Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

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Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

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What functions are associated with Azithramycine?


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What lipids are associated with Azithramycine?

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What genes are associated with Azithramycine?

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What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Azithramycine

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Authors Title Published Journal PubMed Link
Fortner JH et al. Tapetal effect of an azalide antibiotic following oral administration in beagle dogs. 1993 Fundam Appl Toxicol pmid:8405779
Narcio Reyes LE et al. [Efficacy and safety of azithromycin in the treatment of female genital Chlamydia trachomatis infections]. 1993 Ginecol Obstet Mex pmid:8406112
Donowitz GR and Earnhardt KI Azithromycin inhibition of intracellular Legionella micdadei. 1993 Antimicrob. Agents Chemother. pmid:8285604
Gomberg MA and MashkilleÄ­son AL [Use of azithromycin in long existing urogenital chlamydia infections and its association with primary syphilis]. 1993 Antibiot. Khimioter. pmid:8060178
Sidorenko SV [Azithromycin--an antibiotic of the azalide group]. 1993 Antibiot. Khimioter. pmid:8060181
Lopatkin NA et al. [Use of azithromycin ("Sumamded") in the treatment of infectious-inflammatory diseases of the lower urinary tract and male genitalia]. 1993 Antibiot. Khimioter. pmid:8060189
Guerra LG et al. Rapid response of AIDS-related bacillary angiomatosis to azithromycin. 1993 Clin. Infect. Dis. pmid:8399879
Workowski KA et al. Azithromycin in chlamydial urethritis. 1993 JAMA pmid:8411548
Genç M et al. An economic evaluation of screening for Chlamydia trachomatis in adolescent males. 1993 JAMA pmid:8411572
Lazarova Z et al. Azithromycin (Sumamed-Pliva) in the treatment of chlamydial genital tract infections in infertile marriages. 1992 Nov-Dec Int J STD AIDS pmid:1337473
Martin DH et al. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group. 1992 N. Engl. J. Med. pmid:1325036
Gingras BA and Jensen JB Activity of azithromycin (CP-62,993) and erythromycin against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro. 1992 Am. J. Trop. Med. Hyg. pmid:1326232
Cynamon MH and Klemens SP Activity of azithromycin against Mycobacterium avium infection in beige mice. 1992 Antimicrob. Agents Chemother. pmid:1329622
Ballow CH and Amsden GW Azithromycin: the first azalide antibiotic. 1992 Ann Pharmacother pmid:1330097
Nilsen A et al. A double blind study of single dose azithromycin and doxycycline in the treatment of chlamydial urethritis in males. 1992 Genitourin Med pmid:1330880
Jones AB and Herbert CM The in vitro profile of selected 14-membered azalides. 1992 J. Antibiot. pmid:1334956
Engel JN Azithromycin-induced block of elementary body formation in Chlamydia trachomatis. 1992 Antimicrob. Agents Chemother. pmid:1280057
Peters DH et al. Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy. 1992 Drugs pmid:1280567
Frank MO et al. In vitro demonstration of transport and delivery of antibiotics by polymorphonuclear leukocytes. 1992 Antimicrob. Agents Chemother. pmid:1336337
O'Reilly T et al. Relationship between antibiotic concentration in bone and efficacy of treatment of staphylococcal osteomyelitis in rats: azithromycin compared with clindamycin and rifampin. 1992 Antimicrob. Agents Chemother. pmid:1336342