Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

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Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

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What functions are associated with Azithramycine?


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What lipids are associated with Azithramycine?

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What genes are associated with Azithramycine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Azithramycine

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Authors Title Published Journal PubMed Link
Bogdanov MB and Chernen'kaia TV [Microbiological evaluation of antibiotics for empirical therapy of community-acquired infections of the lower respiratory tract]. 2000 Antibiot. Khimioter. pmid:11212394
Budanov SV [Azithromycin (sumamed)--basic properties and therapy of community-acquired pneumonia]. 2000 Antibiot. Khimioter. pmid:11212397
Solomon AW et al. Pilot study of the use of community volunteers to distribute azithromycin for trachoma control in Ghana. 2001 Bull. World Health Organ. pmid:11217675
Bregani ER et al. Azithromycin in the treatment of Plasmodium falciparum gametocytes. Preliminary observation. 2000 Panminerva Med pmid:11218625
Mizen L The activity of antibiotics against Legionella pneumophila: in vitro and in vivo studies. 2001 J. Antimicrob. Chemother. pmid:11222573
Weiss LM et al. The treatment of babesiosis. 2001 N. Engl. J. Med. pmid:11236789
Ranque S The treatment of babesiosis. 2001 N. Engl. J. Med. pmid:11236790
Dagan R et al. Antibiotic treatment in acute Otitis Media promotes superinfection with resistant Streptococcus pneumoniae carried before initiation of treatment. 2001 J. Infect. Dis. pmid:11237804
Hyde TB et al. Azithromycin prophylaxis during a hospital outbreak of Mycoplasma pneumoniae pneumonia. 2001 J. Infect. Dis. pmid:11237807
Cascaval RI and Lancaster DJ Hypersensitivity syndrome associated with azithromycin. 2001 Am. J. Med. pmid:11247598
Duran JM and Amsden GW Azithromycin: indications for the future? 2000 Expert Opin Pharmacother pmid:11249533
Amábile-Cuevas CF et al. Comparative in vitro activity of moxifloxacin by E-test against Streptococcus pyogenes. 2001 Clin. Infect. Dis. pmid:11249826
De Diego JI et al. Comparison of amoxicillin and azithromycin in the prevention of recurrent acute otitis media. 2001 Int. J. Pediatr. Otorhinolaryngol. pmid:11249979
Sahm DF et al. Need for annual surveillance of antimicrobial resistance in Streptococcus pneumoniae in the United States: 2-year longitudinal analysis. 2001 Antimicrob. Agents Chemother. pmid:11257013
Baumann U et al. Buccal adherence of Pseudomonas aeruginosa in patients with cystic fibrosis under long-term therapy with azithromycin. 2001 Jan-Feb Infection pmid:11261763
Lietman T and Fry A Can we eliminate trachoma? 2001 Br J Ophthalmol pmid:11264123
Grand A et al. [Subacute infectious endocarditis due to the agent of cat scratch fever: Bartonella henselae]. 2001 Arch Mal Coeur Vaiss pmid:11265556
Graybill JR and Bocanegra R Treatment alternatives for Mycobacterium kansasii. 2001 J. Antimicrob. Chemother. pmid:11266413
Ferwerda A et al. Efficacy, safety and tolerability of 3 day azithromycin versus 10 day co-amoxiclav in the treatment of children with acute lower respiratory tract infections. 2001 J. Antimicrob. Chemother. pmid:11266417
Butler T et al. In vitro effects of azithromycin on Salmonella typhi: early inhibition by concentrations less than the MIC and reduction of MIC by alkaline pH and small inocula. 2001 J. Antimicrob. Chemother. pmid:11266420