Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wubbel L et al. | Etiology and treatment of community-acquired pneumonia in ambulatory children. | 1999 | Pediatr. Infect. Dis. J. | pmid:10048679 |
Nightingale CH | Pharmacokinetics and pharmacodynamics of newer macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109156 |
Block SL | Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109158 |
Tarlow MJ et al. | Future indications for macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109159 |
Meyer Sauteur PM et al. | Neuroinvasive Mycoplasma pneumoniae infection without intrathecal antibody response. | 2012 | Pediatr. Infect. Dis. J. | pmid:22760530 |
Dagan R et al. | Resistant organisms and otitis media. | 2005 | Pediatr. Infect. Dis. J. | pmid:16148862 |
Fleming-Dutra KE et al. | Variations in Antibiotic and Azithromycin Prescribing for Children by Geography and Specialty-United States, 2013. | 2018 | Pediatr. Infect. Dis. J. | pmid:28746259 |
Arnež M and Ružić-Sabljić E | Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans. | 2015 | Pediatr. Infect. Dis. J. | pmid:26186104 |
Schaad UB and Heynen G | Evaluation of the efficacy, safety and toleration of azithromycin vs. penicillin V in the treatment of acute streptococcal pharyngitis in children: results of a multicenter, open comparative study. The Swiss Tonsillopharyngitis Study Group. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878223 |
Iroh Tam PY | Approach to common bacterial infections: community-acquired pneumonia. | 2013 | Pediatr. Clin. North Am. | pmid:23481110 |
Chand DH et al. | Trial of metronidazole vs. azithromycin for treatment of cyclosporine-induced gingival overgrowth. | 2004 | Pediatr Transplant | pmid:15009842 |
Verma A and Dhawan A | Re: Trial of metronidazole vs. azithromycin for treatment of cyclosporine-induced gingival overgrowth. | 2005 | Pediatr Transplant | pmid:15667627 |
Schwerk N et al. | Chronic Mycoplasma pneumoniae infection in a child after renal transplantation. | 2010 | Pediatr Transplant | pmid:19490490 |
Yang E et al. | Early Mycoplasma pneumoniae infection presenting as multiple pulmonary masses: an unusual presentation in a child. | 2008 | Pediatr Radiol | pmid:18172636 |
Mileusnic D et al. | Pathological case of the month: sudden death in a child as a result of pancreatitis during valproic acid therapy. | 2002 Sep-Oct | Pediatr Pathol Mol Med | pmid:12396903 |
Liu YL et al. | Pediatric round pneumonia. | 2014 | Pediatr Neonatol | pmid:23597522 |
Trent M et al. | Pelvic inflammatory disease in adolescents: care delivery in pediatric ambulatory settings. | 2005 | Pediatr Emerg Care | pmid:16027575 |
Dickson SD and Alter SJ | Cutaneous gonococcal abscess of the abdomen in a child. | 2011 | Pediatr Emerg Care | pmid:21926887 |
Madhogaria S et al. | Childhood cutaneous lymphoid hyperplasia following feline scratches. | 2010 May-Jun | Pediatr Dermatol | pmid:20609149 |
Meyer Sauteur PM et al. | Fuchs syndrome associated with Mycoplasma pneumoniae (Stevens-Johnson syndrome without skin lesions). | 2011 Jul-Aug | Pediatr Dermatol | pmid:20678095 |
Bauer KA et al. | Drug reaction with eosinophilia and systemic symptoms (DRESS) associated with azithromycin in acute Epstein-Barr virus infection. | 2011 Nov-Dec | Pediatr Dermatol | pmid:22010986 |
Suesaowalak M et al. | Chlamydophila pneumoniae myopericarditis in a child. | 2009 | Pediatr Cardiol | pmid:18953592 |
Paul SR et al. | Polymorphous hemangioendothelioma in a child with acquired immunodeficiency syndrome (AIDS). | 2008 | Pediatr Blood Cancer | pmid:16991137 |
Lancioni C et al. | Pulmonary tuberculosis presenting as fever without source in a pediatric patient with acute lymphoblastic leukemia. | 2009 | Pediatr Blood Cancer | pmid:19618457 |
Jenson A et al. | Patient-centered communication of community treatment assistants in Tanzania predicts coverage of future mass drug administration for trachoma. | 2018 | Patient Educ Couns | pmid:29329726 |
Valcanis M et al. | Outbreak of locally acquired azithromycin-resistant Shigella flexneri infection in men who have sex with men. | 2015 | Pathology | pmid:25474524 |
Carbon C | [Azithromycin: from macrolides to azalides]. | 1995 | Pathol. Biol. | pmid:8539067 |
[Special issue devoted to azithromycin]. | 1995 | Pathol. Biol. | pmid:8539068 | |
Bergogne-Bérézin E | [Azithromycin: tissue pharmacology]. | 1995 | Pathol. Biol. | pmid:8539071 |
Singlas E | [Clinical pharmacokinetics of azithromycin]. | 1995 | Pathol. Biol. | pmid:8539072 |
Felstead S | Azithromycin drug interactions. | 1995 | Pathol. Biol. | pmid:8539073 |
Modaï J | [Azithromycin: clinical assessment]. | 1995 | Pathol. Biol. | pmid:8539076 |
Gehanno P | [Use of azithromycin in ORL]. | 1995 | Pathol. Biol. | pmid:8539077 |
Leophonte P | [Azithromycin and bronchopulmonary infections]. | 1995 | Pathol. Biol. | pmid:8539078 |
Micoud M and Pépin LF | [Azithromycin and genital infections]. | 1995 | Pathol. Biol. | pmid:8539079 |
Coulaud JP | [Azithromycin: new orientations]. | 1995 | Pathol. Biol. | pmid:8539080 |
Reinert P | [Effects of azithromycin on the virulence of Pseudomonas aeruginosa]. | 1995 | Pathol. Biol. | pmid:8539081 |
Mégraud F et al. | [Helicobacter pylori and azithromycin]. | 1995 | Pathol. Biol. | pmid:8539082 |
Derouin F | [New pathogens and mode of action of azithromycin: Toxoplasma gondii]. | 1995 | Pathol. Biol. | pmid:8539083 |
Perronne C | [Azithromycin and Mycobacterium avium infection]. | 1995 | Pathol. Biol. | pmid:8539084 |
Edelstein PH | Review of azithromycin activity against Legionella spp. | 1995 | Pathol. Biol. | pmid:8539085 |
Lefèvre JC et al. | In vitro evaluation of activities of azithromycin, clarithromycin and sparfloxacin against Chlamydia trachomatis. | 1993 | Pathol. Biol. | pmid:8233628 |
Le Normand Y et al. | [An example of simulation for a better understanding of PK/PD relationship of antibiotics]. | 2004 | Pathol. Biol. | pmid:15596309 |
Fernando S et al. | Failure of oral antibiotic therapy, including azithromycin, in the treatment of a recurrent breast abscess caused by Salmonella enterica serotype Paratyphi A. | 2012 | Pathog Glob Health | pmid:23182142 |
Perez AC et al. | Residence of Streptococcus pneumoniae and Moraxella catarrhalis within polymicrobial biofilm promotes antibiotic resistance and bacterial persistence in vivo. | 2014 | Pathog Dis | pmid:24391058 |
Olszewska-Sosińska O et al. | Persistence of non-typeable Haemophilus Influenzae in the pharynx of children with adenotonsillar hypertrophy after treatment with azithromycin. | 2016 | Pathog Dis | pmid:26546328 |
Tripathi R et al. | Blood schizontocidal activity of azithromycin and its combination with alpha/beta arteether against multi-drug resistant Plasmodium yoelii nigeriensis, a novel MDR parasite model for antimalarial screening. | 2005 | Parasitology | pmid:16178350 |
Meamar AR et al. | Cryptosporidium parvum bovine genotype oocysts in the respiratory samples of an AIDS patient: efficacy of treatment with a combination of azithromycin and paromomycin. | 2006 | Parasitol. Res. | pmid:16416289 |
Molefe NI et al. | Oral administration of azithromycin ameliorates trypanosomosis in Trypanosoma congolense-infected mice. | 2017 | Parasitol. Res. | pmid:28674747 |
Hoerauf A et al. | Effects of 6-week azithromycin treatment on the Wolbachia endobacteria of Onchocerca volvulus. | 2008 | Parasitol. Res. | pmid:18421478 |
Montazeri M et al. | Activities of anti-Toxoplasma drugs and compounds against tissue cysts in the last three decades (1987 to 2017), a systematic review. | 2018 | Parasitol. Res. | pmid:30088074 |
Last AR et al. | The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa. | 2017 | Parasit Vectors | pmid:29282126 |
Checa R et al. | Efficacy, safety and tolerance of imidocarb dipropionate versus atovaquone or buparvaquone plus azithromycin used to treat sick dogs naturally infected with the Babesia microti-like piroplasm. | 2017 | Parasit Vectors | pmid:28292316 |
Rudoler N et al. | Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. | 2015 | Parasit Vectors | pmid:25888870 |
Pellicano R et al. | Efficacy of azythromicin-based triple therapy for Helicobacter pylori infection: a retrospective study. | 2008 | Panminerva Med | pmid:18927531 |
Barbon V | On the efficacy of macrolide-based therapy for Helicobacter pylori infection. | 2009 | Panminerva Med | pmid:19352310 |
Bregani ER et al. | Azithromycin in the treatment of Plasmodium falciparum gametocytes. Preliminary observation. | 2000 | Panminerva Med | pmid:11218625 |
Kigen G et al. | Collateral benefits arising from mass administration of azithromycin in the control of active trachoma in resource limited settings. | 2014 | Pan Afr Med J | pmid:25852799 |
Sultana N et al. | Degradation studies of azithromycin and its spectrophotometric determination in pharmaceutical dosage forms. | 2006 | Pak J Pharm Sci | pmid:16751118 |
Yousef AA and Jaffe A | The role of azithromycin in patients with cystic fibrosis. | 2010 | Paediatr Respir Rev | pmid:20416547 |
Shinkai M and Rubin BK | Macrolides and airway inflammation in children. | 2005 | Paediatr Respir Rev | pmid:16153572 |
Wood N and McIntyre P | Pertussis: review of epidemiology, diagnosis, management and prevention. | 2008 | Paediatr Respir Rev | pmid:18694712 |
Cooper WO et al. | Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations. | 2009 | Paediatr Perinat Epidemiol | pmid:19228311 |
Pocock JM et al. | Septic arthritis of the hip in a Cambodian child caused by multidrug-resistant Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin treated with ceftriaxone and azithromycin. | 2014 | Paediatr Int Child Health | pmid:24749773 |
Williams PCM and Berkley JA | Guidelines for the management of paediatric cholera infection: a systematic review of the evidence. | 2018 | Paediatr Int Child Health | pmid:29790841 |
Chang CC et al. | Disseminated cat-scratch disease: case report and review of the literature. | 2016 | Paediatr Int Child Health | pmid:25940800 |
Ovetchkine P and Cohen R | Shortened course of antibacterial therapy for acute otitis media. | 2003 | Paediatr Drugs | pmid:12529165 |
Korppi M | Community-acquired pneumonia in children: issues in optimizing antibacterial treatment. | 2003 | Paediatr Drugs | pmid:14658923 |
Brook I | Antibacterial therapy for acute group a streptococcal pharyngotonsillitis: short-course versus traditional 10-day oral regimens. | 2002 | Paediatr Drugs | pmid:12390046 |
Zar HJ | Neonatal chlamydial infections: prevention and treatment. | 2005 | Paediatr Drugs | pmid:15871630 |
Kowey PR and Yan GX | Discarding the baby with the bathwater. | 2007 | Pacing Clin Electrophysiol | pmid:18070294 |
Huang BH et al. | Azithromycin-induced torsade de pointes. | 2007 | Pacing Clin Electrophysiol | pmid:18070319 |
Granowitz EV et al. | Potentially fatal interaction between azithromycin and disopyramide. | 2000 | Pacing Clin Electrophysiol | pmid:11025903 |
Samarendra P et al. | QT prolongation associated with azithromycin/amiodarone combination. | 2001 | Pacing Clin Electrophysiol | pmid:11707055 |
Kim MH et al. | Polymorphic ventricular tachycardia with a normal QT interval following azithromycin. | 2005 | Pacing Clin Electrophysiol | pmid:16359290 |
El-Shitany NA and El-Desoky K | Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression. | 2016 | Oxid Med Cell Longev | pmid:27274777 |
Don DM et al. | Antimicrobial therapy for children with adenotonsillar hypertrophy and obstructive sleep apnea: a prospective randomized trial comparing azithromycin vs placebo. | 2005 | Otolaryngol Head Neck Surg | pmid:16213930 |
Murray JJ et al. | Efficacy and safety of a novel, single-dose azithromycin microsphere formulation versus 10 days of levofloxacin for the treatment of acute bacterial sinusitis in adults. | 2005 | Otolaryngol Head Neck Surg | pmid:16087013 |
Marple BF | Editorial commentary: dilemma in trial design: do current study designs adequately evaluate effectiveness antibiotic in ABRS? | 2005 | Otolaryngol Head Neck Surg | pmid:16087014 |
Munson PD et al. | Cat-scratch disease of the head and neck in a pediatric population: surgical indications and outcomes. | 2008 | Otolaryngol Head Neck Surg | pmid:18722212 |
Elzir L and Saliba I | Bullous hemorrhagic myringitis. | 2013 | Otolaryngol Head Neck Surg | pmid:23239808 |
Nemes-Nikodém É et al. | [Antimicrobal resistance of Neisseria gonorrhoeae strains in Hungary]. | 2015 | Orv Hetil | pmid:25639637 |
Arvai M et al. | [Purulent keratoconjunctivitis due to Neisseria gonorrhoeae and Chlamydia trachomatis coinfection]. | 2013 | Orv Hetil | pmid:23692878 |
Schilling F | [Chronic recurrent multifocal osteomyelitis. Opinion exchange concerning the article by T. Seidl et al in Der Orthopäde (2003) 32:535-540]. | 2003 | Orthopade | pmid:14655012 |
Glansdorp FG et al. | Using chemical probes to investigate the sub-inhibitory effects of azithromycin. | 2008 | Org. Biomol. Chem. | pmid:18972042 |
Allard FD et al. | Dacryocystitis secondary to intranasal cocaine abuse: a case report and literature review. | 2013 | Orbit | pmid:23909455 |
Atkin PA and Simms ML | Orofacial granulomatosis: an unsuccessful response to weekly azithromycin pulse therapy. | 2018 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:29477603 |
Kusafuka Y et al. | Effect of single-dose extended-release oral azithromycin on anticoagulation status in warfarinized patients. | 2013 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:23182375 |
Tomás I et al. | Susceptibility of oral obligate anaerobes to telithromycin, moxifloxacin and a number of commonly used antibacterials. | 2007 | Oral Microbiol. Immunol. | pmid:17803626 |
Haffajee AD et al. | Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis. | 2008 | Oral Microbiol. Immunol. | pmid:18279183 |
Pajukanta R | In vitro antimicrobial susceptibility of Porphyromonas gingivalis to azithromycin, a novel macrolide. | 1993 | Oral Microbiol. Immunol. | pmid:8265209 |
Gregory AR et al. | Ophthalmomyiasis caused by the sheep bot fly Oestrus ovis in northern Iraq. | 2004 | Optom Vis Sci | pmid:15300116 |
Tabbara KF et al. | Single-dose azithromycin in the treatment of trachoma. A randomized, controlled study. | 1996 | Ophthalmology | pmid:8637698 |
Karcioglu ZA et al. | Pharmacokinetics of azithromycin in trachoma patients: serum and tear levels. | 1998 | Ophthalmology | pmid:9544640 |
Biebesheimer JB et al. | Complete local elimination of infectious trachoma from severely affected communities after six biannual mass azithromycin distributions. | 2009 | Ophthalmology | pmid:19744717 |
Dave SB et al. | Changes in ocular flora in eyes exposed to ophthalmic antibiotics. | 2013 | Ophthalmology | pmid:23415422 |
Wladis EJ et al. | Oral Antibiotics for Meibomian Gland-Related Ocular Surface Disease: A Report by the American Academy of Ophthalmology. | 2016 | Ophthalmology | pmid:26707417 |
Dave SB et al. | Ophthalmic antibiotic use and multidrug-resistant staphylococcus epidermidis: a controlled, longitudinal study. | 2011 | Ophthalmology | pmid:21856006 |
Wolle MA et al. | Constant ocular infection with Chlamydia trachomatis predicts risk of scarring in children in Tanzania. | 2009 | Ophthalmology | pmid:19091415 |
Kim SJ and Toma HS | Ophthalmic antibiotics and antimicrobial resistance a randomized, controlled study of patients undergoing intravitreal injections. | 2011 | Ophthalmology | pmid:21420176 |