to sheep. | 2005 | J. Vet. Pharmacol. Ther. | pmid:16207311 |
Don DM et al. | Antimicrobial therapy for children with adenotonsillar hypertrophy and obstructive sleep apnea: a prospective randomized trial comparing azithromycin vs placebo. | 2005 | Otolaryngol Head Neck Surg | pmid:16213930 |
West SK et al. | Infection with Chlamydia trachomatis after mass treatment of a trachoma hyperendemic community in Tanzania: a longitudinal study. | 2005 | Lancet | pmid:16214600 |
Blasi F et al. | Azithromycin and lower respiratory tract infections. | 2005 | Expert Opin Pharmacother | pmid:16218893 |
Galetin A et al. | Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. | 2006 | Drug Metab. Dispos. | pmid:16221752 |
Schmutz JL et al. | [Azithromycin and Stevens-Johnson syndrome]. | 2005 Aug-Sep | Ann Dermatol Venereol | pmid:16230934 |
Drehobl MA et al. | Single-dose azithromycin microspheres vs clarithromycin extended release for the treatment of mild-to-moderate community-acquired pneumonia in adults. | 2005 | Chest | pmid:16236879 |
Gilbert D and Gerber MA | Regarding "antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders". | 2005 | Biol. Psychiatry | pmid:16242119 |
Budman C et al. | Regarding "antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders". | 2005 | Biol. Psychiatry | pmid:16242121 |
Gaillac N et al. | Legionella pneumophila pneumonia during pregnancy: a case report. | 2006 | J. Infect. | pmid:16246423 |
Sharma JB et al. | Comparative efficacy of two regimens in syndromic management of lower genital infections. | 2006 | Arch. Gynecol. Obstet. | pmid:16247610 |